姓　　名：刘峰
职称职务：教授
联系电话：
电子邮箱：fliu2@suda.edu.cn
办公地址：苏州市工业园区仁爱路199号药学院云轩楼1125
个人简介：

一、学习工作经历
2018.7至今：教授，苏州大学医学部药学院
2012.9—2018.7：特聘副教授，苏州大学医学部药学院
2009.5 —2012.8：博士后研究助理，北卡罗来纳大学教堂山分校药学院
2009.1—2009.5；助理研究员，中科院上海有机所
2003.9—2009.1：研究生，中科院上海有机所
1999.9 —2003.7：本科， 厦门大学化学系

二、研究方向

（1）表观遗传蛋白小分子调控剂的设计与合成
（2）神经疾病和癌症的“靶向治疗”药物研发
（3）有机合成新方法在药物研发中的应用
三、主要学术科研成果
回国后主持国家自然科学基金青年项目和江苏省自然科学基金项目各一项，曾参与国家自然科学基金重点项目、美国NCI、NIH、美国国防部等项目研究，发表SCI论文30余篇。
（论文引用见：http://scholar.google.com/citations?user=h_j1fQYAAAAJ&hl=en）
2017
31) Qin, H.-T.; Xu, X.; Liu, F.*“Aerobic Oxidation of Alkynes into 1,2-Diketones via Organic Photoredox Catalysis” ChemCatChem2017, DOI: 10.1002/cctc.
30) Qin, H.-T.; Wu, S.-W.; Liu, J.-L.; Liu, F.*“Photoredox-Catalysed Redox-Neutral Trifluoromethylation of Vinyl Azides for the Synthesis of a–Trifluoromethylated Ketones”Chem. Commun.2017, 53, 1696-1699.
29) Qin, H.-T.; Li, H.-Q.;*Liu, F.* “Selective histone deacetylase small molecule inhibitors: recent progress and perspectives” ExpertOpin.Ther. Pat.2017, DOI: 10.1080/**.2017.**
2016
28) Wu, S.-W.; Liu, F.*“Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation” Org. Lett.2016,18, 3642-3645.
27) Li, Z.-R.; Bao, X.-X.; Sun, J.; Shen, J.; Wu, D.-Q.; Liu, Y.-K.; Deng, Q.-H.*; Liu, F.* “Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3-containing dihydronaphthalene derivatives” Org. Chem. Front.2016,3, 934-938. 26) Wu, S.-W.; Liu, J.-Li.; Liu, F.* “Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins” Org. Lett.2016,18, 1-3.2015
25) Simon, J. M.; Parker, J. S.; Liu, F.; Rothbart, S. B.; Ait-Si-Ali, S.; Strahl, B. D.; Jin, J.; Davis, I. J.; Mosley, A. L.; Pattenden, S. G.“A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin”J. Biol. Chem.2015, 290(43):26088-26102. DOI: 10.1074/jbc.M115.654459. PMID: ) Zhang, Y.; Xu, L.; Zhang, Z.; Zheng, L.; Li, D.; Li, Y.; Liu, F.; Yu, K.; Hou, T.; Zhen, X. “Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors” J. Chem. Inf. Model.2015, 55, 1994-2004. DOI: 10.1021/acs.jcim.5b**) Shi, D.; Qin, H.; Zhu, C;* Liu, F.* “Selectfluor–Bu₄NI-Mediated C(sp³)–H Oxidation in Aqueous Media: Synthesis of Δ²-Isoxazolines from Oximes” Eur.J. Org. Chem.2015,5084-5088. DOI: 10.1002/ejoc.
22) Wang, L.; Xie, L.; Ramachandran, S.; Lee, Y.; Yan, Z.; Zhou, L.; Krajewski, K.;Liu, F.; Zhu, C.; Chen, DavidJ.; Strahl, BrianD.; Jin, J.; Dokholyan, NikolayV.; Chen, X. “Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX”Chem. Biol.2015, 22, 7, 849-861. DOI: 10.1016/j.chembiol.2015.05.014.
21) Zhang, Z.; Liu, F.* “CuX₂-mediated oxybromination/aminochlorination of unsaturated amides: synthesis of iminolactones and lactams” Org. Biomol. Chem. 2015, 13, 6690-6693. DOI: 10.1039/c5ob00520e
20) Dong, K.; Qin, H.; Liu, F.*; Zhu, C.*“Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins”Eur.J. Org. Chem.2015,1419-1422. DOI: 10.1002/ejoc.
2014
19) Liu, C.; Yu, Y.; Liu, F.; Wei, X.; Wrobel, J. A.; Gunawardena, H. P.; Zhou, L.; Jin, J.; Chen, X. “A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing” Nat. Commun.2014, 5:5733. DOI: 10.1038/ncomms6733. 18) Dong, K.; Qin, H.; Bao, X.; Liu, F.*; Zhu, C.* “Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin” Org. Lett.2014,16, 5266-5268.17) Sundriyal, S.; Malmquist, N. A.; Caron, J.; Blundell, S.; Liu, F.; Chen, X.; Srimongkolpithak, N.; Jin, J.; Charman, S. A.; Scherf, A.; Fuchter, M. J. “Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds” ChemMedChem, 2014, 9, 2360-2373.
16) Lehnertz, B.; Pabst, C.; Su, L.; Miller, M.; Liu, F.;Yi, L.; Zhang, R., Krosl, J., Yung, E., Kirschner, J., Rosten, P., Underhill, T. M., Jin, J., Hébert, J., Sauvageau, G., Humphries, R. K., Rossi, F. M. “The methyltransferase G9a regulates HoxA9-dependent transcription in AML” Genes Dev.2014, 28, 317-327.
15) Konze, K. D.; Pattenden, S. G.; Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Simon, J. M.; Davis, I. J.; Vedadi, M.; Jin, J.“A chemical tool for in vitroand in vivoprecipitation of lysine methyltransferase G9a” ChemMedChem, 2014, 9, 549-553.14) Liu, F.*; Li. C. “ Total synthesis of (S)-14-azacamptothecin”, Org. Biomol. Chem.2014, 12, 637-642.
