晁彦杰 研究员 | 博士生导师

学科 微生物学

课题组 微生物RNA系统生物学研究组




电话 +86
邮箱 yjchao@ips.ac.cn
地址 上海市岳阳路320号生命科学实验楼B711

研究方向
微生物RNA系统生物学





个人简介 2001.9-2005.7 华中农业大学 本科
2005.9-2008.7 华中农业大学 硕士
2008.9-2014.9 德国柏林洪堡大学/马普感染生物学研究所 博士
2014.9-2016.8 德国维尔茨堡大学 博士后
2016.8-2020.8 美国塔夫茨大学/霍华德-修斯医学研究所 博士后
2020.9-至今 中国科学院上海巴斯德研究所 研究员


学术兼职 BMC Genomics 副主编


发表论文和专利 1.Wang C, Chao Y, Matera G, Gao Q, Vogel J. (2020) The conserved 3′ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration. Nucleic Acids Research. 48 (4), 2126-2143.
2.Li L, F？rstner KU, Chao Y#. (2018)Computational analysis of RNA-protein interactions via deep sequencing. Methods in Molecular Biology. 1751:171-182.
3.Chao Y, Li L, Girodat D, F？rstner KU, Said N, Corcoran C, Smiga M, Papenfort K, Reinhardt R, Wieden HJ, Luisi BF, Vogel J. (2017) In vivo cleavage map illuminates thecentral role ofRNase E in coding and non-coding RNApathways.Molecular Cell. 65(1):39-51.
[Previewed in Mol Cell] [Recommendation by F1000prime]
4.Chao Y, Vogel J. (2016) A 3’ UTR-derived small RNA provides the regulatory noncoding arm of the inner membrane stress response. Molecular Cell. 61(3):352-63.
5.Westermann AJ, F？rstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J. (2016) Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions. Nature. 529(7587):496-501.
[Commentary in Nature] [Highlighted in Nat. Rev. Genet.] [Recommendation by F1000] [Press coverage]
6.Saadeh B, Caswell CC, Chao Y, Berta P, Wattam AR, Roop II M, O'Callaghan D. (2016) Transcriptome-wide identification of Hfq-associated RNAs in Brucella suisby deep sequencing. J Bacteriol. 198(3):427-435.
7.Fan B, Li L*, Chao Y*, F？rstner K, Vogel J, Borriss R, Wu XQ. (2015) dRNA-seq reveals genomewide TSSs and noncoding RNAs of plant beneficial rhizobacteriumBacillus amyloliquefaciensFZB42. PLoS ONE. 10(11): e**
8.Miyakoshi M, Chao Y, Vogel J. (2015) Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA. EMBO J. 34:1478-1492.
[Previewed in EMBO J]
9.Miyakoshi M, Chao Y, Vogel J. (2015) Regulatory small RNAs from the 3' regions of bacterial mRNAs. Curr Opin Microbiol. 24:132-139.
10.Caldelari I, Chao Y, Romby P, Vogel J. (2013) RNA-mediated regulation in pathogenic bacteria. Cold Spring Harb Perspect Med. 3:a010298.
11.Papenfort K, Corcoran CP, Gupta SK, Miyakoshi M, Heidrich N, Chao Y, Fr？hlich KS, Sharma CM, Ziebuhr W,B？hm A, and Vogel J. (2013) Regulatory Mechanisms of Special Significance: Role of Small RNAs in Virulence Regulation. Regulation of Bacterial Virulence(eds. Vasil ML, Darwin AJ), ASM Press. pp: 493-527.
12.Chao Y, Papenfort K, Reinhardt R, Sharma CM, Vogel J. (2012) An atlas of Hfq-bound transcripts reveals 3' UTRs as a genomic reservoir of regulatory small RNAs. EMBO J. 31(20):4005-19.
[Previewed in EMBO J] [Multiple recommendations by F1000]
13.Kr？ger C, Dillon SC, Cameron AD, Papenfort K, Sivasankaran SK, Hokamp K, Chao Y, Sittka A, Hébrard M,H？ndler K, Colgan A, Leekitcharoenphon P, Langridge GC,Lohan AJ, Loftus B, Lucchini S, Ussery DW, Dorman CJ,Thomson NR, Vogel J, HintonJC. (2012) The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium. Proc Natl Acad Sci U S A. 109(20):E1277-86.
[Press coverage]
14.Deltcheva E, Chylinski K*, Sharma CM*, Gonzales K, Chao Y, Pirzada ZA, Eckert MR, Vogel J, Charpentier E. (2011) CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature. 471(7340):602-7.
[Previewed in Nature] [Multiple recommendations by F1000][Press coverage] [Kavli Prize Collection] [2020 Nobel Prize Collection]
15.Chao Y, Vogel J. (2010) The role of Hfq in bacterial pathogens. Curr Opin Microbiol. 13(1):24-33.
[Top 5 most cited articles in COM, 2011-2015]
16.Sun Z*, Chao Y*, Zhang X, Zhang J, Li Y, Qiu Y, Liu Y, Nie L, Guo A, Li C. (2008) Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China. J Clin Microbiol. 46:4075-7.
17.Chen Y*, Chao Y*, Deng Q*, Liu T, Xiang J, Chen J, Zhou J, Zhan Z, Kuang Y, Cai H, Chen H, Guo A. (2009) Potential challenges to the Stop TB Plan for humans in China; cattle maintain M. bovis and M. tuberculosis. Tuberculosis(Edinb). 89:95-100.
18.Yan BF*, Chao YJ*, Chen Z, Tian KG, Wang CB, Lin XM, Chen HC, Guo AZ. (2008) Serological survey of bovine herpesvirus type 1 infection in China. Vet Microbiol. 127:136-41.
19.Xu Z*, Chao Y*, Si Y, Wang J, Jin M, Guo A, Qian P, Zhou R, Chen H. (2008) The GTP binding sites interacted with RNA-dependent RNA polymerase of classical swine fever virus in de novo initiation. In Silico Biol. 8(1):21-32.
20.Han H, Wang F, Xiao Y, Ren Y, Chao Y, Guo A, Ye L. (2007) Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosisisolates in Wuhan, China. J Med Microbiol. 56:1219-23.


