陈益华 教师
生命科学学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校： 中科院上海药物研究所
学位： 博士
学历： 博士研究生
邮编： 200241
联系电话：
传真：
电子邮箱： yhchen@bio.ecnu.edu.cn
办公地址： 东川路500号生命科学学院大楼537室
通讯地址： 上海市东川路500号生命科学学院大楼537室

教育经历
1997-2001年，南昌大学，化学系，学士
2001-2006年，中国科学院上海药物研究所，药物化学，博士，导师：南发俊 研究员
2006-2009年，University of Illinois at Chicago，药物化学，博士后，合作导师：Alan P. Kozikowski 教授


工作经历
2015.12-至今，华东师范大学，上海市调控生物学重点实验室，研究员，博士生导师。
? 2009.12 -2015.12，华东师范大学，上海市调控生物学重点实验室，副教授

个人简介

社会兼职
中国化学会会员
中国药学会会员
中国抗癌协会肿瘤微环境专委会青年委员会委员
《天然产物研究与开发》青年编委
Anti-cancer Agents in Medicinal Chemistry, Editorial Board Member



研究方向
化学生物学、药物化学


开授课程
现代药学概论


科研项目
主持：
1）国家自然科学基金面上项目：USP15选择性抑制剂的设计、合成与优化及其抗肿瘤活性研究，56万元，2017/01-2020/12，在研。
2) 国家自然科学基金面上项目：Myoferlin蛋白小分子抑制剂的发现与活性评价,55万元，2020/01-2023/12，在研。
3）国家自然科学基金青年基金：具有TGFbeta受体激酶抑制活性的咔啉类化合物结构优化及抗肿瘤转移功能研究，23万元，2013/01-2015/12，已结题。
4）上海市“科技创新行动计划”生物医药领域科技支撑项目：泛素特异性蛋白酶特异性抑制剂的发现、结构优化及其抗肿瘤作用研究，50万元，2015/07月-2018/06，已结题。
5）教育部博士点基金（新教师类）：一类新型HDAC抑制剂的构效关系及抗肿瘤作用评价，4万元，2013/01-2015/12，已结题。



