孙少琛 详细介绍
性别 男
职称 教授
最高学历 博士
毕业院校 韩国忠北国立大学 Chungbuk National University
专业领域 生殖生物学 Reproductive Biology
联系方式 E-mail: sunsc@njau.edu.cn; 电话:
研究方向 配子生物学、生殖毒理学
参加学术团体
及任职情况 孙少琛，南京农业大学动物科技学院教授、博士生导师，国家优秀青年基金获得者、江苏省****基金获得者、教育部霍英东青年教师奖获得者、江苏省333人才工程中青年带头人、江苏省优秀博士学位论文指导教师。山东省招远市人，2006年毕业于东北农业大学；2009年中科院动物所/广西大学联合培养，提前一年获得硕士学位；2012年2月毕业于韩国忠北国立大学，提前半年获得博士学位。2012年3月南京农业大学高层次人才引进回国工作。研究方向为哺乳动物卵子成熟的影响因素及分子调控机制。已发表SCI 论文100多篇，承担国家重点研发计划、国家重点基础研究计划、国家自然科学基金等10多项课题。Sci Rep、PLoS ONE、PeerJ杂志学术编辑，J Anim Sci Biotechnol与生物技术通报杂志编委，EMBO J、J Cell Sci、Hum Reprod、Biol Reprod等40多种SCI 国际期刊及数种中文核心期刊审稿人，中国畜牧兽医学会高级会员，中国动物学会生殖生物学会理事，中国动物学会细胞与分子显微技术学会常务理事、中国生理学会生殖发育委员会委员，江苏省细胞与发育生物学会生殖专业委员会委员。
承担项目 已结题973项目、国家自然科学基金等项目11项，目前在研课题：国家重点研发计划（2018YFC**，2018YFC**)。
奖励及荣誉 2018 教育部自然科学二等奖（2/5）2018 教育部霍英东青年教师奖2016 国家优秀青年基金获得者；2016 江苏省优秀博士学位论文指导教师；2015 中国生殖生物学会首届青年科技奖；2014 江苏省****基金获得者; 2011 国家优秀自费留学生; 2011 计生委科技进步一等奖；
论文论著
实验室概况 Our Lab
实验室团队现有教授1名（孙少琛），讲师1名（张羽），博士生4名，硕士研究生9名。实验室研究生有12人次获得校长奖学金、国家优秀研究生奖学金；1人次获得江苏省优秀博士学位论文；3人次获校优秀博/硕士学位论文；1人次获南农好榜样荣誉；3人次获国际会议优秀海报奖；研究生前往泰国、越南等地参加国际会议，并做会议报告3人次。实验室承担本科2年级国家级SRT项目、本科4年级毕业设计等多项，指导本科生获得校优秀毕业设计特等奖、一等奖各1项。
实验室在Development、Hum Reprod、Biol Reprod、Archi Toxicol 等学科权威期刊已发表SCI 论文100多篇，其中第一/通讯作者SCI 论文70多篇。研究成果在Cell Cycle、Mol Hum Reprod、Biol Cell等获得编辑和同行专家特邀评论、8篇研究论文当选为当期杂志封面文章，被多本英文著作如Oogenesis收录并介绍，并做WCRB，ARBS等多个国际大会特邀报告。

研究生招生就业情况：实验室学术型与专业型硕士均招收，方向偏重基础研究，毕业生倾向于医院和高校就业。毕业博士/出站博士后共7人（5人高校工作，2人事业单位工作）；已毕业硕士13人（8人英国澳洲韩国等攻读博士学位，5人企事业单位）。

研究概况 Our Research
本课题组的研究重点在哺乳动物卵子质量的影响因素和分子调控机制。卵子质量的下降会引起受精或者胚胎发育失败，直接关系到动物生产的经济效益，也是导致人类生殖障碍的重要因素。影响卵子质量的因素主要分为内部和外部两个方面。内部因素主要是卵子成熟的自身分子调控，包括细胞周期、细胞骨架及线粒体功能等生物学时间；外部因素主要是环境因素影响，包括饲料毒性、温度、应激等。本实验室具体的研究方向为：
1）卵母细胞成熟过程中细胞骨架的分子调控
卵母细胞生发泡破裂后，染色质凝集成染色体，微管在附近组装形成纺锤体并牵引染色体在中央排列。微丝推动纺锤体/染色体迁移到卵母细胞的皮层下，染色体分离，通过不均等分裂形成一个大的卵子和一个小的极体。纺锤体组装与染色体分离保证了遗传物质的稳定和准确性，微丝介导的不均等分裂为受精和早期胚胎发育保留母系物质。因此，探清微丝对卵子成熟的分子调控机制对于卵子质量控制和预防生殖缺陷是非常重要的。
