符垚 副教授　
单位：四川大学华西药学院药剂学系
地址：成都市人民南路三段17号四川大学华西药学院 610041
Email: yfu4@scu.edu.cn

简历
2000 – 2004年， 四川大学华西药学院，理学学士
2004 – 2007年，四川大学华西药学院，理学硕士
2007 – 2012年，美国威斯康辛大学-麦迪逊分校药学院，博士学位
2012 – 2014年，美国威斯康辛大学-麦迪逊分校生物医学工程系，从事博士后研究
2014年3月至今，四川大学华西药学院药剂学系，副教授
研究方向
新型生物材料的设计、合成及在构建递药载体中的应用和评价

主要研究课题
1.国家自然科学基金面上项目，原位自组装缓控释系统用于间质纤维化局部免疫治疗的研究，**，2018/01 – 2021/12
2.四川大学优秀青年****科研基金A类，模拟细胞外基质复合水凝胶支架用于治疗细胞传递和慢性创伤修复的研究，2017SCU04A23，2017/01 – 2018/12
3.国家自然科学基金青年科学基金项目，糖苷介导肾靶向聚合物胶束递药载体的构建和靶向治疗慢性肾病的研究，**， 2016/01 – 2018/12
4.四川大学引进人才科研启动基金，以糖苷和糖苷衍生物为载体的靶向药物构效关系和摄取机制研究，2014年6月– 2016年6月
代表性论文
1.Wang SY, Liu RH, Fu Y*, Kao WJ*. Release Mechanisms and Applications of Drug Delivery Systems for Extended-Release. Expert Opin Drug Deliv. 2020. DOI: 10.1080/**.2020.**. (Invited review)
2.Chen KX, Chen X, Han XR, Fu Y*. A comparison study on the release kinetics and mechanism of bovine serum albumin and nanoencapsulated albumin from hydrogel networks. Int J Biol Macromol. 2020, 163, 1291-1300.
3.Han XR, Qin S, Qin XY, Gong T, Zhang ZR, Fu Y*. Noncovalent protein glycosylation strategy via in situ nanoencapsulation. ACS Applied Bio Materials 2020, 3(7), 3987-3991.
4.Chen X, Wang M, Hu Y, Gong T, Zhang ZR, Yu RL, Fu Y*. Low-dose paclitaxel via hyaluronan functionalized bovine serum albumin nanoparticulate assembly for metastatic melanoma treatment. J Mater Chem B. 2020, 8(10), 2139-2147.
5.Xu YY, Qin S, Niu YN, Gong T, Zhang ZR, Fu Y*. Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells. Acta Pharm Sin B. 2020, 10(4), 680-692.
6.Hu Y, Chen X, Xu YY, Han XR, Wang M, Gong T, Zhang ZR, Kao WJ, Fu Y*. Hierarchical assembly of hyaluronan coated albumin nanoparticles for pancreatic cancer chemoimmunotherapy. Nanoscale. 2019,11(35),16476-16487.
7.Cao X, Hu Y, Luo S, Wang YJ, Gong T, Sun X, Fu Y*, Zhang ZR*. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma. Acta Pharm Sin B. 2019, 9(3), 575-589.
8.Qin XY, Qiao WZ, Wang YJ, Li TY, Li X, Gong T, Zhang ZR, Fu Y*. An extracellular matrix-mimicking hydrogel for full thickness wound healing in diabetic mice. Macromol Biosci. 2018,18(7), e**.
9.Wang Y, Gong T, Zhang Z, Fu Y*. Matrix stiffness differentially regulates cellular uptake behavior of nanoparticles in two breast cancer cell lines. ACS Appl Mater Interfaces. 2017, 9(31), 25915-25928.
10.Zhou X, Qin XY, Gong T, Zhang Z, Fu Y*. D-Fructose modification enhanced internalization of mixed micelles in breast cancer cells via GLUT5 transporters. Macromol Biosci. 2017, 17(7), **.
11.Luo Shi, Li PW, Du ZW, Hu X, Fu Y*, Zhang ZR*. N,N-dimethyl tertiary amino group mediated dual pancreas- and lung-targeting therapy against acute pancreatitis. Mol Pharm. 2017,14(5),1771-1781.
12.Wang XY, Qi BW, Su HF, Li JB, Sun X, He Q, Fu Y*, Zhang ZR*. Pyrilamine-sensitive proton-coupled organic cation (H⁺/OC) antiporter for brain-specific drug delivery. J Control Release. 2017, 254, 34-43.
13.Zhou ML, Li JB, Li CH, Guo L, Wang XY, He Q, Fu Y*, Zhang ZR*. Tertiary amine mediated targeted therapy against metastatic lung cancer. J Control Release. 2016, 241, 81-93
14.Cao X, Zhou X, Wang Y, Gong T, Zhang ZR, Liu RH, Fu Y*. Diblock- and triblock-copolymer based mixed micelles with high tumor penetrationin vitroandin vivo. J Mater Chem B. 2016, 4, 3216-3224. (Hot paper)
15.Long D, Gong T, Zhang Z, Ding R, Fu Y*. Preparation and evaluation of a phospholipid-based injectable gel for the long-term delivery of leuprolide acetate. Acta Pharm Sin B. 2016, 6(4), 329-35.
16.Zhou X, Liu RH, Qin S, Yu RL, Fu Y*. Current Status and future directions of nanoparticulate strategy for cancer immunotherapy. Curr Drug Metab. 2016,17(8),755-762.
17.Wang MX, Shan FY, Zou Y, Sun X, Zhang ZR, Fu Y*, Gong T*. Pharmacokinetic and pharmacodynamics study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016, 230, 45-56.
18.Li WH, Yi XL, Liu X, Zhang ZR, Fu Y*, Gong T*. Hyaluronic acid ion-pairing nanoparticles for targeted tumor therapy. J Control Release. 2016, 225, 170-182.
19.Hu M, Zhang Y, Xiang NX, Zhong Y, Gong T, Zhang ZR, Fu Y*. Long-acting phospholipid gel of exenatide for long-term therapy of type II diabetes. Pharm Res. 2016, pp1-9
20.Yi XL, Lian XH, Dong JX, Wan ZY, Xia CY, Song X, Fu Y*, Gong T*, Zhang ZR. Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers. Mol Pharm. 2015, 12, 4085-4098.
21.Cao X, Luo JW, Gong T, Zhang ZR, Sun X, Fu Y*. Coencapsulated doxorubicin and bromotetrandrine lipid nanoemulsion in reversing multidrug resistance in breast cancer in vitro and in vivo. Mol Pharm. 2015, 12, 274-286.
专著
Fu Y, Kao WJ. Proteomic approaches to characterize surface-bound proteins and material-mediated cellular proteins. Proteins at Interfaces III: State of the Art Book series: ACS Symposium Series. Editors: T Horbett, J Brash, W Norde. 2012,1120,809-837.

授权专利
Kao WJ, Fu Y. Multifunctional in situ polymerized network via thiol-ene and thiol-maleimide chemistry, Patent No.: US**B2


编辑：四川大学华西药学院