周洲 副教授 (硕士生导师)

单位：四川大学华西药学院药剂系
通讯地址：成都市人民南路三段17号四川大学华西药学院
E-mail: zhou_zhou610@163.com
简历
2005-2009中山大学药学院，获理学学士学位
2009-2015 四川大学华西药学院，获药剂学博士学位
2015-　 四川大学华西药学院药剂系任讲师、副教授
2018-2019 美国犹他大学药学院访问****
研究方向
靶向给药系统的构建及其作用机制研究
主要研究课题
1.国家自然科学基金委员会，青年基金项目，**，“一靶多效”的肿瘤细胞线粒体内膜靶向的HPMA聚合物交联胶束的构建与机制研究，2017至2019，主持。
2.四川省科技厅，重点研发项目，2018SZ0032，可靶向肿瘤细胞和肿瘤相关巨噬细胞的复合靶向递药系统研究，2018至2019，主持。
3.四川大学青年教师启动基金，2016SCU11008，具有溶酶体逃逸和细胞核靶向双功能的胶束给药系统的研究，2016至2017，主持。

代表性论著
1. Liu, Yuanyuan#; Zhou, Zhou#; Lin, Xi; Xiong, Xiaofeng; Zhou, Rui; Zhou, Minglu; Huang, Yuan*. Enhanced Reactive Oxygen Species Generation by MitochondriaTargeting of Anticancer Drug To Overcome Tumor Multidrug Resistance, Biomacromolecules, 2019, 20(10): 3755-3766.
2. Yanxi Liu， Qiuyi Li， Xiaofeng Xiong， Zhou Zhou*. Improved mitochondrial targeting effect of HPMA copolymer by SS20 peptide mediation and nonendocytosis pathway, Journal of Peptide Science, 2019, 25(2): e3144.
3. Liu Yanxi; Li Qiuyi; Xiong Xiaofeng; Huang Yuan; Zhou Zhou*. Mitochondriatargeting and cell-penetrating peptides-co-modified HPMA copolymers for enhancing therapeutic efficacy of α-tocopheryl succinate, Journal of Materials, Chemistry B, 2018, 6(46): 7674-7683.
4. Yanxi Liu, Qiuyi Li, Xiaofeng Xiong, Yuan Huang and Zhou Zhou*. Enhanced cellular uptake by non-endocytic pathway for tumor therapy, Journal of Materials Chemistry B, 2018, 6(45): 7411-7419.
5. Wang, Fengling; Li, Lian; Sun, Wei; Li, Lijia; Liu, Yuanyuan; Huang, Yuan; Zhou, Zhou*. A novel alpha(V) beta(3) ligand-modified HPMA copolymers for anticancer drug delivery, Journal of Drug Targeting, 2018, 26(3): 231-241.
6. Zhou Zhou; Liu Yanxi; Wu Lei; Li Lian; Huang Yuan*. Enhanced nuclear delivery of anti-cancer drugs using micelles containing releasable membrane fusion peptide and nuclear-targeting retinoic acid, Journal of Materials Chemistry B, 2017, 5(34): 7175-7185.
7. Manling Tang, Minglu Zhou, Yuan Huang, Jiaju Zhong, Zhou Zhou* and Kui Luo*. Dual-sensitive and biodegradable core-crosslinked HPMA copolymer– doxorubicin conjugate-based nanoparticles for cancer therapy, Polymer Chemistry, 2017, 8(15): 2370-2380.
8. Zhou Zhou, Xiuli Xu, Lian Li, Yuan Huang*. Improvement of anti-tumor abilities on human non-small cell lung carcinoma by micellization and cross-linking of N- (2-hydroxypropyl) methacrylamide copolymers. Journal of Drug Targeting. 2015, 23(9): 821-831.
9. Zhou, Zhou; Li, Lian; Yang, Yang; Xu, Xiuli; Huang, Yuan*. Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles, Biomaterials, 2014, 35(24): 6622-6635.



编辑：四川大学华西药学院