赵权 教授





办公电话：
邮政编码： 210023

联系地址：
电子邮件： qzhao@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
赵权，南京大学生命科学学院教授、博士生导师，江苏省生物化学与分子生物学学会副理事长, 入选教育部“新世纪优秀人才支持计划”及江苏省“333高层次人才培养工程”第二层次人才计划。1988年毕业于南京大学生物化学系，获学士学位；2002年毕业于澳大利亚墨尔本La Trobe大学生物化学系，获博士学位并于皇家墨尔本医院骨髓研究所进行博士后工作。2006年受聘于南京大学生命科学院，主要从事基因转录与表观遗传学调控机理研究。相关研究成果以通讯作者发表Nature Structural & Molecular Biology、Nature Communications、Blood、Cancer Research、Nucleic Acids Research、Haematologica、J Biol Chem等高影响力国际论文。

学术兼职
中国生物化学与分子生物学学会理事、
江苏省生物化学与分子生物学学会副理事长



研究方向
研究方向：
1. 基因转录及表观遗传学调控机制;
2. 癌症的发生机理与防治研究
主要研究介绍：
基因表达调控是操纵生命体活动的核心。表观遗传调控（包括组蛋白修饰、DNA修饰等）为基因表达调控一种重要方式，参与细胞命运的决定，目前已成为生命科学研究中发展迅速的新兴前沿领域。
课题组主要研究基因转录及表观遗传调控过程中生物大分子的修饰模式及相关新型分子识别调节机制与生物学功能，重点关注癌症（肺癌、结直肠癌、乳腺癌、胃癌、白血病等）及遗传性血液病等重大疾病发生发展过程中发生的分子事件，解析细胞内外影响因素对基因表达变化的时空调节机制，明确肿瘤细胞恶性增殖、异常分化及转移和细胞重编程的分子机理，为癌症等的个体化精准治疗提供新靶点和新策略。在此基础上，我们积极开展相关新型表观药物发现及基于结构的功能分子改造研究。







获奖情况
江苏省科学技术进步二等奖（1999, No. 2-54-02）
Cooley's Anemia Foundation Research Fellowship, USA （2006-2008）
教育部“新世纪优秀人才支持计划” （2007）

