学术学位博导
--> 职称：教授
**
单位：药理学系
snli@njmu.edu.cn
专业：药理学
个人简介
围绕CF家族类小分子肽展开了一<<
发表论文:
Urocortin increased LPS-induced endothelial permeability by regulating the cadherin-catenin complex via corticotrophin-releasing hormone receptor 2.
Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice.
High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells.
Different effects of corticotropin-releasing factor and urocortin 2 on apoptosis of prostate cancer cells in vitro.
STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway.
NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer.
S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA 2 phosphorylation.
CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis.
Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells.
教材专著:
科研成果:
促肾上腺皮质激素释放因子家族肽在心脑血管疾病中的作用机制研究
目前承担的科研项目:
CRF家族肽-受体系统在周围血管炎症的性别差异中的作用及其机制研究(NSFC面上项目 81273510，)
大鼠高血压血管重构与新型血管活性因子Urocortin关系的研究
CRH & Urocortin与小鼠动脉粥样硬化形成及斑块破裂之间关系的研究
CRF家族肽Urocortin对肝癌新生血管生成的影响及其机制研究
各亚型CRF受体通过影响PLA2表达变化而影响肿瘤生长的研究
已经完成的科研项目:
CRH & Urocortin与小鼠动脉粥样硬化形成及斑块破裂之间关系的研究
大鼠高血压血管重构与新型血管活性因子Urocortin关系的研究
Urocortin对肝癌细胞移植瘤的影响
1)CRF家族肽-受体系统在周围血管炎症的性别差异中的作用及其机制研究
Urocortin 通过S1P-S1PR3-PLA2参与血管炎症及下游通路机制研究
CRF-CRFR1对小鼠脑血管通透性的影响及其机制研究
