姓名：甘肖箐 博士
职称：研究员
E-MAIL: xiaoqinggan@fudan.edu.cn
WWW: http://www.------


研究方向
1.细胞信号转导
2.代谢和生殖
重要学术贡献
Wnt信号调控胚胎发育，组织和器官生成，干细胞自我更新和分化等重要生理过程；Wnt信号通路的失调与肿瘤、阿尔茨海默症、糖尿病和性别发育或者生殖缺陷等多种慢性或遗传性疾病密切相关。课题组主要通过研究Wnt信号通路的转导机制，包括新转录因子、新蛋白质相互作用、新靶点等的揭示，以期发现Wnt信号在葡萄糖代谢、脂肪产热代谢和配子细胞发育等领域的生物学功能。主要研究成果被NCB、JCB、JBC、 MCB等专业期刊发表。当前研究主要在以下方向：（1）Wnt和mTOR信号交互通讯分子机理研究，揭示细胞内葡萄糖代谢的信号调控网络；（2）Wnt信号通路及相关转录因子在脂肪分化和能量代谢中的调控机理研究；（3）相关转录因子和Wnt信号通路协同调控配子发育的研究。
荣誉与获奖
无
国内外学术团体任职
无
受邀审稿学术刊物
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校内学术机构任职
无
受邀学术报告 （近5年国内大会报告、国际重要会议专题报告以上）
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发表论文
1.Wei Zhu, Xinyu He, Yue Hua, Qian Li, Jiyong Wang, and Xiaoqing Gan*. (2017) The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. J. Biol. Chem. 292:11178-11188
2.Qian Li, Yue Hua, Yilin Yang, Xinyu He, Wei Zhu, Jiyong Wang, and Xiaoqing Gan*.(2018) TCF7/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of Wnt/b-catenin pathway. Molecular and Cellular Biology. 2018 Jan 22. doi: 10.1128/MCB.00562-17.
3.Xiaoqing Gan, Chen Wang, Maulik Patel, Barry Kreutz, Maggie Zhou, Tohru Kozasa, and Dianqing Wu. (2013) Different Raf Protein Kinases Mediate Different Signaling Pathways to Stimulate E3 Ligase RFFL Gene Expression in Cell Migration Regulation. J.Biol.Chem. 288(47):33978-33984
4.Xiaoqing Gan, Jiyong Wang, Chen Wang, Eeva Sommer, Tohru Kozasa, Srinivasa Srinivasula, Dario Alessi, Stefan Offermanns, Melvin I. Simon and Dianqing Wu. (2012) PRR5L degradation promotes mTORC2-mediated PKC-? phosphorylation and cell migration downstream of G?12. Nat. Cell Biol. 14: 686-696.
5.Xiaoqing Gan, Jiyong Wang, Bing Su and Dianqing Wu. (2011) Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphophate. J. Biol. Chem. 286: 10998-11002
6.Xiaoqing Gan, Jiyong Wang, Ying Xi, Zhili Wu, Yiping Li, and Lin Li. (2008) Nuclear Dishevelled, c-Jun, ?-Catenin and TCF form a complex leading to stabilization of ?-catenin/TCF interaction. J. Cell Biol. 180:1087-1100.
7.Xiaoqing Gan, Zhihai Ma, Ning Deng, Jiyong Wang, Jiangping Ding, and Lin Li. (2004) Involvement of the C-terminal proline-rich motif of G protein-coupled receptor kinases in recognition of activated rhodopsin. J. Biol. Chem. 279: 49741-49746.
8.Xiaoqing Gan, Jiyong Wang, Qiheng Yang, Zhong Li, Feng Liu, Gang Pei, and Lin Li. (2000) Interaction between the conserved region in the C-terminal domain of GRK2 and Rhodopsin is necessary for GRK2 to catalyze receptor phosphorylation. J. Biol. Chem. 275: 8469-8474.
学术专著
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申请或授权专利
授权专利
1.中国专利: ZL0.0：“蓬乱蛋白和b-连环蛋白之间相互作用的调节剂”， 李林，甘肖箐，王计勇，席莹
2.中国专利： ZL1.5：“c-Jun参与经典Wnt信号转导途径的新功能”，李林，甘肖箐，王计勇，席莹，王伟
3.中国专利：ZL4.X：“G蛋白偶联受体激酶的新用途：，李林，甘肖箐，马志海，邓宁，王计勇
申请专利
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