张冬梅 教授





办公电话：
邮政编码： 210093

联系地址： 生科楼B413
电子邮件： zdm@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
教授，硕士生导师。南京大学本科、硕士和博士毕业。南京大学百课程主持人，主讲“生物化学”。主编“十二五”普通高等教育本科国家级规划教材、江苏省“十三五”规划重点教材，主持“生物化学实验”慕课。
科研方向代谢综合征肾损伤病理机制及中药活性成分的保护作用。主持国家自然科学基金、江苏省“六大人才高峰”高层次人才培养计划、江苏省自然科学基金、中央高校基本业务费自由探索项目等科研项目，同时作为学术骨干参加国家重点基础研究发展计划973计划、国家自然科学基金、江苏省自然科学基金在内多个研究项目。发表SCI研究论文33篇，其中一作或通讯作者文章14篇。



学术兼职



研究方向
代谢综合征肾损伤的病理机制研究及中药活性成分的保护作用
代谢重编程诱发足细胞损伤的作用机制


获奖情况
1.2019年度高等学校科学研究优秀成果奖（科学技术）一等奖
基于降尿酸策略发现中药保护代谢综合征组织损伤新机制
孔令东李建梅潘颖张冬梅焦瑞清
2. 2014年 江苏省“六大人才高峰”高层次人才培养计划 A类
张冬梅 孔令东 王明星 张青玉


