贺小华
化学与分子工程学院??????


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个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 化学与分子工程学院
毕业院校：
学位：
学历：
邮编：
联系电话： (办), **(实)
传真：
电子邮箱： xhhe@chem.ecnu.edu.cn
办公地址： 化学楼423室
通讯地址： 上海市闵行区东川路500号华东师范大学化学系. 邮编:200241

教育经历

工作经历

个人简介

社会兼职
Journal Articles Reviewer
Chemical Communications, Macromolecules, Polymer Chemistry, Acta Biomaterialia
Macromolecular Rapid Communications, Journal of Materials Chemistry, Langmuir
Biomacromolecules, Journal of Polymer Science Part A: Polymer Chemistry
Soft Matter, Polymer, Polymer Journal, Reactive and Functional Polymers
European Polymer Journal, Journal of Applied Polymer Science


研究方向
研究方向:
自组装功能材料；生物医用高分子材料

研究兴趣
研究兴趣主要包含以下三个方面：
（1）偶氮苯液晶共聚物的超分子结构及其光响应机理。合成一系列新型拓扑结构的含偶氮苯液晶基元的共聚物，实现多重响应共聚物的制备，并研究其自组装行为，揭示共聚物超分子结构的微观结构及其光响应机理。
（2）新型结构聚肽共聚物的合成。合成一系列结构新颖、不同构造的杂化聚肽体系，拓展其在药物控释等生物材料应用前景。
（3）智能型载药体系的构筑。合成一系列结构新颖、不同拓扑结构的、生物相容性良好的共聚物，并将其修饰到无机纳米粒子上（如超顺磁性四氧化三铁纳米粒子和金纳米粒子等），构筑出智能型载药体系，提高抗癌药物的疗效。
本课题组招收博士和硕士，欢迎同学们报考本课题组！


开授课程


科研项目


学术成果

1、主持项目情况
主持并完成教育部留学回国人员科研启动基金1项、上海市自然科学基金1项（10ZR**)和企业项目1项。目前主持国家自然科学基面上项目1项（**)和上海市基础重点项目1项。以第一作者或通讯联系人在Angew. Chem. Int. Ed., Polym. Chem.,J. Mater. Chem.和Langmuir等国际著名期刊上发表科研论文40多篇，申报专利12项。荣获湖南省自然科学基金二等奖（排名第5），指导硕士生吴晓萌同学的学位论文获得2014年度上海市优秀硕士学位论文。
2、代表性论文
(12).Xin Cai, Liang Zhong, Yue Su, Shaoliang Lin, Xiaohua He.* Novel pH-tunable Thermoresponsive Polymers Displaying Lower and Upper Critical Solution Temperatures. Polym. Chem., 2015, 6:3875-3884.
Text: Novel pH-tunable thermoresponsive 3-azido-2-hydroxypropyl methacrylate-based polymers displaying LCST and UCST in phosphate buffer solutions were successfully synthesized by ATRP.
(11).Wei Wang, Can Du, Xiaofan Wang, Xiaohua He,* Jiaping Lin, Lei Li,* Shaoliang Lin*. Directional Photomanipulation of Breath Figure Arrays. Angew. Chem. Int. Ed., 2014, 53(45):12116-12119.
Text:Directional photofluidization of azobenzene groups manipulates the shape transformation of the round pores in an ordered breath figure array. Depending on the irradiation time and polarization direction of the incident polarized light, rectangular, rhombic, or parallelogramshaped pores can be obtained.
(10). Wuqiong Sun, Xiaohua He*, Chunyan Gao, Xiaojuan Liao, Meiran Xie, Shaoliang Lin, Deyue Yan, Novel amphiphilic and photo-responsive ABC 3-miktoarm star terpolymers: synthesis, self-assembly and photo-responsive behavior. Polym. Chem., 2013, 4: 1939-1949.
Text: Novel ABC 3-miktoarm star terpolymers containing azobenzene moieties can self-assemble into the bowl-shaped or multibowl-shaped structures compound vesicles in waters.

