董素珍
化学与分子工程学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 化学与分子工程学院
毕业院校：
学位：
学历：
邮编：
联系电话：
传真：
电子邮箱： szdong@brain.ecnu.edu.cn
办公地址： 中山北路理科大楼B1513
通讯地址： 中山北路3663号

教育经历

工作经历

个人简介

社会兼职


研究方向
1.抗肿瘤小分子化合物的筛选及其抗肿瘤机制研究；
2.肽脱甲酰基酶及吲哚胺2,3加氧酶新型抑制剂的筛选及其抗肿瘤作用研究；
3.阿尔茨海默病分子病理机制及相关化合物作用研究；



开授课程


科研项目


学术成果

1.Hu X , He J, Dong S, Zhao Q, YuJ, Zhou J. Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes. Nature Communication. 2020. 11:5500.
2.Han, Y, Ren, Z, Wu, Y, Chen, Y, Cui, Z, Zhu, T, Ma, M, Du, Y, andDong, S^*,Pharmacological activation of the p53 pathway by a new compound CYZ2017 exerts anti-tumor effects.Biochem Biophys Res Commun. 2020, 533: 1069-1075.
3.Ji, J, Sajjad, F, You, Q, Xing, D, Fan, H, Reddy, AGK, Hu, W^*, and Dong, S^*,Synthesis and biological evaluation of substituted pyrrolidines and pyrroles as potential anticancer agents.Arch Pharm (Weinheim).2020, e**.
4.Hu, L^#, Cai, X^#, Dong, S^#, Zhen Y, Hu J, Wang, S, Jiang J, Huang J, Han Y, Qian Y*, Yuan Y*, Hu, W, Synthesis and Anti-cancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. Journal of Medicine Chemistry. 2020, 63, (13): 6959–6978.
5.Yu, Y., Han, Y., Zhang, F., Gao, Z., Zhu, T.,Dong, S.^*, and Ma, M.^*, Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors. J Med Chem,2020.63, 6, 3028-3046
6.You, Q., Gong Q., Han Y.Q., P R.i, Du Y., andDong S.*, Role of miR-124 in the regulation of retinoic acid-induced Neuro-2A cell differentiation. Neural Regen Res, 2020. 15(6): p. 1133-1139.
7.Song, L., Ni, D., Jia, S., Pi, R., Dong, S., Yang, F., Tang, J., and Liu, S., C(sp2)-H Bond Multiple Functionalization in Air for Construction of Tetrahydrocarbazoles with Continuous Quaternary Carbons and Polycyclic Diversification. Org Lett,2020. 22(5): p. 1846-1851.
8.He, L., Bao J., Yang, Y. Dong S., Zhang, L. Qi Y., and. Zhang J.Z.H, Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning. J Chem Inf Model,2019. 59(9): p. 3871-3878.
9.Niu, L., Pi R., Dong S., and Liu S., Aromatic C-H Bond Functionalized via Zwitterion Intermediates to Construct Bioxindole Containing Continuous Quaternary Carbons. J Org Chem,2019. 84(23): p. 15192-15200.
10.Li, Z., Jia, K., Duan, Y., Wang, D., Zhou, Z., and Dong, S.*,Xanomeline derivative EUK1001 attenuates Alzheimer's disease pathology in a triple transgenic mouse model.Molecular Medicine Reports,2017. 16(5): 7835-7840.
11.Jia, K., Lv, X., Xing, D., Che, J., Liu, D., Thumar, N.J., Dong, S.*, and Hu, W.*,Synthesis and biological evaluation of 3-amino-3-hydroxymethyloxindoles as potential anti-cancer agents.Rsc Advances,2017. 7(38): 23265-23271.
12.Lei, R., Wu, Y., Dong, S., Jia, K., Liu, S., and Hu, W.,A Diastereoselective Multicomponent Reaction for Construction of Alkynylamide-Substituted alpha,beta-Diamino Acid Derivatives To Hunt Hits.Journal of Organic Chemistry,2017. 82(6): 2862-2869.
13.Jing, C., Li, Z., Jia, K., Chen, C., Liu, X., Wang, B., Hu, W., Li, J., Zhu, T.*, and Dong, S.*,Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors.Archiv Der Pharmazie,2017. 350(1).
14.Dong, S., Lei, Y., Jia, S., Gao, L., Li, J., Zhu, T., Liu, S., and Hu, W.,Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.Bioorganic & Medicinal Chemistry Letters,2017. 27(4): 1105-1108.
15.Wang, X., Dong, S., Feng, D., Chen, Y., Ma, M., and Hu, W.*,Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications.Tetrahedron,2017. 73(16): 2255-2266.
