学术学位博导
--> 职称：教授
**
单位：药理学系
lgsheng@njmu.edu.cn
专业：药理学
个人简介
1999.9-2003.7 中国药科大学 药学学士2003.9-2008.7 中国药科大学 药理学博士2008.10-2013.10 美国密西根大学 博士后2013.10-至今 南京医科大学 教授
发表论文:
NF-κ B–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL in mice
Intracellular lipid content is a key intrinsic determinant for hepatocyte viability and metabolic and inflammatory states in mice
LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL)
Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons
High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice
Sirt6 deletion in hepatocytes increases insulin sensitivity of female mice by enhancing ERα expression
Wogonin attenuates isoprenaline-induced myocardial hypertrophy in mice by suppressing the PI3K/Akt pathway
Microglial Trem2 induces synaptic impairment at early-stage and prevents amyloidosis at late-stage in APP/PS1 mice
教材专著:
科研成果:
目前承担的科研项目:
长链非编码RNA—SRA调控肝脏PPARγ转录活性，促进小鼠非酒精性脂肪肝发展的分子机制研究
脂代谢紊乱疾病的转化医学研究
已经完成的科研项目:
非酒精性脂肪肝发展的可能机制：NIK诱导肝脏PPARα的下调
NIK通过抑制肝脏PPARα同时激活SREBP-1，促进非酒精性脂肪肝的发展
