袁榴娣
教授 医学院
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办公地点：丁家桥校区综合楼南403 电子邮箱：yld@seu.edu.cn
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研究方向


1.神经系统发育及相关疾病的分子机制研究
2.B细胞发育及相关疾病的分子机制研究




荣誉奖励


东南大学第十届青年教师授课竞赛二等奖
江苏省“青蓝工程”优秀青年骨干教师培养对象
东南大学教学工作优秀一等奖
江苏省生物化学与分子生物学学会理事




学术成果


1. Yuan L*, Ren X, Zheng Y, Qian J, Xu L, Sun M. MiR-315 is required for neural development and represses the expression of dFMR1 in Drosophila melanogaster.Biochem Biophys Res Commun. 2020 Apr 30;525(2):469-476.
2. Yang X, Song H, Zi Z, Kou J, Chen S, Dai Y, Wang J, Yuan L*, Gao K*.Circ_** promotes hepatocellular carcinoma progression by suppression of microRNA-335. J Cell Physiol. 2019 Dec; 234(12):21937-21946.
3. Younis M, Faming W, Hongyan Z, Mengmeng T, Hang S, Liudi Y*. Iguratimod encapsulated PLGA-NPs improves therapeutic outcome in glioma, glioma stem-like cells and temozolomide resistant glioma cells. Nanomedicine. 2019 Nov;22:102101.
4. Wang C, Ge L, Wu J, Wang X, Yuan L*. MiR-219 represses expression of dFMR1 in Drosophila melanogaster. Life Sci. 2019 Feb; 218:31-37.
5. Song H, Zhang Y, Liu N, Wan C, Zhang D, Zhao S, Kong Y, Yuan L*. Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2. J Physiol Biochem. 2016 Dec;72(4):733-744.
6. Song H, Zhang Y, Liu N, Zhao S, Kong Y, Yuan L*. MiR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/β-Catenin and Notch-1/Akt Signaling Pathways. Int J Mol Sci. 2016 Oct 27;17(11).1799.
7. Yan Kong, Ke Li , Tingting Fu, Chao Wan , Dongdong Zhang, Hang Song , Yao Zhang, Na Liu , Zhenji Gan , Liudi Yuan*. Quercetin Ameliorates Aβ Toxicity in Drosophila AD Model by Modulating Cell Cycle-Related Protein Expression. Oncotarget. 2016 Oct 18;7(42):67716-67731.
8. Song H, Zhang Y, Liu N, Wan C, Zhang D, Zhao S, Kong Y, Yuan L*. MiR-92b regulates glioma cells proliferation, migration, invasion, and apoptosis via PTEN/Akt signaling pathway. J Physiol Biochem. 2016 Jun;72(2):201-11.
9. Qian J, Tu R, Yuan L*, Xie W*. Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2. Exp Cell Res. 2016 Jun;344(2):183-93.
10.Peng J, Wang C, Wan C, Zhang D, Li W, Li P, Kong Y, Yuan L*. MiR-184 is Critical for the motility related PNS development in Drosophila. Int J Dev Neurosci. 2015 Nov;46:100-7.
11.Zheng Y, Yu M, Padmanabhan A, Aster RH, Yuan L, Wen R, Wang D. Critical role of CD4 T cells in PF4/heparin antibody production in mice. Blood. 2015 Mar;125(11):1826-9.
12.Wang C, Feng T, Wan Q, Kong Y, Yuan L*. MiR-124 controls Drosophila behavior and is required for neural development. Int J Dev Neurosci. 2014, 38C:105-112.
13.Zheng Y, Yu M, Podd A, Yuan L, Newman DK, Wen R, Arepally G, Wang D. Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood. 2013, 25; 121(17): 3484-92.
14.Li P, Peng J, Hu J, Xu z, Xie W, Yuan L*. Localized expression pattern of miR-184 in Drosophila. Molecular Biology Reports. 2011, 38(1): 355-358.
15.Lv W, Ding J, Hu J, Wang C, Xu L, Fang M, Yuan L*. A GAL4/UAS luciferase system to identify the miRNAs target mRNAs in Drosophila S2 cells. Mol Biol Rep. 2009 Jul;36(6):1627-31.
16.Yuan L, Zhou J, Wan Y, Sun M, Ding J, Dou F, Xie W. Identification of RNA binding sequences of Drosophila SR protein DX16. Mol Cell Biochem. 2007 Aug;302(1-2):119-24.