课题组的工作证明GTP酶家族RhoA主导的ROCK-LIMK-Cofilin、以及微丝聚合因子家族NPFs-Arp2/3信号通路调控微丝骨架动力学变化参与卵母细胞中微丝介导的纺锤体迁移和胞质分裂，Arp2/3通路已被收录入Oogenesis等英文著作中。我们的结果揭示了GTP酶家族、微丝聚合因子等两大类微丝骨架调控因子在卵子中的作用，提出了控制卵子不均等分裂的Arp2/3和RhoA主导的两条信号通路。
2）环境对卵子质量的危害及机制
近年来国内食品环境安全问题频发，女性生殖障碍相关问题日益增多；在家畜养殖中发霉饲料中霉菌毒素则造成家畜流产死胎等现象，极大影响了家畜生产的经济效益。对于人类及家畜出现的各种繁殖问题，卵子质量下降是重要原因之一。研究环境毒素对于卵子质量的影响，有利于为防治这一问题提供理论基础。
近期实验室采用体内/体外模型，报道了摄食含有霉菌毒素饲料的小鼠和猪的卵子质量下降，发育能力、亚细胞结构分布和定位均发生异常。我们证明霉菌毒素能够诱发卵子氧化应激，从而导致卵子发生细胞凋亡和自噬； 此外，霉菌毒素处理改变了卵子DNA和组蛋白甲基化的水平可能是霉菌毒素对卵子毒性的另外一个原因。此外，褪黑素的添加能够有效缓解氧化应激水平，挽救霉菌毒素造成的毒性损伤。实验室同时也研究三聚氰胺，丙烯酰胺，双酚A等环境污染物对卵子的毒性损伤。


2020
1. Sun MH, Li XH, Xu Y, Xu Y, Sun SC*. Exposure to PBDE47 affects mouse oocyte quality via mitochondria dysfunction-induced oxidative stress and apoptosis. Ecotoxicol Environ Saf. 2020. 198:110662
2. Sun MH, Li XH, Xu Y, Xu Y, Pan ZN, Sun SC*. Citrinin exposure disrupts organelle distribution and functions in mouse oocytes. Environ Res. 2020. 185:109476.
3. Pan MH, Wan X, Wang HH, Pan ZN, Zhang Y, Sun SC*. FMNL3 regulates FASCIN for actin-mediated spindle migration and cytokinesis in mouse oocytes. Biol Reprod. 2020.
4. Lan M, Zhang Y, Wan X, Pan MH, Xu Y, Sun SC*. Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes. Environ Pollut. 2020, 256:113374.
5. Wang QC, Wan X, Jia RX, Xu Y, Liu X, Zhang Y, Sun SC*. Inhibition of N-WASP affects actin-mediated cytokinesis during porcine oocyte maturation. Theriogenology. 2020, 144:132-138.
2019
1.Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC*. Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development. 2019
2.Pan ZN, Lu Y, Tang F, Pan MH, Wan X, Lan M, Zhang Y, Sun SC*. RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis. Biol Reprod. 2019.
3.Duan X, Sun SC*. Actin cytoskeleton dynamics in mammalian oocyte meiosis. Biol Reprod. 2019.
4. Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC*. RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis. Mol Hum Reprod. 2019, 25:359-372
5. Zhang L#, Li L#, Xu J, Pan MH, Sun SC*.HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo development. Reprod Toxciol. 2019
6.Zhang Y, Wu LL, Wan X, Wang HH, Li XH, Pan ZN, Sun SC*. Loss of PKC mu function induces cytoskeletal defects in mouse oocyte meiosis. J Cell Phyisol. 2019
7.Ou XH, Zhu CC, Sun SC*. Effects of obesity and diabetes on the epigenetic modification of mammalian gametes. J Cell Physiol. 2019
8. Xu Y, Zhang KH, Sun MH, Lan M, Wan X, Zhang Y, Sun SC*. Protective effects of melatonin against zearalenone toxicity on porcine embryos in vitro. Front Pharmacol. 2019, 10:327

2018
1.Zhang Y, Wang T, Lan M, Zang XW, Li YL, Cui XS, Kim NH, Sun SC*. Melatonin protects oocytes from MEHP exposure-induced meiosis defects in porcine. Biol Reprod. 2018. 98(3):286-98 (IF=3.5)
2.Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. BBA-Mol Cell Res. 2018, 1865(2):455-462. (IF=5.3)(入选BBA collection)
3.Lan M, Han J, Pan MH, Wan X, Pan ZN, Sun SC*. Melatonin protects against defects induced by deoxynivalenol during mouse oocyte maturation. J Pineal Res. 2018. E12477 (IF=11.8)
4.Zhang Y, Wang HH, Wan X, Xu Y, Pan MH, Sun SC*. Inhibition of protein kinase D disrupts spindle formation and actin assembly during porcine oocyte maturation. Aging. 2018; 10(12):3736-44.
5.Tang F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC*. Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis. Cell Div. 2018, 13:8. (IF=4.6)
6.Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. J Cell Physiol. 2018. 233(3):2270-78.（封面文章）(IF=4.1)
7.Duan X, Zhang Y, Chen KL, Zhang HL, Wu LL, Liu HL, Wang ZB, Sun SC*. The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis. J Cell Physiol. 2018. 233(8):6088-97. (IF=4.1)
8.Lu Y, Zhang Y, Liu JQ, Zou P, Jia L, Su YT, Sun YR, Sun SC*. Comparison of the toxic effects of different mycotoxins on porcine and mouse oocyte meiosis. PeerJ. 2018.
9.Duan X, Zhang HL, Wu LL, Liu MY, Pan MH, Ou XH*, Sun SC*. Involvement of LIMK1/2 in actin assembly during mouse embryo development. Cell Cycle. 2018 （封面文章）
10.Wan X, Zhang Y, Lan M, Pan MH, Tang F, Zhang HL, Ou XH*, Sun SC*. Meiotic arrest and spindle defects are associated with altered KIF11 expression in porcine oocytes. Environ Mol Mutagen. 2018
11.Tang F, Pan MH, Lu Y, Wan X, Zhang Y, Sun SC*. Involvement of Kif4a in spindle formation and chromosome segregation in mouse oocytes. Aging Dis. 2018. (IF=5.8)
12.Liu J, Wang QC, Duan X, Cui XS, Kim NH, Zhang Y, Sun SC*. Profilin 1 plays feedback role on actin-mediated polar body extrusion in mouse oocytes. Reprod Fertil Dev. 2018. 30(5):752-58.
