姜晓宏 副教授





办公电话：
邮政编码： 210023

联系地址： 生科院B325-2
电子邮件： xiaohongjiang@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
姜晓宏，生命科学学院，副教授，硕士生导师。2006年于南京大学化学化工学院获学士学位，2011年于南京大学生命科学学院获博士学位，并于博士期间在美国加州大学伯克利分校公共卫生学院学习研究。2011-2014年作为助理研究员在南京大学生命科学学院从事研究工作，2014年起担任南京大学副教授。任江苏省生理科学会青年委员。

学术兼职
江苏省生理科学会青年工作委员。


研究方向

从事哺乳动物代谢性疾病的研究，尤其是肥胖导致的Ⅱ型糖尿病和心血管疾病。主要是从转录和转录后加工水平对线粒体的功能进行研究，从线粒体的生理功能到病理转变的全新角度，解释多种代谢性疾病潜在的分子生物学机制与联系。对各种代谢性疾病，尤其是肥胖引起的代谢综合症，从回复线粒体功能，恢复机体能量平衡的角度寻找新的更有效治疗途径和药物靶点。
1）肥胖与2型糖尿病的分子机制
2）心血管疾病的分子机制与治疗
3）肿瘤恶病质对机体代谢的影响及治疗



获奖情况
2011年，高等学校科学研究优秀成果奖自然科学一等奖


科研成果
代表性论文：
Gain of metabolic benefit with ablation of miR-149-3p from subcutaneous adipose tissue in diet-induced obese mice. Mol Ther Nucleic Acids. 2019 Dec 6; 18:194-203. Zheng S, Guo S, Sun G, Shi Y, Wei Z, Tang Y, He F, Shi C, Dai P, Chong H, Samuelson I, Zen K, Zhang CY, Zhang Y, Li J, Jiang X.
The potential atheroprotectiverole of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J NutrBiochem. (2018) Jul; 57: 197-205. HouD, He F, Ma L, Cao M, Zhou Z, Wei Z, XueY, Sang X, Chong H, TianC, ZhengS, Li J, Zen K, Chen X, Hong Z, Zhang CY, Jiang X.
The Jun/miR-22/HuRregulatory axis contributes to tumorigenesisin colorectal cancer. MolCancer. (2018) Jan 19; 17(1):11. Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, Zhao C, Ding M, Sun W, Liu Z, Sun F, Zhang C, Zhou Z, Jiang, X, Chen X.
Characterization of serum miRNAsas molecular biomarkers for acute Stanford type A aortic dissection diagnosis. SciRep. (2017) Oct 20; 7(1):13659. XuZ, Wang Q, Pan J, Sheng X, HouD, Chong H, Wei Z, ZhengS, XueY, Zhou Q, Cao H, Zhang CY, Wang D, Jiang X.
Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nature Communications. (2016)May 31; 7:11533. Ding H, ZhengS, Garcia-Ruiz D, HouD, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY, Li J, Jiang X.
MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis.(2015)Aug; 241(2):671-81. XueY, Wei Z, Ding H, Wang Q, Zhou Z, ZhengS, Zhang Y, HouD, Liu Y, Zen K, Zhang CY, Li J, Wang D, Jiang X
Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell. (2015) Jun;6(6):391-6.Li J, Zhang Y, Li D, Liu Y, Chu D, Jiang X, HouD, Zen K, Zhang CY
Norathyriolreverses obesity- and high-fat-diet-induced insulin resistance through inhibition of PTP1B. Diabetologia. (2014) Oct; 57(10):2145-54.Ding H, Zhang Y, XuC, HouD, Li J, Zhang Y, PengW, Zen K, Zhang CY, Jiang X.
MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. Protein Cell. (2014) Cao M, NieW, Li J, Zhang Y, Yan X, Guan X, Chen X, Zen K, Zhang CY, Jiang X, HouD
Directing RNaseP-mediated cleavage of target mRNAs by engineered externalguide sequences in cultured cells. Methods MolBiol. (2014) 1103:45-56. Jiang X, SunkaraN, Lu S, Liu F. （专著）
Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J BiolChem. (2014) Mar 21; 289(12):8432-41. Shi L, Zhang Q, XuB, Jiang X, Dai Y, Zhang CY, Zen K
miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signallinginhibitor 1. EurJ Cancer. (2014) Mar; 50(5):1013-24. Cao M, HouD, Liang H, Gong F, Wang Y, Yan X, Jiang X, Wang C, Zhang J, Zen K, Zhang CY, Chen X.
The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoSPathog. (2013) Aug; 9(8):e **. Dai X, Yu X, Gong H, Jiang X, AbenesG, Liu H, ShivakotiS, Britt WJ, Zhu H, Liu F, Zhou ZH.
Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J BiolChem. (2013) Aug 9; 288(32):23586-96. Li J, Zhang Y, Liu Y, Dai X, Li W, CaiX, Yin Y, Wang Q, XueY, Wang C, Li D, HouD, Jiang X, Zhang J, Zen K, Chen X, Zhang CY.
Effective inhibition of cytomegalovirus infection by external guide sequences in mice. ProcNatlAcadSciUSA. (2012) Aug 7; 109 (32):13070-5. Jiang X, Gong H, Chen YC, Vu GP, TrangP, Zhang CY, Lu S, Liu F.
RibonucleaseP-mediated inhibition of human cytomegalovirus gene expressionand replication induced by engineered external guide sequences. RNA Biol. (2012) Sep 9 (9):1186-95. Jiang X,Chen YC, Gong H, TrangP, Lu S, Liu F.