杨四海 教授





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邮政编码：

联系地址：
电子邮件： sihaiyang@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
南京大学生命科学学院教授、博导，主要从事进化遗传学、生物信息学相关研究。



学术兼职



研究方向
主要从事分进化遗传学、生物信息学研究方向：
（1）基因组遗传变异的分子机制；
（2）植物抗病基因的起源、遗传变异与保存机制、功能等；
（3）基因组学、功能基因组学；
详细请访问实验室网站：http://gattaca.nju.edu.cn/

代表性研究论文：
Wang L, Sun, Y, Sun X, Yu L, Xue L, He Z, Huang J, Tian D, Hurst LD*,Yang S* (2020)Repeat-induced point mutation inNeurospora crassacauses the highest known mutation rate and mutational burden of any cellular life.Genome Biol21:142(IF5y=19.0）

Jiang M, He Y, Chen X, Zhang X, Guo Y,Yang S, Huang J, Traw M* (2020) CRISPR-based assessment of genomic structure in the conserved SQUAMOSA promoter-binding-like gene clusters in rice.Plant J(Accepted)

Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WS*,Yang S*(2019) Large-scale identification and functional analysis ofNLRgenes in blast resistance in the Tetep rice genome sequence.PNAS10.1073/pnas.(IF5y=10.5）

Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Yu Sheng1 , Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S , Cheng T, Laux T, Gao Q, Peng Y, Liu N*,Yang S*, Shi J* (2019) Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation.Nature Plants10.1038/s41477-018-0323-6 （IF=14.5）

Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M,Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J,Yang S*, Hurst LD* and Tian D*. (2019)The architecture of intra-organism mutation rate variation in plants.Plos Biol17(4):e** (IF5y=9.5）

Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*,Yang S*. (2019) High resolution insight into recombination events at the SD1 locus in rice.Plant JDOI: 10.1111/tpj.14154

Chen X, Tian X, Xue L, Zhang X,Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice.Plant Physiol180(4):2091-2105(IF5y=7.3)

Liu H, Huang J, Sun X, Li J, Hu Y, Yu L,Liti G, Tian D, Hurst LD*,Yang S*. (2018) Tetrad analysis in plants and fungifinds large differences in gene conversion rates but no GC bias.Nature Ecol Evol2, 164–173 (IF=12.5)

Huang J, Li J, Zhou J, Wang L,Yang S, Hurst LD, Li W-H* & Tian D*. (2018) Identifying a Large Number of High-Yield Genes in Rice by Pedigree Analysis, Whole-Genome Sequencing, and CRISPR-Cas9 Gene Knockout.PNAS115(32): E7559-E7567

Liu H, Jia Y, Sun X, Tian D, Hurst LD*,Yang S*.(2017) Direct determination of the mutation rate in the bumblebeereveals evidence for weak recombination-associated mutation and an approximaterate constancy in insects.Mol Biol Evol34: 119-130 （IF5y=14.5)

Gu L, Wu Y, Jiang M, Si W, Zhang X, TianD*,Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Riceat Early-Tillering Stage under Nutrient-Deficient and Nutrient-SufficientCondition.Plant Physiol172: 1142-1153 (IF5y=7.367)

Xie Z, Wang L, Wang L, Wang Z, Lu, Z, TianD,Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progenysequencing of the perennial peach I. A low rate in woody perennials and ahigher mutagenicity in hybrids.P Roy Soc B-Biol Sci283: **.(IF5y=5.366)

Wang L, Zhang Y, Qing C, Tian D,Yang S*,Hurst LD.* Mutation rate analysis via parent-progeny sequencing of theperennial peach II: No evidence for recombination-associated mutation.P RoySoc B-Biol Sci283: ** (IF5y=5.366)

Yang S, Wang L, Huang J, Zhang X, Yuan Y,Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates highermutation rates in heterozygotes.Nature523 :463-467 (IF5y=41.5)

Liu H#, Zhang X#, Huang J, Chen JQ, Tian D,Hurst LD*,Yang S*.(2015) Causes and consequences of crossing-over evidencedvia a high-resolution recombinational landscape of the honey bee.Genome Biology16:15（IF5y=18.5)

Si W, Yuan Y, Huang J, Zhang X, Zhang Y,Zhang Y, Tian D, Wang C, Yang YH*,Yang S*. (2015) Widely distributed hot andcold spots in meiotic recombination as shown by sequencing of rice F2 plants.New Phytologist206 :1491-1502 （IF5y=7.84)

Zhang X#,Yang S#, Wang J#, Jia Y#, HuangJ#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*.(2015) A genome-wide survey reveals abundant rice blast R-genes in resistantcultivars.Plant J84 :20-28 (IF5y =6.963)

Yang S#, Li J#, Zhang X#, Zhang Q, Huang J,Chen J-Q, Hartl DL*, Tian D*. (2013) Rapidly evolving R genes in diverse grassspecies confer resistance to rice blast disease.Proc Natl Acad Sci U S A110:18572-18577. （IF5y=10.73)

Yang S#, Yuan Y#, Wang L#, Li J, Wang W,Liu H, Chen JQ, Hurst LD*, Tian D*. (2012) Great majority of recombinationevents in Arabidopsis are gene conversion events.Proc Natl Acad Sci U S A109:20992–20997. （IF5y=10.73)

Yue J-X, Meyers BC, Chen J-Q, Tian D*,YangS*. (2012) Tracing the origin and evolutionary history of plantnucleotide-binding site-leucine-rich repeat (NBS-LRR) genes.New Phytologist193: 1049–1063.（IF5y=7.84)

Tian D, Wang Q, Zhang P, Araki H,Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes.Nature455:105-108



