学术学位博导
--> 职称：教授
单位：人体解剖学系
dsmiao@njmu.edu.cn
专业：人体解剖与组织胚胎学（人解）
个人简介
发表论文:
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotension system in 1α-hydroxylase knockout mice
Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration
Parathyroid Hormone Contributes to Regulating Milk Calcium Content and Modulates Neonatal Bone Formation Cooperatively with Calcium
Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null allel
Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein
Early lethality in Hyp mice with targeted deletion of Pth gene
Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice
Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development
Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34
Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis
教材专著:
Molecular Biology of the Parathyroid
Alkaline phosphatase
Novel approaches to treatment of osteoporosis
科研成果:
骨增量牙种植技术在复杂颌骨缺损功能重建中的应用
一种钙磷合剂及其应用
钙调激素在调节骨骼和骨外健康中的作用和机制研究
吡咯喹啉醌在制备防治骨质疏松症产品中的应用
目前承担的科研项目:
Bmi1和其它表观遗传学调节分子在介导甲状旁腺素相关肽抗衰老中的作用（30911120486）
甲状旁腺素相关肽核定位序列和C末端在抗衰老中的作用机制研究（30830103）
MSC自我更新与分化的信号调控机制
椎间盘细胞谱系来源及命运决定机制研究
1,25(OH)2D3和Bmi-1在骨骼发育和相关疾病中的作用和机制
两种表观遗传调节因子和活化分子的基因学研究
活性维生素D通过调节细胞衰老发挥抗衰老和抗肿瘤双重作用
Bmi-1在维持雄性生殖功能中的作用及机制研究
活性维生素D缺乏在骨质疏松发生中的作用及机制研究
表观遗传调节因子Brpf1在小鼠生长发育中的作用研究
已经完成的科研项目:
甲状旁腺素和钙在促进骨形成中的相互作用及机制研究
活性维生素D和钙在促进骨形成中的协同作用
甲状旁腺素相关肽85-139在抗衰老中作用机制研究
甲状旁腺素相关肽在抗衰老中的作用机制研究
