程家高 教授、博导
（E-mail: jgcheng@ecust.edu.cn）

个人简介
程家高：博士、教授、博导，1978年生于山东。2000年7月毕业于山东曲阜师范大学化学系，获理学学士学位；2005年7月毕业于中科院上海药物研究所，获有机化学药物设计方向博士学位，导师：陈凯先院士、蒋华良院士；2007年9月华东理工大学药学院博士后出站后留校在钱旭红院士团队工作，2009年晋升副教授，2016年晋升教授。

主要研究方向：1）作用于烟碱乙酰胆碱受体、GABA受体等重要医药、农药靶标的活性分子设计、合成及构效关系研究；2）重磅杀虫剂品种的作用机制、生态毒性及抗性机制研究。

在JAFC; Chem. Biol. Drug. Des.;QSAR Comb. Sci.; J. Org. Chem.; Chem. Phys. Lett.;Bioorg. Med. Chem. Lett.; J. Phys. Org. Chem；JACS等国际重要学术期刊上发表外文SCI论文七十余篇。作为课题负责人，共承担国家自然科学基金4项、国家重点研发计划子课题1项、教育部博士点基金等省部级科研基金3项、中央高校基本科研业务费3项；作为骨干研究人员，承担国家973、863、科技支撑课题等国家重点课题多项。

代表性科研项目
[1] 国家重点研发计划项目课题，农药对靶沉积的界面作用过程与传输机制，编号：2017YFD**，2017.07-2020.12；课题骨干兼子课题负责人（雾滴对靶沉积的界面效应与关系模型，编号：2017YFD）。
[2] 国家自然科学基金，低蜂毒新烟碱杀虫剂创新关键问题研究，编号：**，2020.01-2023.13，负责人。
[3] 国家自然科学基金，基于昆虫和鱼类GABA受体差异研究的低鱼毒杀虫剂合理设计，编号：**，2016.01-2019.12，负责人。
[4] 国家自然科学基金，分子聚集态及分子间相互作用对化合物生物活性的影响研究，编号：**，2012.01-2015.12，负责人。
[5] 国家自然科学基金，计算机辅助新烟碱－烟碱乙酰胆碱受体的作用模式及新烟碱类杀虫剂的设计研究，编号：**，2009.01-2011.12，负责人。


