步文博
化学与分子工程学院??????


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开授课程
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个人资料
部门： 化学与分子工程学院
毕业院校：
学位：
学历：
邮编：
联系电话：
传真：
电子邮箱： wbbu@chem.ecnu.edu.cn；wbbu@mail.sic.ac.cn;
办公地址： 中山北路校区化学馆 B205 室
通讯地址： 上海市中山北路3663号，华东师范大学化学馆 B205 室

教育经历

工作经历

个人简介

社会兼职
中国科学院上海硅酸盐研究所特聘研究员、复旦大学附属华山医院客座教授


研究方向
稀土生物化学与医用功能材料（招生专业：物理化学、药物化学、应用化学）：
1.新型光/电/磁功能材料的化学合成方法学研究
2. 稀土功能材料的光磁学、分子影像学与疾病（肿瘤）高效诊疗研究
3. 新型多功能材料用于脑科学研究（脑神经显像与智能调控）

注：本课题组生物化学研究方向隶属多学科交叉领域，热诚欢迎具有化学、材料学、物理学、生物学、药学、医学等专业背景的学生（本科生、硕士生、博士生），加入我们课题组学习、交流与合作。

2019年【稀土生物化学与医用功能材料团队】诚聘以下人员：
华东师范大学紫江青年****、专职科研人员（青年研究员、副研究员）、优秀博士后（基础年薪不低于 30万元/年）：
【http://hr.ecnu.edu.cn/s/116/t/209/74/55/info95317.htm】
【http://hr.ecnu.edu.cn/s/116/t/209/4e/b9/info151225.htm】


开授课程


科研项目


学术成果
个人简介：

步文博：华东师范大学-化学与分子工程学院，博士、教授（二级）、博士生导师，“国家****基金”获得者、科技部中青年科技创新领军人才；兼职中国科学院上海硅酸盐研究所特聘研究员、复旦大学附属华山医院客座教授。2002年于南京工业大学获博士学位，同年进入中国科学院上海硅酸盐研究所工作，2005年晋升为副研究员，2008年破格晋升为研究员，2009年聘任为博士生导师，2011年起担任高性能陶瓷和超微结构国家重点实验室副主任，2016年作为****加入华东师范大学化学与分子工程学院，目前担任上海市绿色化学与化工过程绿色化重点实验室常务副主任、华东师范大学第三届科学研究委员会委员、化学院学术委员会副主任。
研究方向为稀土生物化学与医用功能材料（招生专业：物理化学、应用化学和药物化学）：1.新型光电磁功能材料的化学合成方法学研究; 2. 稀土功能材料的光磁学、分子影像学与疾病（肿瘤）高效诊疗研究；3. 新型多功能材料用于脑科学研究（神经显像与神经调控）。
近五年内，研究工作聚焦于稀土多功能材料的结构设计、化学可控合成及其生物医学应用的基础研究，选择稀土上转换（UCNP）材料体系，围绕无机生物材料的“多模态影像与多功能治疗的高效融合”关键科学问题，在新型UCNP稀土功能材料的设计与制备中做出了系统性创新工作：（1）揭示了UCNP无机影像探针的磁共振影像机理，构建了基于UCNP的系列新型多模态影像探针，实现了单一探针的结构影像和功能影像的高效融合与协同增强成像。（2）发现了UCNP稀土功能材料的“放疗增敏效应”，提出了“克服乏氧、利用乏氧、规避乏氧”三类材料设计策略，实现了精准影像介导下的多功能协同增强的乏氧肿瘤高效治疗；（3）提出了“化学动力学疗法”和“离子干扰疗法”新概念，拓展了无机功能材料用于“肿瘤饥饿疗法”新思路，实现了基于肿瘤微环境特异性诱导激活的高效治疗。该系列研究为解决“常规医学影像探针性能低、常规肿瘤治疗技术（化疗、放疗）固有缺陷”等临床医学瓶颈问题提供了新的研究思路。
近年来，在国家自然科学基金委和上海市科委的资助下，作为项目负责人，先后主持承担了包括七项国家自然科学基金（****、专项、面上）在内的多项国家级科研项目。作为项目骨干，全程参与完成了包括973计划、863计划、国家自然基金重点项目等多项国家级科研项目。
自2008年独立工作以来，作为第一作者 / 通讯作者，在“Nature Nanotechnology”、“Chem”、“J. Am. Chem. Soc.”、“Angew. Chem. Int. Ed.”、“Adv. Mater.”等国际核心SCI学术期刊上发表研究论文60余篇，受邀著名综述类学术期刊“Chem. Rev.”、“Chem. Soc. Rev.”、“Acc. Chem. Res.”、“Coordin.Chem. Rev.”等撰写了多篇专题综述论文，论文SCI他引9200余次，入选Clarivate Analytics（科睿唯安）全球高被引科学家（2019）；其中，1篇研究论文入选“2012年中国百篇最具影响国际学术论文”，18篇研究论文入选 ESI “Highly Cited Papers”，10篇研究论文被 Nature/SciBX、Chemical& Engineering News、ChemistryViews、Asian Scientist、ChemistryWorld、Phys.org等国际著名专业新闻媒体作为研究亮点进行了专题报道和评述。获授权中国发明专利多项。
兼任：中国生物材料学会影像材料与技术分会副主任委员、中国生物材料学会理事、中国生物医学工程学会生物材料分会委员、中国生物材料学会青年委员会委员、新型电子元器件基础材料及精细工艺国家重点实验室学委会委员、中国材料学会特种陶瓷分会理事、中国硅酸盐学会薄膜与涂层分会理事、中国研究型医院学会消化内镜分子影像学专业委员会常务委员；国际学术期刊“Bioconjugate Chemistry”、“Recent Patents on Materials Science”、“American Journal of Nuclear Medicine and Molecular Imaging”、“Reviews in Nanoscience and Nanotechnology”等编委。
曾先后入选（荣获）：Clarivate Analytics（科睿唯安）全球高被引科学家（2019），国家****基金（2017），科技部中青年科技创新领军人才（2017），上海市优秀学术带头人计划（2016年），中国科学院优秀研究生指导教师奖（2016年）、上海市青年科技启明星跟踪计划（2012年），中国科学院上海分院第三届****科技创新人才提名奖（2012年），上海市长宁区第七轮专业技术拔尖人才奖（2010年）、第五届柳大纲优秀青年科技奖（2008年）、上海市青年科技启明星计划（2007年）、国防科学技术二等奖（2004年）等多项荣誉称号。