13.Cao Y, Shen M, Jiang Y, Sun SC, Liu H. Melatonin reduces oxidative damage in mouse granulosa cells via restraining JNK-dependent autophagy. Reproduction. 2018 Mar;155(3):307-319
2017
1.Lu Y, Zhang Y, Pan MH, Kim NH, Sun SC*, Cui XS*. Daam1 regulates fascin for actin assembly in mouse oocyte meiosis. Cell Cycle. 2017 Jul 18;16(14):1350-1356.（封面文章）
2.Shen M*, Jiang Y, Guan Z, Cao Y, Li L, Liu H*, Sun SC*. Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy. Autophagy. 2017 Jun 9:1-22 (IF=11.2)
3.Zhang Y, Wang QC, Liu J, Xiong B, Cui XS, Kim NH, Sun SC*. The small GTPase CDC42 regulates actin dynamics during porcine oocyte maturation. J Reprod Dev. 2017
4.Zhang Y, Jia RX, Pan MH, Lu Y, Cui XS, Kim NH, Sun SC*. HT-2 toxin affects development of porcine parthenotes by altering DNA and histone methylation in oocytes matured in vitro. Theriogenology. 2017; 103:110-116.
5.Wu BJ, Zhao LX, Zhu CC, Chen YL, Wei MY, Bao SQ, Sun SC*, Li XH*. Altered apoptosis/autophagy and epigenetic modifications cause the impaired postimplantation octaploid embryonic development in mice. Cell Cycle. 2017; 16(1):82-90
6.Li X, Liu X, Gao M, Han L, Qiu D, Wang H, Xiong B, Sun S, Liu H, Gu L. HDAC3 promotes meiotic apparatus assembly in mouse oocytes via modulating tubulin acetylation. Development. 2017
7.Shen M, Jiang Y, Guan Z, Cao Y, Sun SC, Liu H*. FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Sci Rep. 2016 Nov 30;6:38090
2016
1.Jia RX, Duan X, Song SJ, Sun SC*. LIMK1/2 inhibitor LIMKi 3 suppresses polar body extrusion during porcine oocyte maturation. PeerJ. 2016; 4:e2553.
2.Song SJ, Wang QC, Jia RX, Cui XS, Kim NH, Sun SC*. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3; 6:34415.
3.Zhang Y, Han J, Zhu CC, Tang F, Cui XS, Kim NH, Sun SC*. Exposure to HT-2 toxin causes oxidative stress induced apoptosis/autophagy in porcine oocytes. Sci Rep. 2016 Sep 23;6:33904
4.Wang T, Han J, Duan X, Xiong B, Cui XS, Kim NH, Liu HL, Sun SC*. The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro. Oncotarget. 2016;7(22):32554-32565.
5.Han J, Wang QC, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC*. Deoxynivalenol exposure induces autophagy/apoptosis and epigenetic modification changes during porcine oocyte maturation. Toxicol Appl Pharmacol. 2016. 300:70-76 （IF=3.85）
6.Zhu CC, Zhang Y, Duan X, Han J, Sun SC*. Toxic effects of HT-2 toxin on mouse oocytes and its possible mechanisms. Arch Toxicol. 2016; 90(6): 1495-1505 (IF=6.64)
7.Hou YJ, Zhu CC, Duan X, Liu HL, Wang Q, Sun SC*. Both diet and gene mutation induced obesity affect oocyte quality in mice. Sci Rep. 2016. 6:18858
8.Duan X, Liu J, Zhu CC, Wang QC, Cui XS, Kim NH, Xiong B, Sun SC*. RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis. Cell Cycle. 2016. 15(3):471-7.
9.Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol. 2016, 23(5):387-94 (IF=13.3)
10.Huang XJ, Ma X, Wang X, Zhou X, Li J, Sun SC, Liu H. Involvement of G9A-like protein (GLP) in the development of mouse preimplantation embryos in vitro. Reprod Fertil Dev. 2016 , 28:1733-1740.
11.Liu X, Li X, Ma R, Xiong B, Sun SC, Liu H, Gu L. Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation. Oncotarget. 2016, 7(33):53330-53338.
12.Dai XX, Zhang M, Lu Y, Miao Y, Zhou C, Sun S, Xiong B*. Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Oncotarget. 2016 7(21):30155-65.
