李忠 教授
Tel: ; Fax: ; E-mail: lizhong@ecust.edu.cn
个人简介
李忠：博士，教授，博士生导师，教育部新世纪优秀人才，上海市优秀学科带头人。1968年7月出生。1990年获华东理工大学应用化学专业工学学士学位，1993年获华东理工大学物理化学专业理学硕士学位，1996年获华东理工大学精细化工专业工学博士学位。1995年在华东理工大学留校工作，1998年被聘为副教授，2003年被聘为教授，2004年被聘为博士生导师。期间于1999－2001年，获得日本国立AIST和ITIT博士后基金资助，在日本工业技术研究院从事博士后研究。现任华东理工大学药物化工研究所所长，国家“
在国际重要学术刊物（如J. Am. Chem. Soc.; J. Org. Chem.; Org. Lett.; J. Agri. Food Chem.; Tetrahedron Lett.; Bioorg. Med. Chem.; Bioorg. Med. Chem. Lett.; SYNLETT; J. Fluorine Chem.; New J. of Chem.等）发表学术论文三十余篇。作为课题负责人，先后主持国家“863”高科技攻关项目两项，国家自然科学基金两项；作为课题副组长承担国家“973”计划项目一项；此外，还主持了多个上海市科委重大攻关及重点攻关项目。
近年来，主要从事绿色化学农药分子设计及合成的研究，并在顺式硝基烯类新烟碱杀虫剂创制研究方面取得突破性进展，发现了三类具有全新结构的超高活性化合物，活性显著超越目前最著名的杀虫剂品种吡虫啉，并对抗性品系超高效。申请国际PCT发明专利3项，中国发明专利7项（2项已获授权），相关专利化合物的国内实施许可权已经以2000****民币的价格转让给江苏克胜集团。
研究方向
1）昆虫行为调控剂的分子设计、合成及作用机制研究
主要包含：昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等绿色农药的创制研究；
2）含硒化合物的设计合成及生物性能研究
主要包含：含硒除草剂、含硒植物生长调节剂的创制及生物性能研究
获奖情况
2009年：上海市优秀学科带头人
2007年：(1)教育部新世纪优秀人才；(2)“科创杯”上海高校学生创造发明奖一等奖（第一指导老师）
2006年：(1)上海市教委“曙光****人才”；(2) 第一届“上海市科教党委系统青年科技创新人才奖”
2005年：第四届徐汇区徐光启奖银奖
2007年-今代表性论著
1. Feng Fan, Jiagao Cheng, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Novel dimer based descriptors with solvational computation for QSAR study of oxadiazoylbenzoyl-ureas as novel isect-growth regulators”. Journal of Computational Chemistry. 2009, published online, DOI: 10.1002/jcc.2135
2. Feng Fan, Zhiqi You, Zhong Li*, Jiagao Cheng, Yun Tang, Zhenhua Tang. “A Butterfly Effect: Highly Insecticidal Resistance Caused by Only a Conservative Residue Mutated of Drosophila Melanogaster Acetylcholinesterase”. Journal of Molecular Modeling, 2009, 15, 1229-1236
3. Xusheng Shao, Zhong Li*, Xuhong Qian, Xiaoyong Xu*. “Design, Synthesis, and Insecticidal Activities of Novel Analogues of Neonicotinoids: Replacement of Nitromethylene with Nitroconjugated System”. J. Agric. Food Chem. 2009, 57, 951–957
4. Xusheng Shao, Wenwen Zhang, Yanqing Peng, Zhong Li*, Zhongzhen Tian, Xuhong Qian *, “cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine”, Bioorg. Med. Chem. Lett., 2008, 18, 6513-6516.
5. Xiaobao Yang, Hongbin Zhai,* Zhong Li*, “Enantiocontrolled Synthesis of (-)-9-epi- Pentazocine and (-)-Aphanorphine”. Org. Lett., 2008, 10 , 2457–2460.
6. Xiaobao Yang, Li Zhu,Yuedong Zhou, Zhong Li*, Hongbin Zhai*, “Efficient Synthesis of Monosubstituted 3-Alkynylfurans via Suzuki Coupling”, Synthesis, 2008, (No.11), 1729–1732.
7. Xiaobao Yang, Bin Cheng, Zhong Li*, Hongbin Zhai*, “Formal Asymmetric Synthesis of (–)-Aphanorphine via Ring- Closing Metathesis Reaction”, SYNLETT, 2008, (No.18), 2821-2822.
8. Shaoyong Ke, Zhong Li, Xuhong Qian*, “1,3,4-Oxadiazole-3(2H)- carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety”. Bioorg. Med. Chem., 2008, 16, 7565–7572.
9. Chuanxiang Liu, Xuhong Qian,* Guangqiang Sun, Liwei Zhao and Zhong Li*, Chromogenic and fluorescent chemodosimeter for fluoride ion based on novel anion-catalyzed intramolecular hydrogen transfer, New J. Chem., 2008, 32, 472-476.
10. Chuanxiang Liu, Xuhong Qian*, Jiaobing Wang, Zhong Li*, Anion recognition by a novel Fipronil-based receptor: efficient deprotonation or stable intermolecular hydrogen bonding, Tetrahedron Lett., 2008, 49, 1087-1090.
11. Ming-Yi Cai, Zhong Li*, Qingchun Huang, and Gonghua Song* “{[1-(Arylmethyl) piperidin-4-yl]oxy} -(trifluoromethyl)- pyridines: Ketanserin Analogues with Insect Growth Regulating Activity” Chem. Biodivers, 2008, 1844-1855.
12. Yanli Wang, Jiagao Cheng, Xuhong Qian*, Zhong Li*. “Actions between neonicotinoids and key residues of insect nAChR based on an ab initio quantum chemistry study: Hydrogen bonding and cooperative π—π interaction”. Bioorgan. Med.Chem. 2007, 15, 2624-2630.
13. Feng Fan, Zhong Li*, Xiaoyong Xu, Xuhong Qian*. “Quantitative Aggregation- Activity Relationship (QAAR): Supermolecular view, dimer as the simplest aggregation state and monomolecule.” QSAR & Combinatorial Science, 2007, 26, 737-743.
14. Zhongzhen Tian, Zhaoxing Jiang, Zhong Li*, Gonghua Song*, Qingchun. Huang. “Syntheses and Biological Activities of octahydro-1H-cyclopenta[d] pyrimidine derivatives”. J. Agric. Food Chem., 2007, 55, 143-147.
15. ZhongzhenTian, Xusheng Shao, Zhong Li*, Xuhong Qian*, Qingchun Huang, “Synthesis, Insecticidal Activity, and QSAR of Novel Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis Configuration and Exo-Ring Ether Modification”, J. Agric. Food Chem., 2007, 55, 2288-2292.
