学术学位博导
--> 职称：教授
**
单位：校长办公室
ghu@njmu.edu.cn
专业：药理学
个人简介
发表论文:
AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells.
Opening of microglial K channels inhibits rotenone-induced neuroinflammation.
Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis.
Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation.
Aquaporin 4 knockout resists negative regulation of neural cell proliferation by cocaine in mouse hippocampus.
Iptakalim ameliorates MPP(+)-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoK(ATP) channels.
KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes.
Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation.
Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake.
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway.
教材专著:
科研成果:
亲代谢型谷氨酸受体和ATP敏感性钾通道与帕金森病的相关性研究
ATP敏感性钾通道与帕金森病的相关性研究
ATP敏感性钾通道与肺动脉高压的相关性及实验治疗学研究
靶向SUR2/Kir6.x防治肺动脉高压新途径的研究
目前承担的科研项目:
Kir6.1/K-ATP通道：帕金森病神经保护的新靶标
防治神经退行性疾病、自身免疫性疾病和恶性肿瘤新药的临床前药效学评价技术平台(国家科技重大专项课题,2009ZX09303-001)
膜通道与帕金森病的相关性研究（国家杰出青年科学基金30625038）
脑卒中神经损伤与神经保护机制的研究（国家973课题2009CB521906）
AD、PD防治新策略的应用基础研究（国家973课题2006CB5007006）
Iptakalim: A Potential Antipsychotic Drug with Novel Mechanisms(国际合作项目07R-1775)
已经完成的科研项目:
ATP敏感性钾通道开放剂IPT对帕金森病模型神经保护作用的细胞与分子机制研究(30572172)
ATP敏感性钾通道与帕金森病的相关性研究(05KJA31014)
