巢杰
教授 博士生导师，主任
联系电话： 办公时间：7：30 am-- 6：00 pm
传 真： 主页网址：http://jszy.seu.edu.cn/_s1380/main.psp
办公地点：丁家桥校区基二楼211室 电子邮箱：chaojie@seu.edu.cn
通讯地址：东南大学医学院生理学系












研究方向


肺部炎症及纤维化的基础与临床研究
矽肺是由于长期吸入游离二氧化硅（SiO2）粉尘所引起的以肺组织持续慢性炎症、进行性肺纤维化为主，并伴有全身系统性炎症为特征的全身性疾病。矽肺一旦发生，肺损伤呈进行性发展，即使停止粉尘暴露，肺部病变依然进展，导致肺功能障碍，呼吸衰竭，甚至死亡。由于对矽肺的发病机制知之甚少，临床主要面临两个问题：（1）早期缺少筛检诊断方法，当经胸片确诊时，肺损伤已无逆转可能；（2）后期肺纤维化缺乏特效治疗措施，这是由于目前缺少肺纤维化进程评价指标，临床也无明确治疗靶标，因此发现矽肺早期诊断分子标志物以及干预肺纤维化进程的靶标已成为迫切需要解决的问题。
本课题组着重于研究粉尘吸入引起肺部细胞激活，释放的细胞因子和化学趋化因子，参与炎症反应和肺纤维化的过程及其机制，进而为现有矽肺诊断和治疗提供新的理论依据，对临床治疗策略的选择和治疗药物靶标的遴选提供指导。



科研项目


◆“环状RNA介导的失巢凋亡抵抗在矽肺中作用机制研究”，国家自然科学基金委-面上项目，**，55万元，2020-2023，负责人
◆“干细胞体内示踪的生物机制”，科学技术部-国家重点研发计划，2017YFA**，701万元，2017-2021，课题骨干
◆“ciR-**靶向调控ZC3H4在矽肺炎症和纤维化中的作用研究”，国家自然科学基金委-面上项目，**，50万元，2018-2021，负责人
◆“治疗矽肺炎性反应及肺纤维化的新靶点-MCPIP1 (ZC3H12A）的作用机制研究”，国家自然科学基金委-面上项目，**， 73万元，2015-2018，负责人
◆“矽肺炎症和纤维化治疗新靶点-MCPIP1的作用机制研究”，江苏省科技厅-面上项目，BK**，10万元，2014-2017，负责人
◆“p53/PUMA参与矽肺炎症和肺纤维化的作用机制研究”，江苏省卫生厅-江苏省“六大人才”高峰，3万元，2015，负责人
◆“矽肺炎症和纤维化治疗新靶点-MCPIP1 的作用机制研究”，中华人民共和国人力资源和社会保障部-留学人员科技活动项目，3万元，2015年，负责人
◆“肺缺氧致微循环炎症反应的机制研究”（Mechanisms of microvascularinflammation induced by alveolarhypoxia），美国心脏协会（American Heart Association, AH)，52000美元，2008-2010，负责人

友情链接：南京胸科医院 中国煤矿尘肺病防治基金会（CMPF）

本课题组招收博士后！欢迎加入！





荣誉奖励


? Nature出版集团旗下期刊Scientific Reports编委会成员 (Editorial Board Member)
? 2015年度江苏省“六大人才高峰”高层次人才
? 江苏省生理科学学会理事

? 美国毒理学会（Society of Toxicology，SOT）会员
? 美国生理学会（American Physiological Society，APS）会员

?Pre-doctoral Fellowship from the American HeartAssociation, Midwest Affiliate entitled “Mechanisms of microvascular inflammation induced by alveolar hypoxia” from July 2008 to June 2010（美国优秀博士生奖学金，美国心脏协会）

?First place of oral presentation in Cardiovascular Biology research topics of KUMC Student Research Forum 2009（美国堪萨斯大学学生论坛心血管分论坛演讲一等奖）





