张慧灵 教授
2005年获苏州大学医学博士学位。2006年11月-2008年11月在美国哈佛大学脑中风实验室做博士后。2009年任苏州大学教授。2002年被评为苏州市新世纪高级青年专业技术人才及江苏省“青蓝工程”优秀骨干教师。2002年获苏州大学讲课比赛一等奖。2006年被确定为江苏省六大人才高峰。
目前承担及参与的科研项目
1国家自然科学基金面上项目(**):Nec-1抑制缺血性脑中风诱导的神经元和星形胶质细胞Necroptosis的信号机制,2012-2015,60万
2 国家自然科学基金面上项目(**):自噬/溶酶体途径激活在缺血性脑中风中星形胶质细胞死亡中的作用及机制,2010-2012,32万
3 教育部留学回国人员基金项目(K):自噬/溶酶体途径激活在缺血性脑中风中星形胶质细胞死亡中的作用及机制,2010-2012,4万
●Qin AP, Liu CF, Qin YY, Hong LZ, Xu M, Yang L, Liu J, Qin ZH,Zhang HL.Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. Autophagy 2010,6:738-53.
●Zhang HL, Xu M, Wei C, Qin AP, Liu CF, Hong LZ, Zhao XY, Liu J, Qin ZH.Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with PPARγ-mediated suppression of NF-kB signaling pathway. Neuronscience 2011, 176:381-395.
● Xu M, Zhang HL. Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin 2011 Aug 1 [Epub ahead of print]
● Zhang HL, Gu ZL, Savitz SI, Han F, Fukunaga K, Qin ZH. Neuroprotective effects of prostaglandin A1 are associated with NF-kB inhibition and PPAR γupregulation in rat models of focal ischemia. J Neuroscience Res 2008, 86: 1132-1147.
● Wang X, Qin ZH, Shi H, Savitz SI, Qin AP, Jiang Y, Zhang HL. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkB/NF-kB signaling pathway in a rat model of permanent focal cerebral ischemia. Brain Research 2008, 1234:8-15.
● Zhang HL, Huang Z, Gu ZL, Zhu Y, Liang ZQ, Han R, Wang XX, Chase TN, Qin ZH. Neuroprotective effects of prostaglandin A
● Zhang HL,Chen ZX, Gu ZL, Chen BW, Han R, Reid PF, Raymond LN, Qin ZH. Opiate and acetylcholine-independent analgesic actions of crotoxin. Toxicon 2006, 48: 175-182.