朱丽娟
博士生导师 东南大学医学院
联系电话： 办公时间：
传 真： 主页网址：
办公地点：综合楼803 电子邮箱：lijuan_zhu2004@126.com
通讯地址：南京市鼓楼区丁家桥87号东南大学医学院












研究方向


（1）情感障碍疾病的发病机制
（2）情绪产生和调节的神经机制




荣誉奖励


1 中国科协“青年人才托举”工程
2 江苏省****基金获得者
3 江苏省六大人才高峰高层次人才
4 仲英青年****







学术成果



发表论文
1. Zhu LJ, Li TY, Luo CX,Jiang N, Chang L, Lin YH, Zhou HH, Chen C, Zhang Y, Lu W, Gao LY, Ma Y, ZhouQG, Hu Q, Hu XL, Zhang J, Wu HY, Zhu DY*. CAPON-nNOS coupling can serve as atarget for developing new anxiolytics. NatMed. 2014 Sep;20(9):1050-4.
2. Zhu LJ*, Shi HJ, Chang L,Zhang CC, Si M, Li N, Zhu DY*. nNOS-CAPON blockers produce anxiolytic effectsby promoting synaptogenesis in chronic stress-induced animal models of anxiety.Br J Pharmacol. 2020 Apr 28.
3. Liu MY#, Yin CY#, ZhuLJ#, Zhu XH, Xu C, Luo CX, Chen H*, Zhu DY*, Zhou QG*. Sucrosepreference test for measurement of stress-induced anhedonia in mice. Nat Protoc. 2018 Jul;13(7):1686-1698. (co-firstauthor)
4. Zhu LJ*, Ni HY, Chen R,Chang L, Shi HJ, Qiu D, Zhang Z, Wu DL, Jiang ZC, Xin HL, Zhou QG, Zhu DY.Hippocampal nuclear factor kappa B accounts for stress-induced anxietybehaviors via enhancing neuronal nitric oxide synthase (nNOS)-carboxy-terminalPDZ ligand of nNOS-Dexras1 coupling. JNeurochem. 2018 Sep;146(5):598-612.
5. Zhou QG#, Zhu LJ#, Chen C, Wu HY,Luo CX, Chang L, Zhu DY*. Hippocampal neuronal nitric oxide synthase mediatesthe stress-related depressive behaviors of glucocorticoids by downregulatingglucocorticoid receptor. JNeurosci. 2011 May25;31(21):7579-90. (co-first author)
6. Zhu LJ, Xu C, Ren J,Chang L, Zhu XH, Sun N, Meng GL, Liu MY, Zhang J, Li YY, Tang YL, Zhou QG*.Dentate nNOS accounts for stress-induced 5-HT_1A receptor deficiency:Implication in anxiety behaviors. CNSNeurosci Ther. 2020 Apr;26(4):453-464.
7. Zhu LJ*, Chang L, ShiHJ, Li N. Systemic administration of ZLc-002 exerts anxiolytic-like effects bydissociation of nNOS from CAPON in adult mice. Biochem Biophys Res Commun. 2020 Mar 5;523(2):299-306.
8. Xu Y#, Fang SJ#, ZhuLJ#, Zhu LQ*, Zhou XZ*. DNA-PKcs-SIN1 complexation mediates low-doseX-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation. BiochemBiophys Res Commun. 2014 Oct 24;453(3):362-7. (co-first author)
9. Zhu LJ#, Liu MY#, Li H#,Liu X, Chen C, Han Z, Wu HY, Jing X, Zhou HH, Suh H, Zhu DY, Zhou QG*. Thedifferent roles of glucocorticoids in the hippocampus and hypothalamus inchronic stress-induced HPA axis hyperactivity. PLoS One. 2014 May15;9(5):e97689.
10. Liu MY#, Zhu LJ#, Zhou QG*.Neuronal nitric oxide synthase is an endogenous negative regulator ofglucocorticoid receptor in the hippocampus. Neurol Sci. 2013 Jul;34(7):1167-72.(co-first author)
11. Hu Y, Wu DL, Luo CX, ZhuLJ, Zhang J, Wu HY, Zhu DY. Hippocampal nitric oxide contributes to sexdifference in affective behaviors. ProcNatl Acad Sci U S A. 2012 Aug 28;109(35):14224-9.
12. Zhou QG, Hu Y, Wu DL, ZhuLJ, Chen C, Jin X, Luo CX, Wu HY, Zhang J, Zhu DY. Hippocampaltelomerase is involved in the modulation of depressive behaviors. J Neurosci.2011 Aug 24;31(34):12258-69.
13. Zhang J, Huang XY, Ye ML, LuoCX, Wu HY, Hu Y, Zhou QG, Wu DL, Zhu LJ,Zhu DY*. Neuronal nitric oxide synthase alteration accounts for the role of5-HT1A receptor in modulating anxiety-related behaviors.J Neurosci. 2010 Feb 17;30(7):2433-41.
14. Shen X, Sun Y, Wang M, Shu H,ZhuLJ, Yan PY, Zhang JF, Jin X. Chronic N-acetylcysteine treatmentalleviates acute lipopolysaccharide-induced working memory deficit throughupregulating caveolin-1 and synaptophysin in mice. Psychopharmacology(Berl).2018 Jan;235(1):179-191.
15. Zhang J, Cai CY, Wu HY, Zhu LJ, Luo CX, Zhu DY.CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1areceptors in modulating anxiety behaviors. Sci Rep. 2016 Jul12;6:29551.


主持项目：

1.国家重点研发计划神经发育过程中突触囊泡的特化、2016/07-2021/06、课题骨干；
2.国家自然科学基金面上项目、海马RASD1调控应激诱导的焦虑行为的神经机制、2017/01-2020/12、主持；
3.国家自然科学基金面上项目、Dexras1通过抑制海马苔藓纤维释放BDNF调控抑郁行为、2020/01-2023/12、主持；
4.国家自然科学基金青年基金、Dexras1调控焦虑行为的作用及机制研究、2015/01-2017/12、主持；
5.中国科协青年人才托举、药理学、2016-2018年、主持
6.江苏省****基金、抑郁症分子机制研究、2017/07-2020/06、主持；
7.江苏省青年基金、Dexras1-BDNF-突触结构可塑性通路在抑郁行为调控中的作用研究、2014/07-2017/06、主持；
8.江苏省“六大人才高峰”高层次人才、焦虑症的神经机制研究、2019/07-2022/06、主持