科研成果


发表SCI文章
1. Kang Linlin, Zhang Dongmei, Jiao Ruiqing,Pan Shuman, Zhao Xiaojuan, Zheng Yanjing, Chen Tianyu, Kong Lingdong. Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway. Oxidative Medicine and Cellular Longevity. 2019. **.DOI:10.1155/2019/**.
2. Gao Lei^#, Lu Xiancai, Liu Huan, Li Juan, Li Weijie, Song Rongbin, Wang Ruiyong, Zhang Dongmei, Zhu Junjie. Mediation of Extracellular Polymeric Substances in Microbial Reduction of Hematite by Shewanella oneidensis MR-1. Frontiers in Microbiology. 2019 9,1490（DOI:10.3389/fmicb.2010.00575).
3. Gu, Ting-Ting^#; Chen, Tian-Yu; Yang, Yan-Zi; Zhao, Xiao-Juan; Sun, Yang; Li, Tu-Shuai; Zhang, Dong-Mei*; Kong, Ling-Dong*. Pterostilbene alleviates fructose-induced renal fibrosis by suppressing TGF-beta1/TGF-beta type I receptor/Smads signaling in proximal tubular epithelial cells. European journal of pharmacology. 2018.10.16. 2018. 842: 70-78.
4. Minzan Zuo, Weirui Qian, Zuqiang Xu, Wei Shao, Xiao-Yu Hu,* Dongmei Zhang,* Juli Jiang,* Xiaoqiang Sun, and Leyong Wang. Multi-Responsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery. Small. 2（DOI: 10.1002/smll.）(02 August 2018) .
5. Yanjing Zheng^#, Yumei Li, Hongyan Long, Xiaojuan Zhao, Keke Jia1, Juan Li, Leyong Wang, Ruiyong Wang, Xiancai Lu and Dongmei Zhang*. bifA Regulates Biofilm Development of Pseudomonas putida MnB1 as a Primary Response to H2O2 and Mn2+. Frontiers in Microbiology. 2018 9,1490（DOI:10.3389/fmicb.2018.01490) (10 July 2018)
6. Lin, Xin^#; Jia, Keke^#; Wang, Yichen; Shao, Wei ; Yao, Chenhao ; Peng, Luming; Zhang, Dongmei*; Hu, Xiao-Yu*; Wang, Leyong. Dual-Responsive Bola-Type Supra-Amphiphile Constructed from Water-Soluble Pillar[5]arene and Naphthalimide-Containing Amphiphile for Intracellular Drug Delivery. ACS Applied Materials & Interfaces. 9: 4843-4850. 2017.1.18.
7. Gao Lei^#, Wang Tingting, Jia Keke, Wu Xuan, Yao Chenhao, Shao Wei, Zhang Dongmei, Hu XiaoYu *, and Wang Leyong *. Glucose-Responsive Supramolecular Vesicles Based on Water- Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. Chemistry - A European Journal. 2017.5.11, 23, 6605–6614.
8. Zhang Dong-Mei^#, Jiao Rui-Qing, Ling-Dong Kong*. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients. 2017.4, 9(4), 335; doi:10.3390/nu**. 2017.3.29.
9. Gu Ting-Ting^#, Song Lin^#, Chen Tian-Yu, Wang Xing, Zhao Xiao-Juan, Ding Xiao-Qin, Yang Yan-Zi, Pan Ying, Zhang Dong-Mei*, Kong Ling-Dong*. Fructose down-regulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin. Molecular Nutrition & Food Research. 2017.8;61(8). doi: 10.1002/mnfr..
10. Kang Lin-Lin^#, Zhang Dong-Mei^#, Ma Chun-Hua, Zhang Jian-Hua, Jia Ke-Ke, Liu Jia-Hui, Wang Rong, Kong Ling-Dong*. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Scientific Reports. 2016.6.8; 6:27460.
11. Ma Chun-Hua^#, Kang Lin-Lin, Ren Hong-Mei，Zhang Dong-Mei，Kong Ling-Dong*. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-kappaB/NLRP3 inflammasome activation in high fructose-fed rats. Journal of Ethnopharmacology. 2015.8.22;172:108-117.
12. Yang Ying^#，Zhang Dong-Mei，Liu Jia-Hui，Hu Lin-Shui，Xue Qiao-Chu，Ding Xiao-Qin，Kong Ling-Dong*. Wuling San protects kidneydysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasomeactivation in high fructose-induced hyperuricemic mice. Journal of Ethnopharmacology. 2015.7.1; 169:49-59.
13. Liu Lei^#, Zhang Dong-Mei^#, Wang Ming-Xing, Fan Chen-Yu, Zhou Fan, Wang Shui-Juan, Kong Ling-Dong*. The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats. Human & experimental toxicology. 2015.11; 34(11):1148-1161.
14. Wang Ming-Xing^#, Liu Yang-Liu, Yang Ying, Zhang Dong-Mei, Kong Ling-Dong*. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. European journal of pharmacology. 2015.1.15;15(747):59-70.
15. Hu Xiao-Yu^#, Jia Ke-Ke, Cao Yu, Li Yan, Qin Shan, Zhou Fan, Lin Chen, Zhang Dong-Mei,Wang Leyong*. Dual photo- and pH-responsive supramolecular nanocarriers based on water-soluble pillar[6]arene and different azobenzene derivatives for intracellular anticancer drug delivery. Chemistry-A European Journal. 2015.1.12;21(3):1208-1220.