学术成果


2021
1. Dai X, Cheng Y, Wang C, Huang J, Chao J#. Role of Circular RNAs in Visceral Organ Fibrosis. Food Chem Toxicol. 2021. (SCI, IF:4.679, Q1)

2. Jiang R#, Han L, Gao Q, Chao J#. ZC3H4 Mediates Silica-induced EndoMT via ER Stress and Autophagy. Environ Toxicol Pharmacol. 2021, DOI: 10.1016/j.etap.2021.103605.(SCI, IF:3.292, Q2) PubMedPDF

2020

1. Huang J, Huang J, Ning X, Luo W, Chen M, Wang Z, Zhang W, Zhang Z#, Chao J#. CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. J Mater Chem B. 2020, 8 (8), 1713-1727. (SCI, IF:5.344, Q1) PubMedPDF

2.Huang J, Huang, J, Bao H, Ning X, Yu C, Chen Z, Chao J#, Zhang Z#. CT/MR dual-Modal Imaging tracking of mesenchymal stem cells labeled with Au/GdNC@SiO2 nanotracer in pulmonary fibrosis. ACS Applied Bio Materials. 2020, 3, 2489-2498. ACSPDF
3. Zhang W, Zhu T, Chen L, Luo W, Chao J#. MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2020,318(1):H59-H71. (SCI, IF:3.864, Q1) PubMedPDF
4.Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, Cheng Y, Zhu T#, Chao J#. circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress. RNA Biology. 2020, 17(2):240-253.(SCI, IF:5.35, Q1) PubMed PDF
2019

1. Chu H, Wang W, Luo W, Zhang W, Cheng Y, Huang J, Wang J, Dai X, Fang S, Chao J#. circHECTD1 mediates pulmonary fibroblast activation via HECTD1. Ther Adv Chronic Dis. 2019, Vol. 10: 1-18.(SCI, IF:4.257,Q1) PubMedPDF
2. Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J#. SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2. Exp Cell Res.2019, 383(1):111492. (SCI, IF:3.383, Q2) PubMedPDF
3. Cheng Y, Luo W, Li Z, Cao M, Zhu Z, Han C, Dai X, Zhang W, Wang J, Yao H, Chao J#. CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress andaautophagy. Am J Resp Cell Mol Biol. 2019, 61(3):380-391. (SCI, IF:5.373, Q1) PubMedPDF
4. Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J#. The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial tomesenchymal transition. Toxicol Lett. 2019; 307:26-40. (SCI, IF:3.569, Q2) PubMedPDF
5. Zhang Y, Huang R, Cheng M, Wang L, Chao J, Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 2019; 7(1):116. (SCI, IF:11.607, Q1) PubMedPDF
6. Cheng Y, Chao J, Chen C, Lv L, Han Y, Liu B#. The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy. J Pharm Pharmacol. 2019, 71(3):338-347. (SCI, IF:2.571, Q2) PubMedPDF
7. Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H. Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis. Toxicol Lett. 2019; 301:53-63. (SCI, IF:3.569, Q2) PubMedPDF
8. Zhao L, Du L, Zhang Y, Chao J, Duan M, Yao H, Shen C, Zhang Y. Role of PUMA in the methamphetamine-induced migration of microglia. Metab Brain Dis. 2019, 34(1):61-69.(SCI, IF:2.726, Q2) PubMedPDF

9. Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z, Yao H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry. 2018 Nov 9. doi: 10.1038/s41380-018-0285-0. (SCI, IF:12.384, Q1) PubMedPDF
2018

1. Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W#, Chao J#. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis. 2018;9(3):396. (SCI, IF:5.959, Q1)PubMedPDF
2. Yang X*, Wang J*, Zhou Z*, Jiang R, Huang J, Chen L, Cao Z, Chu H, Han B, Cheng Y, Chao J#. Silica-induced initiation of circZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. FASEB J. 2018, 32(6):3264-3277. (SCI, IF:5.391, Q1) PubMedPDF
3. Zhou Z, Jiang R, Yang X, Guo H, Fang S, Zhang Y, Cheng Y, Wang J, Yao H, Chao J#. circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Theranostics. 2018; 8:575-592. (SCI, IF:8.063, Q1) PubMedPDF
4. Chao J#, Lv Y, Chen J, Wang J, Yao H. SiO2-induced release of sVEGFRs from pulmonary macrophages. Respir Physiol Neurobiol. 2018; 247:1-8. (SCI, IF:1.582, Q3) PubMedPDF
5. Xie X*, Zhu T*#, Chen L, Ding S, Chu H, Wang J, Yao H, Chao J#. MCPIP1-induced autophagy mediates ischemia/referfusion injury in endothlial cells via HMGB1 and CaSR. Sci Rep. 2018; 8(1):1735. (SCI, IF:4.011, Q1) PubMedPDF
6. Zhang Y, Shu G, Bai Y, Chao J, Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers. Metab Brain Dis. 2018, 33(5):1585-1597. (SCI, IF:2.411, Q2) PubMedPDF
7. Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. Autophagy. 2018;14:1164-1184. (SCI, IF:11.059, Q1) PubMedPDF
8. Han B, Chao J, Yao H. Circular RNA andits mechanisms in disease: From the bench to the clinic.Pharmacol Ther. 2018, 187:31-44. (SCI, IF:9.396, Q1) PubMedPDF
9. Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H.Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity. J Neurosci.2018; 38:32-50. (SCI, IF:6.074, Q1) PubMedPDF
10.Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Autophagy. 14(3):404-418. (SCI, IF:11.059, Q1) PubMedPDF 65.005

2017
1. Cao Z*, Xiao Q*, Dai X*, Zhou Z, Jiang R, Cheng Y, Yang X, Guo H, Wang J, Xi Z, Yao H, Chao J#. circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica. Cell Death Dis. 2017; 8:3212. (SCI, IF:5.638, Q1) PubMedPDF
2. Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J#, Liao H#: BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death Dis. 2017; 8:e2657. (SCI, IF:5.638, Q1) PubMedPDF
3. Chao J, Zhang Y, Du L, Zhou R, Wu X, Shen K, Yao H. Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.Sci Rep. 2017; 7(1):11540. (SCI, IF:4.122, Q1)PubMedPDF
4. Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage. Front Cell Neurosci. 2017; 11:377. (SCI, IF:4.3, Q2) PubMedPDF

5. Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H, Chao J, Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior. Front Behav Neurosci. 2017; 11:203. (SCI, IF:3.138, Q2) PubMedPDF
6. Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y, Chao J, Teng G, Yao H. An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 26:1981-1987(SCI, IF:1.598, Q4) PubMed PDF
7. Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H. Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy. 2017,13(10):1722-1741. (SCI, IF:11.1, Q1) PubMedPDF

8. Casillan AJ, Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by iNOS-dependent increased nitric oxide availability. J Appl Physiol. 2017,123(4):974-982. (SCI, IF:3.256, Q2) PubMed PDF
9. Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39. (SCI, IF:3.309, Q2) PubMedPDF

10. Zhu X, Dong J, Xia Z, Zhang A, Chao J, Yao H. Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress. Neurochem Int. 2017;110:25-37. (SCI, IF:3.603, Q2) PubMed PDF
11. Cheng Y, Chao J, Dai D, Dai Y, Zhu D, Liu B. AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress. Clin Exp Pharmacol Physiol. 2017; 44:1106-1115. (SCI, IF:2.092, Q3) PubMed PDF 47.794

2016









1. Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H#, Chao J#. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part Fibre Toxicol. 2016; 13: 55. (SCI, IF:8.577, Q1) PubMedPDF
2. Chao J*#, Wang X*, Zhang Y*, Zhu T, Zhang W, Zhou Z, Yang J, Han B, Cheng Y, Tu X, Yao H#. Role of MCPIP1 in the endothelial-mesenchymaltransition induced by silica. Cell Physiol Biochem. 2016; 40:309-325. (SCI, IF:5.104, Q1) PubMedPDF

