姓　　名：王光辉
职称职务：教授、博导
联系电话：**
电子邮箱：wanggh@suda.edu.cn
办公地址：云轩楼2405
个人简介：
一、学习工作经历
1、学历背景：
1981.9-1987.7 上海医科大学本科
1987.9-1990.7 上海医科大学组织胚胎学硕士生
1997.4-2001.3 日本东京大学医学部神经内科Ph.D
2001.4-2001.10 新加坡国立大学博士后
2001.11-2003.8 美国依阿华大学医学院博士后
2、国外学习研究经历：
1995.10-1997.3 日本东京大学附属医院访问****
3、工作经历：
1990.8-1995.9 上海医科大学组织胚胎学助教、讲师
2003.10-2011.5 中国科学技术大学教授、博导
2011.5-至今 苏州大学药学院教授、博导
二、研究方向
1）帕金森病中的线粒体损伤和清除的机制
2）帕金森病中神经元与胶质细胞相互作用在疾病发生中的作用
3）神经退行性疾病相关蛋白的功能和机制研究
三、近年来主要研究成果
近年来，在EMBO J、Mol Psychiatry、Cell Death Differ、Brain、Hum Mol Genet、Oncogene、Cell Death Dis、Science Signaling和JBC等期刊发表通讯作者论文60余篇，其中，2010年发表在Cell Death Differ上关于帕金森病的线粒体蛋白Omi与自噬的论文被Nature网站列为神经科学特色论文；2011年发表在Mol Psychiatry上有关精神分裂症dysbindin在神经发育中的机制研究被选为封面论文；2012年发表的帕金森病蛋白Omi调控小胶质细胞激活的研究以封面论文发表在Science子刊Science Signaling上，并受到该杂志电话采访，也被Nature Immunology编辑Laurie Dempsey作为研究亮点在Nature Immunology评述。2016年发表在EMBO J上的有关TDP-43与自噬的研究被列为封面论文，并被该期刊专题评述。
一）近年来代表性通讯作者论文
1. Mao J, Xia Q, Liu C, Ying Z, Wang H, Wang G. A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation. Hum Mol Genet.2017; 26: 1877-1889.
2. Gu C, Zhang Y, Hu Q, Wu J, Ren H, Liu CF, et al. P7C3 inhibits GSK3beta activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo. Cell Death Dis. 2017; 8: e2858.
3. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z*, Wang G*. TDP-43 loss of fuction increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J.2016; 35:121-142. （封面论文）
4. Xia Q, , Wang H, Hu Q, Ying Z*,Wang G*. Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet.2016; 25: 83-96.
5. Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H, Wang G*. TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners. Autophagy .2016,4,707-708.
6. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet, 2015, 24: 2426-41.
7. Gao F, Chen D, Si J, Hu Q, Fang M and Wang G*. Impairment of Nix-mediated mitophagy is linked to the pathogenesis of Parkinson's disease. Hum Mol Genet, 2015, 24: 2528-38.
8. Zhou L, Wang H, Ren H, Hu Q, Ying Z*,Wang G.* Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.2015, 52:1180-9.
9. Xu R, Hu Q, Ma Q, Liu C, Wang G*.The protease Omi regulates mitochondrial biogenesis through the GSK3b/PGC-1a pathway. Cell Death and Dis. 2014, 5:e1373.
10. Ren H, Fu K, Mu C, Zhen X, Wang G*. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener. 2012, 7:40.
11. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G* The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation. Science Signal.2012, 5:ra61.（封面论文，并被该杂志电话采访）
12. Wang H, Ying Z, Wang G* Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains.J Biol Chem. 2012, 287:28576-28585.
13. Ren H, Fu K, Wang D, Mu C, Wang G* Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.J Biol Chem.2011, 286: 35308-35317.
14. Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G* DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene.2011, 31:1311-1322.
15. Ma X, Fei E, Fu C, Ren H, Wang G* Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry.2011, 16:1105-1116.（封面论文）
16. Ying Z, Wang H*, Fan H, Wang G* The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem. 2011, 286: 20835-20844.
17. Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J, Wang G* Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression. J Biol Chem.2010285：38630-38640.
18. Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G* Parkin mono-ubiquitinates BCL-2 and regulates autophagy. J Biol Chem. 2010, 285：38214-38223.
19. Li B,Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N,Wang G* Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death & Differ2010, 17:1751-1759.
20. Ren H, Fu K, Mu C, Li B, Wang D, Wang G*DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells. Cancer Lett2010, 297:101-108.
21. Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J, Wang G* and Swaab D* Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain2010, 133: 3069-3079.
22. Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G* DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity. J Biol Chem 2008, 283:4022-4030.
23. Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, and Wang G*Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. J Biol Chem 2007, 282:14558-14566

二）近年来主持的课题
1) 项目来源：国家自然基金国际合作项目()
课题名称：具有抗帕金森病的小分子化合物的筛选和鉴定
起止时间：2017/01-2019/12
资助经费: 200万元
2) 项目来源：国家自然科学基金重点项目（**）
课题名称：帕金森病遗传与环境因素对小胶质细胞的激活及机制
起止时间：2014/01-2018/12
资助经费: 307万元
3) 项目来源：国家重点研发计划（2016YFC**）子课题
课题名称：遗传、环境、老化因素及其之间的交互作用在帕金森病发生发展机制中的作用
起止时间：2016/01-2020/12
资助经费: 35 万元

三）专利
1)发明专利：OMI蛋白及其编码基因的一种新用途ZL 2.5 (授权日2011.7.27)
四）主要荣誉
2004年入选中国科学院“****”
2011年入选江苏省“双创计划”
2014年入选江苏省“双创计划”团队核心成员