仇文卫




个人资料
部门： 化学与分子工程学院
性别： 男
专业技术职务： 教授 博士生导师
毕业院校：
学位：
学历： 博士
联系电话：
电子邮箱： wwqiu@chem.ecnu.edu.cn
办公地址： 华东师大化学系（闵行）525室
通讯地址： 华东师大化学系（闵行）525室
邮编：
传真：


工作经历
2019.12-今：华东师范大学 化学与分子工程学院 教授
2009.12-2019.12：华东师范大学 化学与分子工程学院 副教授

2010.10-2011.10：哈佛大学访问****（Professor E. J. Corey）
2006.09-2009.12：华东师范大学 化学与分子工程学院 讲师




教育经历
2003.09-2006.07：中科院上海药物研究所 理学博士
2000.09-2003.07：华东师范大学 理学硕士
1993.09-1997.07：常州大学 工学学士






个人简介



社会兼职



研究方向
1.甾体新药发现
2.甾体药物绿色制造工艺研究



开授课程
研究生：《有机合成工艺研究》
本科生：《有机化学实验》、《药物合成-从实验室到工业化》



科研项目
主持科研项目：


1、 国家自然科学基金面上项目：HMGCR泛素化降解剂的设计、合成及其降胆固醇活性研究。（项目号：**），执行年限2021.1-2024.12
2、国家自然科学基金重大研究计划子课题：蛋白质胆固醇动态修饰的调控机制、化学干预和功能研究。（项目编号：14303-41211-18025），执行年限2018.1-2021.12
3、上海市自然科学基金：抗结肠癌先导化合物的发现、结构优化及其抗肿瘤活性研究。（项目号：18ZR**），执行年限：2018.7-2021.6
4、 国家自然科学青年基金：新型PTP1B抑制剂-山楂酸衍生物的分子设计?合成与活性研究。（项目号：**）执行年限：2009.1-2011.12
5、教育部博士点新教师基金：新型蛋白酪氨酸酯酶IB抑制剂－山楂酸衍生物的构效关系研究。（项目号：9）执行年限：2009.1-2011.12
6、上海市自然科学基金：甾类衍生物的设计合成及其促羟甲基戊二酰辅酶A还原酶的泛素化降解活性研究。（项目号：12ZR**）执行年限：2012.7-2015.6
7、 华东师范大学创新基金面上项目：水溶性白桦脂酸衍生物的设计、合成及其对破骨细胞生成抑制的活性研究。（项目号：**）执行年限：2013.1-2014.12




学术成果
发表文章及专利：


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41.Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang,Jiuqing Xie, Xiaotao Li, Wenwei Qiu*, Zhengfang Yi1* and Mingyao Liu*.A novel BMI-1 inhibitor QW24 for the treatment of stem-likecolorectalcancer.J. Exp. Clin. Cancer Res. 2019, 38, 422.
40. Huiqing Chen, Yajing Xing, Jia Xie, Jiuqing Xie, Dong Xing,Jie Tang,Fan Yang, Zhengfang Yi* and Wen-Wei Qiu*. Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potentialantiproliferative agents for castration-resistantprostate cancer.RSC Advances 2019, 9, 33794–33799.
39. Zhen Chen, TuoShao, Wei Gao,Hualong Fu,ThomasLee Collier, Jian Rong, Xiaoyun Deng, Qingzhen Yu, Xiaofei Zhang, April T. Davenport, James B. Daunais, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Wen-Wei Qiu*, and StevenLiang*. Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2(LRRK2) in Parkinson’s Disease. ChemMedChem 2019, 14, 1580-1585.
38.Jie Bai, Jia Xie, Yajing Xing, Li-Ting Wang, Jiuqing Xie, Fan Yang, Ting Liu, MingyaoLiu, Jie Tang, Zhengfang Yi, Wen-Wei Qiu*, Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oralanti-late-onset hypogonadism agents,Eur. J. Med. Chem. 2019, 176, 21-40.
37. Jie Bai, Jia Xie, Li-Ting Wang, Yajing Xing, Qian-Ru Jiang, Fan Yang, Jie Tang, Zhengfang Yi*, Wen-Wei Qiu*. Discoveryof methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter. RSC Advances 2019, 9, 9709–9717.
36. Huiqing Chen, Jia Xie, Dong Xing, Jinping Wang, Jie Tang, Zhengfang Yi, Fei Xia, Wen-Wei Qiu*, Fan Yang*, Diastereoselective synthesis of 3,3-disubstituted-3-nitro-4-chromanone derivatives as potential antitumor agents. Org. Biomol. Chem. 2019, 17, 1062-1066.

