姓名:
徐华强性别:
男
职称:
研究员学历:
博士
电话:
021-20231976传真:
电子邮件:
Eric.Xu@mail.shcnc.ac.cn个人主页:
通讯地址:
上海市浦东新区海科路501号 201203
简历:
1980-1985清华大学核子物理工程专业,学士学位
1985-1988清华大学生物物理专业,硕士学位
1989-1990美国杜克大学植物遗传系
1991-1994美国德州大学西南医学中心,生物化学与分子生物学专业,博士学位
1994-1996美国麻省理工学院(MIT)生物系,哈佛休斯医学研究所,研究助理
1996-1999美国格兰素威康研究所结构化学系,一级研究院
1999-2001美国格兰素威康研究所结构化学系,二级研究员
2001-2002美国GSK研究所结构科学部,高级研究人员
2002-2007.3美国VanAndel研究所结构科学部实验室负责人,资深PI/教授
2007.3-2009.12美国VanAndel研究所结构科学部实验室负责人,杰出PI/教授
2010.1-至今美国VanAndel研究所结构科学与药物发现中心主任,实验室负责人,杰出PI/教授
2010.7-至今2009年入选国家****,现担任中国科学院上海药物研究所研究员
研究方向:
蛋白质结构与药物开发
专家类别:
研究员;****
职务:
教授,研究员
科研成果:
专利:1.ActivatorsofPPARdelta.USPatentNumber6,710,063.Issued03/23/2004.
2.ActivatorofPPARdelta.USPatentNumber6,723,740.Issued04/20/2004.
3.ActivatorofPPARdelta.USPatentApplicationSerialNumber10/383,011.Filed03/06/2003.
4.CrystallizedPPARαLigandBindingDomainPolypeptideandScreeningMethodsEmployingSame.USPatentApplicationSerialNumber10/467,048.Filed08/01/2003.
5.CrystallizedGlucocorticoidReceptorLigandBindingDomainPolypeptideandScreeningMethodsEmployingSame.USPatentApplicationSerialNumber10/484,061.Filed01/16/2004.
6.LigandsforOrphanNuclearHormoneReceptorSteroidogenicFactor-1(SF-1).USPatentApplicationSerialNumber11/348,207.Filed02/06/2006.
7.LigandsforMineralocorticoidReceptor(MR)andMethodsforScreeningfororDesigningMRLigands.PCTPatentApplicationSerialNumberPCT/US2006/044620.Filed11/15/2006.
文章:2009年发表ABA受体研究新成果文章“脱落酸受体晶体结构与分子机制”发表在《自然》封面文章,被《科学》杂志评为2009年十大突破之一。
承担科研项目情况:
1.12/01/07-11/30/12,VanAndel研究所研究项目,项目负责人
2.08/01/09-06/30/13,美国NIHRO1,项目负责人
3.08/01/07-06/30/11,美国NIHRO1,项目负责人
4.07/01/06-07/31/11,美国NIHRO1,项目负责人
5.08/01/05-07/31/10,美国NIHRO1,项目负责人
6.01/01/08-12/31/09,Schering-PloughCorporation,项目负责人
7.“****”启动资金,国家多个重大专项或基金项目
社会任职:
获奖及荣誉:
- 1993年获美国德州大学西南医学中心theTwenty-FifthSigmaXi研究生研究奖
- 1999年获格兰素威康杰出研究奖
- 2001年9月获GSK杰出研究奖
代表论著:
2009-2011年发表论文
- HeY,XuY,ZhangC,GaoX,Dykema,KJ,MartinKR,KeJ,HudsonEA,KhooSK,ResauJH,AlbertsAS,MacKeiganJP,FurgeKA,andXuHE(2011).Identificationofalysosomalpathwaythatpotentlymodulatesglucocorticoidsignalingandinflammationresponse.ScienceSignaling(2011)(inpress).
- SerkanK,BeddowSA,SamuelVT,MillerP,Previs,SF,Suino-PowellK,SchulmanG,XuHE,KliewerSA,andMangelsdorfD(2011)FGF19isapostprandial,insulin-independentactivatorofhepaticproteinandglycogensynthesis.Science(inpress)
- HuhJR,LeungMWL,HuangP,RyanDA,KroutMR,MalapakaR,ChowJ,ManelN,CiofaniM,KimSV,CuestaA,SantoriFR,LafailleJJ,XuHE,GinDY,RastinejadF,andLittmanDR.(2011).DigoxinanditsderivativessuppressTh17celldifferentiationbyantagonizingRORγtactivity.Nature(inpress).
- ZhouXE,Suino-PowellKM,XuY,ChanCW,KruseSW,ReynoldsR,EngelJD,XuHE.(2010)TheorphannuclearreceptorTR4isavitaminA-activatednuclearreceptor.JBiolChem.2010Nov9.[Epubaheadofprint](featuredasPaperoftheweek)
- PalK,SwaminathanK,XuHE,PioszakAA.(2010).2.StructuralbasisforhormonerecognitionbythehumanCRFR2alphaGprotein-coupledreceptor.JBiolChem.2010Oct21.[Epubaheadofprint]
- MelcherK,ZhouXE,andXuHE(2010)Thirstyplantsandbeyond:structuralmechanismsofabscisicacidperceptionandsignaling.CurrentOpinioninStructuralBiology(Inpress).
