王少华
教授 东南大学附属中大医院
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办公地点：东南大学附属中大医院5号楼内分泌科 电子邮箱：gyjwsh@126.com
通讯地址：江苏省南京市鼓楼区丁家桥87号












研究方向


糖尿病慢性并发症的防治策略
糖尿病情感认知障碍的基础与临床研究
妊娠糖尿病的预防及早期干预策略





荣誉奖励


奖励
2010.01.25教育部自然科学奖一等奖（排名第十）
2010.08.01江苏省医学新技术引进奖一等奖（排名第二）
2012.12.28江苏医学科技奖二等奖（排名第三）
2013.01.23江苏省科学技术奖三等奖（排名第三）
2015.01.06江苏省科学技术奖一等奖（排名第九）


学术任职
江苏省医学会糖尿病学分会委员会委员
江苏省医学会微循环学分会委员会委员








学术成果



??1. ??????????Huang X, Wang C, Tian S, Huang R, Guo D, Zhang H, Shi J, Wang S.Higher Plasma Level of Nampt Presaging Memory Dysfunction in Chinese Type 2 Diabetes Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2019.
2. An K, Huang R, Tian S, Guo D, Wang J, Lin H, Wang S. Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis. Lipids in health and disease. 2019;18(1):121.
3. Huang R, Tian S, Han J, Lin H, Guo D, Wang J,Wang S. U-??Shaped Association Between Serum Uric Acid Levels and Cognitive Functions in Patients with Type 2 Diabetes: A Cross-Sectional Study. ??????????Journal of Alzheimer's disease : JAD. 2019;69(1):135-44.
4. Wang J, Huang R, Tian S, Lin H, Guo D, An K, Wang S. Elevated Plasma Level of D-dimer Predicts the High Risk of Early Cognitive Impairment in Type 2 Diabetic Patients as Carotid Artery Plaques become Vulnerable or Get Aggravated. Current Alzheimer research. 2019;16(5):396-404.
5. Huang R, Tian S, Cai R, Sun J, Shen Y, Wang S. Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis. Frontiersin genetics. 2018;9:541.
6. Tian S, Huang R, Han J, Cai R, Guo D, Lin H, Wang J, Wang S. Increased plasma Interleukin-1beta level is associated with memory deficits in type 2 diabetic patients with mild cognitive impairment. Psychoneuroendocrinology. 2018;96:148-54.
7. Yin H, Tian S, Huang R, Cai R, Guo D, Lin H, Wang J, Wang S. Low Plasma Leptin and High Soluble Leptin Receptor Levels Are Associated With Mild Cognitive Impairment in Type 2 Diabetic Patients. Frontiers in aging neuroscience. 2018;10:132.
8. Wang J, Yuan Y, Cai R, Huang R, Tian S, Lin H, Guo D, Wang S. Association between Plasma Levels of PAI-1, tPA/PAI-1 Molar Ratio, and Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus. Journal of Alzheimer's disease : JAD. 2018;63(2):835-45.
9. Cai R, Huang R, Han J, Sun H, Sun J, Xia W, Tian S, Dong X, Shen Y, Wang S. Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes. Scientific reports. 2017;7(1):12311.
10. Tian S, Han J, Huang R, Sun J, Cai R, Shen Y, Wang S. Increased Plasma Homocysteine Level is Associated with Executive Dysfunction in Type 2 Diabetic Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2017;58(4):1163-73.
11. Huang R, Tian S, Cai R, Sun J, Xia W, Dong X, Shen Y, Wang S. Saitohin Q7R polymorphism is associated with late-onset Alzheimer's disease susceptibility among caucasian populations: a meta-analysis. Journal of cellular and molecular medicine. 2017;21(8):1448-56.
12. Huang R, Han J, Tian S, Cai R, Sun J, Shen Y, Wang S. Association of plasma ghrelin levels and ghrelin rs** polymorphism with mild cognitive impairment in type 2 diabetic patients. Oncotarget. 2017;8(9):15126-35.
13. Dong X, Cai R, Sun J, Huang R, Wang P, Sun H, Tian S, Wang S. Diabetes as a risk factor for acute coronary syndrome in women compared with men: a meta-analysis, including 10 856 279 individuals and 106 703 acute coronary syndrome events. Diabetes/metabolism research and reviews. 2017;33(5).
14. Wang S, Sun H, Huang R, Wang P, Cai R, Xia W, Sun J, Tian S, Dong X. Glycogen synthase kinase-3β (GSK-3β) rs334558 polymorphism is not associated with mild cognitive impairment in Chinese Han type 2 diabetic patients. International Journal of Clinical and Experimental Medicine. 2017;10(1):1267-74.
15. Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ. Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis. Scientific reports. 2017;7:39982.