学术成果

科研论文与专利：
2020年：
1. Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi,* Mingyao Liu* and Yihua Chen*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Cancer Progression. Adv. Sci. 2020, DOI: 10.1002/advs..
2. Weikai Guo, Yajing Xing, Qiansen Zhang, Jiuqing Xie, Dongxia Huang, Haijun Gu, Peng He, Miaoran Zhou, Shifen Xu, Xiufeng Pang, Mingyao Liu,* Zhengfang Yi,* Yihua Chen*. J. Med. Chem. 2020, 63, 676-695.
3. Kewen Hu, Kun Li, Jing Lv, Jie Feng, Jing Chen, Haigang Wu, Feixiong Cheng, Wenhao Jiang, Jieqiong Wang, Haixiang Pei, Paul J. Chiao, Zhenyu Cai, Yihua Chen*, Mingyao Liu*, Xiufeng Pang*. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.J. Clin. Invest. 2020, pii: 124049. DOI: 10.1172/JCI124049.
4. Tingting Fan, Weikai Guo, Ting Shao, Wenbo Zhou, Pan Hu, Mingyao Liu, Yihua Chen*and Zhengfang Yi*. Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane. Eur. J. Med. Chem. 2020, 190, 112141.
5. Feifei Yang, Na Zhao, Lina Han, Yang Yang, Di Ge*, Hua Zhang*, Yihua Chen*Synthesis and Biological Evaluation of Novel Thiophene-based N-bis-substituted Aromatic Amide Hydroxamic Acid Derivatives as Histone Deacetylase Inhibitors with Antitumor Activities. Future Med. Chem. 2020, accepted.
6. Ting Shao, Wenshu Tang, Yunqi Li, Dan Gao, Kaiyang Lv, Peng He, Yajuan Song, Song Gao, Mingyao Liu*, Yihua Chen*, Zhengfang Yi*. Research on Function and Mechanisms of a Novel Small Molecule WG449E for Hypertrophic Scar. J. Eur. Acad. Dermatol., 2020, 34, 608-618.
2019年：
7. Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Peili Wang, Xin Wang, Mingyao Liu,* Zhengfang Yi,* Yihua Chen*. Modification and Biological Evaluation of a Series of 1,5-Diaryl- 1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. J. Med. Chem. 2019, 62, 4949-4966.
8. Liqiang Su, Jiahui Li, Zhen Zhou, Dongxia Huang, Yuanjin Zhang, Haixiang Pei, Weikai Guo, Haigang Wu, Xin Wang, Mingyao Liu, Cai-Guang Yang*, Yihua Chen*. Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. Eur. J. Med. Chem. 2019, 162, 203-211.
9. Haixiang Pei, Juliang Qin, Fengmian Wang, Binghe Tan, Zeda Zhao, Yangrui Peng, Fangfei Yu, Ennian Li, Mingyao Liu, Rong Zhang, Bo Liu*, Bing Du*, Yihua Chen*.Discovery of Potent Ureido Tetrahydrocarbazole Derivatives for Cancer Treatments through targeting Tumor-associated Macrophages. Eur. J. Med. Chem. 2019,183, 111741.
10. Haixiang Pei, Yangrui Peng, Qiuhua Zhao*, Yihua Chen*. Small Molecule PROTACs: An Emerging Technology for Targeted Therapy in Drug Discovery. RSC Advances, 2019, 9, 16967-16976.
11. Peng He, Wenbo Zhou, Mingyao Liu, and Yihua Chen*. Recent Advances of Small Molecular Regulators Targeting G Protein-Coupled Receptors Family for Oncology Immunotherapy. Curr. Topics Med. Chem.2019, 19, 1464-1483.
12. Feifei Yang, Na Zhao, Di Ge, Yihua Chen*, Next-Generation of Selective Histone Deacetylase Inhibitors. RSC Advances, 2019, 19571-19583.
13. Di Ge, Lina Han, Feifei Yang*, Na Zhao, Yang Yang, Hua Zhang* and Yihua Chen*Development of Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-substituted Aromatic Amides with Antitumor Activities. MedChemComm, 2019, 10, 1828-1837.
14. Yang-jiong Xiao, Yang Yu, Dan Gao, Wangrui Jin, Pengcheng Jiang, Yuhong Li, Chao Wang, Yuning Song, Peng Zhan, Fei Gu, Cancan Zhang, Bin Wang, Yihua Chen*, Bing Du*, Rong Zhang*. Inhibition of CDC25B with WG-391D impedes the tumorigenesis of ovarian cancer. Frontiers in Oncology. 2019, 9, 236.
2018年：
15. Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen*, Zhengfang Yi* and Mingyao Liu*. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat. Commun., 2018, 9, 3726.
16. Tao Zhang*, Jingjie Li, Xiaojun Ma, Yang Yang, Yuan He, Wangrui Jin, Wei Sun, Lei Wang, Yingqi Hua, Zhengfang Yi, Mingyao Liu, Yihua Chen*, Zhengdong Cai*.Inhibition of HDACs-EphA2 signaling Axis with WW437 demonstrates promising preclinical antitumor activity in breast cancer. EBioMedicine, 2018, 31, 276-286.
2017年：
17. Haixiang Pei, Yunqi Li, Mingyao Liu, Yihua Chen*, Targeting Twist Expression with small molecules. MedChemComm. 2017, 268-275.
18. Jingjing Hu, Yihua Chen, Yunqi Li, Zhengjie Zhou, Yiyun Cheng*, A thermo- degradable hydrogel with light-tunable degradation and drug release. Biomaterials.2017, 112, 133-140.
