杨劲松教授（博士生导师）
单位：四川大学华西药学院天然药物学系
通信地址：成都市人民南路三段17号四川大学华西药学院（610041）
E-mail：yjs@scu.edu.cn, yjscd@163.com


学习和研究工作简历
1988年9月—1992年7月：四川大学化学系化学专业本科。
1992年9月—1995年7月：南开大学化学系有机化学专业硕士生。
1995年9月—1998年7月：华西医科大学药学院药物化学专业博士生。
1998年9月—1998年12月：华西医科大学药学院天然药物化学教研室助教。
1998年12月—1999年12月：在日本东邦大学药学部村上泰兴教授的研究组进行博士后研究。
2000年1月—2001年6月：四川大学华西药学院天然药物化学教研室讲师。
2001年7月—2007年6月：四川大学华西药学院天然药物化学教研室副教授。
2007年7月至今：四川大学华西药学院天然药物学系教授，博士研究生导师。入选2008年度教育部新世纪优秀人才支持计划以及四川省****学科带头人培养计划。研究方向为糖化学，以通讯作者身份发表SCI研究论文20余篇；近5年来，作为课题负责人承担了3项国家自然科学基金面上项目，参编出版两种本科教材。两次荣获四川大学青年骨干教师奖励。


研究方向
糖化学。


近年来主持的纵向课题
1.基于氢键活化策略的β-L-鼠李糖苷化和α-D-唾液酸糖苷化反应研究，国家自然科学基金面上项目(**)；2018-2021。
2.立体选择性合成Kdo糖苷键的新方法及其应用研究，国家自然科学基金面上项目(**)；2016-2019。
3.阿拉伯和半乳呋喃寡糖合成新方法及其应用研究，国家自然科学基金面上项目(**)；2014-2017。
4.抗alpha-正链RNA病毒活性成分芫花叶白前苷元C及其皂苷的全合成，国家自然科学基金面上项目(**)；2012-2015。
5.以曲二糖为模板的α-葡萄糖苷酶抑制剂的设计、合成及活性研究，教育部新世纪优秀人才支持计划(NCET-08-0377)；2009-2011。
6.新型二糖类α-葡萄糖苷酶抑制剂的设计、合成及活性研究，教育部博士点基金(082)；2011-2013。
7.曲二糖类似物的合成及其α-葡萄糖苷酶抑制活性研究，2008年度四川省****学科带头人培养计划(08ZQ026-029)；2008-2010。