13.Shen M, Jiang Y, Guan Z, Cao Y, Sun SC, Liu H. FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Sci Rep. 2016;6:38090
2015
1.Duan X, Wang QC, Chen KL, Zhu CC, Liu J, Sun SC*. Acrylamide toxic effects on mouse oocyte quality and fertility in vivo. Sci Rep. 2015; 5:e11562 (IF=5.58)
2.Duan X, Wang T, Dai XX, Liu HL, Sun SC*. Melamine negatively affects oocyte architecture, oocyte development and fertility in mice. Hum Reprod; 30(7):1643-52. (IF=4.58)
3.Liu J, Wang QC, Han J, Xiong B, Sun SC*. Aflatoxin B1 is toxic to porcine oocyte maturation. Mutagenesis 2015; 30(4):527-35. (IF=3.5)
4.Han J, Wang T, Fu L, Shi LY, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC*. Altered oxidative stress, apoptosis/autophagy, and epigenetic modifications in Zearalenone-treated porcine oocytes. Toxicol Res. 2015; 4:1184-94 (IF=3.98)(封面文章)
5.Wang F, Zhang L, Duan X, Zhang GL, Wang ZB, Wang Q, Xiong B, Sun SC*. RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis. Cell Cycle. 2015; 14(17):2835-43. (IF=5.01)（专题评论：Cell Cycle 14(18):2879-2880）(封面文章)
6.Zhang Y, Wang F, Niu YJ, Liu HL, Rui R, Cui XS, Kim NH, Sun SC*. Formin mDia1, a downstream molecule of FMNL1, regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis. BBA-Mol Cell Res. 2015; 1853:317-27 (IF=5.3)
7.Dai XX, Duan X, Cui XS, Kim NH, Xiong B, Sun SC*. Melamine induces oxidative stress in mouse ovary. PLoS ONE. 2015. e142564
8.Zhang Y, Zhu CC, Sun SC*. Cyclin B3: an anaphase onset controller in meiosis. Cell Cycle. 2015 14(19):3013.
9.Wang QC, Liu J, Duan X, Cui XS, Kim NH, Xiong B, Sun SC*. Dynamin 2 inhibitor Dynasore affects actin filament distribution during mouse early embryo development. J Reprod Dev. 2015;61(1):49-53 (IF=1.6)
10.Hou YJ, Zhu CC, Xu YX, Cui XS, Kim NH, Sun SC*. Zearalenone exposure affects mouse oocyte meiotic maturation and granulosa cell proliferation. Environ Toxicol. 2015; 30(10):1226-33 (IF=3.2)
11.Dai X, Zhang M, Lu Y, Miao Y, Zhou C, Sun SC, Xiong B. Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs. PLoS One. 2015 Dec 3;10(12):e**
12. Zhang L, Han L, Ma R, Hou X, Yu Y, Sun S, Xu Y, Schedl T, Moley KH, Wang Q.Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes. Cell Cycle. 2015;14(18):2959-68.
2014
1.Zhang Y, Duan X, Cao R, Liu HL, Cui XS, Kim NH, Rui R, Sun SC*. Small GTPase RhoA regulates cytoskeleton dynamics during porcine oocyte maturation and early embryo. Cell Cycle 2014; 13(21):3390-3403 (IF=5.01)
2.Shen M, Liu Z, Li B, Teng Y, Zhan J, Tang Y, Sun SC*, Liu H*. Involvement of Foxo1 in the effects of follicle stimulating hormone on inhibition of apoptosis in mouse granulosa cells. Cell Death & Disease. 2014 5:e1475.
3.Zhu CC, Hou YJ, Han J, Cui XS, Kim NH, Sun SC*. Zearalenone exposure affects epigenetic modifications of mouse eggs. Mutagenesis 2014;29(6):489-95
4.Zhu CC, Hou YJ, Han J, Liu HL, Cui XS, Kim NH, Sun SC*. Effect of mycotoxin-containing diets on epigenetic modifications of mouse oocytes by fluorescence microscopy analysis. Microsc Microanal. 2014; 24(4):1158-66.
5.Zhang Y, Wang QC, Han J, Cao R, Cui XS, Kim NH, Rui R, Sun SC*. Involvement of Dynamin 2 in actin-based polar body extrusion during porcine oocyte maturation. Mol Reprod Dev. 2014;81(8):725-34.
