研究队伍
姓名:
　杨春皓性别:
　男
职称:
　研究员学历:
　博士
电话:
　021-50806600-3512传真:
　021-50806770
电子邮件:
　chyang@mail.shcnc.ac.cn个人主页:
　
通讯地址:
　上海市浦东新区祖冲之路555号　201203

简历：
1992年毕业于苏州大学化学系。1995年于华东师范大学化学系硕士毕业。其后任职于南通医学院，从事有机化学的教学工作。2003年获中国科学院上海药物研究所理学博士学位。2008年在GeorgiaStateUniversity化学系做访问学者。


研究方向：

1. 新型抗肿瘤药物研发
2. 生物活性为导向的杂环方法学研究

专家类别：
研究员

职务：
中科院上海药物所研究员

科研成果：


承担科研项目情况：

1. 新型PARP1抑制剂的设计优化和成药性研究(2012ZX09103-101-071），“十二五”国家重大新药创制重大专项，2012.1－2015.12
2. 高选择性PARP-1抑制剂的设计、合成及抗肿瘤活性研究（21072205），国家自然基金面上项目，2011.1－2013.12
3. 以PI3K－Akt－mTOR为通路的特异性抑制剂设计、优化及信号转导研究（90713034），国家自然基金重大研究计划“化学小分子探针”项目，2008.1—2010.12
4. PI3K-mTOR双重/多重抑制剂的设计、合成及信号机制研究（09JC1416600），上海市科委基础研究重大项目，2009.9－2011.8
5. 雌激素受体β亚型选择性配体的设计、合成与生物活性研究（20502028），国家自然基金面上项目，2006.1—2008.12

