学术学位博导
--> 职称：教授
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单位：生物化学与分子生物学系
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专业：生物化学与分子生物学
个人简介
主要从事糖、脂代谢调控的分子机制研究，集中在使用细胞和疾病动物模型研究肥胖，糖尿病和脂肪肝的发病机制，为治疗和预防脂肪代谢性疾病提供新的理论依据和潜在的药物靶蛋白。
发表论文:
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.
Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb.
Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation.
Cideb, an ER-and lipid droplet-Associated protein, mediated VLDL lipidation and maturation by interacting with Apolipoprotein B.
A Feed-forward Loop Amplifies Nutritional Regulation of PNPLA3.
New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)（综述）
Long non-coding RNA Bhmt-AS attenuates hepatic gluconeogenesis via modulation of Bhmt expression
The Patatin-Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection
教材专著:
科研成果:
目前承担的科研项目:
PNPLA7调节脂滴形成以及脂代谢的分子机制
代谢性炎症在NAFLD和高脂血症发病中的作用(973)
PNPLA7调节脂滴形成以及脂代谢的分子机制
PNPLA7蛋白调控肝脏脂肪代谢和非酒精性脂肪肝病的作用和分子机制研究
孕期、哺乳期营养成分影响子代肥胖发生的机制
长链非编码RNA Gm26584 调控肝脏胆固醇代谢的作用及机制研究
脂代谢紊乱疾病的转化医学研究
脂滴及互助细胞器的新型蛋白质机器与脂质稳态调控
：PNPLA7调控脂肪细胞线粒体自噬在脂肪-肝脏代谢交流中的 作用及机制
已经完成的科研项目:
PNPLA7调节脂滴形成以及脂代谢的分子机制