参与的科研项目
1.高选择性的有机合成新反应与新策略，国家自然科学基金创新群体科学基金项目(**)，2011-2013。
2.具有重要生物活性的天然产物的化学合成，科技部973课题(2010CB833202)，2010-2014。
近期发表论文
1.Wei Huang, Ying-Yu Zhou, Xing-Ling Pan, Xian-Yang Zhou, Jin-Cai Lei, Dong-Mei Liu, Yue Chu, Jin-Song Yang*. Stereodirecting Effect of C5-Carboxylate Substituents on the Glycosylation Stereochemistry of 3?Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Thioglycoside Donors: Stereoselective Synthesis of α- and β?Kdo Glycosides, J. Am. Chem. Soc. 2018, 140, 3574.
2.Yuan Xu, Hua-Chao Bin, Fu Su, Jin-Song Yang*. Stereoselective synthesis of aryl 1,2-cis-furanosides and its application to the synthesis of the carbohydrate portion of antibiotic hygromycin A, Tetrahedron Lett. 2017, 58, 1548.
3.Peng-Cheng Gao, San-Yong Zhu, Hui Cao, Jin-Song Yang*. Total Synthesis of Marine Glycosphingolipid Vesparioside B, J. Am. Chem. Soc. 2016, 138, 1684.
4.Kai Zhu, Jin-Song Yang*. Synthesis of tri- and tetrasaccharide glycosides of (4S)-4-hydroxy-D-proline relevant to the cell wall O-glycans of green alga Chlamydomonas reinhardtii, Tetrahedron 2016, 72, 3113.
5.Jia-Sheng Huang, Wei Huang, Xue Meng, Xin Wang, Peng-Cheng Gao, Jin-Song Yang*. Stereoselective Synthesis of α-3-Deoxy-D-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using 5,7-O-Di-tert-butylsilylene-Protected Kdo Ethyl Thioglycoside Donors, Angew. Chem. Int. Ed. 2015, 54, 10894.
6.Shuai Wang, Xue Meng, Wei Huang, Jin-Song Yang*. Study on the Influence of Silyl Protections on the Anomeric Reactivity of Galactofuranosyl Thioglycosides and Application of the Silylated Thiogalactofuranosides to One-Pot Synthesis of Diverse β-D-Oligogalactofuranosides, J. Org. Chem. 2014, 79, 10203.
7.San-Yong Zhu, Jia-Sheng Huang, Shan-Shan Zheng, Kai Zhu, Jin-Song Yang*. First Total Synthesis of the Proposed Structure of Batatin VI, Org. Lett. 2013, 15, 4154.
8.Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. β-Arabinofuranosylation Using 5-O-(2-Quinolinecarbonyl) Substituted Ethyl Thioglycoside Donors, Org. Lett. 2013, 15, 3974.
9.Xing-Yong Liang, Hua-Chao Bin, Jin-Song Yang*. Tuning Effect of Silyl Protecting Groups on the Glycosylation Reactivity of Arabinofuranosyl Thioglycoside, Org. Lett. 2013, 15, 2834.
10.Xing-Yong Liang, Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. One-Pot Synthsis of Branched Oligosaccharide by Use of Galacto- and Mannopyranosyl Thioglycoside Diols as Key Glycosylating Agent, Org. Biomol. Chem. 2013, 11, 3903.
11.Xing-Yong Liang, Li-Ming Deng, Jin-Song Yang*. Review on Synthesis and Occurrence of Oligoaranbino-, Oligogalacto- and Oligofructo furanoses, Chin. J. Org. Chem. 2013, 33, 245.
12.Jia Shao, Jin-Song Yang*. A Diastereoselective Cyclic Imine Cycloaddition Strategy to Access Polyhydroxylated Indolizidine Skeleton: Concise Syntheses of (+)-/(–)-Lentiginosines and (–)-2-epi-Steviamine, J. Org. Chem. 2012, 77, 7891.
13.San-Yong Zhu, Jin-Song Yang*. Synthesis of Tetra- and Hexasaccharide Fragments Corresponding to the O-Antigenic Polysaccharide of Klebsiella Pneumoniae, Tetrahedron 2012, 68, 3795.
14.Li-Min Deng, Xia Liu, Xing-Yong Liang, Jin-Song Yang*. Regioselective Glycosylation Method Using Partially Protected Arabino- and Galactofuranosyl Thioglycosides as Key Glycosylating Substrates and Its Application to One-Pot Synthesis of Oligofuranoses, J. Org. Chem. 2012, 77, 3025.
15.Lin Xie, San-Yong Zhu, Xiao-Qiu Shen, Li-Li He, Jin-Song Yang*. Total Synthesis of Batatoside L, J. Org. Chem. 2010, 75, 5764.
16.Xing-Yong Liang, Li-Min Deng, Xia Liu, Jin-Song Yang*. Efficient One-pot Syntheses of α-D-Arabinofuranosyl Tri- and Tetrasaccharides Present in Cell Wall Polysaccharide of Mycobacterium Tuberculosis, Tetrahedron 2010, 66, 87.
17.Xiao-Qiu Shen, Lin Xie, Liang Gao, Li-Li He, Qian Yang, Jin-Song Yang*. Synthetic Studies on the Trisaccharide Intermediate of Resin Glycoside Merremoside H2, Carbohydr. Res. 2009, 344, 2063.
18.Ming Lei, Liang Gao, Jin-Song Yang*. Microwave-assisted Palladium-catalyzed Cross-coupling Reactions between Pyranoid Glycals and Aryl Bromides. Synthesis of 20-Deoxy C-Aryl-β-glycopyranosides, Tetrahedron Lett. 2009, 50, 5135.
19.Qian Yang; Ming Lei; Qin-Jian Yin; Jin-Song Yang*. Silver(I) oxide-mediated Regioselective 2-Monoacylation in 3-O-Benzyl-α-L-rhamnopyranosides and Application in Synthesis of a Protected Tetrasaccharide Fragment of Potent Cytotoxic Saponins Gleditsiosides C and D, Carbohydr. Res. 2007, 342, 1175.
20.Qiang Tian, Xing-Mei Zhu, Jin-Song Yang*. Amberlyst 15-Catalyzed Efficient Synthesis of 2,3-Unsaturated Glycosides via Ferrier Rearrangement for Glycal. Synth. Commun. 2007, 37, 691.
21.Qiang Tian, Shuo Zhang, Qian Yu, Mei-Bo He; Jin-Song Yang*. Amberlyst 15 as a Mild and Effective Activator for the Glycosylation with Disarmed Glycosyl Trichloroacetimidate Donors. Tetrahedron 2007, 63, 2142.
22.Xing-Mei Zhu, Li-Li He, Guang-Li Yang, Ming Lei, Si-Shi Chen, Jin-Song Yang*. Syntheses of the Macrolide Subunits of Merremoside-type Resin Glycosides. Synlett 2006, 3510.
23.Qian Yang, Xing Mei Zhu, Jin Song Yang*. Silver(I) Oxide Mediated Regioselective Monoacylation of 2,4-Dihydroxyls in L-Rhamnopyranosides. Chin. Chem. Lett. 2006, 17, 1009.

编辑：四川大学华西药学院