3. Zhang W, Zhang M, Wang Z, Cheng Y, Liu H, Zhou Z, Han B, Chen B, Yao H#, Chao J#. Neogambogic Acid Prevents Silica-induced Fibrosis via Inhibition of High-mobility group box1 and MCP-1-induced protein 1. Toxicol Appl Pharmacol. 2016; 309:129-140. (SCI, IF:3.791, Q1) PubMedPDF

4. Zhu T, Yao Q, Wang W, Yao H, Chao J#. iNOS induced vascular endothelial cell migration andapoptosis via autophagy in ischemia/reperfusion injury. Cell Physiol Biochem. 2016; 38: 1575-1588. (SCI, IF:5.104, Q1) PubMedPDF
5. Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, Cheng Y, Fang S, Zhang Y, Yao H, Chao J#: MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica. Toxicol Sci. 151(1):126-38. (SCI, IF:4.081, Q1) PubMedPDF
6. Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol-Lung C. 2016; 310(2):L121-L132. (SCI, IF:4.281, Q1) PubMedPDF
7. Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W, Chao J, Zhou R, Hu G, Yao H. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2015; 6:35642. (SCI, IF:4.259, Q1) PubMedPDF
8. Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H.Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis andautophagy: Implications for methamphetamine-mediated neurotoxicity. Autophagy. 2016,12(9):1538-59. (SCI, IF:8.593, Q1) PubMedPDF
9. Zhu X, Shen K, Bai Y, Zhang A, Xia Z, Chao J, Yao H.NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy. Free Radic Biol Med. 2016; 94:230-242. (SCI, IF:5.606, Q1) PubMedPDF

10. Zhu X, Dong J, Shen K, Bai Y, Chao J, Yao H. Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.Brain Res Bull. 2016. 121:138-47. (SCI, IF:3.033, Q3) PubMed PDF
11. Zhang Y, Huang R, Zhang Y, Yi H, Bai Y, Chao J, Yao H. IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel. Inflammopharmacology. 2016, 24(1):33-42. (SCI, IF:2.59, Q3) PubMed 55.019

2015

1. Wang W, Liu H, Dai X, Fang S, Wang X, Zhang Y, Yao H, Zhang X#, Chao J#: p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Sci Rep. 2015; 5:16900. (SCI, IF:5.228, Q1) PubMedPDF

2. Zhu T, Yao Q, Hu X, Chen C, Yao H, Chao J#: The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis. Cell Physiol Biochem. 2015;37:577-591.(SCI, IF:4.652, Q1) PubMedPDF
3. Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H, Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. Toxicol Appl Pharmacol. 2015; 288:152-160. (SCI, IF:3.847, Q1) Global Medical DiscoveryPubMedPDF

4. Chao J, Dai X, Pena T, Doyle DA, Guenther TM, Carlson MA: MCPIP1 regulates fibroblast migration in 3-D collagen matrices downstream of MAP kinases and NF-kappa B. J Invest Dermatol. 2015; 135:2944-54. (SCI, IF:6.915, Q1) PubMedPDF
5. Bai Y*, Zhu X*, Chao J*, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H: Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGFR expression: Implications for stroke. PLoS One. 2015;10:e**. (SCI, IF:3.057, Q1) PubMedPDF
6. Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, Duan M, Buch S, Chen L, Yao H: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulationof its own expression. J Neuroinflammation. 2015;12:29. (SCI, IF:4.667, Q1) PubMedPDF

7. Zhang Y, Zhu T, Zhang X, Chao J, Hu G, Yao H: Role of high-mobility group box 1 inmethamphetamine-induced activation and migration of astrocytes. J Neuroinflammation.2015;12:156. (SCI, IF:4.667, Q2) PubMedPDF
8. Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X, Chao J, Yao H: NMDA receptor NR2b subunits contribute to ptz-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015;114:70-78.(SCI, IF:2.572, Q3) PubMedPDF 35.605