6.Duan X, Chen KL, Zhang Y, Cui XS, Kim NH, Sun SC*. ROCK inhibition prevents mouse early embryo development. Histochem Cell Biol. 2014; 142(2):227-233.
7.Wang F, Zhang L, Zhang GL, Wang ZB, Cui XS, Kim NH, Sun SC*. WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep. 2014; 4:5596
8.Wang QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC*. Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell. 2014; 106(6):193-202 (Cover Story).
9.Zhang Y, Duan X, Xiong B, Cui XS, Kim NH, Rui R, Sun SC*. ROCK inhibitor Y-27632 prevents porcine oocyte maturation. Theriogenology. 2014; 82(1):49-56
10.Duan X, Liu J, Dai XX, Liu HL, Cui XS, Kim NH, Wang ZB, Wang Q, Sun SC*. Rho-GTPase Effector ROCK Phosphorylates Cofilin in Actin-Meditated Cytokinesis During Mouse Oocyte Meiosis. Biol Reprod. 2014; 90(2):37.
11.Hou YJ, Xiong B, Zheng WJ, Duan X, Cui XS, Kim NH, Wang Q, Xu YX, Sun SC*. Oocyte quality in mice is affected by a mycotoxin-contaminated diet. Environ Mol Mutagen. 2014. 55(4):354-62.
12.Dai XX, Duan X, Liu HL, Cui XS, Kim NH, Sun SC*. Chk2 regulates cell cycle progression during mouse oocyte maturation and early embryo development. Mol Cells. 2014; 37(2):126-32.
13.Wang F, An GY, Zhang Y, Liu HL, Cui XS, Kim NH, Sun SC*. Arp2/3 complex inhibition prevents meiotic maturation in porcine oocytes. PLoS One. 2014 Jan 31;9(1):e87700
14.Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H, Sun QY. The Root of Reduced Fertility in Aged Women and Possible Therapeutic Options: Current Status and Future Perspects. Mol Aspects Med. 2013 38:54-85 (Review) (IF=10.2)
15.Zhang JQ, Shen M, Zhu CC, Yu FX, Liu ZQ, Ally N, Sun SC, Li K, Liu HL. 3-nitropropionic Acid induces ovarian oxidative stress and impairs follicle in mouse. PLoS One. 2014 Feb 5;9(2):e86589
16.Ma RJ, Yang XJ, Zhang L, Sun SC, Schedl T, Moley K, Wang Q*. Rab5a is required for spindle length control andkinetochore-microtubule attachment during meiosis in oocytes. FASEB J. 2014; 28(9):4026-35
17.Huang XJ, Wang X, Ma X, Sun SC, Zhou X, Zhu C, Liu H. EZH2 is essential for development of mouse preimplantation embryos. Reprod Fertil Dev. 2014 26(8):1166-75.
2013
1.Liu J, Wang QC, Cui XS, Wang ZB, Kim NH, Sun SC*. MKlp2 Inhibitior paprotrain affects Polar Body Extrusion during Mouse Oocyte Maturation. Reprod Biol Endocrinol. 2013;11(1):117.
2.Sun SC*, Kim NH*. Molecular mechanisms of asymmetric division in oocytes. Microsc Microanal. 2013. 19(4):883-97 (Review)
3.Hou YJ, Zhao YR, Xiong B, Cui XS, Kim NH, Xu YX, Sun SC*. Mycotoxin-containing diet causes oxidative stress in the mouse. PLoS ONE. 2013; e60374.
4.Wang QC, Liu J, Wang F, Duan X, Dai XX, Wang T, Liu HL, Cui XS, Kim NH, Sun SC*. Role of nucleation-promoting factors in mouse early embryo development. Microsc Microanal. 2013; 19(3):559-64
5.Sun SC*. Meiotic spindle assembly in a mouse oocyte. Mol Reprod Dev. 2013. 80(11):881.