社会任职：


获奖及荣誉：


代表论著：

1. Yu-QinWang,Xiao-HuaLi,QianHe,YiChen,Yu-YuanXie,JianDing,Ze-HongMiao,*andChun-HaoYang*Design,synthesisandbiologicalevaluationofsubstituted11H-benzo[a]carbazole-5-carboxamidesasnovelantitumoragents.Eur.J.Med.Chem.2011,inpress.
2. XiaochuanYang,GuojingSun,ChunhaoYang,*BingheWang.*NovelRheinAnaloguesasPotentialAnticancerAgents.ChemMedChem2011,DOI:10.1002/cmdc.201100384.
3. HaixiaPeng,XuxingChen,YanhongChen,QianHe,YuyuanXie,ChunhaoYang*Solvent-freesynthesisofδ-carbolines/carbazolesfrom3-nitro-2-phenylpyridines/
   2-nitrobiphenylderivativesusingDPPEasareducingagent.Tetrahedron2011,67，5725-5731.
4. YanhongChen,HaoyueXiang,YuyuanXie,andChunhaoYang﹡Convenientone-potsynthesisof3-aryl-2H-chromene-4-carbonitrilesviaatandemO-alkylation-Knoevenagelcondensation.Heterocycles2011,83(6),1355-1361.
5. TingLi,JiaWang,XiangWang,NaYang,Si-mengChen,Lin-jiangTong,Chun-haoYang,Ling-huaMeng,andJianDing.WJD008,aDualPhosphatidylinositol3-Kinase(PI3K)/MammalianTargetofRapamycinInhibitor,PreventsPI3KSignalingandInhibitstheProliferationofTransformedCellswithOncogenicPI3KMutant.J.Pharmacol.Exp.Ther.2010,334,830-838.
6. YanhongChen，ChunhaoYang,*YuyuanXie.Synthesisof4-Azachromeno[2,3-b]indol-11(6H)-oneanditsDerivativesasAnaloguesofEllipticine.Heterocycles2010，80（1），251－258.
7. MinJiang,TingLi,LinghuaMeng,ChunhaoYang,*YuyuanXie,andJianDing.DirectPalladium-CatalyzedArylationsofArylBromideswith2/9-SubstitutedPyrimido[5,4-b]indolizines.JournalofCombinatorialChemistry2009,11,806-808.
8. ZhangC,YangN,YangC-h,DingH-s,LuoC,etal.S9,aNovelAnticancerAgent,ExertsItsAnti-ProliferativeActivitybyInterferingwithBothPI3KAkt-mTORSignalingandMicrotubuleCytoskeleton.PLoSONE2009,4(3):e4881.
9. ChenDD,XuJ,YangCH,*XieYY.*FacileSynthesisof1,2,3,4-Tetrahydrobenzo[b][1,8]-naphthyridin-2-oneviaBaylis-HillmanAdducts.ChineseJournalofChemistry,2009,27,787—790.
10. ChunhaoYang,*HaofeiYu,NaYang,LinghuaMeng,JingXu,RongpingZhang,YuyuanXieandJianDingSynthesisof4-(5-benzyl-2-phenylpyrimidin-4-yl)morpholinesasnovelPI3KinhibitorsviaacetatesofBaylis-Hillmanadductsandbenzamidines.LettersinOrganicChemistry2009,6(2),134-140.
11. MinJiang,QianHe,ChunhaoYang,*YuyuanXie.Synthesisof2-substitutedpyrimido[5,4-b]indolizinederivativesfromacetatesofBaylis-Hillmanadducts.Heterocycles2008,75(11),2659-2666.
12. WuhongChen,ZhaohuLin,MengmengNing,,ChunhaoYang,*XuemingYan,YuyuanXie,XuShen,andMing-WeiWang*Azaanaloguesofequol:NovelligandsforestrogenreceptorβBioorganic&MedicinalChemistry15,2007,5828-5636.
13. MaojiangWu,QimingSun,ChunhaoYang,*DongdongChen,JianDing,*YiChen,LipingLinandYuyuanXieSynthesisandactivityofCombretastatinA-4analogues:1,2,3-thiadiazolesaspotentantitumoragents.Bioorganic&MedicinalChemistryLetters17(4),2007,869–873.
14. MNing,CZhou,JWeng,SZhang,DChen,CYang,*HWang,JRen,LZhou,CJinandM-WWang.*Biologicalactivitiesofanovelselectiveoestrogenreceptormodulatorderivedfromraloxifene(Y134)BritishJournalofPharmacology2007,150(1),19-28.
15. WuhongChen,BoLiu,ChunhaoYang,*YuyuanXie.Convenientsynthesisof1,2,3,4-tetrahydroquinolinesviadirectintramolecularreductiveringclosureTetrahedronLett.2006,47(40),7191-7193.
16. ChunhaoYang,*GuangyuXu,JiaLi,XihanWu,BoLiu,XuemingYan,MingweiWang,YuyuanXie.BenzothiophenescontainingapiperazinesidechainasselectiveligandsfortheestrogenreceptorαandtheirbioactivitiesinvivoBioorg.Med.Chem.Lett.2005,15(5),1505-1507.
17. QinggangJi,JieGao,JunboWang,ChunhaoYang*,XinHui,XuemingYan,XihanWu,YuyuanXie,Ming-WeiWangBenzothieno[3,2-b]indoleDerivativesasPotentSelectiveEstrogenReceptorModulatorsBioorg.Med.Chem.Lett.2005,15(11),2891-2893.
18. HuashengDing,ChaoZhang,XihanWu,ChunhaoYang,*XiongwenZhang,JianDing,YuyuanXieNovelIndoleα-Methylene-γ-lactonesasPotentInhibitorsforAKT-mTORSignalingPathwayKinasesBioorg.Med.Chem.Lett.2005,15,4799-4802.
19. BoLiu,ChunhaoYang,GuangyuXu,YonghongZhu,JingrongCui,XihanWuandYuyuanXieSynthesesofquinolonehydrochlorideenantiomersfromsynthons(R)-and(S)-2-methylpiperazineBioorg.Med.Chem.2005,13(7),2451-2458.
20. YuliXie,HuashengDing,LihuiQian,XuemingYan,ChunhaoYang,andYuyuanXieSynthesisandbiologicalevaluationofnovelbisphosphonateswithdualactivitiesonboneinvitroBioorg.Med.Chem.Lett.2005,15(13),3267-3270.