研究队伍
姓名:
　岳建民性别:
　男
职称:
　研究员学历:
　博士
电话:
　021-50806718传真:
　021-50806718
电子邮件:
　jmyue@mail.shcnc.ac.cn个人主页:
　
通讯地址:
　上海市祖冲之路555号　201203

简历：
1984年毕业兰州大学化学系,并于1984-1990年在兰州大学化学系相继获硕士及博士学位；1990-1993年在昆明植物研究所作博士后研究；1993-1994年在英国Bristol大学从事博士后研究工作；1994-1996年在昆明植物所任副研究员；1996-1999年联合利华实验室先后任高级研究员和项目组长；1998-至今在中国科学院上海药物研究所任研究员，博士生导师。

研究方向：
主要从事具有重要生物活性天然先导结构的发现与研究。内容包括新颖结构活性天然化合物的发现、结构优化和合成、构效关系研究、新药研究与开发。

专家类别：
研究员；杰青

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：
岳建民长期从事天然产物化学研究，在结构多样、新颖天然活性物质的发现，以及药物先导结构的优化、构效关系与功能研究中，取得了系统和创新性的成绩。他对超过100种药用植物（含常用中药）进行了系统的化学研究，获得3000余个结构多样化的天然化合物，其中新化合物近800个，新骨架化合物70多个（含骨架重排、降解、扩展等），并对大多数新骨架化合物的生源途径进行了探讨，已有30个新颖结构的化合物被NaturalProductReports选为研究热点。发现具有显著生物活性的各类化合物90余个，对其中11类进行了结构优化和构效关系研究，得到了大量的新衍生物，有50余个活性比其母体显著增强，由此获得3个创新药物候选结构，正在进行临床前研究。


承担科研项目情况：
主持完成和承担国家杰出青年基金、国家自然科学基金重点项目、“973”课题、“重大新药创制”和中国科学院重要方向性项目等20余项。

社会任职：


获奖及荣誉：
2000年获得国家杰出青年基金，2003年获上海市优秀学科带头人基金,2005年获得中国科学院“百人计划”、2012年入选“上海领军人才”；2010年获上海市自然科学一等奖。

代表论著：

1. Sheng-PingYang,Xiao-WeiZhang,JingAi,Li-SheGan,Jin-BiaoXu,YingWang,Zu-ShangSu,LuWang,JianDing,Mei-YuGeng*,andJian-MinYue*PotentHGF/c-MetAxisInhibitorsfromEucalyptusglobulus:theCouplingofPhloroglucinolandSesquiterpenoidIsEssentialfortheActivityJournalofMedicinalChemistry2012,55,8183?8187.
   
2. Hong-BingLiu,HuaZhang,PingLi,Zhao-BingGao,andJian-MinYue*,ChukrasonesAandB:PotentialKv1.2PotassiumChannelBlockerswithNewSkeletonsfromChukrasiatabularis,OrganicLetters,2012,14(17),4438-4441.
   
3. TaoYuan,Rong-XiuZhu,Sheng-PingYang,HuaZhang,Chuan-RuiZhang,Jian-MinYue*,SerratustonesAandBRepresentinganUnprecedentedDimerizationPatternofTwoTypesofSesquiterpenoidsfromChloranthusserratus,OrganicLetters,2012,14(12),3198-3201.
   
4. Mei-LingHan,HuaZhang,Sheng-PingYangandJian-MinYue*,WalsucochinoidsAandB:NewRearrangedLimonoidsfromWalsuracochinchinensis,OrganicLetters,2012,14(2),486-489.
   
5. Hong-BingLiu,HuaZhang,PingLi,YanWu,Zhao-BingGao,andJian-MinYue*,Kv1.2PotassiumChannelInhibitorsfromChukrasiatabularis,Org.Biomol.Chem.,2012,10,1448-1458.
   
