研究队伍
姓名:
　张翱性别:
　男
职称:
　研究员学历:
　博士
电话:
　021-50806035传真:
　
电子邮件:
　aozhang@mail.shcnc.ac.cn个人主页:
　
通讯地址:
　上海市祖冲之路555号　201203

简历：
1988年9月至1992年7月，就读于西华师范大学化学系，获学士学位；1992年9月至1995年7月，就读于南开大学元素有机化学研究所，获硕士学位；1997年10月至2000年10月，中科院上海有机化学研究所，获博士学位，导师为姜标研究员。1995年7至1997年9月，在中科院上海有机化学研究所工作，任研究实习员。2001年2月至2002年3月，在美国乔治敦大学(GeorgetownUniversity)医药中心作博士后访问学者；2002年4月至2006年2月，在美国哈佛大学(HarvardUniversity)医学院工作，任哈佛医学院Instructor,McLeanHospital药物化学研究室AssistantDirector,美国化学会东北分会会刊《TheNucleus》副编辑；2005年获中科院“百人计划”称号，2006年至今在中国科学院上海药物研究所工作，获中科院“百人计划”择优支持。2010年获中科院百人计划终期评估优秀奖，2011年获国家杰出青年基金。

研究方向：
张翱研究组主要从事创新药物研发及相关基础研究，尤其是靶向G-蛋白偶联受体（GPCR）和酪氨酸激酶（RTK）新型小分子药物的设计与合成研究。主要是通过发展新颖简捷合成方法实现类药性优势骨架的高效合成，以及基于活性天然产物类药性骨架进行多样性合成和衍生化，结合现代药物结构优化策略，探索药物的结构与活性、结构与靶向性、结构与成药性等规律，进而开发具有抗神经退行性疾病和抗肿瘤活性的新型药物。研究组目前正在进行的研究课题主要有：【1】具有抗肿瘤活性的类药性天然产物的合成及基于成药性的结构优化；【2】靶向酪氨酸激酶或DNG修复等特异性或多靶性抑制剂抗肿瘤药物的设计与合成；【3】靶向G-蛋白偶联受体小分子药物的设计及抗神经退行性疾病活性研究。

专家类别：
研究员；百人计划；国家杰出青年

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：


承担科研项目情况：


社会任职：


获奖及荣誉：
2004年获哈佛医学院McLeanHospital年度最高学术奖-ALFREDPOPEAWARD；同年还获得哈佛医学院McLeanHospital-ADAMCORNEELYOUNGINVESTIGATORAWARD；2010年获中科院“百人计划”终期评估优秀奖；2011年获国家杰出青年基金。

代表论著：
1、SELECTEDPUBLICATIONS(2009-2011)

1. ChengtangDu,FulongLi,XuefengZhang,WenxiangHu,QizhengYao,AoZhang.LewisAcid-CatalyzedCyclizationofGlycals/2-deoxy-D-ribosewithArylAmines:AdditionalFindingsonProductStructureandReactionDiastereoselectivity.J.Org.Chem.2011,76,8833-8839.
   
2. JunSun,XuefengZhang,FulongLi,ChunyongDing,WenjuanWu,AoZhang.Base-promotedreactionofmethyl4,6-O-benzylidene-3-deoxy-hexopyranosid-2-uloseandvariousarylaminesTetrahedronLett.2011,52,5693-5696.
   
3. YuanxiangWang,JingAi,GangLiu,MeiyuGeng,AoZhang.Expeditiousone-potsynthesisofC3-piperazinyl-substitutedquinolines:keyprecursorstopotentc-Metinhibitors.Org.Biomol.Chem.2011,9,5930-5933.
   
4. HaiZhang,NaYe,ShanglinZhou,LinGuo,LongtaiZheng,ZhiliLiu,BoGao,XuechuZhen,andAoZhang:IdentificationofN-Propylnoraporphin-11-yl5-(1,2-Dithiolan-3-yl)pentanoateasaNewAnti-Parkinson'sAgentPossessingaDopamineD2andSerotonin5-HT1ADual-AgonistProfile.J.Med.Chem.2011,54,4324-4338.
   
5. AilingZhao,XinGao,YuanxiangWang,JingAi,YingWang,YiChen,MeiyuGeng,AoZhang:Discoveryofnovelc-Metkinaseinhibitorsbearingathieno[2,3-d]pyrimidineorfuro[2,3-d]pyrimidinescaffold.Bioorg.Med.Chem.2011,19,3906-3918.
   
6. ZhiqingLiu,QingzhangZhu,FuyingLi,LinaZhang,YingLeng,AoZhang:N-(5-SubstitutedThiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)PropanamidesasGlucokinaseActivators.MedChemComm2011,2(6),531-535.
   
7. FulongLi,ChunyongDing,MeiningWang,QizhengYao,AoZhang:InBr3-CatalyzedGlycosidationofGlycalswithArylamines:AnAlternativeApproachToAccess4-Aminocyclopent-2-enones.J.Org.Chem.2011,76,2820–2827.
   
8. YuanxiangWang,JingAi,YingWang,YiChen,LuWang,GangLiu,MeiyuGeng,AoZhang:Synthesisandc-Metkinaseinhibitionof3,5-di-and3,5,7-tri-substitutedquinolines:identificationof3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolineasanovelanticanceragent.J.Med.Chem.2011,54,2127–2142.
   
