姓名:
王贺瑶性别:
女
职称:
研究员学历:
博士
电话:
86-21-50806600-2208传真:
86-21-50805785
电子邮件:
hywang@mail.shcnc.ac.cn个人主页:
通讯地址:
上海市浦东新区祖冲之路555号 201203
简历：
1997年毕业于日本神户大学，获医学博士学位。1997至2003年先后在日本千叶大学医学研究院分子病态学研究室、细胞分子医学研究室做研究员；2003至2005年在日本国立国际医疗中心研究所代谢疾病研究部做研究员；2005年至今任上海药物研究所研究员、研究组长、日本国立国际医疗中心研究所客座研究员。
研究方向：
主要研究方向为代谢失调性疾病的新药发现与药理药效学研究，以及代谢失调性疾病发生发展分子机制和药物新靶标确认研究。
1.选择与代谢性疾病相关(肥胖、糖尿病、高脂、高尿酸血症、脂肪肝以及皮肤色素代谢失调)的G-蛋白偶联受体、酶分子作为药物筛选的主要靶点，建立细胞或分子水平的高通量筛选模型，通过筛选和评价，从中发现具有良好开发前景的药物先导化合物。
2.胰岛β-细胞糖脂毒性机制的研究以及β-细胞保护药物的发现研究。
3.棕色、白色脂肪细胞分化的分子机制研究及其药物干预的研发。
4.黑色素代谢的信号通路研究以及黑色素代谢失调性疾病干预的药物研发。
5.基于激酶B-RafV600E的抗皮肤黑色素瘤药物发现与研究。
专家类别：
研究员
职务：
中科院上海药物所研究员、博士生导师、研究组长
科研成果：
承担科研项目情况：
主持科技部“863”项目，国家自然科学基金委面上项目，上海市科委项目、中国科学院创新工程项目多项，参与科技部“973”项目，科技部重大新药创制项目等。
社会任职：
获奖及荣誉：
代表论著：
- JinweiWu,PengSun,XiaodongZhang,HongLiu,HualiangJiang,WeiliangZhu,HeyaoWang*.InhibitionofGPR40protectsMIN6β-cellsfrompalmitate-inducedERstressandapoptosis.JournalofCellularBiochemistry.2011Epub.
- XiaoHu,JinweiWu,XiaodongZhang,QinshiZhao,JianmingHuang,He-YaoWangandAijunHou.IsoprenylatedFlavonoidsandAdipogenesis-PromotingConstituentsfromMorusnigra.JournalofNaturalProducts.74(4)(2011):816-24.
- XiaoHu,JunJi,MengWang,JinweiWu,QinshiZhao,HeyaoWang,AijunHou.Newisoprenylatedflavonoidsandadipogenesis-promotingconstituentsfromMorusnotabilis.Bioorganic&MedicinalChemistryLetters21(2011)4441-4446.
- LiangcaiZhao,XiaodongZhang,HeyaoWang,DonghaiLin.1HNMR-basedmetabonomicanalysisofmetabolicchangesofserumandliverinZuckerobeserats.AnalyticalLetters44(2011):1579-1590.
- Liang-CaiZhao,Xiao-DongZhang,Shi-XianLiao,Hong-ChangGao,HeyaoWang,Dong-HaiLin.AMetabonomicComparisonofUrinaryChangesinZuckerandGKRats.JournalofBiomedicineandBiotechnology.2010:431894.Epub2010Oct13.
- Xiao-dongZhangJian-weiYan,Gui-ruiYanXiao-yunSun,JunJi,Yi-mingLi,You-hongHu*,He-yaoWang*.Pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgain,hyperlipidemia,andhepaticsteatosisindb/dbmice.ActaPharmacologicaSinica.31(2010),1470-1477.
- XiaodongZhang,GuiruiYan,YimingLi,WeiliangZhu,HeyaoWang,DC260126,asmallmoleculeantagonistofGPR40,improvesinsulintolerancebutnotglucosetoleranceinobeseZuckerrats.Biomedicine&Pharmacotherapy.64(9)(2010):647-51.
- XiangyuGuo，YingDuan，JuaneLi，LixiaYang，LianshaHuang，ZhichengWang，HeyaoWang.TonghuaLiu.AntidiabeticeffectsofTangnaikangonobeseZuckerratsandthemechanism.JournalofChineseIntegrativeMedicine.8(6)2010:535-540.
- XiaodongZhang,JunJi,GuruiYan,JinweiWu,XiaoyunSun,JingshanShen,HualiangJiang?,HeyaoWang?.SildenafilpromotesadipogenesisthroughaPKGpathway.BiochemicalandBiophysicalResearchCommunications.396(2010),1054-1-1059.
- HaiyanCai,GuiruiYan,XiaodongZhang,GorbenkoO,HeyaoWang?,WeiliangZhu?.Discoveryofhighlyselectiveinhibitorsofhumanfattyacidbindingprotein4(FABP4)byvirtualscreening.BioorgMedChemLett.20(12)(2010):3675-3679.
