程义云 研究员博士生导师
生命科学学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校： 中国科学技术大学
学位： 博士
学历： 研究生
邮编： 200241
联系电话：
传真：
电子邮箱： yycheng@mail.ustc.edu.cn
办公地址： 生命科学学院135室
通讯地址： 上海市闵行区东川路500号华东师范大学生命科学学院135室

教育经历

工作经历

个人简介

社会兼职
2020年至今：Giant编委
2019年至今：Biomaterials Science编委
2019年至今：Chinese Chemical Letters编委
2014年至今：Letters in Drug Design & Discovery编委
2010年至今：Current Drug Discovery Technologies编委
2016年：Topics in Current Chemistry客座编辑



研究方向
* 基因、蛋白质胞内递送
* 高分子转化医学
* 全小分子动态化学键功能材料


开授课程


科研项目


学术成果
围绕高分子生物材料研究?在Nat. Mater., Nat. Nanotechnol., Nat. Commun.,Sci. Adv., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等国际知名刊物发表第一作者/通讯作者SCI论文150余篇，多项研究工作被ScienceDaily, The New York Times,ACS,EurekAlert,Faculty of 1000推荐报道，主编英文著作2部，论文被国内外其他课题组公开引用8000余次。近期发表的代表性论文如下：（*通讯作者）

1) Xu J, Lv J, Zhuang Q, Yang Z, Cao Z, Xu L, Pei P, Wang C, Wu H, Dong Z, Chao Y, Wang C, Yang K, Peng R*, Cheng YY*, Liu Z*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol., 2020, https://doi.org/10.1038/s41565-020-00781-4.
2) Lv J., Wang C, Li H, Li Z, Fan Q, Zhang Y, Li Y. Wang H*,Cheng YY*. Bifunctional and bioreducible dendrimer bearing a fluoroalkyl tail for efficient protein delivery both in vitro and in vivo.Nano Lett., 2020,DOI:10.1021/acs.nanolett.0c03287.
3) Rong GY, Wang CP, Chen LJ, Yan Y, Cheng YY*. Fluoroalkylation promotes cytosolic peptide delivery. Science Advances, 2020, 6, eaaz1774.
4) Shen W, Wang R, Fan Q, Gao X, Wang H, Shen Y, Li YW*, Cheng YY*. Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery. CCS Chem.,2020, 2(3), 146–157.
5) Ren L, Lv J, Wang H, Cheng YY*. A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery. Angew. Chem. Int. Ed., 2020, 59, 4711-4719.
6) Liu CY, Wang T, Wang H, Zhang S, Ping Y*, Cheng YY*. A Boronic acid-rich Dendrimer with Robust and Unprecedented Efficiency for Cytosolic Protein Delivery and CRISPR-Cas9 Gene Editing. Science Advances, 2019, 5, eaaw8922.