(9). Xiaohua He*, Chunyan Gao, Wuqiong Sun, Wei Huang, Shaoliang Lin, Deyue Yan, Synthesis and Photo-Responsive Behavior of Azobenzene-Containing Side-Chain Liquid Crystalline Diblock Polymers with Polypeptide Block, J. Polym. Sci. Part A: Polym. Chem., 2013, 51: 1040-1050.
Text: Well-defined azobenzene-containing side-chain liquid crystalline diblock copolymers with helical polypeptide block were prepared by a combination of ATRP, ROP and click reaction.

(8). Shaoliang Lin, Wenjie Zhu, Xiaohua He*, Yaohui Xing, Liyuan Liang, Tao Chen, Jiaping Lin, Multicompartmental Hollow Micelles Formed by Novel Linear ABC Triblock Copolymers in Aqueous Medium, J. Phys. Chem. B, 2013, 117: 2586-2593.
(7). Shaoliang Lin, Yingying Wang, Chunhua Cai, Yaohui Xing, Jiaping Lin, Tao Chen, Xiaohua He*, Tuning self-assembly and photo-responsive behavior of azobenzene-containing triblock copolymers by combining homopolymers, Nanotechnology, 2013, 24(8): 085602.
(6). Xiaohua He*, Xiaomeng Wu,Xin Cai, Shaoliang Lin, Meiran Xie, Xinyuan Zhu, Deyue Yan. Functionalization of Magnetic Nanoparticles with Dendritic-Linear-Brush-Like Triblock Copolymers and Their Drug Release Properties, Langmuir, 2012, 28:11929-11938.
Text: A two-step ATRP was successfully carried out to prepare water-soluble dendritic-linear-brush-like triblock copolymer-modifted Fe₃O₄ nanoparticles through “grafted from” approach, which show pH-sensitive drug release behaviors as the drug delivery.

(5). Xiaohua He*, Liang Zhong, Xiaomeng Wu, Xin Cai, Meiran Xie, Shaoliang Lin, Deyue Yan. Synthesis and Self-Assembly of Amphiphilic Brush-Dendritic-Linear Poly[poly(ethylene glycol) methyl ether methacrylate]-b-Polyamidoamine-b-Poly(e-caprolactone) Copolymers, J. Polym. Sci. Part A: Polym. Chem., 2012, 50: 2841-2853.
Text: A series of novel amphiphilic brush-dendritic-linear poly[poly(ethylene glycol) methyl ether methacrylate]-b-polyamidoamine-b-poly(ε-caprolactone) copolymers (PPEGMEMA-b-D_m-b-PCL) were synthesized by the combination techniques of click chemistry, ATRP and ROP. The introduction of PPEGMEMA into PCL can low the crystallinity of PCL, therefore, adjust the biodegradation rate and mechanical properties of PCL. The brush-dendritic-linear copolymers can also self-assemble into spherical micellar structures in aqueous solution with average diameters of about 500 nm.
(4). Yingying Wang, Shaoliang Lin, Minghui Zang, Yaohui Xing, Xiaohua He*, Jiaping Lina, Tao Chen, Self-assembly and photo-responsive behavior of novel ABC₂-type block copolymers containing azobenzene moieties, Soft Matter, 2012, 8: 3131-3138.
(3). Yi Han, Chao Gao*, Xiaohua He*, Reversible photoswitching self-assembly of azobenzene-functionalized hyperbranched polyglycerol induced by host-guest chemistry, Sci China Chem., 2012, 55(4):604-611.
(2). Xiaomeng Wu, Xiaohua He*, Liang Zhong, Shaoliang Lin, Dali Wang, Xinyuan Zhu, Deyue Yan, Water-soluble dendritic-linear triblock copolymer-modified magnetic nanoparticles: preparation, characterization and drug release properties, J. Mater. Chem., 2011, 21:13611-13620.
Text: Dendritic-linear block copolymers-modified magnetic nanoparticles show thermosensitive drug release behaviors and can be used for the drug delivery.

(1). Xiaohua He*, Xiaomeng Wu, Chunyan Gao, Kai Wang, Shaoliang Lin, Wei Huang, Meiran Xie, Deyue Yan, Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) copolymer to form micelles for drug delivery,React. Funct. Polym., 2011, 71: 544-552.
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