殷武 教授 博士生导师





办公电话：
邮政编码： 210093

联系地址：
电子邮件： wyin@nju.edu.cn








个人简介
研究方向
科研成果





个人简介


学术兼职
江苏省生物化学与分子生物学学会理事
世界中医药学会-中药免疫学学会理事
中国药理学会、江苏省药理学会会员
江苏省科技咨询专家
《中国药理学报APS》《生化药理学BP》等多种SCI期刊审稿人
南京大学硕士生导师
中国科协“分子影像技术在药物研发中的作用” 青年科学家论坛执行主席
国家级\教育部科技奖励评审专家
中国博士后基金\国家自然科学基金\霍英东基金评审专家
南京科技创新领军人才


研究方向
??生化与分子药理学、细胞生物学、生物化学与分子生物学
1：钠钾ATP酶及其配体的新生物学功能研究
Na,K-ATPaseisaubiquitousionpumpacrossmembrane,inrecentyears,increasingevidencerevealsthatbesidesion-pumpingactivity,thisiontransporterisalsoactivelyinvolvedinmanypatho-physiologicalregulationviamultiplesignalingpathway.Furthermore,theendogenousNa,K-ATPaseinhibitorsareseparatedandidentifiedfromhumanserumorurine,butthebiologicalfunctionoftheseactivecomponentsremainselusive.OurcurrentprojectistoexplorethenovelbiologicalfunctionofNa,K-ATPaseaswellasitsinhibitorsincancerorinflammation.
2：炎症因子mRNA转录后水平调控机制及其在药物筛选中的应用价值
Thepost-transcriptionalregulationofinflammatorycytokinesplaysacriticalroleinavarietyofimmuneregulation,whichallowsthecellstoelaboratelycontroltheprogressionofimmunereaction.ManystrategiesareadoptedbycellstoregulatecytokinesmRNAturnover,suchasmiRNAorRNAbindingproteins(RBPs).Amongthem,wepayspecialattentiontoRBPssuchasHuR,andtrytouncoverthenovelfunctionoftheseRBPsincontrollingcytokinesmRNAturnover.WearealsointerestedinthespecialintercellularorganellesthatareresponsibleformRNAreprogramming.Basedonthesemechanisms,weexpecttoscreenanti-inflammatoryherbalmedicineextracts,andtoidentifynewchemicalsandnovelmechanisms.
3：小分子抗肿瘤或增敏剂活性物质的寻找与机制研究
Ithaslongbeenrecognizedthatnotallcancercellsaresensitivetoacertainchemotherapeuticdrug,suchasAs2O3.Inviewofthisdeficiency,toincreasetumorcellssensitivitytowardsanti-tumordrugshasbecomeaheattopic.Weshowgreatinterestinlookingforsmallmoleculesthatcansignificantincreasecancercellssensitivitytowardstumor-targetingdrugsfromthelibraryofthenatureproducts,andexpecttoidentifythepromisingdrugtargetforcancertherapy.
4:中药抗肿瘤分子药理学
Theherbalmedicinehasmadegreatcontributiontothediscoveryofnewanti-cancerdrug.Recently,manychemicalsforherbalmedicinehaveshownsignificantanti-tumoreffect,butthemolecularmechanismsremainnotfullyunderstood.Onthisproject,weexpecttoidentifythemechanismsofsomeofthesenaturalproductsbymultiplemolecularaswellascellularapproaches.



获奖情况
教学
2010年 南京大学 “中国银行奖教金”

科研
2006 南京大学青年骨干教师培养对象
2009 中国药理学会生物化学与分子药理学优秀论文一等奖
2009 中国药理学会“施维雅”青年药理学工作者奖
2009 法国驻华领事“优秀科技创新”人才奖
2010 江苏省“青蓝工程”学术骨干
2010 中国药理学会临床药理学会议青年优秀论文一等奖
2011 教育部新世纪优秀人才
2011 江苏省“333”工程中青年科学技术带头人
2012 南京市创新型科技领军人才


科研成果
论文
1. Cao D, Bian JJ, Hua ZC, Ma L, Chen W, Cheng S, Sun W, Jiao QC, and Yin W*. Modulation of TNF-a mRNA Stability by Human Antigen R and miR181s in Sepsis-Induced Immunoparalysis. EMBO mol Med. 2014 DOI - 10.15252/emmm. (5 year IF: 9.186)

2. Yin W, Cheng W, Shen W, Shu L, Zhao J, Zhang J, Hua ZC. Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide. Leukemia. 2007; 21: 1669-78.(IF: 10.132)

3. Yin, W, Sonia, D., & Zhou, X. H2O2 is necessary but not sufficient to the stimulatory effect of low K on the Na,K-ATPase. J. Am. Soc. Nephrol. 2002;13:482. (IF:9.466)