35. Shi-You Jiang, Hui Li, Jing-Jie Tang, Jie Wang,Jie Luo, Bing Liu, Jin-Kai Wang, Xiong-Jie Shi,Hai-Wei Cui, Jie Tang, Fan Yang,Wei Qi, Wen-Wei Qiu*, Bao-Liang Song*. Discovery of a potent HMG-CoA reductase degrader that eliminatesstatin-induced reductase accumulation and lowers cholesterol. Nat. Commun. 2018, 9, 5138.
34. Xiao-Long He, Li-Ting Wang, Xiang-Zhong Gu,Jie-Xin Xiao, Wen-Wei Qiu*. A facilesynthesis of ursodeoxycholic acid and obeticholic acid from cholic Acid, Steroids 2018, 140, 173-178.
33. Lian-Fang Yang, Yajing Xing, Jie-Xin Xiao, JiaXie, Wei Gao, Jiuqing Xie, Li-Ting Wang, Jinhua Wang, Mingyao Liu, Zhengfang Yi*, Wen-WeiQiu*. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-MediatedAntitumor Agents. ACS Med. Chem. Lett. 2018, 9, 1105-1110.
32.Xiao-Long He, Yajing Xing, Xiang-Zhong Gu, Jie-Xin Xiao, Ying-Ying Wang, Zhengfang Yi, Wen-Wei Qiu*.The synthesis and antitumor activity of lithocholic acid and its derivatives.Steroids2017, 125, 54-60.
31. Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui,Xiao-Long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-Liang Li, Wen-Wei Qiu*,Bao-Liang Song*.Cholesterol ModificationofSmoothenedIsRequiredforHedgehog Signaling.Mol. Cell2017, 66, 154-162.

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30.Gao Wei, Yalan Wu, Xiao-Long He, Ting Liu, Mingyao Liu, Jian Luo*, Wen-Wei Qiu*.Synthesis of heterocyclic ring-fu??sed tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption.Eur. J. Med. Chem.2017,131, 48-67.
??

29.Ying-Ying Wang, Yu?an He, Lian-Fang Yang, Shi-Hong Peng, Xiao-Long He,Jin-Hua Wang, Fang Lv, Yun Hao, Ming-Yao Liu, Zhengfang Yi*, Wen-Wei Qiu*.Synthesis of novel diterpenoidanalogs with in-vivo antitumoractivity.Eur. J. Med. Chem.2016,120, 13-25.

28.Hai-WeiCui, ShihongPeng, Xiang-ZhongGu, HuangChen, YuanHe, WeiGao, FangLv,Jin-HuaWang, YanWang, JiaXie, Ming- YaoLiu, ZhengfangYi*,Wen-Wei Qiu*.Synthesisand biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosteronederivatives as antitumor agents.Eur. J. Med. Chem.2016,111, 126-137.


???


27.Ying-Ying Wang, Yuan-Xue Gao, Wei Gao, Yuan Xu, Ya-Zhou Xu, Yun-Jie Wang, Sai Chang, Li-Gang Yu, Lu-Yong Zhang, Hong Liao, Lian-Fang Yang, Tao Pang*, Wen-Wei Qiu*.Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.Eur. J. Med. Chem. 2015, 103, 396-408.



26.Hai-Wei Cui,Yuan He,Jinhua Wang, Wei Gao, Ting Liu, Min Qin, Xue Wang, Cheng Gao, Yan Wang, Ming-Yao Liu, Zhengfang Yi *, Wen-Wei Qiu*.Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents.Eur. J. Med. Chem. 2015, 95, 240-248.

25.Li-Gang Yu, Teng-Feng Ni, Wei Gao, Yuan He, Ying-Ying Wang, Hai-Wei Cui, Cai-Guang Yang, Wen-WeiQiu*. The synthesis and antibacterialactivityof pyrazole-fused tricyclic diterpenederivatives. Eur. J. Med. Chem. 2015, 90, 10-20.


24.Gao Cheng, Dai Fu-Jun, Cui Hai-Wei, Peng Shi-Hong, He Yuan, Wang Xue, Yi Zheng-Fang*, Qiu Wen-Wei*. Synthesis of Novel Heterocyclic Ring-Fused 18β-Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity. Chem. Biol. Drug. Des.2014, 84, 223-233.