- HuiHu,Ling-YanHe,ZhenGong,NingLi,Yi-NaLu,Qi-WeiZhai,HongLiu,Hua-LiangJiang,Wei-LiangZhu?,andHe-YaoWang?.AnovelclassofantagonistsfortheFFAsreceptorGPR40.BiochemicalandBiophysicalResearchCommunications,390(3)2009:557-563.
- TingZhao,Gui-RuiYan,Sheng-LiPan,He-YaoWang*,Ai-JunHou*.NewIsoprenylated2-ArylbenzofuransandPancreaticLipaseInhibitoryConstituentsfromArtocarpusnitidus.Chemistry&Biodiversity.6(12)(2009):2209-2216.
- XuSun,Xiao-dongZhang,HuiHu,Yi-NaLu,JieChen,He-YaoWang?.BerberineinducesG1arrestbyregulatingnucleartranslocationofFoxO1inhepaticstellatecellsandpreventsexperimentalliverfibrosis.Biological&PharmaceuticalBulletin.32(9)(2009),1533-7.
- XuSun,XiaodongZhang,GangCheng,YouhongHu,HeyaoWang*.Inhibitionofhepaticstellatecellproliferationbyheatshockprotein90inhibitorsinvitro.MolecularandCellularBiochemistry.330(2009),181-185.
- KazuakiMiyake,WoosungYang,KazuoHara,KazukiYasuda,YukioHorikawa,HaruhikoOsawa,HirotoFuruta,MaggieCYNg,YushiHirota1,HiroyukiMori1,KeisukeIdo,KazuyaYamagata,YoshinoriHinoki,YoshitomoOka,NaokoIwasaki,YasuhikoIwamoto,YuichiroYamada,YutakaSeino,HiroshiMaegawa,AtsunoriKashiwagi,He-YaoWang,ToshihitoTanahashi,NaotoNakamura,JunTakeda,EiichiMaeda,KenYamamoto,KatsushiTokunaga,RonaldCWMaWing-YeeSo,JulianaCNChan,NaoyukiKamatani,HideichiMakino,KishioNanjo,TakashiKadowakiandMasatoKasuga.Constructionofapredictionmodelfortype2diabetesmellitusintheJapanesepopulationbasedon11geneswithstrongevidenceoftheassociation.JournalofHumanGenetics.54(4)(2009),236-41.
- YonggangWang,FengrongZhu,JieChen,FusenHan,HeyaoWang*.EffectsofPro-Arg,anoveldipeptidederivedfromprotaminehydrolysateonH2O2-inducedoxidativestressinhumandiploidfibroblasts.Biological&PharmaceuticalBulletin.32(3)(2009),389-393.
- XiaodongZhang,XiaoHu,AijunHou,*HeyaoWang*.InhibitoryEffectof2,4,2?,4?-tetrahydroxy-3-(3-methyl-2-butenyl)-chalconeoneffectivlydthanndmayundanaturaltyrosinaseinhibitorTyrosinaseActivityandMelaninBiosynthesis.Biological&PharmaceuticalBulletin.32(1)(2009)，86-90.
- YongGangWang,FengRongZhu,FuSengHanandHe-YaoWang*.Productionandcharacterizationofanti-oxidativepeptidesfromprotaminehydrolysate.JournalofFoodBiochemistry.32(2008),654-671.
- KazukiYasuda,KazuakiMiyake,YukioHorikawa,KazuoHara,HaruhikoOsawa,HirotoFuruta,YushiHirota,HiroyukiMori,AnnaJonsson,YoshifumiSato,KazuyaYamagata,YoshinoriHinokio,He-YaoWang,ToshihitoTanahashi,NaotoNakamura,YoshitomoOka,NaokoIwasaki,YasuhikoIwamoto,YuichiroYamada,YutakaSeino,HiroshiMaegawa,AtsunoriKashiwagi,JunTakeda,EiichiMaeda,HyoungDooShin,YoungMinCho,KyongSooPark,HongKyuLee,MaggieCYNg,RonaldCWMa,Wing-YeeSo,JulianaCNChan,ValeriyaLyssenk,TiinamaijaTuomi,PeterNilsson,LeifGroop,NaoyukiKamatani,AkihiroSekine,YusukeNakamura,KenYamamoto,TeruhikoYoshida,KatsushiTokunaga,MitsuoItakura,HideichiMakino,KishioNanjo,TakashiKadowaki&MasatoKasuga.VariantsinKCNQ1areassociatedwithsusceptibilitytotype2diabetesmellitus.Naturegenetics,40(2008),1092-1097.
- NorihideYokoi,ChihiroHayashi,YuukaFujiwara,He-YaoWang,andSusumuSeino.GeneticReconstitutionofAutoimmuneType1DiabetesWithTwoMajorSusceptibilityGenesintheRat.Diabetes,56(2007),506-512.