代表性研究论文

Cong Zhou,Jiagao Cheng*, Ryan Beadle, Fergus G Earley, Zhong Li, Peter Maienfisch*. Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement. Bioorgan. Med. Chem. 2020, DOI: j.bmc.2020.115509.
Lujue He, Keya Xiao, Cong Zhou, Guanglong Li, Hongbin Yang, Zhong Li, Jiagao Cheng*. Insights into pesticide toxicity against aquatic organism: QSTR models on Daphnia Magna.Ecotox. Environ. Safe. 2019, 173, 285-292. (二区)
Chengchun Zhu^#, Guanglong Li^#, Keya Xiao, Xusheng Shao, Jiagao Cheng*, Zhong Li. Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies. Chin. Chem. Lett.,2019, 30(1), 255-258.(二区)
Bo Zhang^#, Lei Zhang^#, Lujue He^#, Xiaodong Yang, Yali Shi, Shaowei Liao, Shan Yang, Jiagao Cheng*, Tianrui Ren*. Interactions of fipronil in fish and insects: experimental and molecular modeling studies. J. Agric. Food Chem. 2018, 66(23), 5756–5761. (一区，封面文章)
Xiaoqing Meng, Chengchun Zhu, Yue Feng, Weihua Li, Xusheng Shao, Zhiping Xu, Jiagao Cheng*, Zhong Li. “Computational Insights into the Different Resistance Mechanism of Imidacloprid versus Dinotefuran in Bemisia tabaci.” J. Agric. Food Chem.2016, 64, 1231-1238. (一区)
Dan-Ping Jiang, Cheng-Chun Zhu, Xu-Sheng Shao, Jia-Gao Cheng*, Zhong Li. “Bioactive conformation analysis of anthranilic diamide insecticides: DFT-based potential energy surface scanning and 3D-QSAR investigations.” Chin. Chem. Lett., 2015, 26, 662-666
Nan Zheng, Jiagao Cheng*, Wei Zhang, Weihua Li, Xusheng Shao, Zhiping Xu,Xiaoyong Xu, Zhong Li*. “Binding Difference of Fipronil with GABA_ARs in Fruitfly and Zebrafish: Insights from Homology Modeling, Docking and Molecular Dynamics Simulation Studies” J. Agric. Food. Chem. 2014, 62, 10646-10653. (一区)
Zheng Wang, Jinjin Ye, Rui Wu, Yang-Zi Liu, John S Fossey, Jiagao Cheng*, Wei-Ping Deng*.Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols. Catal. Sci. Technol.2014, 4, 1909-1913. (二区，封面文章)
Shuang Xia, Yue Feng, Jiagao Cheng*, Haibin Luo, Zhong Li*, Zhengming Li. “QAAR exploration on pesticides with high solubility: An investigation on sulfonylurea herbicide dimers formed through π-π stacking interactions.” Chin. Chem. Lett., 2014, 25(7), 973-977
Shuang Xia, Jiagao Cheng*, Yue Feng, Xusheng Shao, Haibin Luo, Zhiping Xu, Xiaoyong Xu and Zhong Li*. “Computational Investigations about the Effects of Hetero-molecular Aggregation on Bioactivities: a Case of Neonicotinoids and Water.” Chin. J. Chem., 2014, 32(4), 324-334.
Ying Yang, Wei Zhang, Jiagao Cheng*, Yun Tang, Yanqing Peng, Zhong Li*. “Pharmacophore, 3D-QSAR and Bayesian Model Analysis for Ligands Binding at the Benzodiazepine Site of GABA_AReceptors: the Key Roles of Amino Group and Hydrophobic Sites.”Chem. Biol. Drug. Des.2013, 81, 583-590. (封面文章)
Wei Zhang, Shuang Xia, Jinjin Ye, Yun Tang, Zhong Li*, Weiping Zhu, Jiagao Cheng*. Structural Features of GABA_AReceptor Antagonists: Pharmacophore Modeling and 3D-QSAR Studies. Med. Chem. Res.2013,22, 5961-5972.
Hou-ling Dai, Li-xin Gao, Ying Yang, Jing-ya Li, Jiagao Cheng*, Jia Li*, Ren Wen, Yan-qing Peng, Jian-bin Zheng*. Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors. Bioorgan. Med. Chem. Lett. 2012,22, 7440-7443.
Wenwen Zhang, Yefeng Fan, Tao Yu, Zhiping Xu, Xiaoyong Xu*, Jiagao Cheng*, Zhong Li. Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues.Chin. J. Chem., 2012, 30(2), 357-361.
Lingyan He^#,Jiagao Cheng^#, Tao Wang, Caimei Li, Zhen Gong, Hong Liu, Bu-Bing Zeng, Hualiang Jiang, Weiliang Zhu. Cation-π complexes formed between cyclooctantetraene and alkaline earth metals: predicted and recorded NMR features. Chem. Phys. Lett. 2008, 462, 45-58. (^#并列一作）
Jiagao Cheng, WeiLiang Zhu, YanLi Wang, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang*. The Open-Close Mechanism of M2 Channel Protein in Influenza A Virus: A Computational Study on the Hydrogen Bonds and Cation-pi interactions among His37 and Trp41. Sci. China Ser. B-Chem, 2008, 51(8), 768-775.
Jiagao Cheng, XiaoMin Luo, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang. WeiLiang Zhu,Research Progress in Cation-pi interactions, Sci. China Ser. B-Chem, 2008, 51(8), 709-717.
Jiagao Cheng, Zhen Gong, Weiliang Zhu, Yun Tang, Weihua Li, Zhong Li, Hualiang Jiang. Cation sitting in aromatic cages: ab initio computational studies on tetramethylammonium–(benzene)n (n=3–4) complexes. J. Phys. Org. Chem., 2007, 20, 448-457
Jiagao Cheng, Weiliang Zhu, Yun Tang, Yufang Xu, Zhong Li, Kaixian Chen, Hualiang Jiang. Effect of cation-π interaction on NMR: A theoretical investigation on complexes of Li+, Na+, Be2+, and Mg2+ with aromatics. Chem. Phys. Lett. 2006, 422, 455-460.
Jiagao Cheng, Congmin Kang, Weiliang Zhu, Xiaomin Luo, Chum Mok Puah, Kaixian Chen, Jianhua Shen*, Hualiang Jiang*. “N-Methylformamide-Benzene Complex as a Prototypical Peptide N-H???πHydrogen-Bonded System: Density Functional Theory and MP2 Studies.J. Org. Chem.2003, 68(2), 7490-7495.