主要承担的科研项目（项目负责人）：
国家自然科学基金类（七项）：
1.国家自然科学基金（****），项目编号：**，期限：2018-2022，400万元（在研）
2. 国家自然科学基金（面上），项目编号：**，期限：2019-2022， 60万元（在研）
3. 国家自然科学基金（面上），项目编号：**，期限：2014-2017， 80万元（结题）
4. 国家自然科学基金（专项），项目编号：**，期限：2009-2012，140万元（结题）
5. 国家自然科学基金（面上），项目编号：**，期限：2010-2012， 36万元（结题）
6. 国家自然科学基金（面上），项目编号：**，期限：2007-2009， 29万元（结题）
7. 国家自然科学基金（青年），项目编号：**，期限：2006-2006， 9万元（结题）
上海市基金类（三项）：
1.上海市基础重大研究计划，项目编号：19JC**，期限：2019-2022，400万元（在研）
2. 纳米技术专项（重点），项目编号：11nm**，期限：2011-2014，50万元（结题）
3. 纳米技术专项（重点），项目编号：0852nm03900，期限：2008-2010，40万元（结题）

人才计划基金类（四项）：

1. 上海市优秀学术带头人计划，项目编号：16XD**，期限：2016-2019（在研）
2. 上海市人才发展资金资助计划，项目编号：**，期限：2012-2014（结题）
3. 上海市青年科技启明星计划（跟踪），项目编号：12QH**，期限：2012-2014（结题）
4. 上海市青年科技启明星计划（A类），项目编号：07QA14061，期限：2007-2009（结题）
项目合作与协作单位：
复旦大学附属肿瘤医院
复旦大学附属华山医院
复旦大学附属华东医院
复旦大学放射医学研究所
同济大学附属第十人民医院
第二军医大学附属长海医院
National University of Singapore
The University of Queensland, Australia
Science University of Technology Sydney, Australia
发表论文与引用情况（GoogleCitations）：
https://xues.glgoo.net/citations?user=7lOXzeoAAAAJ&hl=zh-CN（链接点击）】