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23.Jun Xu? Zhenxi Li? Jian Luo? Fan Yang? Ting Liu? Mingyao Liu?* Wen-Wei Qiu?* and Jie Tang*. Synthesis and Biological Evaluation of Heterocyclic Ring-fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption. J. Med. Chem. 2012?55? 3122-3134. (Highlighted by "SicBX")


22.Hui Li? Hui Zou? Lixin Gao? Ting Liu? Fan Yang? Jingya Li? Jia Li?* Wen-Wei Qiu?* and Jie Tang. Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B. Heterocycles2012? 85? 1117-1139.

21.Hui Li,Jin-Ping Wang, Fan Yang, Ting Liu, Wen-Wei Qiu, Jing-Ya Li, Jia Li,*Jie Tang. Design, synthesis and biological activity evaluation of 2-mercapto-4(3H)-quinazolinone derivatives as novel inhibitors of protein tyrosine phosphatase 1 B.Heterocycles2012? 85? 1897-1911.

20.Wu X? Li Z? Yang Z? Zheng C? Chen Y? Ye X? Lian X? Qiu Wen-Wei? Yang F? Tang J? Xiao J? Liu M? Luo J. CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPKs/AP-1 and Ca2+-NFAT signaling pathways. J. Bone Miner. Res. 2012, 27, 1298-1308.

19.Jing-jie Tang? Jia-gui Li? Wei Qi? Wen-wei Qiu? Pei-shan Li? Bo-liang Li? and Bao-Liang Song. Inhibition of SREBP by a small molecule? betulin? improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab. 2011? 13? 44-56.
18.Wen-wei Qiu? Karavadhi Surendra? Liang Yin? and E. J. Corey? Selective formation of six-membered oxa- and carbocycles by the In(III)-activated ring closure of acetylenic substrates. Org. Lett. 2011? 13? 5893-5895.
17.Karavadhi Surendra? Wen-wei Qiu? and E. J. Corey. A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade. J. Am. Chem. Soc. 2011? 133? 9724-9726.
16.Chun Li? Wen-wei Qiu? Zhengfeng Yang? Jian Luo? Fan Yang*? Ming-yao Liu? Juan Xie and Jie Tang*. Steroslective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803. Steroids? 2010? 75? 859-869.
15.Cheng-hai Li? Zheng-feng Yang? Zhen-xi Li? Yu Ma? Li-peng Zhang? Chun-bing Zheng? Wen-wei Qiu? Xian Wu? Xiu Wang? Hui Li? Jie Tang? Min Qian? Da-li Li1? Ping Wang? Jian Luo?? Ming-yao Liu. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways. J. Bone. Miner. Res. 2011? 26? 644-656.
14.Cheng-hai Li? Zheng-feng Yang? Chun-yan Zhai? Wen-wei Qiu? Dali Li? Zheng-fang Yi? Lei Wang? Jie Tang? Min Qian? Jian Luo? and Ming-yao Liu. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway. Mol. Cancer. 2010? 9(73), 1-13.
13.Wen-wei Qiu? Qiang Shen? Fan Yang? Bo Wang? Hui Zou? Jing-ya Li? Jia Li*? Jie Tang*. Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.Bioorg. Med. Chem. Lett.2009?19? 6618-6622.
12. Wen-wei Qiu? Linmei He? Qi Chen? Wanrong Luo? Zhichao Yu? Fan Yang*? Jie Tang*. Imidazolium-modified poly(L-leucine) catalyst: an efficient and recoverable catalyst for Juliá–Colonna reactions. Tetrahedron Lett. 2009? 50? 5225-5227.
11.Wen-wei Qiu? Jie Xu? Xin Li? Li Zhong? Jing-ya Li? Jia Li? Fa-jun Nan. Design and synthesis of matrix metalloprotease photoaffinity trimodular probes.Chin. J. Chem. 2009? 27? 825-833.
10.Bo Wang? Fan Yang? Yifan Shan? Wen-wei Qiu *? Jie Tang *.Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H₂O/CHCl₃system. Tetrahedron2009? 65? 5409-5412.
9.Chun Shen? Wen-wei Qiu*Jie Tang. Enantioselective cyano-ethoxycarbonylation of aldehydes catalyzed by bifunctional salen-Ti complex. Chin. J. Org. Chem. 2009? 29? 426-431.
8.Yong-hua Gong? Wen-wei Qiu? Fan Yang? Pierre Audebert? Gilles Clavier? Fabien Miomander? Jie Tang*. Pyridinium conjugated ferrocenes with thien and bithien bridges: synthesis and electrochemical properties. Chin. J. Chem.2009?27? 1515-1522.
7.Xiu-ling Xu? Wen-wei Qiu? Qing Zhou? Pierre Audebert? Jie Tang*? Fan Yang*? Zhen-rong Sun*? Nonlinear Optical Absorption Properties of Two ultisubstituted p-Dimethylaminophenyl- ethenyl Pyridiniums. J. Phy. Chem. B2008? 112? 4913-4917.
6.Wen-wei Qiu? Jie Xu? Jing-Ya Li? Jia Li? and Fa-Jun Nan. Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes. ChemBioChem. 2007? 8? 1351-1358.
5.Fan Yang? Xiu-Ling Xu? Yong-Hua Gong?Wen-Wei Qiu? Zhen-Rong Sun? Jin-Wei Zhou? Pierre Audebert and Jie Tang. Synthesis and nonlinear optical absorption properties of two new conjugated ferrocene-bridge-pyridinium compounds. Tetrahedron2007? 63? 9188-9194.
4.Wen-wei Qiu? Jie Xu? Da-Zhi Liu? Jing-Ya Li? Yang Ye? Xing-Zu Zhu? Jia Li and Fa-Jun Nan. Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. Bioorg. Med. Chem. Lett. 2006? 16? 3306-3309.
3.徐军? 王晋萍? 钱辰旭? 仇文卫*? 杨帆? 汤杰. 白桦脂酸的研究进展. 生命科学. 2011? 23? 503-510.
2.仇文卫? 汤杰. 化学小分子探针在药物发现中的应用. 化学教学. 2009? 9? 1-4.
1.王博? 仇文卫*? 喻艳华? 杨帆? 汤杰. 山楂酸的研究进展. 生命科学. 2009? 21? 264-269.

