研究队伍
姓名:
　杨财广性别:
　男
职称:
　研究员学历:
　博士
电话:
　021-50806029传真:
　
电子邮件:
　yangcg@mail.shcnc.ac.cn个人主页:
　
通讯地址:
　上海市浦东新区祖冲之路555号　201203

简历：
1993年9月至1997年6月，华中理工大学化学系获学士学位。1997年9月至2002年8月，中国科学院上海有机化学研究所获博士学位（导师：姜标研究员）。2002年12月至2008年4月，芝加哥大学化学系博士后（导师：PhilipEaton&ChuanHe教授）。2008年5月至今，中国科学院上海药物研究所研究员、研究组长。


研究方向：
化学生物学和分子药理学在核酸表观遗传调控以及（抗耐药菌感染等）药物靶标筛选/确证研究中的应用。
具体包括：1.蛋白质/核酸，蛋白质/蛋白质相互作用的机制和调控研究；2.小分子/多肽对重要基因生物学功能的化学干预。


专家类别：
研究员；百人计划

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：


承担科研项目情况：


社会任职：


获奖及荣誉：

1. 2002年荣获中国科学院院长优秀奖
2. 2008年入选百人计划项目

代表论著：

1. XingLiu,XiaoxuSun,YoucongWu,CenXie,WenruZhang,DanWang,XiaoyanChen,DiQu,JianhuaGan,HaoChen,HualiangJiang,LefuLan*,Cai-GuangYang*“Oxidation-sensingRegulatorAbfRRegulatesOxidativeStressResponses,BacterialAggregation,andBiofilmFormationinStaphylococcusepidermidis”,J.Biol.Chem.2013,288,3739-3752.
   
2. BaoenChen^?,FeiYe^?,LuYu^?,GuifangJia,XiaotianHuang,XuejuZhang,ShuyingPeng,MeiningWang,ShouzeGong,RuihanZhang,JinyaYin,YimingYang,HongLiu,JiwenZhang,HaiyanZhang,AoZhang,HualiangJiang,ChengLuo*andCai-GuangYang*“Developmentofcell-activeN6-methyladenosineRNAdemethylaseFTOinhibitor”,J.Am.Chem.Soc.2012,134,17963-17971(^?contributedequallytothiswork).
   
3. ChengqiYi,BaoenChen,BoQi,WenZhang,GuifangJia,LiangZhang,CharlesQ.Li,AaronR.Dinner,Cai-GuangYang*,ChuanHe*“DuplexinterrogationbyadirectDNArepairproteininthesearchofdamage”,Nat.Struct.Mol.Biol.2012,19,671-676.(Coverpaper)
   
4. JingDeng^?,NingLi^?,HongchuanLiu^?,ZhiliZuo^?,AiOwLiew,WeijunXu,GangChen,XianKunTong,WeiTang*,JinZhu,JianpingZuo,HualiangJiang,Cai-GuangYang*,JianLi*,WeiliangZhu*.“DiscoveryofnovelsmallmoleculeinhibitiorsofdengueviralNS2B-NS3proteaseusingvirtualscreeningandscaffoldhopping”,J.Med.Chem.2012,55,6278-6293.(^?contributedequallytothiswork).
   
5. JieZhang^?,FeiYe^?,LefuLan,HualiangJiang,ChengLuo*,Cai-GuangYang*“StructuralswitchesofStaphylococcusaureusClpP:akeytounderstandingproteasedynamics”J.Biol.Chem.2011.(^?bothcontributedequallytothiswork).
   
6. Chun-XiaoSong,YaoSun,QingDai,Xing-YuLu,MiaoYu,Cai-GuangYang*,ChuanHe*“Detectionof5-HydroxymethylcytosineinDNAbytransferringaketo-glucosebyusingT4phageb-glucosyltransferase”ChemBioChem2011,12,1682-1685.
   
7. BaoenChen,HongchuanLiu,XiaoxuSun,Cai-GuangYang*“Mechanisticinsightintotherecognitionofsingle-strandedanddouble-strandedDNAsubstratesbyABH2andABH3”Mol.BioSyst.2010,6,2143-2149.
   
8. HaoChen*,ChengqiYi,JinZhang,WenruZhang,ZhiyunGe,Cai-GuangYang*,ChuanHe*“Structuralinsightintotheoxidation-sensingmechanismoftheantibioticresistanceofregulatorMexR”EMBORep.2010,11,685-690.
   
9. ChengqiYi,GuifangJia,GuanhuaHou,QingDai,WenZhang,GuanqunZheng,XingJian,Cai-GuangYang,QiangCui,ChuanHe*“Iron-CatalyzedOxidationIntermediatesCapturedinaDNArepairdioxygenase”Nature2010,468,330-333.
   
10. Cai-GuangYang,KristelGroth,ChuanHe*“DamagesearchingandbaseflippingindirectDNArepair”ChemBioChem.2009,10,417-423.
    
11. KunqianYu,ChengLuo,GuangrongQin,ZhijianXu,XuShen,JianpengMa,QinghuaWang,Cai-GuangYang,WeiliangZhu,HualiangJiang*“WhyareoseltamivirandzanamivireffectiveagainstthenewlyemergedinfluenzaAvirus(A/H1N1)?”CellRes.2009,19,1221-1224.
    
12. ChengqiYi,Cai-GuangYang,ChuanHe*“ANon-HemeIron-MediatedChemicalDemethylationinDNAandRNA”Acc.Chem.Res.2009,42,519-529.
    
13. Cai-GuangYang^?,ChengqiYi^?,EricaM.Duguid,ChristopherT.Sullivan,XingJian,PhoebeA.Rice,ChuanHe*“CrystalstructuresoftheDNA/RNArepairenzymesAlkBandABH2boundtodsDNA”Nature2008,452,961-965.(^?bothcontributedequallytothiswork).
    
14. GuifangJia^?,Cai-GuangYang^?,ShangdongYang,XingJian,ZhiqiangZhou,ChuanHe*“OxidativeDemethylationof3-meTand3-meUinSingle-strandedDNAandRNAbyMouseandHumanFTO”FEBSLett.2008,582,3313-3319.(^?bothcontributedequallytothiswork).
    
15. Cai-GuangYang,ChuanHe*“Gold(I)-CatalyzedIntermolecularAdditionofPhenolsandCarboxylicAcidstoOlefins”J.Am.Chem.Soc.2005,127,6966-6967.
    
16. Cai-GuangYang,NicholasW.Reich,ZhangjieShi,ChuanHe*“IntramolecularAdditionsofAlcoholsandCarboxylicAcidstoInertOlefinsCatalyzedbySilver(I)Triflate”Org.Lett.2005,7,4553-3556.
    
17. Cai-GuangYang,HaoHuang,BiaoJiang*“ProgressinStudiesofNovelMarineBis(indole)Alkaloids”Curr.Org.Chem.2004,8,1691-1720.
    
18. Cai-GuangYang，GangLiu,BiaoJiang*“PreparingFunctionalBis(indole)PyrazinebyStepwiseCross-couplingReactions:AnEfficientMethodtoConstructtheSkeletonofDragmacidinD”J.Org.Chem.2002,67,9392-9396.
    
19. BiaoJiang*,Cai-GuangYang,JunWang“EnantioselectiveSynthesisofMarineIndoleAlkaloidHamacanthinB”J.Org.Chem.2002,67,1396-1398.
    
20. BiaoJiang*,Cai-GuangYang,JunWang“EnantioselectiveSynthesisforthe(-)-AntipodeofthePyrazinoneMarineAlkaloid,HamacanthinA”J.Org.Chem.2001,66,4865-4869.