【近五年内，代表性综述论文列表（5篇）】：
1. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.
Chemical Reviews,2017, 117(9): 6160-6224. (Invited Review)
2. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.
Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.
Chemical Society Reviews, 2017,46, 7438–7468. (Invited Review)
3. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He,Wenbo Bu*.
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.
Accounts of Chemical Research, 2018,51(10), 2502-2511. (Invited Review).
4. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.
Accounts of Chemical Research, 2015, 48 (7): 1797–1805. (Invited Review).
5. Yanyan Liu, Xianfu Meng, Wenbo Bu*.
Upconversion-based Photodynamic Cancer Therapy.
Coordination Chemistry Reviews,2019, 379, 82-98. (Invited Review).
【近五年内，部分代表性学术论文列表】：
1. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.
Nature Nanotechnology, 2017, 12 (4), 378-386.
2. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*.

Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.
Chem, 2019,5 (8): 2171-2182.3. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*.
Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.
Journal of the American Chemical Society,2019, 141 (2), 849-857.4. Chen Zhang, Wenbo Bu*, Dalong Ni,Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.
Journal of the American Chemical Society,2016, 138 (26), 8156–8164.
5. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.
Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.
Journal of the American Chemical Society, 2014, 136 (27), 9701–9709.
6. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048
7. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
8. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.
Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.
Angewandte Chemie-International Edition, 2018, DOI: 10.1002/anie..
9. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.
Angewandte Chemie-International Edition, 2016, 55, 2101-2106.
10. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.
X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.
Angewandte Chemie-International Edition, 2015, 54, 14026–14030.
11.Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.
Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.
Angewandte Chemie-International Edition, 2015, 54, 8105–8109.
12. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.
Angewandte Chemie-International Edition,2015, 54: 1770–1774.
13. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.
Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．
Angewandte Chemie-International Edition, 2014, 53, 4551-4555.
14. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.
Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
15. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin lv, Han Wang, Dayong Jin,Wenbo Bu*

Biodegradable Nanoprodrugs: “Delivering” ROS To Cancer Cells For Molecular Dynamic Therapy.
Advanced Materials, 2019, DOI:10.1002/adma..
16. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.
Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.
Advanced Materials, 2017, 29, **.
17. Wenpei Fan, Wenbo Bu*, Jianlin Shi
On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles.
Advanced Materials, 2016, 28, 3987–4011.
18. Wenpei Fan, Wenbo Bu*, Bo Shen,Qianjun He,Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.
Intelligent MnO₂ Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H₂O₂-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.
Advanced Materials, 2015, 27, 4155–4161.
19. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
Ultrasmall NaGdF₄ Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．
Advanced Materials, 2014, 26, 3867–3872.
通讯地址：上海市中山北路3663号，华东师范大学化学馆B205室.
E - mail：wbbu@chem.ecnu.edu.cn；wbbu@mail.sic.ac.cn
个人网页：http://people.ucas.ac.cn/~buwenbo


【学术论文列表】：


2019年度
1. Yanyan Liu, Xianfu Meng, Wenbo Bu*.
Upconversion-based Photodynamic Cancer Therapy.
Coordination Chemistry Reviews, 2019, 379, 82-98. (Invited Review)
2. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*
Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.
Chem, 2019, 5 (8): 2171-2182.
3. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*
Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.
Journal of the American Chemical Society,2019, 141 (2), 849-857.
4. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.
Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.
Angewandte Chemie-International Edition, 2019, 58 (4), 946-956.
5. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin lv, Han Wang, Dayong Jin, Wenbo Bu*