9. NaYe,QianQianWu,LiyuanZhu,LongtaiZheng,BoGao,XuechuZhen,AoZhang:FurtherSARstudyon11-O-substitutedaporphineanalogues:IdentificationofhighlypotentdopamineD3receptorligands.Bioorg.Med.Chem.2011,19,1999-2008.
   
10. JingZhang,KuiWu,MeiningWang,JianqinJiang,AoZhang:FeCl3.6H2O-promotedskeleton-rearrangementof1-substituted-3-benzazepines:substrateextensionandproductutilization.Tetrahedron2011,67,842-848.
    
11. Tu,S.;Ding,C.;Hu,W.;Li,F.;Yao,Q.;ZhangA.Facilesynthesisofindole-orbenzofuran-fusedbenzo[a]carbazole-1,4-dionesusingatandemtwo-stepreactionsequence.MolDivers.2011,15,91-99.
    
12. FuyingLi,QingzhangZhu,YiZhang,YingFeng,YingLeng,AoZhang:Design,synthesisandpharmacologicalevaluationofN-(4-monoand4,5-disubstitutedthiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamidesasglucokinaseactivators.Bioorg.Med.Chem.2010,18,3875-3884.
    
13. ChunyongDing,ShanghuiTu,QizhengYao,FulongLi,YuanxiangWang,WenxiangHu,AoZhang:One-PotThree-stepSynthesisofNaphtho[2,3-a]carbazole-5,13-dionesUsingTandemRadicalAlkylation-Cyclization-AromatizationReactionSequence.AdvSynCatal2010,352,847-853.
    
14. ZhiliLiu,HaiZhang,NaYe,JingZhang,QianQianWu,PeihuaSun,LinyongLi,XuechuZhen,andAoZhang:SynthesisofDihydrofuroaporphineDerivatives:IdentificationofaPotentandSelectiveSerotonin5-HT1AReceptorAgonist.J.Med.Chem.2010,53,1319-1328.
    
15. YiZhang,ZhaobinHan,FuyingLi,KuilingDingandAoZhang:Highlyenantioselectivehydrogenationofa-aryl-b-substitutedacrylicacidscatalyzedbyIr-SpinPHOX.Chem.Commun.2010,46,156–158.
    
16. JingZhang,AoZhang:UnprecedentedFeCl3·6H2O-PromotedSkeleton-Rearrangementof1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines:aNewStrategyfortheSynthesisofC-1QuaternaryTetrahydroisoquinolines.Chem.Eur.J.2009,15,11119-11122.
    
17. FuyingLi,ChenleiYin,JieChen,JinggenLiu,XinXie,AoZhang:[6,7]-Heterocycle-Fused14-HydroxymorphinanDerivatives:Design,Synthesis,andOpioidReceptorActivity.ChemMedChem2009,4,2103-2110.
    
18. FuyingLi,ChenleiYin,JieChen,JinggenLiu,XinXie,AoZhang:SynthesisandSARstudyofopioidreceptorligands:momo-andbis-indolomorphinans.ChemBiolDrugDes.2009,74,335-342.
    
19. ChunyongDing,ShanghuiTu,FuyingLi,YuanxiangWang,QizhengYao,WenxiangHu,HuaXie,LinghuaMeng,AoZhang:SynthesisStudyonMarmycinA:PreparationoftheC3’-DesmethylAnalogues.J.Org.Chem.2009,74,6111-6119.
    
20. YuanxiangWang,AoZhang:Expeditioussynthesisof2,3-dihydro-2-alkoxy-3-methylenebenzofuransfromN-benzofuran-3-ylmethylN,N,N-trialkylammoniumbromides.Tetrahedron2009,65,6986-6990.
    
21. FuyingLi,ChenleiYin,JieChen,JinggenLiu,AoZhang:Synthesisandopioidreceptoractivityofindolopropellanes.Bioorg.Med.Chem.Lett.2009,19,4603-4606.
    
22. JingZhang,HaiZhang,WenxianCai,LeipingYu,XuechuZhen,AoZhang:“Click”D1receptoragonistswitha5-HT1AreceptorpharmacophoreproducingD2receptoractivity.Bioorg.Med.Chem.2009,17,4873-4880.
    
23. Xue-QinChen,JingZhang,JohnL.Neumeyer,Guo-ZhangJin,Guo-YuanHu,AoZhang,XuechuZhen:ArylbenzazepinesarepotentmodulatorsforthedelayedrectifierK+channel:apotentialmechanismfortheirneuroprotectiveeffects.PLoSOne.2009,4(6):e5811.
    
24. Yu-JunWang,Yi-MinTao,Fu-YingLi,Yu-HuaWang,Xue-JunXu,JieChen,Ying-LinCao,Zhi-QiangChi,JohnL.Neumeyer,AoZhang,andJing-GenLiu:PharmacologicalCharacterizationofATPM,aNovelMixedAgonistandμAgonist/AntagonistThatAttenuatesMorphineAntinociceptiveToleranceandHeroinSelf-AdministrationBehavior.J.Pharm.Exp.Ther.2009,329,306-313.
    
25. ZhiliLi,JingZhang,AoZhang:Designofmultivalentligandtargetingg-protein-coupledreceptors.
    CurrPharmDes.2009,15,682-718.
    
26. JingZhang,BingXiong,XuechuZhen,AoZhang:DopamineD1receptorligands:Wherearewenowandwherearewegoing,Med.Res.Rev.2009,29,272-294.