高栓虎




个人资料
部门： 化学与分子工程学院
性别： 男
专业技术职务： 教授博士生导师
毕业院校： 兰州大学
学位： 博士
学历：
联系电话：
电子邮箱： shgao@chem.ecnu.edu.cn
办公地址： 化学馆 A-303室
通讯地址： 上海市 中山北路3663号 200062 华东师范大学 化学馆 A-303室
邮编： 200062
传真：


工作经历
2010.10－至今：华东师范大学，化学与分子工程学院
上海市绿色化学与化工过程绿色化重点实验室
上海分子治疗与新药创制工程技术研究中心
教授，博士生导师




教育经历
1997.9－2001.7：兰州大学化学化工学院，学士；
2001.9－2006.7：兰州大学，功能有机分子国家重点实验室，博士，导师：涂永强 院士；
2006.7－2010.9：美国西南医学中心，博士后，导师： Chuo Chen 教授；






个人简介
招收博士后（2-3名）启事：
主要研究方向：（1）天然产物全合成；（2）天然产物的药物化学研究。

基本要求：1、博士毕业两年之内，有机化学专业，具有有机合成背景优先考虑；
2、工作勤奋、踏实，具有良好的团队协作精神；
3、英文说写能力良好；能够写作英文科技论文。
待遇：> 30万（税前）+科研奖励+课题组补助（具体面议）

申请者将个人简历、发表论文、研究工作总结发送至：shgao@chem.ecnu.edu.cn

招聘研究助理（1名）启事：
主要研究方向：（1）天然产物全合成；（2）天然产物的药物化学研究；（3）合成工艺开发。

基本要求：1. 本科及以上学历，毕业两年之内，有机化学专业；
2. 具有有机合成背景优先考虑；
3. 工作勤奋、踏实，具有良好的团队协作精神；
工作努力，业务突出者可进一步攻读本组硕士或博士学位。
待遇：10万（税前）+科研奖励+课题组补助
申请者将个人简历发送至：shgao@chem.ecnu.edu.cn




社会兼职


《Organic Chemistry Frontiers》青年编委




研究方向

(1)活性天然产物全合成研究
(2)导向天然产物的合成方法学研究
(3)天然产物药物化学研究


已完成的天然产物目标分子






开授课程
研究生专业必修课《有机反应与合成B》



科研项目
1) 国家自然科学基金委员会，面上项目，多环型呫吨酮类天然产物的全合成研究，2020-01至2023-12；
2) 上海市科委项目，基于碳氢键活化的化学焊接，2018-06至2021-05,；
3) 上海市科委项目，基于不对称光反应的活性天然产物全合成，2018-05至2021-04；
4) 国家自然科学基金委员会，面上项目，Gukulenin类天然产物的合成研究，2018-01至2021-12；
5) 国家自然科学基金委员会，优秀青年基金项目，天然产物合成研究，2015-01至2017-12，；
6) 上海市科委项目，Hamigeran 类天然产物的全合成研究，2014-07至2016-06，；
7) 国家自然科学基金委员会，面上项目，Tetramic Acid类天然产物的仿生合成研究，2013-01至2016-12；
8) 国家自然科学基金委员会，青年科学基金项目，Variecolin类天然产物的全合成研究，2011-09至2014-08





学术成果
55. Hongyuan Zhang, Haibing He, Shuanhu Gao,*
Asymmetric Total Synthesis of Cephanolide A
Angew. Chem. Int. Ed. 2020, 59, DOI: 10.1002/anie..





54. Delu Jiang, Kunyun Xin, Baochao Yang, Yanyu Chen, Quan Zhang, Haibing He, ShuanhuGao*
Total Synthesis of Three Families of Natural Antibiotics: Anthrabenzoxocinones Fasamycins/naphthacemycins and Benastatins
CCS Chemistry, 2020, 2, 800-812.



53.Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma,*Shuanhu Gao,*Xiangbing Qi*
An Alkaloid Initiates Phosphodiesterase 3A–Schlafen 12 Dependent Apoptosis without Affecting the Phosphodiesterase Activity,
Nature Communications, 2020,11,3236.


52.Yonglei Que, Hao Shao, Haibing He, Shuanhu Gao*
Total Synthesis of Farnesin via an Excited-State Nazarov Reaction
Angew. Chem. Int. Ed.2020,59, 7444-7449.
Highlighted bySynfacts.2020, 16,498.









51.Tao Xie, Chaoying Zheng, Kuanwei Chen, Haibing He, Shuanhu Gao*
Asymmetric Total Synthesis of the Complex Polycyclic Xanthone FD‐594
Angew. Chem. Int. Ed.2020,59, 4360-4364.
Highlighted bySynfacts.2020, 16,374.














