研究生导师简介
姓名
王守宇
研究方向：
肿瘤表观遗传


联系方式
sywang@nju.edu.cn

学术兼职：
江苏省环境诱变剂学会理事
中国抗癌学会会员
中国毒理学会会员
中国细胞生物学会会员


个人简介

王守宇，博士，教授，博士生导师。江苏省****基金获得者，江苏省“333工程”培养对象，江苏高校“青蓝工程”中青年骨干教师。近年来主要围绕环境致癌物的诱癌机制和肿瘤表观遗传展开研究，以第一或通讯作者在Nature Cell Biology，Gut, The Journal of Clinical Investigation，Cell Research, Clinical Cancer Research，Nucleic Acids Research，Cancer Letters等杂志发表多篇论文，主持国家自然科学基金多项，以主要完成人获教育部高等学校自然科学奖二等奖（2013年）。

代表性论文[近5年通讯作者和第一作者]

(1) Qiang Wang#, Chen Chen#, Qingqing Ding#, Yan Zhao, Zhangding Wang, Junjie Chen, Zerun Jiang, Yan Zhang, Guifang Xu, Jingjing Zhang, Jianwei Zhou, Beicheng Sun*, Xiaoping Zou*, Shouyu Wang*. METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020 Jul;69(7):1193-1205.
(2) Qiang Wang#, Wei Geng#, Huimin Guo#, Zhangding Wang, Kaiyue Xu, Chen Chen, Shouyu Wang*. Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer. J Hematol Oncol. 2020 May 19;13(1):57.
(3) Zhangding Wang#, Qiang Wang#, Guifang Xu#, Na Meng#, Xinli Huang, Zerun Jiang, Chen Chen, Yan Zhang, Junjie Chen, Aiping Li, Nan Li, Xiaoping Zou, Jianwei Zhou, Qingqing Ding*, Shouyu Wang*. The long noncoding RNA CRAL reverses cisplatin resistance via the miR-505/CYLD/AKT axis in human gastric cancer cells. RNA Biology. 2020 Jan 7:1-14.
(4) Qingsong Hu#, Chunlai Li#, Shouyu Wang#, Yajuan Li#, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin*, Liuqing Yang*, LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. 2019 Apr;29 (4):286-304.
(5) Jie Wu#, Zerun Jiang#, Chen Chen#, Qingsong Hu, Ziyi Fu, Junjie Chen, Zhangding Wang, Qiang Wang, Aiping Li, Jeffrey R. Marks, Changying Guo, Yun Chen, Jianwei Zhou, Liuqing Yang, Chunru Lin, Shouyu Wang*, CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. Cancer Letters. 2018 Aug 28;430:179-192.
(6) Danping Qiu#, Qiang Wang#, Zhangding Wang#, Junjie Chen, Donglin Yan, Yan Zhou, Aiping Li, Ruiwen Zhang, Shouyu Wang*, Jianwei Zhou*, RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2018 May;1864(5 Pt A):1552-1561.
(7) Shouyu Wang#, Ke Liang#, Qingsong Hu#, Jian Song, Yuedong Yang, Jun Yao, Selanere Mangala, Chunlai Li, Wenhao Yang, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Weiya Xia, Mien-Chie Hung, Jeffery R. Marks, Gary E. Gallick, Gabriel Lopez-Berestein, Elsa R. Flores, Anil K. Sood, Suyun Huang, Dihua Yu, Liuqing Yang*, Chunru Lin*, A JAK2-binding Long Noncoding RNA Promotes Breast Cancer Brain Metastasis. Journal of Clinical Investigation. 2017 Dec 1;127(12):4498-4515.
(8) Chunlai Li#, Shouyu Wang#, Zhen Xing, Aifu Lin, Ke Liang, Jian Song, Qingsong Hu, Jun Yao, Zhongyuan Chen, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Shuxing Zhang, Han Liang, Mien-Chie Hung, Gary E. Gallick, Leng Han, Chunru Lin* and Liuqing Yang*, A ROR1-HER3-lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis, Nature Cell Biology, 2017, 19(2):106-119.
(9)Qiang Wang, Jianping Xiong, Dianping Qiu, Xue Zhao, Donglin Yan, Wenxia Xu,Zhangding Wang, Qi Chen, Sapna Panday, Aiping Li,Shouyu Wang*,Jianwei Zhou*.Inhibition of PARP1 activity enhances chemotherapeutic efficiency in cisplatin-resistant gastric cancer cells. Int J Biochem Cell Biol. 2017 Nov;92:164-172.

承担科研项目[项目负责人]

国家自然科学基金面上项目（No. **），长链非编码RNA通过JAK2调控环境因素诱导胃上皮细胞恶性转化的作用机制，2018/01-2021/12
国家自然科学基金面上项目（No. **），miR-28-TXNL1-XRCC1 轴在顺铂诱导胃癌细胞凋亡中的作用及分子机制，2014/01-2017/12
江苏省****基金（No. BK**），环境致癌物诱导胃癌发生的作用机制及干预研究，2017/06-2020/12

获奖情况

教育部高等学校自然科学奖二等奖 (2013，排名第2)