姓名：周平 博士
职称：教授
E-MAIL: zping@shmu.edu.cn
WWW: http://www.------

研究方向
1.肿瘤复发转移的调控机制
2.心血管疾病的发病机制
重要学术贡献
本人在肿瘤复发转移的机制研究方面做了大量的工作，取得了多项重要的研究成果。主要为①在国内外率先提出了CD73与乳腺癌转移密切相关，CD73通过调控AKT/GSK-3β/β-catenin/ cyclinD1、EGFR等信号通路促进肿瘤转移。研究成果在Int J Cancer（影响因子：6.513）等国外SCI期刊发表，文章被Nature Reviews Cancer等国际高水平期刊多次引用。CD73研究领域领军人物Linda F. Thompson教授也给与我们高度的认可和评价：“I have followed your work and been impressed by the quality of your publications. I think you were the first to really find the link between CD73 and breast cancer!”。②率先发现并首次报道了lncRNA-APOC1P1-3在乳腺癌病程中的重要作用，阐明了APOC1P1-3通过其结合蛋白乙酰化等表观遗传学调控机制促进乳腺癌的增殖和转移（Cell Death and Disease影响因子：5.965）。为防治肿瘤的复发转移提供了新的靶点及理论基础。
荣誉与获奖
2009 复旦大学上海医学院优秀教师
2011 复旦大学“三八”红旗手
国内外学术团体任职
2010-今 中国病理生理学会受体与信号转导专业委员会委员
受邀审稿学术刊物
2007-今 Acta Pharmacologica Sinica
2007-今 复旦学报
2007-今 中国癌症杂志（编委）
2010-今 Breast Cancer Research and Treatment
2017-今 Cancer Management and Research
受邀学术报告
2016 长链非编码RNA-APOC1P1-3 在乳腺癌发病中的作用研究，中国病理生理学会第十三届受体专业委员会学术会议，西安
发表论文
1.Jiangang Yu, Xue Wang, Qi Lu, Jigang Wang, Luying Li, Xiaohong Liao, Wei Zhu, Lei Lv, Xiuling Zhi, Jerry Yu, Yiting Jin, Qiang Zou, Zhouluo Ou, Xiuping Liu and Ping Zhou*. Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3β/β-catenin/cyclinD1 signaling pathway. International Journal of Cancer. 2018 Mar 1;142(5):959-967.
2.Yang J, Liao X1, Yu J, Zhou P* . Role of CD73 in disease: promising prognostic indicator and therapeutic target. Curr Med Chem. 2018 Jan 16. doi: 10.2174
3.Jiangang Yu,Xiaohong Liao,Luying Li,Lei Lv,Xiuling Zhi,Jerry Yu,Ping Zhou*.
A preliminary study of the role of extracellular -5'- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition. In Vitro Cell Dev Biol Anim, 2017; 53(2): p.132-140.
4.X-H Liao, J-GWang, L-Y Li, D-M Zhou, K-H Ren, Y-T Jin, L Lv, J-G Yu, J-Y Yang, Q Lu, Q Zou, J Yu, X-P Liu and P Zhou*. Long intergenic non-coding RNA APOC1P1-3 inhibits
apoptosis by decreasing α-tubulin acetylation in breast cancer. Cell Death and Disease 2016;7:2041-4889
5.Jiayin Yang 1,2, Rongrong Jian1,3, Jiangang Yu1, Xiuling Zhi1, Xiaohong Liao1, Jerry Yu1,4, and Ping Zhou*.CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation. IUBMB Life. 2015 November;67(11) :853–860
6.Lingling Zhong, Lei Lv, Jiayin Yang, Xiaohong Liao, Jiangang Yu, Rui Wang and Ping Zhou*.The Inhibitory Effect of Hydrogen Sulfide on Platelet Aggregation and the Underlying Mechanisms. Journal of Cardiovascular Pharmacology. 2014 Nov;64(5):481-7
7.Li Wang, Shaoxian Tang ,ingjian Wang,Siguang Xu,Jerry Yu, Xiuling Zhi,Zhouluo Ou Jiayin Yang ,Ping Zhou*,Zhimin Shao.Ecto-50-nucleotidase (CD73) promotes tumor angiogenesis. Clin Exp Metastasis .2013;30:671–680
8.Xiuling Zhi, Yingjian Wang, Jerry Yu, Lianhua Yin, Ping Zhou*.Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer.
IUBMB Life.2012 November ;64(11): 911–920,
9.Shaoxian Tang, Yuechao Tang, Lingling Zhong, Kumuruz Murat, Gvlqikra Asan,
Jerry Yu, Rongrong Jian, Changchun Wang and Ping Zhou* Short- and long-term
toxicities of multi-walled carbon nanotubes in vivo and in vitro J. Appl. Toxicol.
2012; 32: 900–912
10.Ping Zhou*, Jiayin Yang.NT5E (5'-nucleotidase, ecto (CD73)) Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2012; 16(9)655-657
11. Rongrong Jian, Yong Sun, Yingjian Wang, Jerry Yu, Lingling Zhong and PingZhou*.CD73 protects kidney from ischemia-reperfusion injury through reduction of MIS.2011;120:130-138
12. Xiuling Zhi,Yingjian Wang, Xuerui Zhou,3Jerry Yu,Rongrong Jian, Shaoxian Tang,
Lianhua Yin and Ping Zhou* .RNAi-mediated CD73 suppression induces apoptosis
and cell-cycle arrest in human breast cancer cells Cancer Sci 2010; 101:
2561–2569
13.Yong Sun, Libo Chen, Jerry Yu, Xiuling Zhi, Shaoxian Tang, Ping Zhou*. Folate-bearing doxorubicin-loaded magnetic poly(N- isopropylacrylamide) microsphere as a new strategy for cancer therapy. Anticancer Drugs. 2009 Aug;20(7):607-15.
14.Wang L, Zhou X, Zhou T, Ma D, Chen S, Zhi X, Yin L, Shao Z, Ou Z, Zhou Ping*. Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. J Cancer Res Clin Oncol. 2008 Mar;134(3):365-372
15.Ping Zhou*, Xiuling Zhi,Tingting Zhou,Chen S, Li X, Wang L, Yin L, Shao Z, Ou Z. Overexpression of Ecto-5'-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix. Cancer Biol Ther. 2007 Mar;6(3):426-31.
16.Zhi X, Chen S, Zhou Ping*, Shao Z, Wang L, Ou Z, Yin L.RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin Exp Metastasis. 2007;24(6):439-48.
17.Xuerui Zhou, Xiuling Zhi,Ping Zhou* , Chen S, Zhao F, Shao Z, Ou Z, Yin L. Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo. Oncol Rep. 2007 Jun;17(6):1341-6.
18.Xiaobo Li, Tingting Zhou, Fengdi Zhao, Lianhua Yin, Ping Zhou*.Effect of hypoxia/reoxygenation on CD73 (ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines. Microvasc Res. 2006 Jul-Sep;72(1-2):48-53.
19.Zhou Ping*, Tokunaga Y,Maeda T,Arai R. Distribution of 5'-nucleotidase activity in greater omentum of rats. Kaibogaku Zasshi. 2001 Aug;76(4):381-8.
申请专利
1.发明名称：长链非编码RNA- APOC1P1-3基因及其用途
发明人：周平、廖晓红、吕雷、于建刚、杨佳音、陆齐
申请号：0.X
2.长链非编码RNA -APOC1P1-3基因及其在用于制备靶点标志物中的用途
发明人：周平、廖晓红、吕雷、于建刚、杨佳音、陆齐、李录英
申请号：7.6