7)Zhang S, Wang CP, Chang H, Zhang Q*, Cheng YY*. Off-On Switching of Enzyme Activity by Near-infrared Light-Induced Photothermal Phase Transition of Nanohybrids, Science Advances, 2019, 5, eaaw4252.
8) Zhang ZJ, Shen WW, Ling J, Yan Y, Hu JJ, Cheng YY*. TheFluorination Effect of Fluoroamphiphiles in Cytosolic Protein Delivery, Nat. Commun., 2018, 9, 1377. (Highlighted by Nature Research Chemistry Community; Chemistry of Life)
9) Shen W,Wang Q, Shen Y, Gao X,Li L, Yan Y,Wang H,Cheng YY*.Green Tea Catechin Dramatically Promotes RNAi Mediated by Low Molecular Weight Polymers, ACS Cent. Sci., 2018,4, 1326-1333. (Highlighted by ACS, ScienceDaily, EurekAlert, World Tea News, Phys.Org, Science Foundation in China, 中国科学报)
10) Wang CP, Sang H, Wang Y, Zhu F, Hu X, Wang X, Wang X, Li Y*, Cheng YY*. Foe to Friend: Supramolecular Nanomedicines Consisting of Natural Polyphenols and Bortezomib, Nano Lett., 2018, 18, 7045-7051.
11) Wang CP, Zhang Q, Wang X, Chang H, Zhang S, Tang Y, Xu J, Qi R, Cheng YY*. Dynamic Modulation ofEnzyme Activity by Near-infrared Light, Angew. Chem.Int. Ed., 2017, 56, 6767-6772 (Highlighted by Advanced Science News).
12) Chang H, Lv J, Gao X, Wang X, Wang H, Chen H, He X, Li L, ??????????????????Cheng YY????????*??????????. Rational Design of a Polymer with Robust Efficacy for Intracellular Protein and Peptide Delivery, Nano Lett., 2017, 17, 1678-1684. (Highlighted by Faculty of 1000)
13) Zhou ZJ, Wang YT, Yan Y, ZhangQ*,Cheng YY*.Dendrimer-templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation, ACS Nano, 2016, 10, 4863-4872.
14) Yang JP, Zhang Q,Chang H, Cheng YY*. Surface-engineered Dendrimers in Gene Delivery, Chem. Rev., 2015, 115(11), 5274-5300. (Cover Story, ESI 1% highly cited papers)
15) Wang H, Wang YT, Wang Y,Li TF,Liu HM, Zhang Q, Cheng YY*. Self-assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery. Angew. Chem. Int. Ed., 2015, 54, 11647-11651.
16)Wang MM, Liu HM, Li Lei, Cheng YY*. A Fluorinated Dendrimer Achieves Excellent Gene Transfection Efficiency at Extremely Low Nitrogen to Phosphorus Ratios, Nat. Commun., 2014, 5, 3053.(ESI 1% highly cited papers)
17)Wang XY, Cai XP, Hu JJ, Shao NM, Wang F, Zhang Q, Xiao J*, Cheng YY*. Glutathione-triggered "Off-on" Release of Anticancer Drugs from Dendrimer-encapsulated Gold Nanoparticles,J. Am. Chem. Soc., 2013,135, 9805-9810.
18)Liu HM, Wang H, Yang WJ, Cheng YY*.Disulfide Cross-linked Low Generation Dendrimers with High Gene Transfection Efficacy, Low Cytotoxicity, and Low Cost,J. Am. Chem. Soc.? 2012?134, 17680-17687.
19)Hu JJ, Xu TW, Cheng YY*. NMR Insights into Dendrimer-based Host-guest Systems, Chem. Rev., 2012,112, 3856-3891.
20)Cheng YY*? Zhao LB? Li YW? Xu TW*. Design of Biocompatible Dendrimers for Cancer Diagnosis and Therapy: Current Status and Future Perspectives? Chem. Soc. Rev.? 2011? 40? 2673-2703. (ESI 1% highly cited papers)
21)Zhao LB? Wu QL? Cheng YY*? Zhang JH? Wu JH? Xu TW*. High-throughput Screening of Dendrimer-binding Drugs? J. Am. Chem. Soc.? 2010? 132? 13182-13184.
