李建梅 副教授





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联系地址： 南京市仙林大道163号南京大学
电子邮件： lijm@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
2011/01 - 至今，南京大学，生命科学学院，副教授
2015/05 - 2016/05，美国华盛顿大学医学院，访问****
2008/12 - 2010/12，南京大学，生命科学学院，讲师
2006/09 - 2008/12, 南京大学，生命科学学院，博士后


学术兼职
1. 中国药理学会会员
2. 《中国天然药物》(The Chinese Journal of Natural Medicines, CJNM)青年编委


研究方向
1. 代谢性疾病及抑郁症的发病机制及中药干预；
2. 代谢紊乱引起中枢神经系统损伤的分子机制及药物干预；
3. 肠道菌群对中枢神经系统的影响及机制。



获奖情况
2012年获得江苏省“六大人才高峰”高层次人才项目


科研成果
1. Song L#, Chen TY#, Zhao XJ, Xu Q, Jiao RQ, Li JM[李建梅] *, Kong LD*. Pterostilbene prevents hepatocyte EMT in fructose‐induced liver fibrosis through suppressing miR‐34a/Sirt1/p53 and TGF‐β1/Smads signaling. British Journal of Pharmacology. Br J Pharmacol. 2019, in press.
2. Li JM[李建梅], He X, Yang Y, Li M, Xu C, Yu R. Risk assessment of silica nanoparticles on liver injury in metabolic syndrome mice induced by fructose. Sci Total Environ. 2018; 628-629:366-374.3. Xu MX, Yu R, Shao LF, Zhang YX, Ge CX, Liu XM, Wu WY, Li JM[李建梅] *, Kong LD*. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain Behav Immun. 2016, S0889-1591(16)30001-0. 6.3
4. Ge CX, Yu R, Xu MX, Li PQ, Fan CY, Li JM[李建梅]*, Kong LD*. Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARαpathway and alleviating ER stress in rats. Eur J Pharmacol. 2016; 770:154-64.5. Li JM[李建梅], Ge CX, Xu MX, Wang W, Yu R, Fan CY, Kong LD*. Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Mol Nutr Food Res. 2015, 59(2):189-202. 5.1
6. Fan CY, Wang MX, Ge CX, Wang X, Li JM[李建梅]*, Kong LD*. Betaine supplementation protects against high-fructose-induced renal injury in rats. J Nutr Biochem. 2014, 25(3):353-62.
7. Li JM[李建梅], Wang W, Fan CY, Wang MX, Zhang X, Hu QH, Kong LD*. Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation. Evid Based Complement Alternat Med. 2013, 2013:303902.
8. Li JM[李建梅], Zhang X, Wang X, Xie YC, Kong LD. Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice. Eur J Pharmacol. 2011, 666(1-3):196-204.
9. Li JM[李建梅], Li YC, Kong LD*, Hu QH. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology. 2010, 51(5): 1555-1566.
10. Li JM[李建梅], Che CT, Lau CBS, Leung PS and Cheng HK*. Desoxyrhaponticin inhibits glucose uptake in the intestine and kidney: a potential agent in the control of postprandial hyperglycemia. J Pharmacol Exp Ther. 2007, 320(1): 38-46.
11. Li JM[李建梅], Che CT, Lau CBS, Leung PS and Cheng HK*. Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin. Int J Biochem Cell B. 2006 (38): 985-995.
12. Li JM[李建梅], Kong LD*, Wang YM, Cheng HK, Zhang WY and Tan WZ. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci. 2003, 74(1): 55-73. Models