- TolbertWD,Daugherty-HoltropJ,GherardiE,VandeWoudeG,andXuHE(2010)Structuralbasisforagonismandantagonismofhepatocytegrowthfactor.PNAS,107:13264-9.
- MelcherK,XuY,NgLM,ZhouXE,SoonFF,Suino-PowellKM,ChinnusamyV,KovachA,,CutlerSR,LiJ,,YongELZhuJK,XuHE(2010)IdentificationandMechanismofABAReceptorAntagonism.NatureStructural&MolecularBiology17(9):1102-8.
- PowellE,HuangSX,XuY,RajskiSR,WangY,PetersN,GuoS,XuHE,HoffmannFM,ShenB,XuW.(2010)IdentificationandcharacterizationofanovelestrogenicligandactinopolymorpholA.BiochemPharmacol.80(8):1221-9.PMID:20599778
- PalK,KumarS,SharmaS,GargSK,AlamMS,XuHE,AgrawalP,SwaminathanK.(2010).CrystalStructureofFull-lengthMycobacteriumtuberculosisH37RvGlycogenBranchingEnzyme:INSIGHTSOFN-TERMINAL{BETA}-SANDWICHINSUBSTRATESPECIFICITYANDENZYMATICACTIVITY.JBC285(27):20897-903.EPUB2010MAY5.
- PioszakAA,HarikumarKG,ParkerNR,MillerLJ,XuHE.(2010)Dimericarrangementoftheparathyroidhormonereceptorandastructuralmechanismforligand-induceddissociation.JBC285(16):12435-44.Epub2010Feb19.PMID:20172855
- ZhouXE,Suino-PowellKM,LiJ,HeY,MackeiganJP,MelcherK,YongEL,andXuHE(2010)IdentificationofSRC3/AIB1asAPreferredCoactivatorforHormone-ActivatedAndrogenReceptor.JBC,January19Epub.(FeaturedasthecoverarticleandthepaperoftheweekbyJBC).Mar19;285(12):9161-71.PMID:20086010
- SchopferFJ,ColeMP,GroegerA,ChenCS,WoodcockSR,KhooN,Golin-BiselloF,MotanyaUN,RudolphTK,RudolphV,BonacciG,BakerPRS,BatthyanyCI,XuHE,Y.ChenYE,HallisTM,andFreemanBA(2010)CovalentPeroxisomeProliferator-ActivatedReceptorγBindingbyNitro-FattyAcids:EndogenousLigandsActasSelectiveModulators.JBC,2010Apr16;285(16):12321-33.Epub2010Jan22.
- ZhouXE,Suino-PowellK,LudidiPL,McDonnellDP,XuHE(2010)Expression,purificationandprimarycrystallographicstudyofhumanandrogenreceptorincomplexwithDNAandcoactivatormotifs.ProteinExprPurif.71(1):21-7.
- MelcherK,NgLM,ZhouXE,SoonFF,XuY,Suino-PowellKM,ParkSY,WeinerJJ,FujiiH,ChinnusamyV,KovachA,LiJ,WangY,LiJ,PetersonFC,JensenDR,YongEL,VolkmanBF,CutlerSR,ZhuJK,XuHE(2009)Agate-latch-lockmechanismforhormonesignalingbyabscisicacidreceptors.Nature2009Dec3;462(7273):602-8(CoverArticle,featuredasoneoftop10breakthroughsof2009byScience).PMID:19898420
- PioszakAA,andXuHE.(2009)Molecularrecognitionofparathyroidhormone-relatedpeptide(PTHrP)bytheextracellulardomainofitsGprotein-coupledreceptorPTH1R.JBC,2009Aug12.[Epubaheadofprint]PMID:19674967
- Knudsen,BS.,ZhaoP,ResauJ,CottinghamS,GherardiE,XuHE,BerghuisB,DaughertyJ,GrabinskiT,ToroJ,GiambernardiT,SkinnerRS,GrossM,HudsonE,KortE,LengyelE,VenturaA,WestRA,XieQ,HayR,VandeWoudeG,andCaoB.2009.Anovelmultipurposemonoclonalantibodyforevaluatinghumanc-Metexpressioninpreclinicalandclinicalsettings.AppliedImmunohistochemistryandMolecularMorphology17(1):56–67.
- WangZ,ZhouXE,etal,XuHE,MangelsdorfDJ.(2009)ControlofNematodeParasitismbyConservedNuclearReceptorSignaling.PNAS106,9138-43.
- MiaoJ,KanamaluruD,MinG,YauPM,EllisE,StormS,Suino-PowellK,XuHE,KemperJK(2009).StabilityofSmallHeterodimerPartner(SHP)isincreasedbybileacidsandfibroblastgrowthfactor19.GenesandDevelopment,23:986-96.
- ChakravarthyMV,LodhiIJ,YinL,MalapakaRV,XuHE,TurkJ,andSemenkovichCF(2009)IdentificationofthePhysiologicallyRelevantEndogenousLigandforPPARαinLiver.Cell,138(3):476-88.PMID:19646743