19. Yongrui Liu, Yuan He, Feifei Yang, Xiaonan Cong, Jinhua Wang, Shihong Peng, Dan Gao, Weifang Wang, Liping Lan, Xuexiang Ying, Mingyao Liu, Yihua Chen*, and Zhengfang Yi*, A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling.Sci. China. Life Sci.2017, 202-214.
20. Weiwei Yu, Weiqiang Lu, Guoliang Chen, Feixiong Cheng, Hui Su, Yihua Chen, Mingyao Liu, Xiufeng Pang*. Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo.Br. J. Pharmacol.2017, 174, 3608-3622.
2016年：
21. Feifei Yang, Shihong Peng, Yunqi Li, Liqiang Su, Yangrui Peng, Jing Wu, Huang Chen, Mingyao Liu, Zhengfang Yi,* and Yihua Chen*. A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities. Org. Biomol. Chem.2016, 14, 1727-35.
22. Xue Wang, Qingxiang Lin, Fang Lv, Ning Liu, Ying Xu, Mingyao Liu*, Yihua Chen*, Zhengfang Yi*. LG-362B Targets PML-RARα and Blocks ATRA Resistance of Acute Promyelocytic Leukemia.Leukemia. 2016, 30, 1465-1474.
23. Wenbo Zhou, Wenshu Tang, Zhenliang Sun, Yunqi Li, Yanmin Dong, Haixiang Pei, Yangrui Peng, Jinhua Wang, Ting Shao, Zhenran Jiang, Zhengfang Yi*, and Yihua Chen*. Discovery and Optimization of N-Substituted 2-(4-pyridinyl) thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways. Sci. Rep. 2016, 6, 33434.
2015年：
24. Wenbo Zhou, Anling Huang, Yong Zhang, Qingxiang Lin, Weikai Guo, Zihua You, Zhengfang Yi, Mingyao Liu and Yihua Chen*Design and optimization of hybrid of 2,4-diaminopyimidine and arylthiazole scaffold as anticancer cell proliferation and migration agent. Eur. J. Med. Chem. 2015, 96c, 269-280.
25. Fujun Dai^?, Yihua Chen^?, Li Huang, Jinhua Wang, Tao Zhang, Jingjie Li, Weiguang Tong, Mingyao Liu, Zhengfang Yi. A Novel Synthetic Small Molecule YH-306 Suppresses Colorectal Tumor Growth and Metastasis via FAK Pathway. J. Cell. Mol. Med. 2015, 19, 383-395. (co-first author)
26. Jingjie Li, Tao Zhang, Feifei Yang, Yuan He, Fujun Dai, Dan Gao, Yihua Chen*, Mingyao Liu* and Zhengfang Yi*. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, through down-regulating EGFR expression. Brit. J. Pharmacol. 2015, 172, 3817-30.
27. Min Qin, Shihong Peng, Ning Liu, Meichun Hu, Yundong He, Guoliang Li, Huang Chen, Yuan He, Ang Chen, Xin Wang, Mingyao Liu, Yihua Chen*and Zhengfang Yi*. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity. J. Pharmacol. Exp. Ther.2015, 355, 473-483.
28. Chunbing Zheng, Wenbo Zhou, Tongtong Wang, Panpan You, Yongliang Zhao, YiqingYang, Xin Wang, Jian Luo, Yihua Chen, Mingyao Liu, Huaqing Chen. A novel TGR5 activator WB403 promotes GLP-1 secretion and preserves pancreatic β-cells in Type 2 diabetic mice. PLoS ONE, 2015, 10, e**.
2014年：
29. Cong Zheng, Yuanzhang Fang, Weiguang Tong, Guoliang Li, Haigang Wu, Wenbo Zhou, Qingxiang Lin, Feifei Yang, Zhengfeng Yang, Peng Wang, Yangrui Peng, Xiufeng Pang, Zhengfang Yi, Jian Luo*, Mingyao Liu*, and Yihua Chen*. Synthesis and biological evaluation of novel tetrahydro-beta-carboline derivatives as anti-tumor growth and metastasis agents through inhibiting the transforming growth factor-beta signaling pathway. J. Med. Chem.2014, 57, 600-612.
30. Feifei Yang, Tao Zhang, Haigang Wu, Yang Yang, Ning Liu, Ang Chen, Qiang Li, Jingjie Li, Liwen Qin, Beier Jiang, Xin Wang, Xiufeng Pang, Zhengfang Yi,* Mingyao Liu* and Yihua Chen*. Design and Optimization of Novel Hydroxamate-Based HDAC Inhibitors of Bis-substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis. J. Med. Chem. 2014, 57, 9357-9369.
31. Jing Wu, Linxi Yu, Feifei Yang, Jingjie Li, Peng Wang, Wenbo Zhou, Liwen Qin, Yunqi Li, Jian Luo, Zhengfang Yi, Mingyao Liu, Yihua Chen*. Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents. Eur. J. Med. Chem.2014, 80c, 340-351.
32. Guoliang Li, Yundong He, Wenbo Zhou, Peng Wang, Yong Zhang, Weiguang Tong, Haigang Wu, Mingyao Liu, Xiyun Ye*, and Yihua Chen*. Identification, synthesis and photoprotection evaluation of arylthiazole derivatives as a novel series of sunscreens. Heterocycles. 2014, 89, 453-464.
33. Tao Zhang, Yihua Chen, Jingjie Li, Feifei Yang, Haigang Wu, Fujun Dai, Meichun Hu, Xiaoling Lu, Yi Peng, Mingyao Liu, Yongxiang Zhao, Zhengfang Yi. Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer. Neoplasia. 2014 16(8), 665-677.
2013年：
34. Yuanzhang Fang, Yihua Chen*, Linxi Yu, Cong Zheng, Ya Qi, Zhenxi Li, Zhengfeng Yang, Yong Zhang, Tieliu Shi, Jian Luo*, Mingyao Liu*. Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFbeta Receptor 1. J. Natl. Cancer Inst. 2013, 105, 47-58.