22)Yavuz MS?? Cheng YY?? Chen JY?? Cobley CM? Zhang Q? Rycenga M? Xie JW? Kim C? Schwartz AG? Wang LV? Xia YN*. Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light? Nat. Mater.? 2009? 8, 935-939. (?共同第一作者; Highlighted byScience Daily? The New York Times; ESI 1% highly cited papers)
23)Gao X, Li L, Cai X, Huang Q, Xiao J*, Cheng YY*. Targeting Nanoparticles for Diagnosis and Therapy of Bone Tumors: Opportunities and Challenges. Biomaterials. 2021, 265, 120404.
24) Lv J, Fan Q, Wang H, Cheng YY*.Polymers for Cytosolic Protein Delivery, Biomaterials, 2019, 218, 119358.
25) Liu CY, Shen WW, Li BN, Li TF, Chang H, Cheng YY*. Natural Polyphenols Augment Cytosolic Protein Delivery by a Functional Polymer, Chem. Mater., 2019, 31, 1956-1965.
26) Li MY, Wang H, Hu JF, Hu J, Zhang S, Yang Z, Li YW, Cheng YY*. Smart Hydrogels with Antibacterial Properties Built from All Natural Building Blocks, Chem. Mater., 2019, doi: 10.1021/acs.chemmater.9b02547.
27) Li GZ, Yuan S, Deng D, Ou T, Li Q, Sun R, Lei Q, Wang X, Shen W, ChengYY*,Liu Z*, Wu S*. Fluorinated Polyethylenimine to Enable Transmucosal Delivery of Photosensitizer-conjugated Catalase for Photodynamic Therapy of Orthotopic Bladder Tumors Postintravesicle Instillation.Adv. Funct. Mater., 2019, **.
28) Xu J, Wang H, Xu LG, Chao Y, Wang C, Han X, Dong Z, Chang H, Peng R*, Cheng YY*, Liu Z*. Nanovaccine Based on a Protein-delivering Dendrimer for Efffective Antigen Cross-presentation and Cancer Immunotherapy, Biomaterials, 2019, 207, 1-9.
29) Li G, Lei Q, Wang F, Deng D, Wang S, Tian L, Shen W, Cheng YY*, Liu Z*, Wu S*. Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy, Small, 2019, **.
30) Zhou ZJ, Fan T, Yan Y, Zhang S, Zhou Y, Deng H, Cai X, Xiao J, Song D, Zhang Q*, Cheng YY*. One Stone with Two Birds: Phytic Acid-capped Platinum Nanoparticles for Targeted Combination Therapy of Bone Tumors, Biomaterials, 2019, 194, 130-138.
31) Zhou Z, Yan Y, Wang L, Zhang Q*, Cheng YY*. Melanin-like Nanoparticles Decorated with an Autophagy-inducing Peptide for Efficient Targeted Photothermal Therapy, Biomaterials, 2019, 203, 63-72.
32) Lv J, He B, Yu J, Wang Y, Wang C, Zhang S, Wang H, Hu J, Zhang Q, Cheng YY*. Fluoropolymers for Intracellular and In Vivo Protein Delivery, Biomaterials, 2018, 182, 167-175.
33) Wang CP, Wang D, Dai TJ, Xu P, Wu PL, Zou Y, Yang P, Hu JJ, Li YW*, Cheng YY*. Skin Pigmentation-Inspired Polydopamine Sunscreens, Adv. Funct. Mater., 2018, **.
34) Wang Y, Huang Q, He X, Chen H, Zou Y, Li Y, Lin K, Cai X, Xiao J, Zhang Q*, Cheng YY*. Multifunctional Melanin-like Nanoparticles for Bone-targeted Chemo-photothermal Therapy of Malignant Bone Tumors and Osteolysis, Biomaterials, 2018, 183, 10-19.
35) Hu JJ, Chen YH, Li YQ, Zhou ZJ, Cheng YY*. A Thermo-degradable Hydrogel with Light-tunable Degradation and Drug Release, Biomaterials, 2017, 112, 133-140. (Highlighted by Faculty of 1000)
36) Zhou Z, Yan Y, Hu K, Zou Y, Li Y, Ma R, Zhang Q*, Cheng YY*. AutophagyInhibitionEnabledEfficient Photothermal Therapy at a Mild Temperature, Biomaterials, 2017, 141, 116-121.
