张阳博士 特聘副研究员 硕士生导师


电话:
E-mail: zhangyang@ecust.edu.cn
地址：华东理工大学 徐汇校区
男，汉族，山东泰安人，中共党员

教育背景
1.2011.9–2017.5，华东理工大学，农药学，农学博士，导师：陶黎明 教授
2.2006.9–2010.6，山东农业大学，生物工程，工学学士

工作经历
1.2019.9–至今，华东理工大学，药物化工研究所，特聘副研究员

2.2017.6–2019.9，华东理工大学，药物化工研究所，博士后，导师：李忠 教授
3.2011.2–2011.8，山东农业大学，团委，思政辅导员
4.2010.7–2011.1，山东农业大学，生命科学学院，院办行政
研究方向
开展农药毒理学方向的研究工作，主要包括：
1. 农药风险监测评价研究
2. 候选农药的生物活性筛选、药效分析及作用方式研究
项目经历
先后参与了农药领域“973计划”项目、“十二五”国家科技支撑计划课题、国家重点研发计划项目以及上海市科技支撑项目等工作。博士后至今，主持国家重点研发计划子课题1项(2017~2020)，中国博士后基金1项（2017~2019）、中央高校基本科研业务费2项（2018~2019，2019~2022），并入选上海市青年科技英才“扬帆计划”等。


研究生招生专业
植物保护（0904）
农药学（090403） (农药毒理学方向)


发表的论文


[1] Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Zhiping Xu, Liming Tao, Zhong Li*, Wenping Xu*. Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage.Ecotoxicol. Environ. Saf. 2019, 183, 109480.
[2] Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Liming Tao, Zhong Li*, Wenping Xu*. The cytotoxic effects of spinetoram on human HepG2 cells by inducing DNA damage and mitochondria-associated apoptosis.Food Agric. Immunol. 2019, 30, 1020-1032.
[3] Yang Zhang, Yangyang Fan, Jufang Gao, Wenping Xu, Zhiping Xu, Yutian Liu, Zhong Li*, Liming Tao*. A new 24-membered macrolide shows insecticidal activity againstPieris rapaepotentially through induction of programmed cell death. Food Agric. Immunol.2019, 30, 727-742.
[4] Yang Zhang, Hui Chen, Yangyang Fan, Yun Yang, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li*, Liming Tao*. Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.Chemosphere. 2019, 230, 182-189.
[5] Yangyang Fan^#, Yang Zhang^#, Yutian Liu, Wenping Xu, Yun Yang, Youwu Hao, Liming Tao*. A natural product enhances apoptosis via mitochondria/caspase-mediated pathway in Hela cells.J. Cell Biochem. 2019, 120(10), 16811-16823.
[6] Youwu Hao^#, Yang Zhang^#, Hongfei Ni, Jufang Gao, Yun Yang, Wenping Xu, Liming Tao.Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung and nerve. J. Environ Sci. Heal, B. 2019, 54(9), 737-744.
[7] Youwu Hao^#, Yang Zhang^#, Wenping Xu, Jufang Gao, Liming Tao*. Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate. J. Pestic. Sci.2019,44(4), 249-254.
[8] Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*. Potential threat of chlorpyrifos to human liver cells via the caspase-dependent Mitochondrial Pathways. Food Agric. Immunol. 2018, 29, 294-305.
[9] Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, Mingjun Yang, Bo Wang, Youwu Hao, Liming Tao*. Cytotoxic effects of avermectin on human HepG2 cells in vitro bioassays.Environ. Pollut. 2017, 220, 1127-1137.
[10]Yang Zhang, Mingming Luo, Wenping Xu, Mingjun Yang, Bo Wang, Jufang Gao, Yaxiao Li, Liming Tao*. Avermectin confers its cytotoxic effects by inducing DNA damage and mitochondria-associated apoptosis. J. Agric. Food Chem. 2016, 64(36), 6895-6902.
[11]Yang Zhang, Songlin Liu, Xing Yang, Mingjun Yang, Wenping Xu, Yaxiao Li, Liming Tao*. Staurosporine shows insecticidal activity against Mythimna separateWalker (Lepidoptera: Noctuidae) potentially via induction of apoptosis. Pestic. Biochem. Physiol. 2016, 128, 37-44.
[12]Xiaoqin Yu^#, Yang Zhang^#, Mingjun Yang, Junfu Guo, Wenping Xu, Jufang Gao, Yaxiao Li, Liming Tao*. Cytotoxic effects of tebufenozide in vitro bioassays.Ecotoxicol. Environ. Saf.2016, 129, 180-188.