中国发明专利(已授权):

1.中国发明专利：抗肿瘤的MA-TNFa药物组合物及其应用，专利号：6.5, 专利授权日期：2013年2月20日，发明人: , 罗剑, 李成海, 杨正峰, 仇文卫, 汤杰
2.中国发明专利：用于制备抗骨质疏松药的桦木酮酸衍生物及其制备和应用，专利号：0.1，专利授权日期：2013年3月12日，发明人：杨帆、、汤杰、罗剑、仇文卫、徐军、李珍惜
3.中国发明专利：喹唑啉酮衍生物及其制备和应用，专利号：3.0，授权公告日：2011年12月28日，发明人：杨帆、汤杰、仇文卫、王利华、赵丽华、穆秋超
4.中国发明专利：季铵盐多聚-L-亮氨酸催化剂及其制备和应用，专利号：3.9，授权公告日：2012年2月8日，发明人：汤杰、杨帆、仇文卫、何林美、王博、周卿
5.中国发明专利：一种通过界面反应制备香兰酰胺类化合物的方法, 专利号：0.3，授权公告日：2012年5月23日，发明人：杨帆、单益凡、汤杰、王博、孙国平、仇文卫
6.中国发明专利：山楂酸衍生物及其制备和应用, 专利号：2.X, 授权公告日：2012年7月4日，发明人：汤杰、李佳、王博、仇文卫、沈强、杨帆、张薇、邹慧
7.中国发明专利：一种桦木酮酸的制备方法, 专利号：3.1，授权公告日：2012年7月4日, 发明人：汤杰、仇文卫、杨帆、刘兵、徐军、龚雪萍
8.中国发明专利：桦木酮酸衍生物及其制备和应用，专利号：2.8，授权公告日：2012年11月14日，发明人：汤杰、、仇文卫、罗剑、杨帆、徐军、李珍惜
9.中国发明专利：抑制破骨细胞分化的桦木酮酸衍生物及其制备和应用，专利号：9.2，专利授权日期：2012年11月14日，发明人：仇文卫、罗剑、汤杰、、杨帆、徐军、李珍惜
10.中国发明专利：一种可循环叔胺环钯化合物催化体系及其应用,专利号：2.X，授权公告日：2011.06.01，发明人：汤杰、沈丹平、张兆国、喻艳华、李慧、仇文卫、杨帆
11.中国发明专利：5a-雄甾-7-甲基-3-羟基-17-酮的制备和应用,专利号：ZL 5.7，授权公告日：2009年4月15日，发明人：杨帆、郑从燊、汤杰、仇文卫










荣誉及奖励