Biodegradable Nanoprodrugs: “Delivering” ROS To Cancer Cells For Molecular Dynamic Therapy.
Advanced Materials 2019, DOI:10.1002/adma..
6. Xiaoyan Chen, Huilin Zhang, Meng Zhang, Peiran Zhao, Ruixue Song, Teng Gong, Yanyan Liu*, Xinhong He*, Kuaile Zhao, and Wenbo Bu*
Amorphous Fe–based Nanoagents for Self–enhanced Chemodynamic Therapy by Re-establishing Tumor Acidosis.
Advanced Functional Materials 2019, DOI: 10.1002/adfm..
7. Aijun Shen, Xianfu Meng, Xiaolong Gao, Xiaowen Xu, Chulun Shao, Zhongmin Tang, Yanyan Liu, Wenbo Bu*, and Peijun Wang*
Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under 3.0T Magnetic Field.
Advanced Functional Materials 2019, 29, **.
8. Xianfu Meng, Hua Zhang, Meng Zhang, Baoming Wang, Yanyan Liu, Yan Wang, Xiangming Fang*, Jiawen Zhang, Zhenwei Yao*, Wenbo Bu*
Negative CT contrast agents for the diagnosis of malignant osteosarcoma.
Advanced Science, 2019, DOI: 10.1002/advs..
9. Meng Zhang, Bo Shen, Ruixue Song, Han Wang, Bin Lv, Xianfu Meng, Yang Liu, Yanyan Liu, Xiangpeng Zheng, Weiwei Su, Changjing Zuo*, and Wenbo Bu*.
Radiation-Assisted Metal Ion Interference Tumor Therapy by Barium Peroxide-Based nanoparticles.
Materials Horizons, 2019,6, 1034 -1040.
10. Peiran Zhao, Zhongmin Tang, Xiaoyan Chen, Ziyu He, Xinhong He, Meng Zhang, Yanyan Liu, Dongdong Ren,* Kuaile Zhao and Wenbo Bu*.
Ferrous-Cysteine-Phosphotungstate Nanoagent with Neutral pH Fenton Reaction Activity for Enhanced Cancer Chemodynamic Therapy
Materials Horizons, 2019, 6, 369-374.
11.Chaolin Song, Xianfu Meng, Yanyan Liu*, Aijun Sheng, Chulun Shao, Kun Wang, Hui Cheng, Xiangming Fang*, Peijun Wang, Wenbo Bu*
Susceptibility-weighted Imaging for Metabolic Pathway Mapping of Low-dosage Nanoparticles in Organisms.
Biomaterials, 2019, DOI: 10.1016/j.biomaterials.2019.119631.
12. Chen Chen, Weiwei Su, Yanyan Liu, Jiawen Zhang, Changjing Zuo*, Zhenwei Yao, Wenbo Bu*.
Artificial Anaerobic Cell Dormancy for Tumor Gaseous Microenvironment Regulation Therapy.
Biomaterials, 2019, 200, 48-55.
2018年度
1. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.
Accounts of Chemical Research, 2018, 51(10), 2502-2511. (Invited Review)
2.Yingying Jin, Dalong Ni, Lu Gao, Xianfu Meng, Yi Lv, Fang Han, Hua Zhang, Yanyan Liu, Zhenwei Yao, Xiaoyuan Feng, Wenbo Bu,* Jiawen Zhang*.
Harness the Power of Upconversion Nanoparticles for Spectral Computed Tomography Diagnosis of Osteosarcoma.
Advanced Functional Materials 2018, 28, **.
3. Chulun Shao, Aijun Shen, Meng Zhang, Xianfu Meng, Chaolin Song, Xiaolong Gao, Yanyan Liu, Peijun Wang*, Wenbo Bu*.
Oxygen Vacancies-Enhanced CeO₂:Gd Nanoparticles for Sensing Tumor Vascular Microenvironment by MRI.
ACS Nano, 2018, 12 (12), 12629–12637.
4. Han Wang, Bin Lv, Zhongmin Tang, Meng Zhang, Weiqiang Ge, Yanyan Liu, Xinhong He, Kuaile Zhao, Xiangpeng Zheng, Mingyuan He, and Wenbo Bu*.
Scintillator-based Nanohybirds with Sacrificial Electron Prodrug for Enhanced X-ray-induced Photodynamic Therapy.
Nano Letters. 2018, 18(9): 5768-5774.
5. Zhongmin Tang, Peiran Zhao, Dalong Ni, Yanyan Liu, Meng Zhang, Han Wang, Hua Zhang, Hongbo Gao, Zhenwei Yao, Wenbo Bu*.
Pyroelectric nanoplatform for NIR-ΙΙ triggered photothermal therapy with simultaneous pyroelectric dynamic therapy.
Materials Horizons, 2018, 5, 946 – 952.
6. Hua Zhang, Yue Wu, Jing Wang, Zhongmin Tang, Yan Ren, Dalong Ni, Hongbo Gao, Ruixue Song, Teng Jin, Qiao Li, Wenbo Bu*, Zhenwei Yao*.
In vivo MR Imaging of Glioma Recruitment of Adoptive T Cells Labeled with NaGdF4-TAT Nanoprobes.
Small, 2018, 14, **.
7.Ruixue Song, Meng Zhang, Yanyan Liu, Zhaowen Cui, Hua Zhang, Zhongmin Tang, Xiaoyan Chen, Haihong Wu*, Zhenwei Yao*, Mingyuan He, Wenbo Bu*.
A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.
Biomaterials, 2018, 175, 123-133.
8. Meng Zhang, Zhaowen Cui, Ruixue Song, Bin Lv, Zhongmin Tang, Xianfu Meng, Xiaoyan Chen, Xiangpeng Zheng, Jiawen Zhang, Zhenwei Yao, Wenbo Bu*
SnWO₄-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy.
Biomaterials, 2018, 155, 135-144.