50. Yang Ji, Zhengyuan Xin, Haibing He, Shuanhu Gao*
Total Synthesis of Viridin and Viridiol
J. Am. Chem. Soc.2019,141, 16208-16212.
Highlighted bySynfacts.2020, 16,119.







49.Jiaxin Zhong, Haibing He,* Shuanhu Gao*
Exploration of 1, 3-dipolar Cycloaddition Reaction to Construct the Core Skeleton of Calyciphylline A-type Alkaloids
Org. Chem. Front.,2019,6, 3781-3785.














48. Jiaxin Zhong, Kuanwei Chen, Yuanyou Qiu, Haibing He, and Shuanhu Gao*
A Unified Strategy To Construct the Tetracyclic Ring of Calyciphylline A Alkaloids: Total Synthesis of Himalensine A
Org. Lett.2019,21, 3741-3745.








47. Dongsheng Xue, Mengmeng Xu, Chaoying Zheng, Baochao Yang, Min Hou, Haibing He, Shuanhu Gao*
Titanium-promoted Intramolecular Photoenolization/Diels–Alder Reaction to Construct Polycyclic Terpenoids: Formal Synthesis of Mycoleptodiscin A
Chin. J. Chem.2019,37, 135-139.











46. Baochao Yang, Shuanhu Gao*
Recent Advances in the Application of Diels-Alder Reactions Involving O-quinodimethanes O-quinone Methides and Aza-o-quinone Methides in Natural Products Total Synthesis
Chem. Soc. Rev.,2018,47, 7926-7953.













45.Yihua Dai, Feixia Ma, Yanfang Shen, Tao Xie, Shuanhu Gao*
Convergent Synthesis of Kibdelone C
Org. Lett.2018,20, 2872–2875.
Highlighted bySynfacts.2018, 14,784.





44. Yuanyou Qiu, Jiaxing Zhong, Shan Du, Shuanhu Gao*
Synthetic Studies on Daphniglaucins
Chem. Commun.,2018,54, 5554-5557.








43. Yingbo Shi, Yang Ji, Kunyun Xin and Shuanhu Gao*
Total synthesis of (?)-Xestosaprol N and O
Org. Lett.2018,20, 732–735.










42. Yingbo Shi, Haibing He,Shuanhu Gao*
Recent Advances in the Total Synthesis of Gracilamine
Chem. Commun.,2018,54, 12905-12913.








41.Yihua Dai, Yanfang Shen,Shuanhu Gao*
Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis
Chin. J. Org. Chem.2018,38, 1608-1625.




40. Baochao Yang,Shuanhu Gao*
The Application of Photochemical Rearrangement of Santonin in Total Synthesis of Complex Natural Terpenoids
Acta Chim. Sinica.2018,76, 161-167.




39. Yingbo Shi, Qiaoling Wang,Shuanhu Gao*
Recent Advances of Using Intramolecular Mannich-reaction in Total synthesis of Alkaloids
Org. Chem. Front.2018,5, 1049 – 1066.




38. Xiaojun Li, Wanbin Zhang,* Shuanhu Gao*
Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies
Chin. J. Org. Chem.2018,38, 2185-2198.



37.Baochao Yang, Kuaikuai Lin, Yingbo Shi,Shuanhu Gao*
Ti(Oi-Pr)₄-promoted photoenolization Diels–Alder reaction to construct polycyclic rings and its synthetic applications
Nature Communications,2017, 8, 622.



36.Xiaojun Li, Qingfei Zheng, Jun Yin, Wen Liu* andShuanhu Gao*
Chemo-enzymatic Synthesis of Equisetin
Chem. Commun.,2017,53, 4695 – 4697.




35.Zheming Xiao, Yayue Li, andShuanhu Gao*
Total Synthesis and Structural Determination of the Dimeric Tetrahydroxanthone Ascherxanthone A
Org. Lett.2017,19, 1834–1837.






34.Dan Wang, Min Hou, Yue Ji, andShuanhu Gao*
Total Synthesis of Scholarisine K and Alstolactine A
Org. Lett.,2017,19, 1922-1925.





33.Ke Li, Jinjie Ou,Shuanhu Gao*
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
Angew. Chem. Int. Ed.2016,55, 14778–14783.





32.Xiaojun Li, Dongsheng Xue, Cheng Wang,Shuanhu Gao*
Total Synthesis of Hamigerans
Angew. Chem. Int. Ed.2016,55, 9942–9946.