6. Chuan-RuiZhang,Cheng-QiFan,Shi-HuiDong,Hong-BingLiu,Wen-BinZhou,YanWu,andJian-MinYue*,AngustimineandAngustifolimine:TwoNewAlkaloidsfromDaphniphyllumangustifolium,OrganicLetters,2011,13(9),2440-2443.
   
7. Sheng-PingYang,Hua-DongChen,Shang-GaoLiao,Bo-JunXie,Ze-HongMiao,andJian-MinYue*,AphanamolideA,aNewLimonoidfromAphanamixispolystachya,OrganicLetters,2011,13(1),150-153.
   
8. Hua-DongChen,Sheng-PingYang,Xiu-FengHe,JingAi,Zhen-KaiLiu,Hong-BingLiu,Mei-YuGeng,andJian-MinYue*,TrigochininsA-C:ThreeNovelDaphnane-typeDiterpenesfromTrigonostemonchinensis,OrganicLetters2010,12(6),1168-1171.
   
9. TaoYuan,Rong-XiuZhu,Sheng-PingYang,Shang-GaoLiaoandJian-MinYue^*，StructureDeterminationofGrandifotaneAfromKhayagrandifoliolabyNMR,X-RayDiffraction,andECDCalculation,OrganicLetters,2010,12(2),252-255.
   
10. Shang-GaoLiao,Hua-DongChen,andJian-MinYue*，PlantOrthoesters,ChemicalReviews,2009,109(3),1092-1140.
    
11. Chuan-RuiZhang,Hong-BingLiu,Shi-HuiDong,Jian-YongZhu,YanWu,andJian-MinYue*,CalycinuminesAandB,twonovelalkaloidsfromDaphniphyllumcalycinum,OrganicLetters,2009,10(20),4692-4695.
    
12. TaoYuan,Sheng-PingYang,Chuan-RuiZhang,ShengZhang,andJian-MinYue*,TwoLimonoids,KhayalenoidsAandBwithanUnprecedented8-Oxa-tricyclo[4.3.2.0^2,7]undecaneMotiffromKhayasenegalensis,OrganicLetters,2009,10(3),617-620.
    
13. Hua-DongChen,Xiu-FengHe,JingAi,Mei-YuGengandJian-MinYue*,TrigochilidesAandB,TwoHighlyModifiedDaphnane-TypeDiterpenoidsfromTrigonostemonchinensis,OrganicLetters,2009,10(18),4080-4083.
    
14. ShengYin,Xiu-FengHe,YanWu,andJian-MinYue*，MonoterpenoidindoleAlkaloidsbearinganN4-iridoidfromGelsemiumelegans,Chemistry-AnAsianJournal,2008,3(10),1824-1829.
    
15. Xiu-FengHe,Xiao-NingWang,Li-SheGan,ShengYin,LeiDong,andJian-MinYue*,TwonoveltriterpenoidsfromDysoxylumhainanense,OrganicLetters,2008,10(19),4327-4330.
    
16. Chuan-RuiZhang,Cheng-QiFan,LiZhang,Sheng-PingYang,YanWu,YangLuandJian-MinYue*，ChuktabrinsAandB,TwoNovelLimonoidsfromtheTwigsandLeavesofChukrasiatabularis,OrganicLetters,2008,10(15),3183-3186.
    
17. Sheng-PingYang,Yu-JunCai,Bang-LeZhang,Lin-JiangTong,HuaXie,YanWu,Li-PingLin,JianDing*andJian-MinYue*,StructuralModificationofAngiogenesisInhibitorDiscoveredfromTraditionalChineseMedicine,andStructureActivityRelationshipStudy,J.MedicinalChemistry,2008,51(1),77-85.
    
18. Zhi-WangZhou,ShengYin,Hai-YanZhang,YanFu,Sheng-PingYang,Xiao-NingWang,YanWu,Xi-CanTang,andJian-MinYue*,WalsucochinsAandBwithanUnprecedentedSkeletonIsolatedfromWalsuracochinchinensis,OrganicLetters,2008,10(3),465-468.
    