2017年度
1. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.
Nature Nanotechnology, 2017, 12 (4), 378-386.
2. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.
Chemical Reviews,2017, 117(9): 6160-6224. (Invited Review)
3. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.
Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.
Chemical Society Reviews,2017,46, 7438–7468. (Invited Review)
4. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.
Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.
Advanced Materials, 2017, 29, **.
5. Han Qiao, Zhaowen Cui, Shengbing Yang, Dingkun Ji, Yugang Wang, Ying Yang, Xiuguo Han, Qiming Fan, An Qin, Tingyu Wang, Xiao-Peng He, Wenbo Bu*, Tingting Tang*.
Targeting Osteocyte to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion-Nanoparticles with Responsive Plumbagin Release.
ACS Nano, 2017, 11 (7), 7259–7273.
6. Dalong Ni, Jiawen Zhang, Jing Wang, Ping Hu, Yingying Jin, Zhongmin Tang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi*.
Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.
ACS Nano, 2017, 11 (4), 4256–4264.
7. Ping Hu, Tong Wu, Wenpei Fan, Lei Chen, Yanyan Liu, Dalong Ni, Wenbo Bu*, Jianlin Shi*.
Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy.
Biomaterials, 2017, 141, 86-95.
2016年度
1. Chen Zhang, Wenbo Bu*, Dalong Ni,Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.
Journal of the American Chemical Society,2016, 138 (26), 8156–8164.
2. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.
Angewandte Chemie-International Edition, 2016, 55, 2101-2106.
3. Wenpei Fan, Wenbo Bu*, Jianlin Shi
On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles.
Advanced Materials, 2016, 28, 3987–4011.
4. Dalong Ni, Zhiwei Shen, Jiawen Zhang, Chen Zhang, Renhua Wu, Jianan Liu, Meizhi Yi, Jing Wang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi
Integrating Anatomic and Functional Dual-Mode Magnetic Resonance Imaging: Design and Applicability of a Bifunctional Contrast Agent.
ACS Nano, 2016, 10 (3), 3783–3790.
5. Jing Wang, Hua Zhang, Dalong Ni, Wenpei Fan, Jianxun Qu, Yanyan Liu, Yingying Jin, Zhaowen Cui, Tianyong Xu, Yue Wu, Wenbo Bu*, Zhenwei Yao*.
High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke.
Small, 2016, 12 (26): 3591-3600.
6. Zhaowen Cui, Wenbo Bu*, Wenpei Fan, Jiawen Zhang, Dalong Ni, Yanyan Liu, Jianan Liu, Jing Wang, Zhenwei Yao, Jianlin Shi*.
Sensitive imaging and effective capture of Cu²⁺: Towards highly efficient theranostics of Alzheimer's disease.
Biomaterials, 2016, 104, 158-167.
7. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Chen Zhang, Zhenwei Yao, Huaiyong Xing, Jing Wang, Fei Duan, Yanyan Liu, Wenpei Fan, Xiaoyuan Feng, Jianlin Shi*.
PEGylated NaHoF₄ nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging.
Biomaterials, 2016, 76, 218–225.
2015年度
1. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.
Accounts of Chemical Research, 2015, 48 (7): 1797–1805. (Invited Review).
2. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.
X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.
Angewandte Chemie-International Edition, 2015, 54, 14026–14030.
3.Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.
Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.
Angewandte Chemie-International Edition, 2015, 54, 8105–8109.
4. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.
Angewandte Chemie-International Edition,2015, 54: 1770–1774.
5. Wenpei Fan, Wenbo Bu*, Bo Shen,Qianjun He,Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.
Intelligent MnO₂ Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H₂O₂-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.
Advanced Materials, 2015, 27, 4155–4161.
6. Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*.
Design of An Intelligent Sub-50 nm Nuclear-targeting Nanotheranostic System for Imaging Guided Intranuclear Radiosensitization.
Chemical Science, 2015, 6, 1747–1753.
7. Jing Wang, Dalong Ni, Wenbo Bu*, Qian Zhou, Wenpei Fan, Yue Wu, Yanyan Liu, Lekang Yin, Zhaowen Cui, Xiaoxue Zhang, Hua Zhang, Zhenwei Yao*.
BaHoF₅ nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke.
Biomaterials, 2015,71: 110–118.
8.Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Dalong Ni, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*.
Intranuclear Biophotonics by Smart Design of Nuclear-targeting Photo-/radio-sensitizers Co-loaded Upconversion Nanoparticles.
Biomaterials, 2015, 69: 89–98.
9. Yanyan Liu, Yong Liu, Wenbo Bu*, Qingfeng Xiao, Yong Sun, Kuaile Zhao, Wenpei Fan, Jianan Liu, Jianlin Shi*.
Radiation-/Hypoxia-induced Solid Tumor Metastasis and Regrowth Inhibited by Hypoxia-specific Upconversion Nanoradiosensitizer.
Biomaterials, 2015,49: 1–8.