第一发明人专利列表：
A.授权专利：
陈益华、、杨飞飞、张涛、易正芳、李静婕。氮原子多取代的芳香酰胺类小分子有机化合物及其衍生物、用途及其制备方法。中国发明专利，专利号：ZL9.7。（已转让）
陈益华、叶希韵、、李国亮、何云东、周文波。一种芳香基噻唑类化合物及其类似物、用途及制备方法。中国发明专利号：ZL2.5.（已转让）
陈益华、吴婧、郁林羲、翟东、易正芳、罗剑、。2,3-二芳香基噻唑啉酮类化合物及其在制备治疗肿瘤药物中的用途。中国发明专利号：ZL3.1。（已转让）
陈益华、罗剑、张勇、郑春兵、童为光、。芳香烷酰基四氢-beta-咔啉及其衍生物在治疗代谢性疾病中的应用。中国发明专利号：ZL3.7。（已转让）
陈益华、、郑春兵、周文波、覃莉雯、陈华青、罗剑。芳香杂环类小分子有机化合物及衍生物、制备方法及医药用途。中国发明专利号：ZL8.8.
陈益华、、李静婕、杨飞飞、易正芳、彭世鸿。含有噻唑啉酮结构的异羟肟酸类小分子有机化合物及其衍生物、用途及制备方法。中国发明专利号：ZL4.4。（已转让）
陈益华、、易正芳、杨飞飞、代付军。酰基吡咯类小分子有机化合物及其衍生物、用途及其制备方法。中国发明专利号：ZL0.7。
陈益华、、杨洋、张涛、杨飞飞、吕方、易正芳、逄秀凤。杂环取代异羟肟酸类芳香酰胺化合物或药学上可接受的盐、及其制备方法和应用。中国发明专利号：ZL1.3。
陈益华，逄秀凤，胡克文，吴海刚，王洁琼，。苯并三氮唑类化合物、制备方法和其医药用途。中国发明专利号：ZL4.4。
陈益华、、郭伟凯，易正芳，林庆祥，张勇。一种芳香基-杂环取代的嘧啶二胺类化合物及其衍生物及其医药用途。中国发明专利号：ZL2.7。
陈益华，易正芳，李云齐，贺源，李静婕，。1,5-二芳香基-1,2,4-三氮唑类化合物及其制药用途。中国发明专利号：ZL2.1。
B. 申请专利：
陈益华、周文波、陈煌、易正芳、逄秀凤、。一类靶向STAT3双功能磷酸化位点的三芳香环类化合物及其应用。中国发明专利申请号：2.X。申请日：2019.07.31.（已转让）
陈益华、、周文波、陈煌、胡盼、易正芳。一种环烷烃并噻吩衍生物及其制备方法和医药用途。中国发明专利申请号：1.0. 申请日：2018.04.19.（已转让）
陈益华, 裴海翔，秦居亮，杜冰，。一类脲基四氢咔唑类小分子有机化合物及用途。中国发明专利申请号：1.6。申请日期：2019.06.18.
陈益华、米大钊、李亮、裴海翔、李大力、。一种基于DCAF15的蛋白降解靶向嵌合体及其制备方法和应用。中国发明专利申请号：9.3。申请日：2019.08.20.
陈益华、郭伟凯、谢玖清、邢雅婧、易正芳、。一类靶向BCL6的芳香环并五元芳杂环类小分子有机化合物及其衍生物及其应用。中国发明专利申请号：0.0。申请日：2019.09.23.
陈益华、、周珍、肖洋炯、陈煌、易正芳、杜冰。一类哌啶并噻吩类小分子有机化合物及其应用。中国发明专利申请号：0.0。申请日：2018.01.29.
陈益华、王平、裴海翔、陈云飞、高丹、、罗剑。一类羟基取代的四氢-β-咔啉类小分子有机化合物及其衍生物和医药用途。中国发明专利申请号：8.3. 申请日：2018.05.25.
陈益华、杨财广、苏立强、李佳慧、赵秋华、吴海刚、。一类四氢咔唑类小分子有机化合物及其在制备抗菌药物中的用途及其制备方法。中国发明专利申请号：4.2。
陈益华、、郭伟凯、邢雅婧、黄懂霞、易正芳、杜冰、张乾森。一类4-嘧啶二胺类小分子有机化合物及其衍生物及其应用。中国发明专利申请号：5.9.
陈益华，逄秀凤，王鹏，胡克文，。含有苯并[b]噻吩结构的化合物及衍生物、制备方法和应用。中国发明专利申请号：3.6.













荣誉及奖励
第十八届中国药学会-施维雅青年药物化学奖（2015）


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