19. ShengYin,Jun-JuanXue,Cheng-QiFan,Ze-HongMiao,JianDing,andJian-MinYue*,EucalyptalsA-CwithAnUnprecedentedSkeletonIsolatedfromEucalyptusglobules,OrganicLetters,2007,9(26),5549-5552.
    
20. Chuan-RuiZhang,Sheng-PingYang,Shang-GaoLiao,Cheng-QiFan,YanWuandJian-MinYue*，ChuktabularinsA-D,FourNewLimonoidswithUnprecedentedCarbonSkeletonsfromtheStemBarkofChukrasiatabularis，OrganicLetters,2007,9(17),3383-3386.
    
21. ShengYin,Xiao-NingWang,Cheng-QiFan,Shang-GaoLiao,andJian-MinYue*,TheFirstLimonoidPeroxideintheMeliaceaeFamily:WalsuronoidAfromWalsurarobusta,OrganicLetters,2007,9(12),2353-2356.
    
22. Sheng-PingYang,Zhao-BingGao,Fang-DaoWang,Shang-GaoLiao,Hua-DongChen,Chuan-RuiZhang,Guo-YuanHuandJian-MinYue*,ChlorahololidesAandB,TwoPotentandSelectiveBlockersofPotassiumChannelIsolatedfromChloranthusholostegius,OrganicLetters,2007,9(5),903-906.
    
23. ShengYin,Cheng-QiFan,Xiao-NingWang,Li-PingLin,JianDingandJian-MinYue*,XylogranatinsA-D:NovelTetranortriterpenoidswithanUnusual9,10-secoScaffoldfromMarineMangroveXylocarpusgranatum,OrganicLetters,2006,8(21),4935-4938.
    
24. Xiao-NingWang,ShengYin,Cheng-QiFan,Fang-DaoWang,Li-PingLin,JianDingandJian-MinYue*,TurrapubesinsAandB,FirstExamplesofHalogenatedandMaleimide-bearingLimonoidsinNaturefromTurraeapubescens,OrganicLetters,2006,8(17),3845-3848.
    
25. Li-SheGan,Sheng-PingYang,YanWu,Li-pingLin,JianDingandJian-MinYue*,FlueggeninesAandB,TwoNovelC,C-linkedDimericIndolizidineAlkaloidsfromFlueggeavirosa,OrganicLetters,2006,8(11),2285-2288.
    
26. Shang-GaoLiao,Zha-JunZhan,Sheng-PingYangandJian-MinYue*,LathyranoicAcidA:FirstSecolathyraneDiterpenoidinNaturefromEuphorbialathyris,OrganicLetters,2005,7(7),1379-1382.
    
27. Sheng-PingYangandJian-MinYue*,FirstDiaminoDaphniphyllumAlkaloid,Daphnipaxinin,withAnUnprecedentedC21HeterohexacyclicSkeletonfromDaphniphyllumpaxianum,OrganicLetters,2004,6(9),1401-1404.
    
28. Zha-JunZhan,Sheng-PingYang,andJian-MinYue*,PaxdaphnidinesAandB,NovelPenta-andTetracyclicAlkaloidsfromDaphniphyllumpaxianum,J.ofOrganicChemistry,2004,69,1726-1729.
    
29. HongLiu,YangLi,MingkeSong,XiaojianTan,Feng,Cheng,SuxinZheng,JianhuaShen,XiaominLuo,Ruyun,Ji,JianminYue*,GuoyuanHu*,HualiangJiang*andKaixianChen,Structure-BasedDiscoveryofPotassiumChannelBlockersfromNaturalProducts-VirtualScreeningandElectro-physiologicalAssayTesting,Chemistry&Biology,2003,10(11),1103-1113.
    
30. Sheng-PingYangandJian-MinYue*,ThreeNovelAlkaloidswithaUniqueFusedHexacyclicSkeletonfromDaphniphyllumsubverticillatum,J.ofOrganicChemistry,2003,68,7961-7966.