2014年度
1. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.
Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.
Journal of the American Chemical Society, 2014, 136 (27), 9701–9709.
2. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.
Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．
Angewandte Chemie-International Edition, 2014, 53, 4551-4555.
3. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
Ultrasmall NaGdF₄ Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．
Advanced Materials, 2014, 26, 3867–3872.
4.Dalong Ni, Wenbo Bu,* Shengjian Zhang, Xiangpeng Zheng, Ming Li, Huaiyong Xing, Qingfeng Xiao, Yanyan Liu, Yanqing Hua, Liangping Zhou, Wenjun Peng, Kuaile Zhao, Jianlin Shi*.
Single Ho³⁺-Doped Upconversion Nanoparticles for High-Performance T2-Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging.
Advanced Functional Materials 2014, 24, 6613-6620.
5. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Huaiyong Xing, Fang Han, Qingfeng Xiao, Zhengwei Yao, Feng Chen, Qianjun He, Jianan Liu, Shengjian Zhang, Wenpei Fan, Liangping Zhou, Weijun Peng, Jianlin Shi*.
Dual-Targeting Upconversion Nanoprobes across the Blood-Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma.
ACS Nano, 2014, 8 (2), 1231–1242.
6.Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Qianjun He, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Dalong Ni, Jianan Liu, Jianlin Shi*.
A Smart Upconversion-based Mesoporous Silica Nanotheranostic System for Synergetic Chemo-/Radio-/Photodynamic Therapy and Simultaneous MR/UCL Imaging.
Biomaterials, 2014, 35: 8992-9002.