获奖情况
第四批国家“****”科技创新领军人才（中组部）
2018年度高校科学研究优秀成果奖自然科学一等奖
2017年科技部“创新人才推进计划”中青年科技创新领军人才（科技部）
2015年入选江苏省“六大人才高峰”第十二批高层次人才支持计划
2014年入选南京大学第二批“登峰人才支持计划”
2013年江苏省教学成果奖（高等教育类）一等奖
2012年度教育部“新世纪优秀人才支持计划”
2010年度江苏省高校“青蓝工程”中青年学术带头人培养对象



科研成果
Wang L, Sun, Y, Sun X, Yu L, Xue L, He Z, Huang J, Tian D, Hurst LD*,Yang S* (2020)Repeat-induced point mutation inNeurospora crassacauses the highest known mutation rate and mutational burden of any cellular life.Genome Biol21:142(IF5y=19.0）
Jiang M, He Y, Chen X, Zhang X, Guo Y,Yang S, Huang J, Traw M* (2020) CRISPR-based assessment of genomic structure in the conserved SQUAMOSA promoter-binding-like gene clusters in rice.Plant J(Accepted)

Wang L, Zhao L, Zhang X, Zhang Q, Jia Y, Wang G, Li S, Tian D, Li WS*,Yang S*(2019) Large-scale identification and functional analysis ofNLRgenes in blast resistance in the Tetep rice genome sequence.PNAS10.1073/pnas.(IF5y=10.5）

Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Yu Sheng1 , Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S , Cheng T, Laux T, Gao Q, Peng Y, Liu N*,Yang S*, Shi J* (2019) Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation.Nature Plants10.1038/s41477-018-0323-6 （IF=14.5）

Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M,Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J,Yang S*, Hurst LD* and Tian D*. (2019)The architecture of intra-organism mutation rate variation in plants.Plos Biol17(4):e** (IF5y=9.5）

Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*,Yang S*. (2019) High resolution insight into recombination events at the SD1 locus in rice.Plant JDOI: 10.1111/tpj.14154

Chen X, Tian X, Xue L, Zhang X,Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice.Plant Physiol180(4):2091-2105(IF5y=7.3)

Liu H, Huang J, Sun X, Li J, Hu Y, Yu L,Liti G, Tian D, Hurst LD*,Yang S*. (2018) Tetrad analysis in plants and fungifinds large differences in gene conversion rates but no GC bias.Nature Ecol Evol2, 164–173 (IF=12.5)

Huang J, Li J, Zhou J, Wang L,Yang S, Hurst LD, Li W-H* & Tian D*. (2018) Identifying a Large Number of High-Yield Genes in Rice by Pedigree Analysis, Whole-Genome Sequencing, and CRISPR-Cas9 Gene Knockout.PNAS115(32): E7559-E7567

Liu H, Jia Y, Sun X, Tian D, Hurst LD*,Yang S*.(2017) Direct determination of the mutation rate in the bumblebeereveals evidence for weak recombination-associated mutation and an approximaterate constancy in insects.Mol Biol Evol34: 119-130 （IF5y=14.5)

Gu L, Wu Y, Jiang M, Si W, Zhang X, TianD*,Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Riceat Early-Tillering Stage under Nutrient-Deficient and Nutrient-SufficientCondition.Plant Physiol172: 1142-1153 (IF5y=7.367)

Xie Z, Wang L, Wang L, Wang Z, Lu, Z, TianD,Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progenysequencing of the perennial peach I. A low rate in woody perennials and ahigher mutagenicity in hybrids.P Roy Soc B-Biol Sci283: **.(IF5y=5.366)

Wang L, Zhang Y, Qing C, Tian D,Yang S*,Hurst LD.* Mutation rate analysis via parent-progeny sequencing of theperennial peach II: No evidence for recombination-associated mutation.P RoySoc B-Biol Sci283: ** (IF5y=5.366)

Yang S, Wang L, Huang J, Zhang X, Yuan Y,Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates highermutation rates in heterozygotes.Nature523 :463-467 (IF5y=41.5)

Liu H#, Zhang X#, Huang J, Chen JQ, Tian D,Hurst LD*,Yang S*.(2015) Causes and consequences of crossing-over evidencedvia a high-resolution recombinational landscape of the honey bee.Genome Biology16:15（IF5y=18.5)

Si W, Yuan Y, Huang J, Zhang X, Zhang Y,Zhang Y, Tian D, Wang C, Yang YH*,Yang S*. (2015) Widely distributed hot andcold spots in meiotic recombination as shown by sequencing of rice F2 plants.New Phytologist206 :1491-1502 （IF5y=7.84)

Zhang X#,Yang S#, Wang J#, Jia Y#, HuangJ#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*.(2015) A genome-wide survey reveals abundant rice blast R-genes in resistantcultivars.Plant J84 :20-28 (IF5y =6.963)

Yang S#, Li J#, Zhang X#, Zhang Q, Huang J,Chen J-Q, Hartl DL*, Tian D*. (2013) Rapidly evolving R genes in diverse grassspecies confer resistance to rice blast disease.Proc Natl Acad Sci U S A110:18572-18577. （IF5y=10.73)

Yang S#, Yuan Y#, Wang L#, Li J, Wang W,Liu H, Chen JQ, Hurst LD*, Tian D*. (2012) Great majority of recombinationevents in Arabidopsis are gene conversion events.Proc Natl Acad Sci U S A109:20992–20997. （IF5y=10.73)

Yue J-X, Meyers BC, Chen J-Q, Tian D*,YangS*. (2012) Tracing the origin and evolutionary history of plantnucleotide-binding site-leucine-rich repeat (NBS-LRR) genes.New Phytologist193: 1049–1063.（IF5y=7.84)

Tian D, Wang Q, Zhang P, Araki H,Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes.Nature455:105-108