郭小可，女，1987年9月出生，副教授，药物化学专业博士生导师。
2009年7月毕业于中国药科大学基础药学理科基地班专业获理学学士学位，2014年6月获理学博士学位，同年留校任教于药学院药物化学系。2015-2018年任主任助理。
主要研究方向为生物活性分子的设计与合成：表观遗传学相关修饰蛋白的小分子调控剂的设计、合成、作用机制及成药性研究。承担国家自然科学基金面上项目一项、青年基金一项，参与国家级项目多项，申请或授权专利6项。主讲《药物化学》、《新药研发与评价》等课程，多次获得省级和国家级教学奖。
代表性论文：
Wei-Lin Chen, Dong-Dong Li, Xin Chen, Ying-Zhe Wang, Jun-Jie Xu, Zheng-Yu Jiang*, Qi-Dong You*, Xiao-Ke Guo*, Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction, Eur. J. Med. Chem., 2020, 188, 112027.
Jing Gu, Jun Xu, Qi-Dong You*, Xiao-Ke Guo*, Recent developments of small molecules targeting RNA m⁶A modulators, Eur. J. Med. Chem., 2020, 196, 112325.
Zhi-Hui Wang, Dong-Dong Li, Wei-Lin Chen, Qi-Dong You*, Xiao-Ke Guo*, Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy, Bioorg. Med. Chem., 2018, 26, 356–365.
Wei-Lin Chen, Dong-Dong Li, Zhi-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Zheng-Yu Jiang, Xiao-Ke Guo*, Qi-Dong You*, Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5, Bioorg. Chem., 2017, 76, 380-385.
Wei-Lin Chen, Hao-Peng Sun, Dong-Dong Li, Zhi-Hui Wang, Qi-Dong You* , Xiao-Ke Guo*, G9a - An Appealing Antineoplastic Target, Curr. Cancer Drug Tar., 2017, 17, 1-14.
Dong-Dong Li, Wei-Lin Chen, Zhi-Hui Wang, Yi-Yue Xie, Xiao-Li Xu, Zheng-Yu Jiang, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity, Eur. J. Med. Chem., 2016, 124, 480-489.
Dong-Dong Li, Zhi-Hui Wang, Wei-Lin Chen, Yi-Yue Xie, Qi-Dong You*, Xiao-Ke Guo*, Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction, Bioorg. Med. Chem., 2016, 24, 6109-6118.
Wei-Lin Chen, Zhi-Hui Wang, Tao-Tao Feng, Dong-Dong Li, Chu-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification, Bioorg. Med. Chem., 2016, 24, 6102-6108
Xiao-Ke Guo, Wei-Lin Chen, Hao-Peng Sun*, Qi-Dong You*, Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity, Curr. Top. Med. Chem., 2016, 16, 1843-1854.
Tao-Tao Feng, Dong-Dong Li, Hai Wang, Jian Zhuang, Fang Liu, Qichao Bao, Yonghua Lei, Wei-Lin Chen, Xiao-Jin Zhan, Xiao-Li Xu, Hao-Peng Sun, Qi-Dong You*, Xiao-Ke Guo*, Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline, Eur. J. Med. Chem., 2015, 105, 145-155.
联系方式：
江宁校区新学院大楼525实验室
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