姓名：朱依纯 博士
职称：教授
国家****科学基金获得者
E-MAIL: yczhu@shmu.edu.cn
http://medicine.fudan.edu.cn/shenglibingshengjiaoyanshi/show.aspx?info_lb=663&flag=630&info_id=1713

研究方向
1.心肌细胞凋亡机制及干预新途径；
2.促进缺血心肌中微血管新生的新途径；
3.硫化氢对心血管系统及其相关离子通道的调控 ；
4.天然植物有效成份对心血管系统的作用 。
重要学术贡献
生理与病理生理学系，教授。小分子活性物质上海高校重点实验室主任。主要研究领域为硫化氢、中药有效成分等小分子活性物质对心血管系统功能的调节及其机制。在Antioxid Redox Signal，Cardiovasc Res等杂志发表70余篇研究论文，获得专利授权15项，获得省部级科技奖励6项。曾获国家****科学基金资助，国家百千****才工程，并被授予“有突出贡献的中青年专家”荣誉称号。主要学术成果包括针对心血管重构创新治疗方法的基础研究、硫化氢多靶点心血管保护作用的发现等，将目前硫化氢生物学研究从生物效应观察推动至揭示其共同原子生物学规律和原理的新台阶。
荣誉与获奖
2013中华医学科技奖三等奖（第一完成人）
2010教育部自然科学奖二等奖（第一完成人）
2010上海市自然科学奖三等奖（第一完成人）
2008中华医学科技奖三等奖（第一完成人）
2005上海市科学技术进步奖三等奖（第一完成人）
2004教育部提名国家自然科学奖二等奖（第一完成人）
2003明治乳业生命科学奖
2001教育部跨世纪优秀人才培养计划
2000霍英东教育基金会第七届高等院校青年教师奖（教学类）
国内外学术团体任职
2014至今 小分子活性物质上海市高校重点实验室，主任
受邀审稿学术刊物
2012至今 Endocrine杂志，编委
2006-2016 Elsevier学术刊物Life Sciences，副主编
校内学术机构任职
学术委员会委员
受邀学术报告
1.2014 Identification of hydrogen sulfide “receptors” in the receptor tyrosine kinase family and ion channels, Third International Conference on Hydrogen Sulfide in Biology and Medicine (H2S 2014), Kyoto, Japan.
2.2014 Identification of the molecular switches and the "receptors" for hydrogen sulfide in angiogenesis, sodium homeostasis and glucose metabolism, International Symposium on Aging and Medicine A Satellite Meeting of ISCTM, Shanghai, China
3.2013 Identification of H2S receptors in promotion of angiogenesis, Second European Conference on the Biology of Hydrogen Sulfide, Exeter, England
发表论文
1.Tao Beibei, Wang Rui, Sun Chen, Zhu Yichun*. 3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine beta-Synthase Nor Cystathionine gamma-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells. Frontiers in Pharmacoloygy. Volume 8, Article ID 657, SEP 20 2017 IF: 4.261
2.Li Xing-Hui#, Xue Wen-Long#, Wang Ming-Jie#, Zhou Yu, Zhang Cai-Cai, Sun Chen, Zhu Lei, Liang Kun, Chen Ying, Tao Bei-Bei, Tan Bo, Yu Bo, Zhu Yi-Chun*. H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression. Scientific Reports. 7, 44807, 2017. IF: 4.259
3.Hou Cui-Lan#, Wang Ming-Jie#, Sun Chen, Huang Yong, Jin Sheng, Mu Xue-Pan, Chen Ying, and Zhu Yi-Chun. Protective Effects of Hydrogen Sulfide in the Ageing Kidney. Oxidative Medicine and Cellular Longevity. Volume 2016, Article ID **, 13 pages IF: 4.593
4.Wang Ming-Jie, Cai Wen-Jie; Zhu Yi-Chun. Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules. Life Sciences. 153: 188-197, MAY 15 2016 IF: 2.936
5.Liu Huan-Di#, Zhang Ai-Jie#, Xu Jing-Jing, Chen Ying, Zhu Yi-Chun*. H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets. Journal of Hematology & Oncology. 9(1):13. Feb 24 2016. doi: 10.1186/s13045-016-0244-7. IF: 6.350
6.Zhou Yu#, Li Xing-Hui#, Zhang Cai-Cai#, Wang Ming-Jie, Xue Wen-Long, Wu Dong-Dong, Ma Fen-Fen, Li Wen-Wen, Tao Bei-Bei, Zhu Yi-Chun*. Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. American Journal of Physiology-Cell Physiology. 310(4): C305-C317, Feb15 2016. IF: 3.602