[13]Youwu Hao, Yang Zhang, Jiagao Cheng, Wenping Xu, Zhiping Xu, Jufang Gao, Liming Tao*. Adjuvant contributes Roundup's Unexpected Effects on A549 Cells. Environ. Res.2020,184, 109306
[14]唐宁，张阳，徐晓勇，陶黎明. 杀虫靶标发现及开发新策略展望[J]. 世界农药，2019,41(06), 17-23.
[15]Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway. Cell Proliferat.2019, 52(2), e12543.
[16]Youwu Hao, Wenping Xu, Jufang Gao, Yang Zhang,Yun Yang, Liming Tao*. Roundup? induced AMPK/mTOR mediated autophagy in human A549 cells. J. Agric. Food Chem.2019, 67, 11364-11372.
[17]Youwu Hao, Nan Zhang, Wenping Xu, Jufang Gao, Yang Zhang,Liming Tao*. A natural adjuvant shows the ability to improve the effectiveness of glyphosate application. J. Pestic. Sci.2019,44(2), 106-111.
[18]Youwu Hao, Hui Chen, Wenping Xu, Jufang Gao, Yun Yang, Yang Zhang, Liming Tao*. Roundup? confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction. Environ. Pollut. 2019,252A, 917-923.
[19]Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenesSSPRC-11339. Nat. Prod. Res.2019, 33(5),659-664.
[20]Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu, Liming Tao*. The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage. Environ. Sci. Pollut. R.2018, 25(24), 24230-24240.
[21]Yun Yang, Jufang Gao,Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway.Environ. Pollut. 2018, 241, 1091-1097.
[22]Wenping Xu, Mingjun Yang, Jufang Gao, Yang Zhang, Liming Tao*. Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells. Food Agric.Immunol. 2018, 29, 171-181.
[23]杨韵，卢淼青，张阳，杨明俊，徐文平，陶黎明*. 高效氯氰菊酯对草地贪夜蛾Sf9细胞自噬的诱导作用[J]. 农药学学报，2017, 19(02), 176-181.
[24]Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in Spodoptera frugiperdaSf9 cells. Chemosphere. 2017, 169, 155-161.
[25]Yun Yang, Mimi Zong, Wenping Xu, Yang Zhang, Bo Wang, Mingjun Yang, Liming Tao*. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem-Biol. Interact.2017, 262, 38-45.
[26]Wenping Xu, Bo Wang, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Tao*. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ. Toxicol Phar. 2017, 49, 89 - 96.
[27]Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, Liming Tao, Jianhua Yao, Wenping Xu*. Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Lett. 2017, 58(3), 190-193.
[28]Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces autophagy of Spodoptera frugiperdaSf9 cells and the activation of AMPK/mTOR signaling pathway. Comp. Biochem. Physiol. C: Pharmacol. Toxicol.2017, 195, 52-59.
[29]Wenping Xu, Songlin Liu, Yang Zhang, Jufang Gao, Mingjun Yang, Xiao Liu, Liming Tao*. Cypermethrin resistance conferred by increased target insensitivity and metabolic detoxification in Culex pipiens pallens Coq. Pestic. Biochem. Physiol. 2017, 142C, 77-82.
[30]Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in Insect cells: A new target? Pestic. Biochem. Physiol. 2017,137, 21-26.
[31]周高辉，罗明明，张阳，于晓芹，陶黎明，徐文平*. 新型N~6-哌嗪取代腺苷衍生物的合成及其抗肿瘤活性[J]. 合成化学, 2016,24(04), 283-287-292.
[32]Mingjun Yang, Guanggang Xiang, Diqiu Li, Yang Zhang, Wenping Xu, Liming Tao*. The insecticide spinosad induces DNA damage and apoptosis in HEK293 and HepG2 cells. Mutat. Res-Gen. Tox. En.2016, 812, 12-19.

专利情况
[1] 中国发明专利授权：陶黎明，吴伟，黄青春，张阳，徐文平，李荻秋，周高辉，罗明明；阿维菌素B1a 荧光标记物及其应用，专利号ZL 2.1，授权日2016年2月24日
[2] 中国发明专利授权：黄青春，张阳，陶黎明，刘寅钊，徐文平，吴锡伟，李荻秋，于晓芹；用于制备昆虫神经元细胞的生理缓冲液、消解液及方法，专利号ZL 2.0, 授权日2016年4月20日
[3] 中国发明专利授权：徐文平，周高辉，陶黎明，黄青春，张阳，罗明明，于晓芹，程亮，杨明俊，吴锡伟；腺苷衍生物及其应用，专利号ZL 2.X，授权日2017年5月24日
[4] 中国发明专利申请：李忠，刘建文，徐晓勇，邵旭升，陈信飞，袁文双，张阳；一种具有抗癌活性化合物的制法和用途，公开号CN A，公开日2018年5月18日
[5] 中国发明专利申请：徐文平，常远森，陶黎明，张阳，郝有武，杨韵，张楠，李延娣；一株米曲霉及其应用，公开号CN A，公开日2019年1月4日