31. Yuanyou Qiu andShuanhu Gao*
Trends in Applying C–H Oxidation to Total Synthesis of Natural Products
Nat. Prod. Rep.,2016,33, 562-581.



30.Shuanhu Gao*, Yuanyou Qiu
Advances of Radical and Photo Reactions in Natural Products Synthesis
Sci. Chin. Chem.2016,59, 1093-1108.



29.Yingbo Shi andShuanhu Gao*
Recent Advances of Synthesis of Fluorenone and Fluorene Containing Natural Products
Tetrahedron,2016,72, 1717-1735.




28.Shuanhu Gao,*Advances of Radical and Photo Reactions in Natural Products Synthesis
A Photo-induced C-C Bond Formation Methodology to Construct Tetrahydrofluorenones and Related Structures
Org. Chem. Front.2016,3, 354-358.





27.Yingbo Shi, Baochao Yang, Shujun Cai, andShuanhu Gao*
Total Synthesis of Gracilamine
Angew. Chem. Int. Ed.2014,53, 9539-9543.
Highlighted bySynfacts,2014,10, 1011.





26.Lili Kong, Mingjin Rao, Jinjie Ou, Jun Yin, Weiqiang Lu, Mingyao Liu, Xiufeng Pang,* andShuanhu Gao*
Total Synthesis and Biological Studies of Cryptocin and Derivatives of Equisetin and Fusarisetin A
Org.Biomol. Chem.,2014,12, 7591-7597.




25.Shujun Cai, Zheming Xiao, Yingbo Shi andShuanhu Gao*
The Photo-Nazarov Reaction: Scope and Applications
Chem.-Eur. J.2014,20, 8677-8681.




24.Dan Wang,Shuanhu Gao*
Sonogashira Coupling in Natural Product Synthesis
Org. Chem. Front.2014,1, 556-566.





23.Zheming Xiao, Shujun Cai, Yingbo Shi, Baochao Yang,Shuanhu Gao*
Photo-induced C-O Bond Formation to Construct Tetrahydroxanthones
Chem. Commun.2014,50, 5254-5257.
(Invited for “2014 Emerging Investigators Issue”)




22.Jun, Yin;Gao Shuanhu*
Total Synthesis of (+)-Fusarisetin A: A Biomimetic Approach
Synlett.2014,25, 1-7.
(Invited Synpacts)




21.Ke Li, Cheng Wang, Baochao Yang,Shuanhu Gao*
Construction of the Basic Skeleton of Ophiobolin A and Variecolin
Org. Biomol. Chem.,2013,11, 7550-7558.




20. Cheng Wang, Dan Wang, andShuanhu Gao*
Total Synthesis of Cyanthiwigins A, C, G and H
Org. Lett.2013,15, 4402-4405.



19. Jun Yin, Lili Kong, Cheng Wang,YingboShi, Shujun Cai, andShuanhu Gao*
Biomimetic Synthesis of Equisetin and (+)-Fusarisetin A
Chem.-Eur. J.2013,39, 13040-13046.
Highlighted inChemistryViews




18. Jun,Yin; Kong, Lili;Gao Shuanhu*
Synthetic Progress of FusarisetinA
Chin. J. Org. Chem.2013, 33, 259-266.





17. Jun Yin? Cheng Wang? LiliKong?Shujun Cai?Shuanhu Gao*
AsymmetricSynthesisand Biosynthetic Implications of (+)-Fusarisetin A
Angew. Chem. Int. Ed.2012?51, 7786-7789.
HighlightedinChemical & EngineeringNews(JUNE 25, 2012)
Highlighted inOrganic Chemsitry Portal
Highlighted inChin. J. Org. Chem.







Publications during Ph. D. and Postdoctor's research


16. Shi, H.; De, S.; Wang, Q.;Shuanhu Gao; Wang, X.;Chuo Chen
Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F
Tetrahedron Lett.2015,56, 3225.



15.Zhiqiang Ma?, Xiaolei Wang?, Xiao Wang, Rodrigo A. Rodriguez,Shuanhu Gao,
Xianghui Tan, Yuyong Ma, Curtis E. Moore, Arnold L. Rheingold, Phil S. Baran and Chuo Chen
Asymmetric syntheses, structural refinement, and biosynthetic implications of sceptrin,
massadine, and ageliferin
Science,2014,346, 219-224.



14.Gao Shuanhu; Chen Chuo
Total Synthesis of Natural Products–At the Frontiers of OrganicChemistry;
Nakiterpiosin (Chapter 2). Li, J. J., Corey, E. J., Eds.; Springer-Verlag:
Berlin/Heidelberg, 2013; 25–38.