6.Sun SC#, Wang XG#, Ma XS, Huang XJ, Li J, Liu HL. TBP dynamics during mouse oocyte meiotic maturation and early embryo development. PLoS ONE. 2013; e55425
7.Sun SC, Xu YN, Lee SE, Cui XS, Kim NH. Actin nucleator Arp2/3 complex is essential for early mouse embryo development. Reprod Fertil Dev. 2013; 25(4):617-623
8.Cui XS#, Sun SC#, Kang YK, Kim NH. Involvement of microRNA-335-5p in cytoskeleton dynamics in mouse oocytes. Reprod Fertil Dev. 2013; 25(4):691-699 (# Co-first author)
9.Cui XS, Shen XH, Sun SC, Cho SW, Heo YT, Kang YK, Wakayama T, Kim NH. Identifying MicroRNA and mRNA expression profiles in embryonic stem cells derived from parthenogenetic, androgenetic and fertilized blastocysts. J Genet Genomics. 2013;40(4):189-200
10.Liang XW, Cui XS, Sun SC, Jin YX, Heo YT, Namgoong S, Kim NH. Superovulation induces defective methylation in line-1 retrotransposon elements in blastocyst. Reprod Biol Endocrinol. 2013 11:69
2012
1.Liu J, Wang QC, Wang F, Duan X, Dai XX, Wang T, Liu HL, Cui XS, Kim NH, Sun SC*. Nucleation promoting factors regulate Arp2/3 complex in meiotic mouse oocyte. PLoS ONE. 2012; e52277
2.Sun SC*, Liu HL, Sun QY. Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis. Biochem Biophys Res Commun. 2012; 421(4):797-800
3.Sun SC, Kim NH. Spindle assembly checkpoint and its regulators in meiosis. Hum Reprod Update. 2012; 18(1):60-72. (Cover Story)
4.Sun SC#, Gao WW#, Xu YN, Jin YX, Wang QL, Yin XJ, Cui XS, Kim NH. Degradation of actin nucleators affects cortical polarity of mouse aged oocyte. Fertil Steril. 2012; 97(4):984-90
5.Lee SE, Sun SC, Choi HY, Uhm SJ, Kim NH. mTOR is required for asymmetric division through small GTPases in mouse oocytes. Mol Reprod Dev. 2012; 79(5):356-66
6.Wang QL, Sun SC, Han J, Kwak YC, Kim NH, Cui XS. Doxorubicin Induces Early Embryo Apoptosis by Inhibiting Poly(ADP ribose) Polymerase. In Vivo. 2012;26(5):827-34.
7.Jin YX, Cui XS, Yu XF, Lee HY, Wang QL, Gao WW, Xu YN, Sun SC, Kong KI, Kim NH. Cat fertilization by mouse sperm injection. Zygote. 2012; 20(4):371-8.
2011
85.Sun SC, Xu YN, Li YH, Lee SE, Jin YX, Cui XS, Kim NH. WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes. Cell Cycle. 2011; 10(11): 1853-60. (Commented in: Cell Cycle 2011; 10(18):3053)
86.Sun SC, Sun QY, Kim NH. JMY is required for asymmetric division and cytokinesis in mouse oocytes. Mol Hum Reprod. 2011; 17(5):296-304 (Cover Story) (Editor’s Choice) (Commented in: Mol Hum Reprod 2011;17(5):273-4)
87.Sun SC, Wang ZB, Lee SE, Xu YN, Cui XS, Kim NH. Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PLoS ONE. 2011; 6(4) e18392.
88.Sun SC, Zhang DX, Lee SE, Xu YN, Kim NH. Ndc80 regulates meiotic spindle organization, chromosome alignment, and the spindle assembly checkpoint in mouse oocytes. Microsc Microanal. 2011;17(3):431-9.
89.Sun SC, Kim NH. The polarity of mouse oocyte. Mol Reprod Dev. 2011; 78(8):551.