16. Tian S, Han J, Huang R, Xia W, Sun J, Cai R, Dong X, Shen Y, Wang S. Association of Increased Serum ACE Activity with Logical Memory Ability in Type 2 Diabetic Patients with Mild Cognitive Impairment. Frontiers in behavioral neuroscience. 2016;10:239.
17. Cai R, Han J, Sun J, Huang R, Tian S, Shen Y, Dong X, Xia W, Wang S. Plasma Clusterin and the CLU Gene rs** Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients. Frontiers in aging neuroscience. 2016;8:179.
18. Sun J, Cai R, Huang R, Wang P, Tian S, Sun H, Xia W, Wang S. Cholesteryl Ester Transfer Protein Intimately Involved in Dyslipidemia-Related Susceptibility to Cognitive Deficits in Type 2 Diabetic Patients. Journal of Alzheimer's disease : JAD. 2016;54(1):175-84.
19. Cai R, Yuan Y, Sun J, Xia W, Huang R, Tian S, Dong X, Shen Y, Wang S. Statins worsen glycemic control of T2DM in target LDL-c level and LDL-c reduction dependent manners: a meta-analysis. Expert opinion on pharmacotherapy. 2016;17(14):1839-49.
20. Shen Y, Cai R, Sun J, Dong X, Huang R, Tian S, Wang S. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis. Endocrine. 2017;55(1):66-76.
21. Sun J, Xia W, Cai R, Wang P, Huang R, Sun H, Tian S, Dong X, Wang S. Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment. Current Alzheimer research. 2016;13(12):1337-45.
22. Wei Q, Sun Z, Yang Y, Yu H, Ding H, Wang S. Effect of a CGMS and SMBG on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus: a Randomized Controlled Trial. Scientific reports. 2016;6:19920.
23. Yang Y, Wei Q, Yu H, Wang P, Xia W, Huang R, Cai R, Sun H, Wang S. Higher pre-pregnancy body mass index is associated with excessive gestational weight gain in normal weight Chinese mothers with gestational diabetes. The journal of obstetrics and gynaecology research. 2016;42(5):511-8.
24. Wang P, Huang R, Lu S, Xia W, Cai R, Sun H, Wang S. RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study. PloS one. 2016;11(1):e**.
25. Xia W, Rao H, Spaeth AM, Huang R, Tian S, Cai R, Sun J, Wang S. Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI. Medicine. 2015;94(48):e2231.
26. Sun H, Yuan Y, Wang P, Cai R, Xia W, Huang R, Wang S. Intensified low-density lipoprotein-cholesterol target of statin therapy and cancer risk: a meta-analysis. Lipids in health and disease. 2015;14:140.
27. Huang R, Wang P, Han J, Xia W, Cai R, Sun H, Sun J, Wang S. Decreased Serum IGF-1/IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2015;47(1):85-94.
28. Wang P, Huang R, Lu S, Xia W, Sun H, Sun J, Cai R, Wang S. HbA1c below 7% as the goal of glucose control fails to maximize the cardiovascular benefits: a meta-analysis. Cardiovascular diabetology. 2015;14:124.
29. Xia W, Wang S, Spaeth AM, Rao H, Wang P, Yang Y, Huang R, Cai R, Sun H. Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study. BioMed research international. 2015;2015:719076.
30. Xia W, Wang S, Rao H, Spaeth AM, Wang P, Yang Y, Huang R, Cai R, Sun H. Disrupted resting-state attentional networks in T2DM patients. Scientific reports. 2015;5:11148.
31. Xia W, Zhang B, Yang Y, Wang P, Yang Y, Wang S. Poorly controlled cholesterol is associated with cognitive impairment in T2DM: a resting-state fMRI study. Lipids in health and disease. 2015;14:47.
32. Sun J, Yuan Y, Cai R, Sun H, Zhou Y, Wang P, Huang R, Xia W, Wang S. An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials. BMJ open. 2015;5(3):e007280.
33. Guo YJ, Wang SH, Yuan Y, Li FF, Ye KP, Huang Y, Xia WQ, Zhou Y. Vulnerability for apoptosis in the hippocampal dentate gyrus of STZ-induced diabetic rats with cognitive impairment. Journal of endocrinological investigation. 2014;37(1):87-96.
34. Wang SH, Huang Y, Yuan Y, Xia WQ, Wang P, Huang R. LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses. Lipids in health and disease. 2014;13:175.