江苏省“333高层次人才培养工程”第二层次人才（2013）


科研成果
代表性论文：
1. LiuM, YaoB, GuiT, GuoC, WuX, LiJ, MaL, DengY, XuP, WangY, YangD, LiQ, ZengX, LiX, HuR, GeJ, YuZ, ChenY, ChenB, JuJ, ZhaoQ*. PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression. Theranostics.2020,10(10): 4437–4452.(*Corresponding author)
2. Nie M, Wang Y, Yu Z, Li X, Deng Y, Wang Y, Yang D, Li Q, Zeng X, Ju J, Liu M, Zhao Q*. AURKB promotes gastric cancer progression via activation of CCND1 expression.Aging (Albany NY). 2020,12(2):1304-1321.
3. Wang Y, Liang H, Jin F, Yan X, Xu G, Hu H, Liang G, Zhan S, Hu X, Zhao Q, Liu Y, Jiang ZY, Zhang CY, Chen X, Zen K. Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway.Proc Natl Acad Sci U S A. 2019,116(13):6162-6171.
4. Nie M, Wang Y, Guo C, Li X, Wang Y, Deng Y, Yao B, Gui T, Ma C, Liu M, Wang P, Wang R, Tan R, Fang M, Chen B, He Y, Huang DCS, Ju J, Zhao Q*. CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells.J Biol Chem.2018, 293(45):17454-17463.
5. Ding M, Lu X, Wang C, Zhao Q, Ge J, Xia Q, Wang J, Zen K, Zhang CY, Zhang C. The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma. Cancer Res.2018, 78(24):6771-6784.
6. Ju J, Zhao Q*. Regulation of γ-globin gene expression and its clinical applications.Yi Chuan. 2018,40(6):429-444. (Review article)
7. Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q*. NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression. Nat Commun.2017,8(1):928.
8.Wang Y, Wang Y, Ma L, Nie M, Ju J, Liu M, Deng Y, Yao B, Gui T, Li X, Guo C, Ma C, Tan R, Zhao Q*. Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ?-Globin Gene Expression.J Biol Chem.2017,292(12):4811-4817.
9.Li X, Fu Z, Liang H, Wang Y, Qi X, Ding M, Sun X, Zhou Z, Huang Y, Gu H, Li L, Chen X, Li D, Zhao Q, Liu F, Wang H, Wang J, Zen K, Zhang CY.H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2.Cell Res.2018,28(2):157-171.
10.Chen D, Zuo Y, Zhang X, Ye Y, Bao X, Huang H, Tepakhan W, Wang L, Ju J, Chen G, Zheng M, Liu D, Huang S, Zong L, Li C, Chen Y, Zheng C, Shi L, Zhao Q, Wu Q, Fucharoen S, Zhao C, Xu X. A Genetic Variant Ameliorates beta-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet.2017,101(1):130-138.
11.Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q*. ?-globin expression is regulated by SUV4-20h1. Haematologica. 2016,101(5):e168-72.
12.Liu M, Huang F, Zhang D, Ju J, Wu XB, Wang Y, Wang Y, Wu Y, Nie M, Li Z, Ma C, Chen X, Zhou JY, Tan R, Yang BL, Zen K, Zhang CY, Chen YG, Zhao Q*. Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a. Cancer Res.2015, 75(21): 4593-604.
13.Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T,Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.WDR5Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.Cancer Res. 2015, 75(23):5143-54.
14.Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q*. Human fetal globin gene expression is regulated by LYAR.Nucleic Acids Res.2014, 42(15):9740-52.
15.He Y, Rank G, Zhang M, Ju J, Liu R, Xu Z, Brown F, Cerruti L, Ma C, Tan R,Jane SM,Zhao Q*.Induction of human fetal hemoglobin expression by adenosine-2’,3’-dialdehyde.J Transl Med.2013, 11(1):14.
16.Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson R, Moritz R, Jane S,Zhao Q*. The role of WDR5in silencing human fetal globin gene expression. Haematologica.2012, 97(11), 1632-40
17.Rank G, Cerruti L, Moritz RL, Simpson RJ, Jane SM, Zhao Q*.Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood.2010, 116(9):1585-92
18.Zhao Q*, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009, 16(3):304-11
19.Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q,Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM. Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis.Cancer Cell. 2011, 20(5):635-48.
20.Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM. Epidermal wound repair is regulated by the planar cell polarity signaling pathway.Dev Cell. 2010, 19(1):138-47.
21.Zhao Q, Zhou WL, Rank G, Sutton R, Wang X, Cumming H, Cerruti L, Cunningham JM, and Jane SM. Repression of human {gamma}-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood.2006, 107 (5):2138-45.
22.McCormack MP, Hall MA, Schoenwaelder SM, Zhao Q, Ellis S, Prentice JA, Clarke AJ, Slater NJ, SalmonJM, Jackson SP, Jane SM, and Curtis DJ. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood. 2006, 108(7):2248-56.
23.Bosè F, Fugazza C, Casalgrandi M, Capelli A, Cunningham JM, Zhao Q, Jane SM, Ottolenghi S, and Ronchi A. Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters. Mol Cell Biol, 2006, 26(10): 3942-3954.
24.Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM. Site-specific Acetylation of the Fetal Globin Activator NF-E4 Prevents Its Ubiquitination and Regulates Its Interaction with the Histone Deacetylase, HDAC1. J Biol Chem.2004, 279(40):41477-86.
25.Zhao Q^#, Zhou W^#, Sutton R, Cumming H, Wang X, Cerruti L, Hall M, Wu R, Cunningham JM, Jane SM. The role of p22 NF-E4 in human globin gene switching. J Biol Chem.2004, 279(25):26227-32. (^#denotes equal contribution)
26.Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells.EMBO J.2002, 21(17):4411-9.