90.Sun SC*, Kim NH. GM130: New insights into oocyte asymmetric division. Cell Cycle. 2011; 10(15): 2419.
91.Lee SE, Hwang KC, Sun SC, Xu YN, Kim NH. Modification of autophagy and development during mouse embryo development. Mol Reprod Dev. 2011; 78(7):498-509
92.Zhang DX, Park WJ, Sun SC, Xu YN, Li YH, Cui XS, Kim NH. Regulation of maternal gene expression by MEK/MAPK and MPF signaling in porcine oocyte during in vitro meiotic maturation. J Reprod Dev. 2011; 57(1):49-56
93.Xu YN, Cui XS, Sun SC, Lee SE, Li YH, Kwon JS, Lee SH, Hwang KC, Kim NH. Mitochondrial dysfunction influences apoptosis and autophagy in porcine parthenotes developing in vitro. J Reprod Dev. 2011; 57(1):143-50
94.Xu YN, Cui XS, Sun SC, Lee SE, Kim NH. Cross species fertilization and development investigated by cat sperm injection into mouse oocytes. J Exp Zool A Ecol Genet Physiol. 2011; 315(6):349-57
95.Wang K, Jiang GJ, Wei L, Liang XW, Miao DQ, Sun SC, Guo L, Wang ZB, Lu SS. Survivin is a critical regulator of spindle organization and chromosome segregation during rat oocyte meiotic maturation. Zygote. 2011;19(4)307-313.
2008-2010
96.Sun SC, Lee SE, Xu YN, Kim NH. Perturbation of Spc25 expression affects meiotic spindle organization, chromosome alignment, and the spindle assembly checkpoint in mouse oocytes. Cell Cycle. 2010; 9(22):4552-9. (Commented in: Cell Cycle 2011;10(6):877-8; Cell Cycle 2011;10(7):1028-9)
97.Sun SC, Lin SL, Zhang DX, Lu SS, Sun QY, Kim NH. Borealin regulates bipolar spindle formation but may not act as chromosomal passenger during mouse oocyte meiosis. Front Biosci. 2010; 2:991-1000.
98.Sun SC, Wei L, Li M, Lin SL, Xu BZ, Liang XW, Kim NH, Schatten H, Lu SS, Sun QY. Perturbation of survivin expression affects chromosome alignment and spindle checkpoint in mouse oocyte meiotic maturation. Cell Cycle. 2009; 8(20):3365-72.
99.Sun SC, Xiong B, Lu SS, Sun QY. MEK1/2 is a critical regulator of microtubule assembly and spindle organization during rat oocyte meiotic maturation. Mol Reprod Dev. 2008; 75(10):1542-8.
100.Zhang DX, Li XP, Sun SC, Shen XH, Cui XS, Kim NH. Involvement of ER-Calreticulin-Ca2+ signaling in regulation of porcine oocyte meiotic maturation and maternal gene expression. Mol Reprod Dev. 2010;77(5):462-71.
101.Lin SL, Qi ST, Sun SC, Li M, Sun QY. PAK1 regulates microtubule organization and chromosome alignment during mouse oocyte meiotic maturation. Front Biosci. 2010; 2:1254-64.
102.Wei L, Liang XW, Zhang QH, Li M, Yuan J, Li S, Sun SC, Ouyang YC, Schatten H, Sun QY. BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. Cell Cycle. 2010; 9(6) 1112-21.
103.Li M, Li S, Yuan J, Wang ZB, Sun SC, Schatten H, Sun QY. Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. PLoS ONE. 2009;4(11):e7701.
104.Xiong B, Sun SC, Lin SL, Li M, Xu BZ, OuYang YC, Hou Y, Chen DY, Sun QY. Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis. Cell Cycle. 2008;7(12):1804-9.
105.Xiong B, Li S, Ai JS, Yin S, Ouyang YC, Sun SC, Chen DY, Sun QY. BRCA1 is required for meiotic spindle assembly and spindle assembly checkpoint activation in mouse oocytes. Biol Reprod. 2008;79(4):718-26.