学术学位博导
--> 职称：教授
单位：生物化学与分子生物学系
hanxiao@njmu.edu.cn
专业：生物化学与分子生物学
个人简介
韩晓，男，47岁，江苏省南京市人
发表论文:
SAD-A and AMPK kinases The “yin and yang” regulators of mTORC1 signaling in pancreatic β cells
Serotonin Receptor 2C and Insulin Secretion
Forkhead box O1 mediates defects in palmitate-induced insulin granule exocytosis by downregulation of calcium/calmodulin -dependent serine protein kinase expression in INS-1 cells
MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction.
SAD-A Potentiates Glucose-Stimulated Insulin Secretion as a Mediator of Glucagon-Like Peptide 1 Response in Pancreatic β Cells
Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines
Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation
Selection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage Display and Its Effects on Pancreatic Cancer Cell lines PANC-1 and CFPAC-1
Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreaticb-cells
AGEs Decrease Insulin Synthesis in Pancreaticb-Cell by Repressing Pdx-1 Protein Expression at the PostTranslational Level
教材专著:
科研成果:
炎症因子导致糖尿病和胰岛beta细胞功能损伤的机制研究
目前承担的科研项目:
SAD-A介导的mTORC1信号在代谢性疾病中调控胰岛β细胞功能和数量的作用
细胞应激介导脂代谢紊乱的分子生理学机制研究
ETS-1在糖尿病胰岛beta细胞功能障碍中的作用研究
江苏省人类功能基因组重点实验室建设
CASK在2型糖尿病胰岛B细胞胰岛素囊泡转运及分泌障碍中的作用及其机制研究
已经完成的科研项目:
江苏省糖尿病临床医学中心/重点学科建设
糖皮质激素通过FoxO1导致胰岛beta细胞功能障碍的信号转导机制的研究
胰岛素分泌异常的分子与细胞机制研究（973课题）