7.Li Na#, Wang Ming-Jie#, Jin Sheng, Bai Ya-Dan, Hou Cui-Lan, Ma Fen-Fen, Li Xing-Hui, Zhu Yi-Chun. The H2S donor NaHS changes the expression pattern of H2S-producing enzymes after myocardial infarction. Oxidative Medicine and Cellular Longevity. Article Number: **, doi: 10.1155/2016/**, Published: 2016 IF: 4.593
8.Ma Shan-Feng#, Luo Yan#, Ding Ying-Jiong, Chen Ying, Pu Shi-Xin, Wu Hang-Jing, Wang Zhong-Feng, Tao Bei-Bei, Wang Wen-Wei, Zhu Yi-Chun*. Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2 to inhibit the Ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction. Antioxidants & Redox Signaling. 23(2): 129-147, July 10 2015. IF: 7.093
9.Jin Sheng, Pu Shi-Xin, Hou Cui-Lan, Ma Fen-Fen, Li Na, Li Xing-Hui, Tan Bo, Tao Bei-Bei, Wang Ming-Jie, Zhu Yi-Chun*. Cardiac H2S generation is reduced in ageing diabetic mice. Oxidative Medicine and Cellular Longevity. 2015;2015:758358. doi: 10.1155/2015/758358. Epub 2015 May 11. IF: 4.492
10.Liang Min, Jin Sheng, Wu Dong-Dong, Wang Ming-Jie, Zhu Yi-Chun*. Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes. Nitric Oxide-Biology and Chemistry. 46(S1):114-222, APR 30 2015. IF: 3.760
11.Ge Shun-Na, Zhao Man-Man, Wu Dong-Dong, Chen Ying, Wang Yi, Zhu Jian-Hua, Cai Wen-Jie, Zhu Yi-Zhun, Zhu Yi-Chun*. Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats. Antioxidants & Redox Signaling. 21(15):2061-2082. Nov 20 2014. IF: 7.407（封面文章）
12.Tao Bei-Bei, Liu Shu-Yuan, Zhang Cai-Cai, Fu Wei, Cai Wen-Jie, Wang Yi, Shen Qing, Wang Ming-Jie, Chen Ying, Zhang Li-Jia, Zhu Yi-Zhun, and Zhu Yi-Chun*. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045–Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxidants & Redox Signaling. 19(5): 448-464. AUG 2013. IF: 7.667（封面文章）
13.Xue Rong#, Hao Dan-Dan#, Sun Ji-Ping#, Li Wen-Wen, Zhao Man-Man, Li Xing-Hui, Chen Ying, Zhu Jian-Hua, Ding Ying-Jiong, Liu Jun, Zhu Yi-Chun*. Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. Antioxidants & Redox Signaling. 19(1): 5-23. JUL 2013 IF: 7.667（封面文章）
14.Zhang Li-Jia, Tao Bei-Bei, Wang Ming-Jie, Jin Hui-Ming, Zhu Yi-Chun*. PI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization. PLoS One. 7(9): e44590. Sep 2012 IF: 3.730
15.Sun Wei-Hua, Liu Fang, Chen Ying, Zhu Yi-Chun*.Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochemical and Biophysical Research Communications. 421(2):164-169, MAY 4 2012. IF: 2.406
16.Liu Jun, Hao Dan-Dan, Zhang Jin-Sheng, Zhu Yi-Chun*. Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a. Biochemical and Biophysical Research Communications. 413(2): 342-347, SEP 23 2011. IF: 2.484
17.Liu Xia, Lu Lei, Tao Bei-Bei, Zhou Ai-Ling, Zhu Yi-Chun*. Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and alpha-smooth muscle actin. Acta Pharmacologica Sinica. 32(1): 70-78 Jan 2011. IF: 1.953
18.Wang MJ, Cai WJ, Zhu YC*. The mechanisms of angiogenesis: a role of hydrogen sulphide (review article). Clinical and Experimental Pharmacology and Physiology. 37(7): 764-771, JUL 2010. IF: 1.960
19.Yao LL, Huang XW, Wang YG, Cao YX, Zhang CC, Zhu YC*. Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3-dependent opening of mPTP. Am J Physiol Heart Circ Physiol. 298(5): H1310-H1319 MAY 2010. IF: 3.881