37)Wang X, Wang CP, Wang XY, Wang YT, Zhang Q*, ??????Cheng YY????*??????. A Poly(dopamine) Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-demand Drug Delivery and Chemo-photothermal Therapy, Chem. Mater., 2017, 29, 1370-1376.
38) Wang YT, Yang J, Liu HM, Wang XY, Zhou ZJ,Huang Q,Song DW,Cai XP, Li L,Lin KL, Xiao JR, Liu PF*, Zhang Q*, ????????????????????????????????????????????????????????????????????????????Cheng YY*??????????????????????????????????????????????????????????????????????????????????.?? ????????????Osteotropic Peptide??-??mediated Bone Targeting for Photothermal Treatment of Bone Tumors, Biomaterials, 2017, 114, 97-105.????
39) Hu JJ, Quan YC, Lai YP, Zheng Z, Hu ZQ, Wang XY, Dai TJ, Zhang Q, ??Cheng YY??*.ASmart Aminoglycoside Hydrogel with Tunable Gel Degradation, on-demand Drug Release, and High Antibacterial Activity, J.Control. Release, 2017,247, 145-152.????????
40)Zhou ZJ,Hu KW, Ma R, Yan Y, Ni B, Zhang YJ, Wen LP, ZhangQ*,Cheng YY*.Dendritic Platinum-Copper Alloy Nanoparticles as Theranostic Agents for Multimodal Imaging and Combined Chemo-photothermal Therapy,Adv. Funct. Mater., 2016,26, 5971-5978. (Cover Story)
41) Wang CP, Wang XY, Dong KY, Luo J, Zhang Q*, Cheng YY*. Injectable and Responsively Degradable Hydrogel for Personalized Photothermal Therapy, Biomaterials, 2016, 104, 129-137.
42)Wang XY,Zhang JS, Wang YT, Wang CP, Xiao J*, Zhang Q*, Cheng YY*. Multi-responsive Photothermal-chemotherapy with Drug-loaded Polydopamine Nanoparticles for Synergetic Tumor Ablation, Biomaterials, 2016, 81, 114-124. (ESI 1% highly cited papers)
43)Wang CP, Cai XP, Zhang JS, Wang XY, Wang Y, Ge H, Yan H, Huang Q, Xiao J*, Zhang Q*, Cheng YY*. Trifolium-like Platinum Nanoparticle-mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model. Small, 2015, 11, 2080-2086. (Highlighted by MaterialsViews China)
44)Wang F, Wang YT, Wang H, Shao NM, Chen YY,Cheng YY*.Synergistic Effect of Amino AcidsModified on Dendrimer Surface in Gene Delivery, Biomaterials,2014, 35, 9187-9198. (Highlighted by Faculty of 1000)
45)Liu HM, Wang Y, Wang MM, Xiao JR, Cheng YY*. Fluorinated Poly(propylenimine) Dendrimers as Gene Vectors, Biomaterials,2014, 35, 5407-5413.
46)Wang MM, Cheng YY*. The Effect of Fluorination on the Transfection Efficacy of Surface-engineered Dendrimers? Biomaterials?2014, 35, 6603-6613.
47) Hu JJ, Su YZ, Zhang HF, Xu TW*,Cheng YY*.Design of Interior-functionalized Fully Acetylated Dendrimersfor Anticancer Drug Delivery, Biomaterials, 2011, 32, 9950-9959.



荣誉及奖励
承担项目及获得的荣誉：
中国化学会高分子青年化学奖（2019）
中国青年化学家元素周期表（2019，代言氟元素）
国家自然科学基金****基金（2017）
上海市青年五四奖章（2016）
中国化学会青年化学奖（2015）
上海市优秀学术带头人（2015）
教育部霍英东教育基金（2015）
国家自然科学基金优秀青年基金（2013）
上海市青年科技启明星（2013）
教育部新世纪优秀人才支持计划（2011）
安徽省优秀博士学位论文（2011）
全国优秀博士学位论文提名（2011）
上海市曙光****（2010）
中国科学院优秀博士学位论文（2010）
Emerging Investigators(JMCB 2014，2018)
Emerging Investigators (Biomater. Sci. 2018)




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