2013
13)Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Xiong, Y.; Korboukh, V.; Huang, X. P.; Allali-Hassani, A.; Janzen, W. P.; Roth, B. L.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Vedadi, M.; Jin, J. “Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP” J. Med. Chem. 2013, 56, 8931-8942.
12) Konze, K. D.; Ma, A.; Li, F.; Barsyte-Lovejoy, D.; Parton, T.; MacNevin, C. J.; Liu, F.; Gao, C.; Huang, X. P.; Kuznetsova, E.; Rougie, M.; Jiang, A.; Pattenden, S. G.; Norris, J. L.; James, L. I.; Roth, B. L.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Hahn, K. M.; Wang, G. G.; Vedadi, M.; Jin, J. “An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1”, ACS Chemical Biology, 2013, 8, 1324-1334.
11）Liu, F.;Li, F.; Ma, A.; Dobrovetsky, E.; Dong, A.; Gao, C.; Korboukh, I.; Liu, J.; Smil, D.; Brown, P.J.; Frye, S. V.; Arrowsmith, C.H.; Schapira, M.; Vedadi, M.; Jin, J. “Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors” J. Med. Chem.2013,56, 2110-2124.
Before 2013
10）Siarheyeva, A.; Senisterra, G.; Allali-Hassani, A.; Dong, A.; Dobrovetsky, E.; Wasney,GregoryA.; Chau, I.; Marcellus, R.; Hajian, T.; Liu, F.; Korboukh, I.; Smil, D.; Bolshan, Y.; Min, J.; Wu, H.; Zeng, H.; Loppnau, P.; Poda, G.; Griffin, C.; Aman, A.; Brown, PeterJ.; Jin, J.; Al-awar, R.; Arrowsmith, CherylH.; Schapira, M.; Vedadi, M. "An Allosteric Inhibitor of Protein Arginine Methyltransferase 3"Structure2012,20, 1425-1435.
9）Liu, F.; Barsyte-Lovejoy, D.; Allali-Hassani, A.; He, Y.; Herold, J. M.; Chen, X.; Yates, C. M.; Frye, S. V.; Brown, P. J.; Huang, J.; Arrowsmith, C. H.; Jin, J. “Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines”.J. Med. Chem. 2011, 54, 6139-6150.
8）Yost, J. M.; Korboukh, I.;Liu, F.; Gao, C.; Jin, J. “Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code”. Curr.Chem.Genomics2011, 5, 72-84. (共同第一作)
7）Vedadi, M#.; Barsyte-Lovejoy, D#.; Liu, F#.; Rival-Gervier, S.; Allali-Hassani, A.; Labrie, V.; Wigle, T. J.; DiMaggio, P. A.; Wasney, G. A.; Siarheyeva, A.; Dong, A.; Tempel, W.; Wang, S.-C.; Chen, X.; Chau, I.; Mangano, T.; Huang, X.-P.; Simpson, C. D.; Pattenden, S. G.; Norris, J. L.; Kireev, D. B.; Tripathy, A.; Edwards, A.; Roth, B. L.; Janzen, W. P.; Garcia, B. A.; Petronis, A.; Ellis, J.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Jin, J. “A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells”. Nature Chem. Biol.2011, 7, 566-574. (共同第一作，Highlighted by News and Views:Nature Chemical Biology, 2011, 7, 499-500 and SciBX, 2011, 4(31), doi:10.1038/scibx.2011.890）
6）Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wigle, T. J.; Wasney, G. A.; Dong, A.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Norris, J. L.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Janzen, W. P.; Arrowsmith, C. H.; Frye, S. V.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines”.J. Med. Chem.2010,53, 5844-5857.
5）Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. “Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a”. J. Med. Chem. 2009, 52, 7950-7953.
4）Ju, Y.; Liu, F.; Li. C. “Palladium-Catalyzed Sequential Cyanation/N-Addition/ N-Arylation in One-Pot: Efficient Synthesis of Luotonin A and Its Derivatives”. Org. Lett.2009,11, 3582-3585.
3）Liu, F.; Li. C. “Intramolecular Formal [4 + 2] Cycloaddition of Nitriles with Amides Triggered by TMSOTf/Et3N: Highly Efficient Construction of Pyrrolo[1,2-a]pyrimidin-4(6H)-ones”. J. Org. Chem.2009, 74, 5699-5702.
2）Liu, F.; Liu, K.; Yuan, X.; Li. C. “5-Exo versus 6-Endo Cyclization of Primary Aminyl Radicals: An Experimental and Theoretical Investigation”.J. Org. Chem.2007, 72, 10231-10234.
1）Zhan, Z.; Lang, K.; Liu, F.; Hu, L. “Water Effects on SmI₂Reductions: A Novel Method for the Synthesis of Alkyl Thiols by SmI₂-Promoted Reductions of Sodium Alkyl Thiosulfates and Alkyl Thiocyanates”. Syn. Commun.2004, 34, 3203.