35. Cai R, Yuan Y, Zhou Y, Xia W, Wang P, Sun H, Yang Y, Huang R, Wang S. Lower intensified target LDL-c level of statin therapy results in a higher risk of incident diabetes: a meta-analysis. PloS one. 2014;9(8):e104922.
36. Guo YJ, Zhou Y, Zhang SY, Wei Q, Huang Y, Xia WQ, Wang SH. Optimal target range for blood glucose in hyperglycaemic patients in a neurocritical care unit. Diabetes & vascular disease research. 2014;11(5):352-8.
37. Guo Y, Wang P, Sun H, Cai R, Xia W, Wang S. Advanced glycation end product-induced astrocytic differentiation of cultured neurospheres through inhibition of Notch-Hes1 pathway-mediated neurogenesis. International journal of molecular sciences. 2013;15(1):159-70.
38. Guo Y, Wei Q, Huang Y, Xia W, Zhou Y, Wang S. The effects of astrocytes on differentiation of neural stem cells are influenced by knock-down of the glutamate transporter, GLT-1. Neurochemistry international. 2013;63(5):498-506.
39. Zhou Y, Yuan Y, Cai RR, Huang Y, Xia WQ, Yang Y, Wang P, Wei Q, Wang SH. Statin therapy on glycaemic control in type 2 diabetes: a meta-analysis. Expert opinion on pharmacotherapy. 2013;14(12):1575-84.
40. Xia W, Wang S, Sun Z, Bai F, Zhou Y, Yang Y, Wang P, Huang Y, Yuan Y. Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology. 2013;38(11):2493-501.
41. Wang SH, Wang L, Zhou Y, Guo YJ, Yuan Y, Li FF, Huang Y, Xia WQ. Prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital. Diabetes & vascular disease research. 2013;10(2):169-78.
42. Wang S, Yuan Y, Xia W, Li F, Huang Y, Zhou Y, Guo Y. Neuronal apoptosis and synaptic density in the dentate gyrus of ischemic rats' response to chronic mild stress and the effects of Notch signaling. PloS one. 2012;7(8):e42828.
43. Wang SH, Guo YJ, Yuan Y, Li L, Li FF, Ye KP, Huang Y. PPARgamma-mediated advanced glycation end products regulate neural stem cell proliferation but not neural differentiation through the BDNF-CREB pathway. Toxicology letters. 2011;206(3):339-46.
44. Wang SH, Sun ZL, Guo YJ, Yang BQ, Yuan Y, Wei Q, Ye KP. Meticillin-resistant Staphylococcus aureus isolated from foot ulcers in diabetic patients in a Chinese care hospital: risk factors for infection and prevalence. Journal of medical microbiology. 2010;59(Pt 10):1219-24.
45. Wang SH, Zhang ZJ, Guo YJ, Sui YX, Sun Y. Notch1 signaling related hippocampal neurogenesis in adult poststroke depression rats: a valid index for an efficient combined citalopram and WAY100635 pharmacotherapy. Behavioural pharmacology. 2010;21(1):47-57.
46. Wang SH, Zhang ZJ, Guo YJ, Sui YX, Sun Y. Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression. Pharmacology, biochemistry, and behavior. 2010;95(1):129-37.
47. Wang SH, Zhang ZJ, Guo YJ, Teng GJ, Chen BA. Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. Psychiatry research. 2009;170(2-3):245-51.
48. Wang SH, Sun ZL, Ruan XZ, Guo YJ, Wang Y, Jin H, Yuan Y, Wei Q. Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital. Chinese medical journal. 2009;122(21):2567-72.
49. Wang SH, Sun ZL, Guo YJ, Yuan Y, Yang BQ. Diabetes impairs hippocampal function via advanced glycation end product mediated new neuron generation in animals with diabetes-related depression. Toxicological sciences : an official journal of the Society of Toxicology. 2009;111(1):72-9.
50. Wang SH, Sun ZL, Guo YJ, Yuan Y, Li L. PPARgamma-mediated advanced glycation end products regulation of neural stem cells. Molecular and cellular endocrinology. 2009;307(1-2):176-84.
51. Wang SH, Zhang ZJ, Guo YJ, Zhou H, Teng GJ, Chen BA. Anhedonia and activity deficits in rats: impact of post-stroke depression. Journal of psychopharmacology. 2009;23(3):295-304.
52. Wang SH, Zhang ZJ, Guo YJ, Teng GJ, Chen BA. Hippocampal neurogenesis and behavioural studies on adult ischemic rat response to chronic mild stress. Behavioural brain research. 2008;189(1):9-16.