学术学位博导
--> 职称：教授
单位：药理学系
wangxr@njmu.edu.cn
专业：药理学
个人简介
发表论文:
Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancer.
Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth.
p70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinoma
Oncogenic miR-9 is a target of erlotinib in NSCLCs
Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression
AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression
Glibenclamide targets sulphonylurea receptor 1 to inhibit p70S6K activity and upregulate KLF4 expression to suppress non-small cell lung carcinoma
p70S6K promotes acquired resistance of erlotinib through induction of epithelial-mesenchymal transition in non-small cell lung carcinoma
教材专著:
药理学
科研成果:
国家发明专利
恶性肿瘤精准诊治新靶标筛选和临床应用
目前承担的科研项目:
Glibenclamide通过靶向SUR1-p70S6K调控细胞代谢酶表达抑制非小细胞肺癌作用机制的研究（81473241）
eIF4E在erlotinib耐药性中作用和机制的研究
IRS-1在头颈部鳞状上皮癌转移中作用和机制的研究
AEG-1磷酸化修饰在胃癌转移中作用机制的研究
已经完成的科研项目:
IRS-1在头颈部鳞状上皮癌转移中作用和机制的研究（81172004）
eIF4E在erlotinib耐药性中作用和机制的研究（81102458）
Glibenclamide通过靶向SUR1-p70S6K调控细胞代谢酶表达抑制非小细胞肺癌作用机制的研究