2013年度
1. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048
2. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
3. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.
Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
4. Feng Chen, Wenbo Bu*, Shengjian Zhang, Jianan Liu, Wenpei Fan, Liangping Zhou, WeijunPeng, Jianlin Shi*.
Gd³⁺-Ion-Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization
Advanced Functional Materials, 2013, 23, 298-307.
5. Huaiyong Xing, Xiangpeng Zheng, Qingguo Ren, Wenbo Bu*, Weiqiang Ge, Qingfeng Xiao, Shengjian Zhang, Chenyang Wei, Haiyun Qu, Zheng Wang, Yanqing Hua, Liangping Zhou, Weijun Peng, Kuaile Zhao, Jianlin Shi*.
Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements.
Scientific Reports, 2013, 3: 1751 (DOI: 10.1038/srep01751).



2012年度

1. Qingfeng Xiao, Wenbo Bu*, Qingguo Ren, Shengjian Zhang, Huaiyong Xing, Feng Chen, Ming Li, Xiangpeng Zheng, Yanqing Hua, Liangping Zhou, Weijun Peng, Haiyun Qu, Zheng Wang, Kuaile Zhao, Jianlin Shi*.
Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging.
Biomaterials, 2012, 33: 7530-7539.
2. Jianan Liu, Wenbo Bu*, Limin Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuaile Zhao, Weijun Peng, Jianlin Shi*.
Simultaneous Nuclear Imaging and Intranuclear Drug Delivery by Nuclear-Targeted Multifunctional Upconversion Nanoprobes.
Biomaterials, 2012, 33: 7282-7290.
3. Huaiyong Xing, Wenbo Bu*, Qingguo Ren, Xiangpeng Zheng, Ming Li, Shengjian Zhang, Haiyun Qu, Zheng Wang, Yanqing Hua, Kuaile Zhao, Liangping Zhou, Jianlin Shi*.
A NaYbF₄: Tm³⁺ nanoprobe for CT and NIR-to-NIR fluorescent bimodal-imaging.
Biomaterials, 2012, 33, 5384-5393.
4. Huaiyong Xing, Wenbo Bu*, Shengjian Zhang, Xiangpeng Zheng, Ming Li, Feng Chen, Qianjun He, Liangping Zhou, Weijun Peng, Yanqing Hua, Jianlin Shi*.
Multifunctional Nanoprobes for Upconversion Fluorescence, MR and CT Trimodal Imaging.
Biomaterials, 2012, 33, 1079-1089.
5. Feng Chen, Wenbo Bu*, Shengjian Zhang, Yu Chen, Qingfeng Xiao, Jianan Liu, Huaiyong Xing, Liangping Zhou, Weijun Peng, Jianlin Shi*.
A Uniform Sub-50 nm sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet oxygen by Using a 980 nm laser.
Chemistry – A European Journal, 2012, 18, 7082-7090.
6. Jianan Liu, Wenbo Bu*, Shengjian Zhang, Feng Chen, Huaiyong Xing, Limin Pan, Liangping Zhou, Weijun Peng, Jianlin Shi*.
Controlled Synthesis of Uniform and Monodisperse Upconversion Core/Mesoporous Silica Shell Nanocomposites for Bimodal Imaging.
Chemistry – A European Journal, 2012, 18, 2335-2341.



2011年度
1. Feng Chen, Wenbo Bu*, Shengjian Zhang, Huaiyong Xing, Jianan Liu, Qingfeng Xiao, Xiaohang Liu, Liangping Zhou, Weijun Peng, Lianzhou Wang, Jianlin Shi*.
Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes.
Advanced Functional Materials 2011, 21, 4285-4294.
2. Feng Chen, Wenbo Bu*, Lingxia Zhang, Yuchi Fan, Jianlin Shi*.
Is Black Iron Oxide Nanoparticle Always a Light Absorber?
Journal of Materials Chemistry, 2011, 21, 7990–7995.
3. Feng Chen, Shengjian Zhang, Wenbo Bu*, Xiaohang Liu, Yu Chen, Qianjun He, Min Zhu, Lingxia Zhang, Liangping Zhou, Weijun Peng, Jianlin Shi*.
A "Neck-Formation" Strategy for an Antiquenching Magnetic/Upconversion Fluorescent Bimodal Cancer Probe.
Chemistry – A European Journal, 2010, 16, 11254-11260.












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