20.Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, Zhu YC*. The hydrogen sulfide donor NaHS promotes Angiogenesis in a rat model of hind limb ischemia. Antioxidants & Redox Signaling. 12(9): 1065-1077 MAY 2010. IF: 8.209（封面文章）
21.Liu X, Lü L, Tao BB, Zhu YC*. All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-beta 1 and Ang II in rat mesangial cells. Acta Pharmacologica Sinica. 29(9):1035-41 SEP 2008. IF: 1.676
22.Sun YG, Cao YX, Wang WW, Ma SF, Yao T, Zhu YC*: Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes. Cardiovascular Research. 79(4): 632-641 SEP 2008. IF: 5.947
23.Shi Y, Cao YX, Lu N, Yao T, Zhu YC*. Hemodynamic-independent anti-natriuretic effect of urotensin II in spontaneously hypertensive rats. Peptides 29(5): 783-794 May 2008. IF: 2.265
24.Shi YX, Chen Y, Zhu YZ, Huang GY, Moore PK, Huang SH, Yao T, Zhu YC*. Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 293 (4): H2093-H2100 OCT 2007. IF: 3.973
25.Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC*. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovascular Research. 76 (1): 29-40 Oct 2007. IF: 6.127（编辑部同期发表专题评论文章推荐这一工作）
26.Yao LL, Wang YG, Cai WJ, Yao T, Zhu YC*. Survivin mediates the anti-apoptotic effect of delta-opioid receptor stimulation in cardiomyocytes. Journal of Cell Science. 120 (5): 895-907 MAR 1 2007. IF: 6.383
27.Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC*. Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction. American Journal of Physiology-Heart and Circulatory Physiology. 292 (1): H348-H359 JAN 1 2007. IF: 3.973
28.Zhu YC, Zhu YZ, Moore PK. The role of urotensin II in cardiovascular and renal physiology and diseases. British Journal of Pharmacology. 148 (7): 884-901 AUG 2006. IF: 3.825
29.Gong H, Wang YX, Zhu YZ, Wang WW, Wang MJ, Yao T, Zhu YC*. Cellular distribution of GPR14 and the positive inotropic role of urotensin II in the myocardium in adult rat. Journal of Applied Physiology. 97 (6): 2228-2235 DEC 2004. IF: 2.824
30.Zhu YC, Zhu YZ, Lu N, Wang MJ, Wang YX, Yao T. Role of angiotensin AT(1) and AT(2) receptors in cardiac hypertrophy and cardiac remodelling. Clinical and Experimental Pharmacology And Physiology. 30 (12): 911-918 DEC 2003. IF: 1.744
31.Lu L, Yao T, Zhu YZ, Huang GY, Cao YX, Zhu YC*. Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology. 285 (4): H1370-H1377 OCT 2003. IF: 3.658
学术专著
/
申请或授权专利
授权专利
1.硫化氢及其供体硫氢化钠在制备治疗糖尿病药物中的用途
2.一种NaHS微囊包裹新剂型及其制备方法
3.硫化氢及其供体硫氢化纳在制备药物中的用途
4.烯丙基半胱氨酸或其类似物的用途及药物组合物（美国专利）
5.炔丙基半胱氨酸在制备治疗阿尔茨海默病药物中的用途
6.烯丙基半胱氨酸及其类似物在制备治疗心肌损伤药物中的用途
7.益母草碱-半胱氨酸缀合物在制备治疗缺血性心肌病药物中的用途
8.益母草的使用及其药物组合物（日本专利）
9.益母草碱在制备防治缺血性心肌病药物中的用途
10.益母草水提物及其在制备药物组合物中的应用
11.钩藤提取物及其在制备降血脂及抗心肌肥厚药物中的用途
12.钩藤醇提取物及其在制备靶器官保护药物中的用途
13.柯楠因在制备治疗心肌损伤性心脏病药物中的用途
14.毛钩藤碱在制备治疗心肌损伤药物中的用途
15.全反式维甲酸在制备治疗心脏成纤维细胞增生药物中的应用
申请专利
1.益母草碱晶体及其在制备胰岛素增敏剂、降糖和降脂药物中的用途
2.益母草碱在制备胰岛素增敏剂中的用途
3.硫化氢及其供体硫氢化钠在制备促造血药物中的用途
4.硫化氢及其供体硫氢化钠在制药中的用途
5.毛钩藤碱类似物及其在制备抗高血压药物中的用途
6.毛钩藤碱类似物及其合成方法与应用
7.柯楠因碱类化合物及其制备方法
8.去氢钩藤碱及其异构体在制备药物中的用途
9.益母草碱在制备防治缺血性中风药物中的用途
10.硫化氢供体在制备治疗中枢神经系统疾病药物中的用途