基础医学博士研究生导师简介
姓 名
杨中州
联系方式
电子邮件：zhongzhouyang@nju.edu.cn


研究方向
心脏发育与先天性心脏病
电话：**

实验室网页


学术兼职

中国细胞生物学会常务理事，发育生物学分会会长
国家心血管病专家委员会先心病专业委员会常委

学习和工作简历

1997年于北京大学医学部获得医学硕士学位；1998年作为访问****在美国宾夕法尼亚大学工作学习；2004年于瑞士巴塞尔大学/弗里德里奇-米歇尔生物医学研究所获得博士学位；2005年进入南京大学工作。

研究方向

利用小鼠模型，研究心脏发育的调控机制及先天性心脏病的发病机理。
研究方向包括：
1．心脏流出道发育
2．第二心场祖细胞发育
3．心肌发育，重塑与再生

科学问题

1．流出道发育过程中细胞转分化的调控机制。
2．细胞器互作及代谢调控心肌发育的机理。

代表性论文[通讯作者]

杨中州心脏发育过程中的细胞命运转变与命运决定（创刊40周年纪念专栏综述）.中国细胞生物学学报41卷第10期(2019年10月)。
Meng Xia, Wen Luo, Hengwei Jin and Zhongzhou Yang*. (2019) HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 146(13). pii: dev177477. (封面文章)
Hengwei Jin, Huijuan Wang, Jie Li, Shan Yu, Mingjie Xu, Zhiqian Qiu, Meng Xia, Jingai Zhu, Qiuting Feng, Jun Xie, Biao Xu and Zhongzhou Yang*. (2019)Differentialcontribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery. Developmental Biology 450：82-89.
Han Hu,Mingyang Jiang,Yangpo Cao,Zhuojun Zhang,Bin Jiang,Feng Tian,Juan Feng,Yali Dou,Myriam Gorospe,Ming Zheng,Lemin Zheng,Zhongzhou Yang*,Wengong Wang*. (2019) HuR regulates phospholamban expression in isoproterenol-induced cardiac remodeling. Cardiovascular Research
Jisheng Hu, Yingchao Shi, Meng Xia, Zhongying Liu, Ruirui Zhang, Hongmei Luo, Tongcun Zhang, Zhongzhou Yang*and Baiyin Yuan*. (2018) WDR1-regulated actin dynamics is required for outflow tract and right ventricle development. Developmental Biology438:124-137.
Qi Xiao, Guoxin Zhang, Huijuan Wang, Lai Chen, Shuangshuang Lu, Dejing Pan, Geng Liu*andZhongzhou Yang*. (2017) A p53based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Development144: 580-589.(Feature文章/封面文章)
Wen Luo, Xia Zhao, Hengwei Jin, Lichan Tao, Jingai Zhu, Huijuan Wang, Brian A. Hemmings and Zhongzhou Yang*. (2015) Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development. Development142, 732-742.
Junwei Nie, Mingyang Jiang, Xiaotian Zhang, Hao Tang, Hengwei Jin, Xinyi Huang, Baiyin Yuan, Chenxi Zhang, Janice Ching Lai, Yoshikuni Nagamine, Dejing Pan, Wengong Wang* and Zhongzhou Yang*. (2015) Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.Cell Reports13:723-732. (封面文章)
Xia Zhao, Shuangshuang Lu, Junwei Nie, Xiaoshan Hu, Wen Luo, Xiangqi Wu, Hailang Liu, Qiuting Feng, Zai Chang, Yaoqiu Liu, Yunshan Cao, Haixiang Sun, Xinli Li, Yali Hu, Zhongzhou Yang*.(2014) Phosphoinositide-dependent Kinase 1 and mTORC2 synergisticallymaintain postnatal heart growth and heart function in mice. Molecular and Cellular Biology 34 (11):1966-75.(spotlight/封面文章)
Baiyin Yuan,Ping Wan,Dandan Chu,Junwei Nie,Yunshan Cao,Wen Luo,Shuangshuang Lu,Jiong Chen* and Zhongzhou Yang*.(2014) A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice.American Journal of Pathology 184 (7):1967-80.
Qiuting Feng, Ruomin Di, Fang Tao, Zai Chang, Shuangshuang Lu, Wenjing Fan, Congjia Shan, Xinli Li*and ZhongzhouYang*.(2010) PDK1 regulates vascular remodelingand promotes epithelial-mesenchymal transition in cardiac development.Molecular and Cellular Biology30: 3711-3721. (spotlight文章)
Zai Chang, Qin Zhang, Qiuting Feng, Jie Xu, Teng Teng, Qing Luan, Congjia Shan, Yali Hu, Brian A Hemmings, Xiang Gao andZhongzhou Yang*. (2010) Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Developmental Biology 347: 384-391.


承担科研项目[项目负责人]

主持在研项目：1. 国家自然科学基金重大计划培育项目一项；2. 国家自然科学基金重点项目一项；3. 科技部“发育编程及其代谢调节”重点研发专项项目一项。

获奖情况

国家科技进步奖二等奖(2016, 排名第3)