16. Wang Xing^#, Zhang Dong-Mei^#, Gu Ting-Ting, Ding Xiao-Qin, Fan Chen-Yu, Zhu Qin, Shi Yun-Wei, Hong Ye, Kong Ling-Dong*. Morin reduces hepatic inflammation-associated lipidaccumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosinephosphate signaling pathway. Biochemical Pharmacology. 2013.12.15.86(12):1791-1804.
17. Guan Fu-Qin^#, Wang Hai-Ting, Shan Yu, Zhang Dong-Mei, Zhao You-Yi, Chen Yu, Wang Qi-Zhi, Wang Ming, Feng Xu*. Bigelovii A induces apoptosis of HL?60 human acute promyelocytic leukaemia cells. Molecular Medicine Reports. 2013.5;7(5):1585-1590.
18. Zhang Dong-Mei^#, Li Yu-Cheng^#, Xu De, Ding Xiao-Qin, Kong Ling-Dong*. Protection ofcurcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Food Chemistry. 2012.10.15;134(4):2184-2193.
19. Yang Jing-Hua^#, Zhao Jing, Xiao Han, Zhang Dong-Mei, Li Gen-Xi*. Study of Hemoglobin and Human Serum Albumin Glycation with Electrochemical Techniques. Electroanalysis. 2010.7.29 .23(2):463-468.
20. Pan Ying^#, Wang Fu-Meng, Qiang Li-Qin, Zhang Dong-Mei, Kong Ling-Dong*. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. 2010.2; 35(2): 272-283.
21. Sun Xue-Song^#, Ge Rui-Guang, Zhang Dong-Mei, Sun Hong-Zhe, He Qing-Yu*. Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcuspyogenes. Journal of Biological Inogranic Chemistry. 2010.11;15: 1265-1273.
22. Liu Tao^#, Zhao Jing, Zhang Dong-Mei, Li Gen-Xi*. Novel Method to Detect DNAMethylation Using Gold Nanoparticles Coupled with Enzyme-Linkage Reactions.Analytical Chemistry. 2010.1.1;82(1): 229-233.
23. Hu Qing-Hua^#, Wang Chuang, Li Jian-Mei, Zhang Dong-Mei, Kong Ling-Dong*. Allopurinol, rutin and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. American Journal of Physiology-Renal Physiology. 2009.10; 297(4): F1080-1091.
24. Lu Hua^#, Shi Ji-Xin, Zhang Dong-Mei, Shen Jie, Lin Yi-Xing, Hang Chun-Hua, Yin Hong-Xia*. Hemolysate-induced Expression of Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant Protein-1 Expression in Cultured Brain Microvascular Endothelial Cells via Through ROS-dependent NF-κB Pathways. Cellular and Molecular Neurobiology. 2009.2; 29:87-95.
25. Zhang Dong-Mei^#, Shen Jie, Wang Cui-Cui, Zhang Xin, Chen Jun-Hui*. GSH-dependent iNOS and HO-1 Mediated Apoptosis of Human Jurkat Cells Induced by Nickel(II). Environmental Toxicology. 2009.8; 24(4): 404-414.
26. Zhang Dong-Mei^#,Zhao Jing, Li Gen-Xi*. Protein-based voltammetric biosensors fabricated with nanomaterials. Protein and Peptide Letters. 2008;15(8):764-771.
27. Zhou Nan-Di^#, Chen Zhen-Yu, Zhang Dong-Mei, Li Gen-Xi*. Electrochemical Assay of Human Islet Amyloid Polypeptide and Its Aggregation. Sensors. 2008.9; 8:5987-5995.
28. Huang Jun-Yi^#, Zhang Dong-Mei, Xing Wei, Ma Xiang, Yin Yan-Xia, Wei Qun, Li Gen-Xi*. An approach to assay the enzymatic activity of calcineurin and the inhibitory effect of zinc ion. Analytical Biochemistry. 2008.4.15; 375(2):385-387.
29. Zeng Yi-Bo^#, Zhang Dong-Mei, Li Hong-Yan, Sun Hong-Zhe*. Binding of Ni2+ to a histidine- and glutamine-rich protein, Hpn-like. Journal of Biological Inorganic Chemistry. 2008.9;13(7): 1121-1131.
30. Zhang Dong-Mei^#; Zhou Nan-Di; Zhou Hhui; Chen Ting; Li Gen-Xi*. Electrochemical study of the inhibitory effect of sinapic acid and its derivatives on tyrosinase reactivity.Chemical Journal of Chinese Universities-Chinese. 2008.2.10;29(2):273-276.
31. Guan Fu-Qin^#,Zhang Dong-Mei^#, Wang Xin-Chang, Chen Jun-Hui*. Nitric Oxide and Bcl-2 Mediated the Apoptosis Induced by Nickel(II) in Human T Hybridoma Cells. Toxicology and Applied Pharmacology. 2007.5.15;211(1):86-94.
32. Liu Lei^#, Zhu Xiao-Li, Zhang Dong-Mei, Huang Jun-Yi, Li Gen-Xi*. An electrochemical method to detect folate receptor positive tumor cells. Electrochemistry communication. 2007.10;9(10): 2547-2550.
33. Mo Shi-Fu^#, Zhou Feng, Lv Yao-Zhong, Hu Qing-Hua, Zhang Dong-Mei,Kong Ling-Dong*. Hypouricemic action of selected flavonoids in mice structure-activity relationships. Biological & Pharmaceutical Bulletin 2007.8; 30(8):1551-1556.