Before 2015
1. Yi H, Bai Y, Zhu X, Lin L, Zhao L, Wu X, Buch S, Wang L, Chao J#, Yao H#: IL-17a induces MIP-1alpha expression in primary astrocytes via Src/MAPK/PI3K/NF-kB pathways:Implications for multiple sclerosis. J Neuroimmune Pharmacol.2014;9:629-641. (SCI, IF:4.11, Q2) PubMedPDF
2. Chao J*, Yang L*, Yao H, Buch S: Platelet-derived growth factor-bb restores HIV Tat -mediated impairment of neurogenesis: Role of GSK-3beta/beta-catenin. J Neuroimmune Pharmacol.2014;9:259-268. (SCI, IF:4.11, Q2) PubMedPDF

3. Chao J, Pena T, Heimann DG, Hansen C, Doyle DA, Yanala UR, Guenther TM, Carlson MA: Expression of green fluorescent protein in human foreskin fibroblasts for use in 2D and 3D culture models. Wound Repair Regen.2014;22:134-140. (SCI, IF:2.768, Q1) Cover story MDLinxGlobal Medical DiscoveryPubMedPDF
4. Chao J, Yang L, Buch S, Gao L: Angiotensin II increased neuronal stem cell proliferation: Role of AT2R. PLoS One.2013;8:e63488. (SCI, IF:3.534) PubMedPDF

5. Yang L*, Chao J*, Kook YH, Gao Y, Yao H, Buch SJ: Involvement of mir-9/MCPIP1 axis in PDGF-bb-mediated neurogenesis in neuronal progenitor cells. Cell Death Dis.2013;4:e960. (SCI, IF:5.177) PubMedPDF


6. Carlson MA, Smith LM, Cordes CM, Chao J, Eudy JD: Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix. Sci Rep.2013;3:1880. (SCI, IF:5.078) PubMedPDF
7. Chao J, Gao J, Parbhu KJ, Gao L: Angiotensin type 2 receptors in the intermediolateral cell column of the spinal cord: Negative regulation of sympathetic nerve activity and blood pressure. Int J Cardiol. 2013;168:4046-4055. (SCI, IF:6.175) PubMedPDF


8. Chao J, Viets Z, Donham P, Wood JG, Gonzalez NC: Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade. Am J Physiol Heart Circ Physiol.2012;303:H168-177. (SCI, IF:3.629) PubMedPDF

9. Gao J, Chao J, Parbhu KJ, Yu L, Xiao L, Gao F, Gao L: Ontogeny of angiotensin type 2 and type1 receptor expression in mice. J Renin Angiotensin Aldosterone Syst.2012;13:341-352. (SCI, IF:2.286) PubMedPDF


10. Chao J, Blanco G, Wood JG, Gonzalez NC: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Am J Physiol Heart Circ Physiol.2011;301:H2264-2270. (SCI, IF:3.708) PubMedPDF

11. Chao J, Wood JG, Gonzalez NC: Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia. Respir Physiol Neurobiol.2011;178:439-448. (SCI, IF:2.242) PubMedPDF

12. Gao J, Zhang H, Le KD, Chao J, Gao L: Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens.2011;24:724-730. (SCI, IF:3.181) PubMedPDF

13. Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC: Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Am J Respir Cell Mol Biol.2011;45:53-61. (SCI, IF:5.125) PubMedPDF

14. Chao J, Wood JG, Gonzalez NC: Alveolar hypoxia, alveolar macrophages, and systemic inflammation. Respir Res.2009;10:54. (SCI, IF:3.36) PubMedPDF

15. Chao J, Wood JG, Blanco VG, Gonzalez NC: The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s). Am J Respir Cell Mol Biol.2009;41:573-582. (SCI, IF:5.125) PubMedPDF

16. Meng X, Chao J, Xiang Y: Identification from diversemammalian poxviruses of host-range regulatory genes functioning equivalently tovaccinia virus C7l. Virology.2008;372:372-383. (SCI, IF:3.351) PubMedPDF 51.971