16.Wang, X., Ding, X., Nan, L., Wang, Y., Wang, J., Yan, Z., Zhang, W., Sun, J., Zhu, W., Ni, B., Dong, S.*, and Yu, L.*,Investigation of the roles of exosomes in colorectal cancer liver metastasis.Oncology Reports,2015. 33(5): 2445-2453.
17.Duan, Y., Zhang, R., Zhang, M., Sun, L., Dong, S., Wang, G., Zhang, J., and Zhao, Z.,Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus.Neural Regeneration Research,2013. 8(25): 2379-2388.
18.Zhang, X., Gong, Q., Zhang, S., Wang, L., Hu, Y., Shen, H., and Dong, S.*,3- 3-(3-florophenyl-2-propyn-1-ylthio)-1, 2, 5-thiadiazol-4-yl -1, 2, 5, 6-tetrahydro-1-methylpyridine oxalate, a novel xanomeline derivative, improves neural cells proliferation and survival in adult mice.Neural Regeneration Research,2012. 7(1): 24-30.
19.Xu, Z.^#, Dong, S.^#, Du, D., Jiang, N., Sun, P., Wang, H., Yin, L., Zhang, X., Cao, X., Zhen, X., and Hu, Y.*,Generation and characterization of hD(5) and C-terminal Mutant hD(5m) transgenic rats.Brain Research,2012. 1448: 27-41.
20.Lu, X., Zhang, N., Meng, B., Dong, S., and Hu, Y.*,Involvement of GPR12 in the regulation of cell proliferation and survival.Molecular and Cellular Biochemistry,2012. 366(1-2): 101-110.
21.Lu, X., Zhang, N., Dong, S., and Hu, Y.,Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells.Brain Research Bulletin,2012. 87(1): 30-36.
22.Duan, Y., Dong, S., Gu, F., Hu, Y., and Zhao, Z.*,Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.Translational neurodegeneration,2012. 1(1): 24-24.
23.Dong, S., Zeng, Q., Mitchell, E.S., Xiu, J., Duan, Y., Li, C., Tiwari, J.K., Hu, Y., Cao, X., and Zhao, Z.*,Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity.Plos One,2012. 7(2).
24.Dong, S., Duan, Y., Hu, Y., and Zhao, Z.*,Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis.Translational neurodegeneration,2012. 1(1): 18-18.
25.Li, C., Dong, S., Wang, H., and Hu, Y.*, Microarray analysis of gene expression changes in the brains of NR2B-induced memory-enhanced mice. Neuroscience, 2011. 197: 121-131.
26.Wu, P., Shen, Q., Dong, S., Xu, Z., Tsien, J.Z., and Hu, Y.*,Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.Neurobiology of Aging,2008. 29(10): 1502-1511.
27.Sun, Q., Wei, X., Feng, J., Zhang, R., Shen, Q., Dong, J., Jin, Y., Dong, S., Li, H., and Hu, Y.*,Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma.Cancer Science,2008. 99(2): 234-240.
28.Dong, S., Li, C., Wu, P., Tsien, J.Z., and Hu, Y.*,Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.European Journal of Neuroscience,2007. 26(1): 101-112.
29.Sun, Q., Feng, J., Wei, X.-L., Zhang, R., Dong, S., Shen, Q., Dong, J., Li, H., and Hu, Y.*,Generation and characterization of a transgenic mouse model for pancreatic cancer.World Journal of Gastroenterology,2006. 12(17): 2785-2788.
30.Fang, L., Zhang, M., Li, C., Dong, S., and Hu, Y.*,Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.Neuroscience Letters,2006. 404(1-2): 148-153.
31.Bi, C., Cui, Y., Mao, Y., Dong, S., Zhang, J., and Sun, X.*,The effect of early auditory deprivation on the age-dependent expression pattern of NR2B mRNA in rat auditory cortex.Brain Research,2006. 1110: 30-38.
32.Mei, B., Li, C., Dong, S., Jiang, C., Wang, H., and Hu, Y.*,Distinct gene expression profiles in hippocampus and amygdala after fear conditioning.Brain Research Bulletin,2005. 67(1-2): 1-12.



荣誉及奖励


招生信息














10 访问


相关教师