13.Gao, Shuanhu; Wang, Qiaoling; Wang, Gelin; Lomenick, Brett; Liu, Jie; Fan, Chih-Wei; Deng, Lih-Wen;Huang,Jing; Lum, Lawrence; Chen, Chuo
The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids
Synlett,2012,23, 2298.






12.Shuanhu Gao; Qiaoling Wang; Lawrence Lum;ChuoChen*.
Chemical and Biological Studies of Nakiterpiosin andNakiterpiosinone
J. Am. Chem. Soc.2010?132? 371.






11.Shuanhu Gao; Qiaoling Wang; ChuoChen*.
Synthesis andStructure Revision of Nakiterpiosin
J. Am. Chem. Soc.2009?131? 1410.






10. J. R.Falck;*Shuanhu Gao; Ravi Naga Prasad; SreenivasuluReddy Koduru.
Electrophilic α-thiocyanation of chiral andachiralN-acyl imides. A convenient route to
5-substituted and 5?5-disubstituted 2?4-thiazolidinediones
Bioorg. Med. Chem. Lett.2008?18? 1768.



9.Shuanhu Gao;Yong-Qiang Tu*; Xiangdong Hu; Rongbao Hua; Yijun Jiang; Yuming Zhao;
Xiaohui Fan; Shuyu Zhang.
Generaland Efficient Strategy for Erythrinan and Homoerythrinan Alkaloids: Syntheses of
(±)-3-demethoxyerythratidinone and (±)-Erysotramidine
Org. Lett.2006?8?2373.



8.Shuanhu Gao;Yong-QiangTu*;Zhenlei Song; Aixia Wang; Xiaohui Fan; Yijun Jiang.
AGeneraland Efficient Strategy for 7-Aryloctahydroindoleandcis-3a-Aryloctahydroindole
Alkaloids:Total Syntheses of (±)-γ-Lycorane and(±)-Crinane
J. Org. Chem.2005?70?6523.


7.Shuanhu Gao; Yanxing, Jia; Xuezhi Zhao; Yongqiang Tu*
A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindonlines
via AlEt3-promoted TandemReductive Rearrangement of Hydroxy Epoxides
Chin. J. Chem.2006,24, 595.


6. Xiang-Dong Hu; Yong-Qiang Tu*;En Zhang;Shuanhu Gao; Shaohua Wang; Aixia Wang;
Chun-An Fan; Min Wang.
TotalSynthesis of (±)-Galanthamine
Org.Lett.2006?8?1823.


5. Ai-Xia Wang; ZhenLei, Song;Shuanhu Gao; Yi-Jun Jiang; Dao-Yi Yuan; Yong-Qiang Tu; Ning-Zi Li.
Studies on Wagner-Meerwein rearrangement of benzospirocyclic β-bromoketones and application toformal synthesis of (±)-Colchicine
Youji Huaxue2007,27, 1171.


4. Ai-Xia Wang; Yong-Qiang Tu; Zhen-Lei Song; Dao-Yi Yuan; Xiang-Dong Hu; Shao-Hua Wang;Shuanhu Gao
Synthetically useful Wagner-Meerwein rearrangement of α-quaternary β-bromovinyl methyl ethers
European Journal of Organic Chemistry,2006,12, 2691.


3.Zhenlei Song; Yongqiang Tu;Shuanhu Gao; Yijun Jiang, Shuyu Zhang.
Studies on the synthesis of morphinan alkaloid: preparation of the key allylic silyl ether precursor
Chinese Chemical Letters,2005,16, 1445.


2. Xue-Zhi Zhao; Lei Peng; Meng Tang; Yong-Qiang Tu;Shuanhu Gao
Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Precise and Stereocontrolled Synthesisof the Key Mother Spiroketal
Tetrahedron Lett.2005,46, 6941.


1. Li, Xin; Wang, Bao-Min; Zhao, Xue-Zhi;Shuanhu Gao; Tu, Yong-Qiang; Li, De-Run
Extensive Studies on the AlEt3/THF-Promoted Diastereoselective Tandem Rearrangement Reduction ofa-Hydroxy (Amino) Heterocyclopropane: An Efficient Approach to 2-Quaternary 1,3-Diheteroatom Units
Chin. J. Chem.2004,22, 1177.





荣誉及奖励

上海市优秀学术带头人（2018）
ACP-Lecture Awards (to Hong Kong and Japan)（2016）
中国化学会青年化学奖 （2014）
国家自然科学基金委优秀青年基金项目（2014）
Thieme Chemistry Journal Award（2014）