4. Feng S, Chen W, Cao D, Gong FY, Cheng W, Chen S, Xu Q, Hua ZC, Yin W*.(2011) Involvement of Na,K-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells. Cell & Mol. Life Sci 68（1）：109-24 (IF:7.1)

5.Shi YL, Feng S, Chen W, Hua ZC, Bian JJ, Yin W*.Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms. Cell Death Dis. 2014 Dec 18;5:e1579. doi: 10.1038/cddis.2014.547. (IF: 6.1)

6. Chen W., Ma L, Feng S, Cao D, Hua ZC, and Yin W. General Control Non-Depressing Kinase 2 Generates Auto-Amplification Loop in Cancer Cell Apoptosis by Posttranslational Mechanisms. Molecular biology of the Cell. 2015 （accepted）(5-year IF: 5.1)

7. Yin W, Li X, Feng S, Cheng W, Tang B, Shi YL, Hua ZC. Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism. Biochem Pharmacol. 2009; 78: 191-202. (IF:4.9)

8. Deng X, Yin F, Lu X, Cai B, Yin W*. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. Toxicol Sci. 2006; 91: 59-69.（IF:4.7)

9. Yin W*, Yin FZ, Shen WX, Cai BC, Hua ZC. Requirement of hydrogen peroxide and Sp1 in the stimulation of Na,K-ATPase by low potassium in MDCK epithelial cells. Int J Biochem Cell Biol. 2008; 40: 942-53. (IF:4.9)

10. Yin W*, Deng XK, Yin FZ, Zhang XC, Cai BC. The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells. Food Chem Toxicol. 2007; 45: 1700-8.

11. Yin W, Deng XK, Li WD, Yin FZ, Lu XY, Zhang XC, Hua ZC, Cai BC. The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism. J Ethnopharmacol. 2006; 106: 179-86.

12. Yin W, Wang TS, Yin FZ, Cai BC. Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica. J Ethnopharmacol. 2003; 88: 205-14.

13. Yin FZ#, Yin W#, Zhang X,Lu TL, Cai BC. Development of an HPLC fingerprint for quality control and species differentiation of Fructus schisandrae Acat chromatographia 2010;22(4):609-621. 共同第一作者

14. Yin W, Jiang G, Takeyasu K, Zhou X. Stimulation of Na,K-ATPase by low potassium is dependent on transferrin. J Membr Biol 2003;193:177-84.

15. Yin W, Cai BC. Role of transferrin in the stimulation of Na,K-ATPase induced by low K+ in Madin Darby canine kidney cells. Acta. Physiol. Sin. 2003; 55: 481-6. (IF:0.6)

16. Yin, W, Yin, FZ., & Cai BC, The mechanism of cytotoxicity of human embryonic kidney cells induced by brucine. Chin. J. Pharmacol. & Toxicol. 2003,17(5):321-327

17. Yin FZ, Lu TL, Cai BC, and Yin W*. Development of a quality control method for Schisandrae chinensis fructus with micellar electrokinetic capillary chromatography. Acta pol. Pharm. 2014 accepted.

18. Yin FZ, Lu TL, Li L, Cai BC, and Yin W*. Quality control of Gardeniae Fructus by HPLC-PDA fingerprint coupled with chemometric methods. Journal of chromatographic science. 2014 accepted

19. Shu L, Yin W, Zhang J, Tang B, Kang YX, Ding F, Hua ZC. Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis. Cell Biol Int. 2007; 31: 784-9.

20. Li S, Dong W, Zong Y, Yin W, Jin G, Hu Q, Huang X, Jiang W, Hua ZC. Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther. 2007; 15: 515-23.

专著
《酶的凝胶电泳检测手册》化学工业出版社 编委
《药食本草》中国中医药科技出版社 副主编
《基因工程实验创新教材》 知识出版社 主编

专利
1. ZL8.9，第一发明人
2. ZL.1，第一发明人
3. ZL7.4，第一发明人
4．蟾蜍甾二烯类化合物在制备治疗脓毒症免疫麻痹药物中的用途,2.2，第一发明人
5．强心甾类化合物在制备治疗脓毒症免疫麻痹药物中的用途，6.3 ，第一发明人
6．miR181s在制备治疗急性肠炎药物中的应用，6.2，第一发明人
7．一种用于治疗脓毒症急性肺损伤的小核酸药物，6.X ，第一发明人
8．以NLRP3为靶点的药物筛选细胞模型及其应用，9.9 ，第一发明人
9．他克莫斯FK506在制备治疗非小细胞肺癌药物中的应用，8.7，第一发明人
10．一种五味子有机酸分析方法，7.3，第二发明人
11．4-氧代戊酸在制备止泻药物中的用途，8.8，第二发明人