博士研究生导师简介
姓名
韩晓冬
研究方向
1生殖与发育
2干细胞与组织再生


联系方式
电话：
Email: hanxd@nju.edu.cn

学术兼职：
教育部高等学校基础医学类专业教学指导委员会委员
江苏省高等学校医药教育研究会副理事长
江苏省解剖学会理事长
《中华男科学杂志》 编委

个人简介

南京大学医学院党委书记，博士，组织胚胎学教授，博士生导师。1984年毕业于南京大学生物系，获学士学位；1987年于南京大学生物系获硕士学位；2004年于南京大学生命科学院获博士学位。2001年，作为高级访问****赴美国哈佛大学医学院Beth Israel Deaconess Medical Center开展合作研究。长期从事生殖与发育、干细胞与组织再生研究，主持并参与国家自然科学基金、国家“973计划”、教育部博士点基金、江苏省自然科学基金等研究项目，在国内外学术刊物共发表论文180余篇。参编《组织胚胎学》、《生殖病理学》教材，主讲的“组织胚胎学”入选南京大学百门优质课程建设。

代表性论文

1. Jin Haibo, Ma Tan, Sha Xiaoxuan, Liu Zhengyu, Zhou Yuan, Meng Xiannan, Chen Yabing, 韩晓冬*, Die Jie*. Polystyrene microplastics induced male reproductive toxicity in mice. Journal of Hazardous Materials, 401 (2021): 123430.
2. Chen Yabing, Wang Jing, Xu Dihui, Xiang Zou, Ding Jie, Yang Xiaoyu, Li Dongmei*, 韩晓冬*. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy, 2020 Jan 31:1-19. doi: 10.1080/**.2020.**.
3. Wang Jing, Chen Yabing, Zhang Changliang, Xiang Zou, Ding Jie*, 韩晓冬*. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials, 2019, 373: 504–518.
4. Wang Jing, Zhang Changliang, Zhu Jinling, Ding Jie, Chen Yabing*, 韩晓冬*. Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. Science of the Total Environment, 2019, 689: 662–678.
5. Meng Xiannan, Peng Haoran, Ding Yuanzhen, Zhang Ling, Yang Jingping*, 韩晓冬*. A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity. Science of the Total Environment, 2019, 667: 563–577.
6. Zhang Changliang, Wang Jing, Zhu Jinling, Chen Yabing*,韩晓冬*. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Science of The Total Environment . 2019 Nov 1:134702. doi: 10.1016/j.scitotenv.2019.134702.
7. Jin Haibo, Wang Bo, Hou Jiwei, MaTan, Qiao Dan, MiaoYingwen, Ding Jie*, 韩晓冬*. The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons. Ecotoxicology and Environmental Safety, 2019, 184:109614.
8. Wang Jing, Chen Yabing, Chen Zhangpeng, Xiang Zou, Ding Jie*, and 韩晓冬*. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicology and Environmental Safety. 2018, 163:391–399.
9. Chen Yabing, Wang Jing, Chen Xiang, Li Dongmei, 韩晓冬*. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels. Aquatic Toxicology. 2018, 199:116-126.
10. Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and 韩晓冬*.Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice. Science of the Total Environment，2018, 643:496–506.
11. Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei, and 韩晓冬*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia. Environmental Pollution. 2018, 242: 1535-1545.
12. Hou Jiwei, Ma Tan, Cao Honghui, Chen Yabing, Wang Cong, Chen Xiang, Xiang Zou, and 韩晓冬*. TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis. Journal of Cellular Physiology. 2018,233(3):2409-2419.
13. Zhang Ling, Meng Xiannan, Xiang Zou, Li Dongmei*, and韩晓冬*. Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis. Toxicological sciences, 2018,161(1):159–170.
14. Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and 韩晓冬*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling. 2018 ,16:89.
15. Chen Xiang, Shi Chaowen, Cao Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and 韩晓冬*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death Disease. 2018,9:639.
16. Chen Yabing, Wang Jing, Pan Chun, Li Dongmei*, 韩晓冬*. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, 2018, 75 (6):1117-1132.
17. Chen Yabing, Wang Jing, Zhang Qin, Xiang Zou, Li Dongmei, 韩晓冬*. Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. Environmental Pollution 2017, 229:964-975.
18. Ding Jie, Wang Jing, Xiang Zou, Diao Weiyi, Su Moxi, Shi Weiwei, Wan Ting, 韩晓冬*. The Organic anion transporting polypeptide 1a5 is a pivotal transporter for the uptake of microcystin-LR by gonadotropin-releasing hormone neurons. Aquatic Toxicology. 2017,182:1-10.
19. Shi Chaowen, Cao Xiaowei, Chen Xiang, Sun Zhaorui, Xiang Zou, Zhao Hang, Qian Weiping*, 韩晓冬*.Intracellular surface-enhanced Raman scattering probes based on TAT peptide-conjugated Au nanostars for distinguishing the differentiation of lung resident mesenchymal stem cells. Biomaterials, 2015 Jul; 58: 10-25.
20. Zhou Yuan, Zou Xiang, Dongmei Li*, 韩晓冬*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014, 48: 6383-6390.

承担科研项目[项目负责人]

1.国家自然科学基金项目（**）：微囊藻毒素长期低剂量暴露引起小鼠学习记忆能力减退的分子机制探讨
2.国家自然科学基金项目（**）：Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究
3.国家自然科学基金项目（**）：微囊藻毒素下调雄性大鼠雄激素（睾酮)合成和分泌的机制研究
4.国家自然科学基金项目（**）：微囊藻毒素低剂量长时间暴露对雄性大鼠生殖系统的影响及其机制研究
5.国家自然科学基金项目（**）：调控Wnt信号通路对特发性肺纤维化发生发展影响的研究
6.国家自然科学基金项目（**）：环境内分泌干扰物烷基酚生殖毒性风险评价标准的探索
7.高等学校博士学科点专项科研基金（20**0）：微囊藻毒素通过下丘脑-垂体-睾丸轴下调雄性激素合成及分泌的机制研究
8.江苏省自然科学基金（BK**）：调控WNT信号通路对特发性纤维化发生发展影响的研究
9.江苏省自然科学基金（BK**）：Hedgehog-Wnt信号通路参与特发性肺纤维化发病的分子机制探讨及疾病干预的基础研究
10.国家重点基础研究发展计划“973”计划课题子项目（2010CB945103）：卵巢早衰的分子机制及其早期预测、诊断生物标记的研究
11.国家重点基础研究发展计划“973”计划课题子项目（2007CB815603）：微生物群落分解矿物的机理及其对生态环境的影响


获奖情况

2018年获南京大学“本科实践教学优秀指导教师”称号。
2017年获“宝钢优秀教师奖”称号。
2010年获南京大学“我最喜爱的教师”称号。