科研进展和成果 通过使用先进的下一代RNA测序技术和一系列实验研究，我们在病原微生物中首次发现了mRNA剪切产生的非编码小RNA及其在代谢和压力反应中的生物学功能，在基因组水平上全面系统地鉴定了mRNA切割位点，阐明了非编码小RNA的发生与mRNA的剪切机制，开创了微生物mRNA来源的非编码小RNA研究领域。另外，通过与2020年诺贝尔化学奖得主Charpentier合作，我们共同发现了微生物来源的CRISPR-Cas9系统和tracrRNA，为真核生物基因组编辑提供了关键工具。


奖励荣誉 德国马普学会国际博士生奖学金
国家优秀自费留学生奖


实验室介绍 本实验室以重大病原菌和有益共生菌为研究对象（如克雷伯氏杆菌或鲍曼不动杆菌），利用独特的高通量RNA测序技术、Tn-Seq功能基因组学技术、分子生物学和其它系统生物学研究方法，分析细菌与宿主在不同生理或病理条件下的转录组变化和关键功能基因，鉴定新型的非编码小RNA、RNA结合蛋白和微型小蛋白，进一步了解RNA-蛋白质之间的互相作用关系和分子机制，加深对微生物致病性、持留耐药和宿主共生机制的认识，推动新型抗菌药物与疫苗的研究开发。

实验室成员(Lab member)
助理研究员：吴可菁 博士
访问****：李恒 博士（苏州大学）
实习生：王婕 （英国帝国理工大学
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招生信息(admission information)
欢迎具有生物学、病原生物学、生物信息学等学科背景的优秀学生加入本团队攻读硕士和博士研究生。
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