姓名:
刘东祥性别:
男
职称:
研究员学历:
博士
电话:
传真:
电子邮件:
dxl@mail.shcnc.ac.cn个人主页:
通讯地址:
上海市浦东新区祖冲之路555号 201203
简历：
1998年毕业于中国科学院上海药物研究所，获博士学位。1998年至2005年曾以博士后、研究科学家和研究助理教授在美国伊利诺大学、伯翰姆研究所等单位学习工作，期间曾设计出作用于Bcl-2的第一个小分子抑制剂—HA14-1，该抑制剂发表于PNAS并获一项美国专利。2005年入选中国科学院百人计划，任上海药物研究所研究员、课题组组长。
研究方向：
- 采用生物化学、结构生物学方法，研究与癌症、神经退行性疾病相关蛋白质的结构与功能。
- 以这些蛋白质为靶标，设计全新化学结构的抑制剂或激动剂，为药物研发提供新的先导化合物。
- 发展蛋白质结构功能研究、药物分子设计的新方法和新技术。
专家类别：
研究员；百人计划
职务：
中科院上海药物所研究员、博士生导师、课题组长
科研成果：
承担科研项目情况：
社会任职：
获奖及荣誉：
代表论著：
- ZhouY,JiangC,ZhangY,LiangZ,LiuW,WangL,LuoC,ZhongT,SunY,ZhaoL,XieX,JiangH,ZhouN,LiuD*,LiuH*.StructuralOptimizationandBiologicalEvaluationofSubstitutedBisphenolADerivativesas?-AmyloidPeptideAggregationInhibitors.JournalofMedicinalChemistry.2010,53(15):5449-66.
- FengY,DingX,ChenT,ChenL,LiuF,JiaX,LuoX,ShenX,ChenK,JiangH,WangH*,LiuH*,LiuD*.Design,SynthesisandInteractionStudyofQuinazoline-2(1H)-ThioneDerivativesasNovelPotentialBcl-xLInhibitors.JournalofMedicinalChemistry,2010,53:3465-79.
- JiangC,FengY,HuangX,XuY,ZhangY,ZhouN,ShenX,ChenK,JiangH*,LiuD*.Anenzyme-linkedimmunosorbentassaytocomparetheaffinityofchemicalcompoundsfor?-amyloidpeptideasamonomer.AnalyticalandBioanalyticalChemistry.2010,396:1745-54.
- ChenL,FengY,ZhouY,ZhuW,ShenX,ChenK,JiangH,LiuD*.DualroleofZn2+inmaintainingstructuralintegrityandsuppressingdeacetylaseactivityofSIRT1.JournalofInorganicBiochemistry.2010,104(2):180-5.
- FengY,LiuD*,ShenX,ChenK,JiangH.StructureassemblyofBcl-xLthroughα5-α5andα6-α6interhelixinteractionsinlipidmembranes.BiochimicaetBiophysicaActa-Biomembranes.2009,1788(11):2389-95.
- FengY,WuJ,ChenL,LuoC,ShenX,ChenK,JiangH,LiuD*.AfluorometricassayofSIRT1deacetylationactivitythroughquantificationofnicotinamideadeninedinucleotide.AnalyticalBiochemistry.2009,395(2):205-10.
- FengY,ZhangL,HuT,ShenX,DingJ,ChenK,JiangH,LiuD*.AconservedhydrophobiccoreatBcl-xLmediatesitsstructuralstabilityandbindingaffinitywithBH3-domainpeptideofpro-apoptoticprotein.ArchivesofBiochemistryandBiophysics.2009,484(1):46-54.
- FengY,ShenX,ChenK,JiangH,LiuD*.AnewassaybasedonfluorescenceresonanceenergytransfertodeterminethebindingaffinityofBcl-xLinhibitors.BioscienceBiotechnologyandBiochemistry.2008,72(7):1936-9.
- FengY,LinZ,ShenX,ChenK,JiangH,LiuD*.Bcl-xLformstwodistincthomodimersatnon-ionicdetergents:implicationsinthedimerizationofBcl-2familyproteins.JournalofBiochemistry.2008,143(2):243-52.
- LiY*,LiuD*,CaoR,KumarS,DongC,AnJ,WilsonSR,GaoYG,HuangZ.CrystalstructureofchemicallysynthesizedvMIP-II.Proteins:Structure,Function,andBioinformatics.2007,67(1):243-6.
- LiuD,MadaniN,LiY,CaoR,ChoiWT,KawatkarSP,LimMY,KumarS,DongCZ,WangJ,RussellJD,LefebureCR,AnJ,WilsonS,GaoYG,PallanschLA,SodroskiJG,HuangZ.Crystalstructureandstructuralmechanismofanovelanti-humanimmunodeficiencyvirusandD-aminoacid-containingchemokine.JournalofVirology.2007,81(20):11489-98.
- LiuD*,XuY,FengY,LiuH,ShenX,ChenK,MaJ,JiangH*.Inhibitordiscoverytargetingtheintermediatestructureofβ-amyloidpeptideontheconformationaltransitionpathway:implicationsintheaggregationmechanismofβ-amyloidpeptide.Biochemistry.2006,45(36):10963-72.
- MoriM*,LiuD*,KumarS,HuangZ.NMRstructuresofanti-HIVD-peptidesderivedfromtheN-terminusofviralchemokinevMIP-II.BiochemicalAndBiophysicalResearchCommunications,2005,335(3):651-8.(SCI,IF2.648)
- LiuD*,YangB*,CaoR,HuangZ.Achemicalstrategytopromotehelicalpeptide-proteininteractionsinvolvedinapoptosis.Bioorganic&MedicinalChemistryLetters,2005,15(20):4467-9.
- YangB*,LiuD*,HuangZ.IdentificationofAffinity-EnhancingMotifsonPro-apoptosispeptidesderivedfromtheBH3domainofBcl-2familyproteins.Bioorganic&MedicinalChemistryLetters,2004,14(6):1403-6.
- LiuD*,HuangZ.Syntheticpeptidesandnon-peptidicmoleculesasprobesofstructureandfunctionofBcl-2familyproteinsandmodulatorsofapoptosis.Apoptosis,2001,6:453-62.
- WangJL*,LiuD*,ZhangZJ,ShanS,HanX,SrinivasulaSM,CroceCM,AlnemriES,HuangZ.Structure-baseddiscoveryofanorganiccompoundthatbindsBcl-2proteinandinducesapoptosisoftumorcells.ProceedingsofTheNationalAcademyofSciencesofTheUnitedStatesofAmerica.2000,97:7124-9.
