姓名：江建海 博士
职称：教授
E-MAIL: jianhaijiang@fudan.edu.cn
WWW: http://medicine.fudan.edu.cn/Biochemisry/show.aspx?info_lb=17&flag=2&info_id=58

研究方向
1.肿瘤干细胞糖生物学
2.肿瘤干细胞标志物CD133的糖链结构、功能和信号通路
3.靶向肿瘤干细胞的糖复合物

重要学术贡献
从糖生物学视角研究肿瘤干细胞特性的分子机制，重点研究干细胞标志物CD133糖链结构和功能，发现CD133-PI3K-AKT信号轴、明晰CD133糖链结构和揭示CD133糖基化酶在肿瘤中的功能和调控。在国际上较早的将糖生物学研究和肿瘤干细胞研究结合，开展肿瘤干细胞糖生物学研究，发现调控肿瘤干细胞特性的糖链合成酶。围绕CD133糖蛋白信号通路的研究，阐释了CD133在肿瘤干细胞中的功能和机制，证实CD133是肿瘤干细胞的功能性标志物。围绕该研究，申请人发表PNAS、J Biol Chem等通讯作者论文。相关研究被Cancer Discovery、欧洲神经肿瘤学协会等报道和J Clin Invest、Mol Aspects Med等知名杂志引用。
荣誉与获奖
2011 上海市医学科技三等奖
2011 上海市卫生系统优秀青年人才
国内外学术团体任职
2016-今 …… 糖复合物专业委员会秘书长、糖复合物专业委员会委员

受邀审稿学术刊物
2010-今 Stem cells、Cancer Letters 审稿人
校内学术机构任职
受邀学术报告
发表论文
1.Chunhong Cui, Xiaoning Chen, Ying Liu, Benjin Cao, Yang Xing, Chanjuan Liu, Fan Yang, Yinan Li, Tianxiao Yang, Lingyang Hua, Mi Tian, Yuanyan Wei*, Ye Gong*, Jianhai Jiang*. β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells. The Journal of biological chemistry, 2017, 293(6): 2219-2230
2.Chanjuan Liu, Yinan Li,Yang Xing, Benjin Cao, Fan Yang, Tianxiao Yang, Zhilong Ai*, Yuanyan Wei*, and Jianhai Jiang*. J Biol Chem, 2016, 291(30), 15540 –15550. The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration.
3.Liu Y,Ren S,Xie L,Cui C,Xing Y,Liu C,Cao B,Yang F,Li Y,Chen X,Wei Y*,Lu H*,Jiang J*. Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth. Oncotarget. 2015, 6(24):20650-60.
4.Yuanyan Wei, Yizhou Jiang, Fei Zou, Yingchao Liu, Shanshan Wang, Nuo Xu, Wenlong Xu, Chunhong Cui, Yang Xing, Ying Liu, Benjin Cao, Chanjuan Liu, Guoqiang Wu, Hong Ao, Xiaobiao Zhang, Jianhai Jiang*. Activation of PI3K/Akt Pathway by CD133-P85 Interaction Promotes Tumorigenic Capacity of Glioma Stem Cells. PNAS 2013,110(17):6829-6834.
5.Yuanyan Wei, Fengbiao Zhou, Yuqing Ge, Hong Chen, Chunhong Cui, Qiuping Li , Dan Liu,Zhiyuan Yang, Guoqiang Wua, Shuhui Sun, Jianxin Gu, Jianhai Jiang*. β1,4-Galactosyltransferase V regulates self-renewal of glioma-initiating cell. Biochemical and Biophysical Research Communications 2010, 396(3): 602–607
6.Yuanyan Wei, Dan Liu, Fengbiao Zhou, Yuqing Ge, Jiejie Xu, xiaojing yun, ,Jianxin Gu, Jianhai Jiang*. Identification of β1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell. Journal of Hepatology 2008, 49 (6): 1029-1037
学术专著
申请或授权专利
授权专利
申请专利
1.O-连接的N-乙酰氨基葡萄糖合成酶OGT在肝癌诊断及抑制肝癌增殖中的应用 , 江建海，魏湲颜，曹本进，梁紫微，邢洋, 申请号：0.7
2.细胞浆定位的CD133作为肝癌预后标志物的应用, 江建海,刘婵娟,魏湲颜, 申请号：7.9